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Current issues in ligand-binding assay bioanalysis / / editors, Lindsay King, Priya Sriraman
| Current issues in ligand-binding assay bioanalysis / / editors, Lindsay King, Priya Sriraman |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd., , 2016 |
| Descrizione fisica | 1 online resource (186 pages) |
| Disciplina | 572.33 |
| Soggetto topico | Ligand binding (Biochemistry) |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-910420-20-4
1-910420-19-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910467795403321 |
| London, England : , : Future Science Ltd., , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Current issues in ligand-binding assay bioanalysis / / editors, Lindsay King, Priya Sriraman
| Current issues in ligand-binding assay bioanalysis / / editors, Lindsay King, Priya Sriraman |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd., , 2016 |
| Descrizione fisica | 1 online resource (186 pages) |
| Disciplina | 572.33 |
| Soggetto topico | Ligand binding (Biochemistry) |
| ISBN |
1-910420-20-4
1-910420-19-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910794851803321 |
| London, England : , : Future Science Ltd., , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Current issues in ligand-binding assay bioanalysis / / editors, Lindsay King, Priya Sriraman
| Current issues in ligand-binding assay bioanalysis / / editors, Lindsay King, Priya Sriraman |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd., , 2016 |
| Descrizione fisica | 1 online resource (186 pages) |
| Disciplina | 572.33 |
| Soggetto topico | Ligand binding (Biochemistry) |
| ISBN |
1-910420-20-4
1-910420-19-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910808161903321 |
| London, England : , : Future Science Ltd., , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology
| Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology |
| Pubbl/distr/stampa | Chichester ; ; New York, : Wiley, 1991 |
| Descrizione fisica | 1 online resource (290 p.) |
| Disciplina |
574.19
574.19245 574.88 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Ligand binding (Biochemistry)
Drugs - Design Protein engineering Protein binding |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-34771-3
9786612347719 0-470-51408-6 0-470-51409-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
HOST-GUEST MOLECULAR INTERACTIONS: FROM CHEMISTRY TO BIOLOGY; Contents; Introduction; Molecular self-assembly processes; Self-assembly in supramolecular systems; General discussion I : Flexibility or rigidity?; Host-guest interactions in thin membranes: selective ion transport and transduction into electronic signals; Molecular recognition and molecular sensors; The natural design of vancomycin family antibiotics to bind to their target peptides; General discussion II : Crystals as supramolecules; Molecular devices and sensors; Clefts as receptor and enzyme analogues; Enzyme mimics
Binding of antibiotics to DNADesign of sequence-specific bifunctional nucleic acid ligands; Synthesis and biochemical studies of dithioate DNA; Conformational flexibility and protein specificity; Protein design: template-assembled synthetic proteins; General discussion III Transition state theory and energy requirements for reaction; Binding of peptides to proteins: an exercise in molecular design; Involvement of water in host-guest interactions; Molecular modelling approaches to host-guest complexes; Summing-up; Index of contributors; Subject index |
| Record Nr. | UNINA-9910144297703321 |
| Chichester ; ; New York, : Wiley, 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology
| Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology |
| Pubbl/distr/stampa | Chichester ; ; New York, : Wiley, 1991 |
| Descrizione fisica | 1 online resource (290 p.) |
| Disciplina |
574.19
574.19245 574.88 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Ligand binding (Biochemistry)
Drugs - Design Protein engineering Protein binding |
| ISBN |
1-282-34771-3
9786612347719 0-470-51408-6 0-470-51409-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
HOST-GUEST MOLECULAR INTERACTIONS: FROM CHEMISTRY TO BIOLOGY; Contents; Introduction; Molecular self-assembly processes; Self-assembly in supramolecular systems; General discussion I : Flexibility or rigidity?; Host-guest interactions in thin membranes: selective ion transport and transduction into electronic signals; Molecular recognition and molecular sensors; The natural design of vancomycin family antibiotics to bind to their target peptides; General discussion II : Crystals as supramolecules; Molecular devices and sensors; Clefts as receptor and enzyme analogues; Enzyme mimics
Binding of antibiotics to DNADesign of sequence-specific bifunctional nucleic acid ligands; Synthesis and biochemical studies of dithioate DNA; Conformational flexibility and protein specificity; Protein design: template-assembled synthetic proteins; General discussion III Transition state theory and energy requirements for reaction; Binding of peptides to proteins: an exercise in molecular design; Involvement of water in host-guest interactions; Molecular modelling approaches to host-guest complexes; Summing-up; Index of contributors; Subject index |
