Autore	Levitan Irena
Pubbl/distr/stampa	Hoboken, : Wiley, 2012
Descrizione fisica	1 online resource (324 p.)
Disciplina	572.5795 612.1/2 612.12
Altri autori (Persone)	BarrantesFrancisco
Soggetto topico	Cholesterol - metabolism Cholesterol -- metabolism Ion Channels - metabolism Ion Channels -- metabolism Membrane Proteins - metabolism Membrane Proteins -- metabolism Cholesterol - Metabolism Ion channels - Metabolism Membrane proteins - Metabolism Proteins Membrane Glycoproteins Sterols Membrane Transport Proteins Metabolic Phenomena Cholestenes Amino Acids, Peptides, and Proteins Carrier Proteins Cholestanes Membrane Lipids Lipids Steroids Drugs Polycyclic Compounds Cholesterol Ion Channels Metabolism Membrane Proteins Human Anatomy & Physiology Health & Biological Sciences Animal Biochemistry
ISBN	1-280-87984-X 9786613721150 1-118-34230-5 1-118-34231-3 1-118-34228-3
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	CHOLESTEROL REGULATION OF ION CHANNELS AND RECEPTORS; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES; 1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.1 CHOLESTEROL-AN ESSENTIAL LIPID FOR NORMAL CELL FUNCTION; 1.2 CHOLESTEROL METABOLISM, SENSING, AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.3 HOW DOES CHOLESTEROL ENTER MAMMALIAN CELLS?; 1.4 VESICULAR CHOLESTEROL TRAFFICKING ALONG THE ENDOCYTIC AND SECRETORY PATHWAY; 1.5 NONVESICULAR CHOLESTEROL TRANSPORT; 1.6 CHOLESTEROL EFFLUX FROM CELLS; REFERENCES 2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES-AN ENERGETIC PERSPECTIVE2.1 INTRODUCTION; 2.2 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS: POSSIBLE MECHANISMS; 2.3 PROTEIN REGULATION BY CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.4 CHOLESTEROL-INDUCED CHANGES IN DGIII bilayer - QUANTITATIVE ESTIMATES; 2.5 METHODS FOR IDENTIFYING PROTEIN REGULATION BY CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.6 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS IN LIVING CELLS 2.7 PHYSIOLOGICAL ROLE OF CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES2.8 CONCLUSION; REFERENCES; II CHOLESTEROL REGULATION OF ION CHANNELS; 3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS; 3.1 INTRODUCTION; 3.2 CHOLESTEROL SUPPRESSES Kir2 ACTIVITY IN VITRO AND IN VIVO; 3.3 EVIDENCE FOR SPECIFIC STEROL-PROTEIN INTERACTIONS IN THE REGULATION OF Kir CHANNELS; 3.4 STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF Kir2 CHANNELS; 3.5 PHYSIOLOGICAL IMPACT OF CHOLESTEROL-INDUCED SUPPRESSION OF KIR2 CHANNELS 3.6 CONCLUDING REMARKS AND FUTURE DIRECTIONSACKNOWLEDGMENTS; REFERENCES; 4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS; 4.1 INTRODUCTION; 4.2 MOLECULAR COMPONENTS OF SOCE; 4.3 LIPID RAFT DOMAINS AND CAVEOLAE; 4.4 THE ROLE OF LIPID RAFT DOMAINS IN THE REGULATION OF TRPC1; 4.5 MOLECULAR COMPLEXITY IN THE REGULATION OF SOCE; 4.6 CONCLUSIONS; REFERENCES; 5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS; 5.1 INTRODUCTION; 5.2 EFFECT OF CHOLESTEROL ON CARDIAC EXCITABILITY; 5.3 MECHANISMS OF CHOLESTEROL EFFECTS ON ION CHANNELS 5.4 CHOLESTEROL AS A TARGET FOR THERAPEUTIC AGENTSREFERENCES; 6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS; 6.1 BK CHANNELS AND STEROIDS; 6.2 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM; 7.1 POTASSIUM CHANNELS IN THE IMMUNE SYSTEM; 7.2 REGULATION OF POTASSIUM CHANNELS BY MEMBRANE CHOLESTEROL AND LIPID RAFT MICRODOMAINS; 7.3 LOCALIZATION OF MAJOR VOLTAGE-DEPENDENT Kv1.3 AND Kv1.5 CHANNELS IN CHOLESTEROL-RICH MEMBRANE MICRODOMAINS IN LEUKOCYTES 7.4 MECHANISMS OF ION CHANNEL REGULATION: THE IMMUNOLOGICAL SYNAPSE
Record Nr.	UNINA-9910141264403321

Autore	Levitan Irena
Edizione	[1st ed.]
Pubbl/distr/stampa	Hoboken, : Wiley, 2012
Descrizione fisica	1 online resource (324 p.)
Disciplina	572.5795 612.1/2 612.12
Altri autori (Persone)	BarrantesFrancisco
Soggetto topico	Cholesterol - metabolism Cholesterol -- metabolism Ion Channels - metabolism Ion Channels -- metabolism Membrane Proteins - metabolism Membrane Proteins -- metabolism Cholesterol - Metabolism Ion channels - Metabolism Membrane proteins - Metabolism Proteins Membrane Glycoproteins Sterols Membrane Transport Proteins Metabolism Cholestenes Amino Acids, Peptides, and Proteins Carrier Proteins Cholestanes Membrane Lipids Lipids Steroids Pharmaceutical Preparations Polycyclic Compounds Cholesterol Ion Channels Membrane Proteins Human Anatomy & Physiology Health & Biological Sciences Animal Biochemistry
ISBN	9786613721150 9781280879845 128087984X 9781118342305 1118342305 9781118342312 1118342313 9781118342282 1118342283
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	CHOLESTEROL REGULATION OF ION CHANNELS AND RECEPTORS; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES; 1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.1 CHOLESTEROL-AN ESSENTIAL LIPID FOR NORMAL CELL FUNCTION; 1.2 CHOLESTEROL METABOLISM, SENSING, AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES; 1.3 HOW DOES CHOLESTEROL ENTER MAMMALIAN CELLS?; 1.4 VESICULAR CHOLESTEROL TRAFFICKING ALONG THE ENDOCYTIC AND SECRETORY PATHWAY; 1.5 NONVESICULAR CHOLESTEROL TRANSPORT; 1.6 CHOLESTEROL EFFLUX FROM CELLS; REFERENCES 2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES-AN ENERGETIC PERSPECTIVE2.1 INTRODUCTION; 2.2 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS: POSSIBLE MECHANISMS; 2.3 PROTEIN REGULATION BY CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.4 CHOLESTEROL-INDUCED CHANGES IN DGIII bilayer - QUANTITATIVE ESTIMATES; 2.5 METHODS FOR IDENTIFYING PROTEIN REGULATION BY CHANGES IN BILAYER PHYSICAL PROPERTIES; 2.6 CHOLESTEROL REGULATION OF MEMBRANE PROTEINS IN LIVING CELLS 2.7 PHYSIOLOGICAL ROLE OF CHOLESTEROL-INDUCED CHANGES IN BILAYER PHYSICAL PROPERTIES2.8 CONCLUSION; REFERENCES; II CHOLESTEROL REGULATION OF ION CHANNELS; 3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS; 3.1 INTRODUCTION; 3.2 CHOLESTEROL SUPPRESSES Kir2 ACTIVITY IN VITRO AND IN VIVO; 3.3 EVIDENCE FOR SPECIFIC STEROL-PROTEIN INTERACTIONS IN THE REGULATION OF Kir CHANNELS; 3.4 STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF Kir2 CHANNELS; 3.5 PHYSIOLOGICAL IMPACT OF CHOLESTEROL-INDUCED SUPPRESSION OF KIR2 CHANNELS 3.6 CONCLUDING REMARKS AND FUTURE DIRECTIONSACKNOWLEDGMENTS; REFERENCES; 4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS; 4.1 INTRODUCTION; 4.2 MOLECULAR COMPONENTS OF SOCE; 4.3 LIPID RAFT DOMAINS AND CAVEOLAE; 4.4 THE ROLE OF LIPID RAFT DOMAINS IN THE REGULATION OF TRPC1; 4.5 MOLECULAR COMPLEXITY IN THE REGULATION OF SOCE; 4.6 CONCLUSIONS; REFERENCES; 5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS; 5.1 INTRODUCTION; 5.2 EFFECT OF CHOLESTEROL ON CARDIAC EXCITABILITY; 5.3 MECHANISMS OF CHOLESTEROL EFFECTS ON ION CHANNELS 5.4 CHOLESTEROL AS A TARGET FOR THERAPEUTIC AGENTSREFERENCES; 6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS; 6.1 BK CHANNELS AND STEROIDS; 6.2 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM; 7.1 POTASSIUM CHANNELS IN THE IMMUNE SYSTEM; 7.2 REGULATION OF POTASSIUM CHANNELS BY MEMBRANE CHOLESTEROL AND LIPID RAFT MICRODOMAINS; 7.3 LOCALIZATION OF MAJOR VOLTAGE-DEPENDENT Kv1.3 AND Kv1.5 CHANNELS IN CHOLESTEROL-RICH MEMBRANE MICRODOMAINS IN LEUKOCYTES 7.4 MECHANISMS OF ION CHANNEL REGULATION: THE IMMUNOLOGICAL SYNAPSE
Record Nr.	UNINA-9910823465003321

Pubbl/distr/stampa	[Place of publication not identified], : Wiley VCH, 2001
Descrizione fisica	1 online resource (371 pages)
Disciplina	660.6
Soggetto topico	Microbial biotechnology Microbial metabolites Anti-Bacterial Agents Biological Transport Membrane Transport Proteins Metabolism Anti-Infective Agents Membrane Proteins Carrier Proteins Therapeutic Uses Proteins Metabolic Phenomena Amino Acids, Peptides, and Proteins Pharmacologic Actions Phenomena and Processes Chemical Actions and Uses Chemicals and Drugs Bioengineering Mechanical Engineering Engineering & Applied Sciences
Soggetto genere / forma	Electronic books.
ISBN	1-280-56093-2 9786610560936 3-527-60272-0
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-9910146238803321

Autore	Lauffenburger Douglas A
Pubbl/distr/stampa	New York, : Oxford University Press, 1996
Descrizione fisica	1 online resource (376 p.)
Disciplina	574.876
Altri autori (Persone)	LindermanJennifer
Soggetto topico	Cell physiology Cell receptors Cellular signal transduction Investigative Techniques Membrane Proteins Biochemical Processes Cell Physiological Processes Signal Transduction Receptors, Cell Surface Models, Theoretical Chemical Processes Cell Physiological Phenomena Biochemical Phenomena Proteins Chemical Phenomena Amino Acids, Peptides, and Proteins Human Anatomy & Physiology Animal Biochemistry Health & Biological Sciences
Soggetto genere / forma	Electronic books.
ISBN	1-280-52892-3 0-19-802294-8
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Contents; 1. Introduction; 2. Cell Surface Receptor/Ligand Binding Fundamentals; 3 Receptor/Ligand Trafficking; 4. Physical Aspects of Receptor/Ligand Binding and Trafficking Processes; 5 Signal Transduction; 6 Receptor-Mediated Cell Behavioral Responses; 7. Future Directions; Index
Record Nr.	UNINA-9910454072503321

Edizione	[1st ed.]
Pubbl/distr/stampa	[Place of publication not identified], : Karger, 1993
Descrizione fisica	1 online resource (X + 168 pages) : : 18 figures, 6 in color, 12 tables
Collana	Issn Series
Soggetto topico	env Gene Products, Human Immunodeficiency Virus Antigens HIV HIV Antigens Deltaretrovirus Antibodies Viral Fusion Proteins Gene Products, env Human Immunodeficiency Virus Proteins Lentiviruses, Primate Antigens, Viral Membrane Fusion Proteins Biological Factors Viral Envelope Proteins Antibodies, Viral Retroviridae Proteins Membrane Proteins Viral Structural Proteins Lentivirus Chemicals and Drugs Antibodies Retroviridae Viral Proteins Immunoglobulins Proteins RNA Viruses Immunoproteins Amino Acids, Peptides, and Proteins Serum Globulins Globulins Vertebrate Viruses Blood Proteins Viruses Organisms Epitopes HIV Envelope Protein gp120 HIV Envelope Protein gp41 HIV Antibodies HIV-1
ISBN	9783318017526 3318017523
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-9910155289103321