| Record Nr. | UNINA-9910830060703321 |
| Chichester ; ; New York, : Wiley, 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology
| Host-guest molecular interactions [[electronic resource] ] : from chemistry to biology |
| Pubbl/distr/stampa | Chichester ; ; New York, : Wiley, 1991 |
| Descrizione fisica | 1 online resource (290 p.) |
| Disciplina |
574.19
574.19245 574.88 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Ligand binding (Biochemistry)
Drugs - Design Protein engineering Protein binding |
| ISBN |
1-282-34771-3
9786612347719 0-470-51408-6 0-470-51409-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
HOST-GUEST MOLECULAR INTERACTIONS: FROM CHEMISTRY TO BIOLOGY; Contents; Introduction; Molecular self-assembly processes; Self-assembly in supramolecular systems; General discussion I : Flexibility or rigidity?; Host-guest interactions in thin membranes: selective ion transport and transduction into electronic signals; Molecular recognition and molecular sensors; The natural design of vancomycin family antibiotics to bind to their target peptides; General discussion II : Crystals as supramolecules; Molecular devices and sensors; Clefts as receptor and enzyme analogues; Enzyme mimics
Binding of antibiotics to DNADesign of sequence-specific bifunctional nucleic acid ligands; Synthesis and biochemical studies of dithioate DNA; Conformational flexibility and protein specificity; Protein design: template-assembled synthetic proteins; General discussion III Transition state theory and energy requirements for reaction; Binding of peptides to proteins: an exercise in molecular design; Involvement of water in host-guest interactions; Molecular modelling approaches to host-guest complexes; Summing-up; Index of contributors; Subject index |
| Record Nr. | UNINA-9910841886103321 |
| Chichester ; ; New York, : Wiley, 1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ligand / / edited by Chandraleka Saravanan, Bhaskar Biswas
| Ligand / / edited by Chandraleka Saravanan, Bhaskar Biswas |
| Pubbl/distr/stampa | London, England : , : IntechOpen, , [2018] |
| Descrizione fisica | 1 online resource (120 pages) |
| Disciplina | 572.33 |
| Soggetto topico | Ligand binding (Biochemistry) |
| ISBN |
1-83881-319-5
1-78923-183-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910317818303321 |
| London, England : , : IntechOpen, , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others]
| Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others] |
| Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (493 p.) |
| Disciplina | 612/.01524 |
| Soggetto topico |
DNA-drug interactions
Ligand binding (Biochemistry) Drugs - Design Pharmaceutical chemistry |
| ISBN |
1-118-69789-8
1-118-69719-7 1-118-69791-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; About the Editor; List of Contributors; Chapter 1 Introduction to Ligand Design in Medicinal Inorganic Chemistry; References; Chapter 2 Platinum-Based Anticancer Agents; 2.1 Introduction; 2.2 The advent of platinum-based anticancer agents; 2.3 Strategies for overcoming the limitations of cisplatin; 2.4 The influence of ligands on the physicochemical properties of platinum anticancer complexes; 2.4.1 Lipophilicity; 2.4.2 Reactivity; 2.4.3 Rate of reduction; 2.5 Ligands for enhancing the anticancer activity of platinum complexes
2.5.1 Ligands for improving DNA affinity2.5.2 Ligands for inhibiting enzymes; 2.6 Ligands for enhancing the tumour selectivity of platinum complexes; 2.6.1 Ligands for targeting transporters; 2.6.2 Ligands for targeting receptors; 2.6.3 Ligands for targeting the EPR effect; 2.6.4 Ligands for targeting bone cancer; 2.7 Ligands for photoactivatable platinum complexes; 2.8 Conclusions; References; Chapter 3 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals; 3.1 Introduction; 3.1.1 Metals in nuclear medicine 3.1.2 The importance of coordination chemistry3.1.3 Overview; 3.2 General metal based radiopharmaceutical design; 3.2.1 Choice of radionuclide; 3.2.2 Production of the radiometal starting materials; 3.2.3 Ligand and chelate design consideration; 3.3 Survey of the coordination chemistry of radiometals applicable to nuclear medicine; 3.3.1 Technetium; 3.3.2 Rhenium; 3.3.3 Gallium; 3.3.4 Indium; 3.3.5 Yttrium and lanthanides; 3.3.6 Copper; 3.3.7 Zirconium; 3.3.8 Scandium; 3.3.9 Cobalt; 3.4 Conclusions; References; Chapter 4 Ligand Design in d-Block Optical Imaging Agents and Sensors 4.1 Summary and scope4.2 Introduction; 4.2.1 Criteria for biological imaging optical probes; 4.3 Overview of transition-metal optical probes in biomedicinal applications; 4.3.1 Common families of transition metal probes; 4.4 Ligand design for controlling photophysics; 4.4.1 Photophysical processes in transition metal optical imaging agents and sensors; 4.4.2 Photophysically active ligand families-tuning electronic levels; 4.4.3 Ligands which control photophysics through indirect effects; 4.4.4 Transition metal optical probes with carbonyl ligands; 4.5 Ligand design for controlling stability 4.6 Ligand design for controlling transport and localisation4.6.1 Passive diffusion; 4.6.2 Active transport; 4.7 Ligand design for controlling distribution; 4.7.1 Mitochondrial-targeting probes; 4.7.2 Nuclear-targeting probes; 4.7.3 Bioconjugation; 4.8 Selected examples of ligand design for important individual probes; 4.8.1 A pH-sensitive ligand to control Ir luminescence; 4.8.2 Dimeric NHC ligands for gold cyclophanes; 4.9 Transition metal probes incorporating or capable of more than one imaging mode; 4.9.1 Bimodal MRI/optical probes; 4.9.2 Bimodal radio/optical probes 4.9.3 Bimodal IR/optical probes |
| Record Nr. | UNINA-9910132205303321 |
| Chichester, England : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others]
| Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others] |
| Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (493 p.) |
| Disciplina | 612/.01524 |
| Soggetto topico |
DNA-drug interactions
Ligand binding (Biochemistry) Drugs - Design Pharmaceutical chemistry |
| ISBN |
1-118-69789-8
1-118-69719-7 1-118-69791-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; About the Editor; List of Contributors; Chapter 1 Introduction to Ligand Design in Medicinal Inorganic Chemistry; References; Chapter 2 Platinum-Based Anticancer Agents; 2.1 Introduction; 2.2 The advent of platinum-based anticancer agents; 2.3 Strategies for overcoming the limitations of cisplatin; 2.4 The influence of ligands on the physicochemical properties of platinum anticancer complexes; 2.4.1 Lipophilicity; 2.4.2 Reactivity; 2.4.3 Rate of reduction; 2.5 Ligands for enhancing the anticancer activity of platinum complexes
2.5.1 Ligands for improving DNA affinity2.5.2 Ligands for inhibiting enzymes; 2.6 Ligands for enhancing the tumour selectivity of platinum complexes; 2.6.1 Ligands for targeting transporters; 2.6.2 Ligands for targeting receptors; 2.6.3 Ligands for targeting the EPR effect; 2.6.4 Ligands for targeting bone cancer; 2.7 Ligands for photoactivatable platinum complexes; 2.8 Conclusions; References; Chapter 3 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals; 3.1 Introduction; 3.1.1 Metals in nuclear medicine 3.1.2 The importance of coordination chemistry3.1.3 Overview; 3.2 General metal based radiopharmaceutical design; 3.2.1 Choice of radionuclide; 3.2.2 Production of the radiometal starting materials; 3.2.3 Ligand and chelate design consideration; 3.3 Survey of the coordination chemistry of radiometals applicable to nuclear medicine; 3.3.1 Technetium; 3.3.2 Rhenium; 3.3.3 Gallium; 3.3.4 Indium; 3.3.5 Yttrium and lanthanides; 3.3.6 Copper; 3.3.7 Zirconium; 3.3.8 Scandium; 3.3.9 Cobalt; 3.4 Conclusions; References; Chapter 4 Ligand Design in d-Block Optical Imaging Agents and Sensors 4.1 Summary and scope4.2 Introduction; 4.2.1 Criteria for biological imaging optical probes; 4.3 Overview of transition-metal optical probes in biomedicinal applications; 4.3.1 Common families of transition metal probes; 4.4 Ligand design for controlling photophysics; 4.4.1 Photophysical processes in transition metal optical imaging agents and sensors; 4.4.2 Photophysically active ligand families-tuning electronic levels; 4.4.3 Ligands which control photophysics through indirect effects; 4.4.4 Transition metal optical probes with carbonyl ligands; 4.5 Ligand design for controlling stability 4.6 Ligand design for controlling transport and localisation4.6.1 Passive diffusion; 4.6.2 Active transport; 4.7 Ligand design for controlling distribution; 4.7.1 Mitochondrial-targeting probes; 4.7.2 Nuclear-targeting probes; 4.7.3 Bioconjugation; 4.8 Selected examples of ligand design for important individual probes; 4.8.1 A pH-sensitive ligand to control Ir luminescence; 4.8.2 Dimeric NHC ligands for gold cyclophanes; 4.9 Transition metal probes incorporating or capable of more than one imaging mode; 4.9.1 Bimodal MRI/optical probes; 4.9.2 Bimodal radio/optical probes 4.9.3 Bimodal IR/optical probes |
| Record Nr. | UNINA-9910816425603321 |
| Chichester, England : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Protein-ligand interactions [[electronic resource] /] / edited by Holger Gohlke
| Protein-ligand interactions [[electronic resource] /] / edited by Holger Gohlke |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, 2012 |
| Descrizione fisica | 1 online resource (361 p.) |
| Disciplina |
572.6
572/.6 615.19 |
| Altri autori (Persone) | GohlkeHolger |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Proteins
Ligands (Biochemistry) Ligand binding (Biochemistry) Drugs - Structure-activity relationships Carrier proteins Ligands Proteins - pharmacokinetics Chemistry Techniques, Analytical - methods Carrier Proteins |
| ISBN |
3-527-64596-9
1-280-66289-1 9786613639820 3-527-64594-2 3-527-64597-7 |
| Classificazione |
CHE 802f
CHE 820f CHE 825f 540 570 610 WD 5100 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Binding thermodynamics -- pt. 2. Learning from biophysical experiments -- pt. 3. Modeling protein-ligand interactions -- pt. 4. Challenges in molecular recognition. |
| Record Nr. | UNINA-9910141446103321 |
| Weinheim, : Wiley-VCH, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
