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Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor
| Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 611/.0187 |
| Altri autori (Persone) | SchulzMegan A |
| Collana | Cell biology research progress |
| Soggetto topico |
Epithelial cells
Monomolecular films Intestinal absorption |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-62081-613-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910465754103321 |
| Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor
| Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 611/.0187 |
| Altri autori (Persone) | SchulzMegan A |
| Collana | Cell biology research progress |
| Soggetto topico |
Epithelial cells
Monomolecular films Intestinal absorption |
| ISBN | 1-62081-613-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910791742703321 |
| Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor
| Caco-2 cells and their uses [[electronic resource] /] / Megan A. Schulz, editor |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 611/.0187 |
| Altri autori (Persone) | SchulzMegan A |
| Collana | Cell biology research progress |
| Soggetto topico |
Epithelial cells
Monomolecular films Intestinal absorption |
| ISBN | 1-62081-613-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- CACO-2 CELLS AND THEIR USES -- CACO-2 CELLS AND THEIR USES -- Library of Congress Cataloging-in-Publication Data -- CONTENTS -- PREFACE -- Chapter 1 THE INDUSTRIAL AND ACADEMIC RATIONALE OF CACO-2 CELL MODELS TODAY -- ABSTRACT -- ABBREVIATIONS -- 1. INTRODUCTION -- 2. CACO-2 CELL ADVANTAGES, DRAWBACKS AND TRANSPORTER-ENZYME EXPRESSION PATTERNS -- 2.1. Applicability of CACO-2 Models to Predict the Fraction of Drug Absorbed in Humans -- 2.2. CACO-2 Transporters and Enzyme Expression and the Comparison with the In Vivo Human Expression -- 3. CACO-2 CELLS AS AN IN VITRO PROGNOSTIC TOOL FOR ASSESSING PHARMACOKINETIC DRUG-GARLIC INTERACTIONS -- 4. CACO-2 CELLS FOR THE EVALUATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS (SMEDDS) -- 4.1. Self-Microemulsifying Drug Delivery Systems:The Objectives and Advantages -- 4.2. Studies Performed to Evaluate SMEDDS Impact on Intestinal Absorption of Drugs -- 4.3. The Mechanism Responsible for Increased Absorption of Furosemide Incorporated in SMEDDS -- CONCLUSION -- REFERENCES -- Chapter 2 A CRITICAL PERSPECTIVE ON CELL LINES STUDIES IN NUTRITION: THE CASE OF INTESTINAL ABSORPTION -- ABSTRACT -- INTRODUCTION -- RESEARCH WITH CELL LINES -- CELL LINES IN INTESTINAL ABSORPTION STUDIES -- NON-HUMAN CELL LINES IN INTESTINAL ABSORPTION STUDIES -- IN VITRO CELL CULTURES AS AN ALTERNATIVE TO ANIMAL TESTING -- INTESTINAL CELL LINES AS AN IN VITRO MODEL OF CLINICAL VALUE -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3 CO-CULTURE SYSTEMS WITH CACO-2 CELLS TO EVALUATE THE BIOACTIVITY OF PLANT EXTRACTS -- ABSTRACT -- INTRODUCTION -- CO-CULTURE SYSTEMS USING CACO-2 CELLS: CELL VIABILITY AND FUNCTIONALITY -- WORKING WITH NATURAL EXTRACTS: CACO-2 AS A FILTER TO SIMULATE THE HUMAN INTESTINAL BARRIER -- WORKING WITH NATURAL EXTRACTS: ARE THESE FILTERED EXTRACTS BIOACTIVE? -- CONCLUSION.
ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4 THE USE OF CACO-2 CELLS IN THE STUDY OF INTESTINAL TRANSPORT -- ABSTRACT -- INTRODUCTION -- USES OF CACO-2 CELLS -- Paracellular Pathway -- Transcellular Pathway -- CONCLUSION -- REFERENCES -- Chapter 5 CACO-2 CELLS AS AN EXPERIMENTAL MODEL FOR THE STUDY OF CELL-MATRIX INTERACTIONS AND WOUND HEALING IN INTESTINAL VILLUS CELLS -- ABSTRACT -- INTRODUCTION -- CACO-2 CELLS AND CELL-MATRIX INTERACTIONS -- CACO-2 CELLS AND CELL-MATRIX INTERACTIONS IN CO-CULTURE -- CACO-2 CELLS IN CO-CULTURE: A WOUND HEALING MODEL -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 6 EFFECT OF POLYUNSATURATED FATTY ACIDS AND BILE SALTS ON BUTYRATE UPTAKE BY INTESTINAL EPITHELIAL CELLS -- ABSTRACT -- INTRODUCTION -- MATERIALS AND METHODS -- CACO-2 Cell Culture -- IEC-6 Cell Culture -- Determination of 14C-BT uptake by CACO-2 and IEC-6 Cells -- Treatment of the Cells with Compounds -- Determination of Cell Viability -- Protein Determination -- Calculation and Statistics -- Materials -- RESULTS -- Effect of Pufas and Bile Acids on 14C-BT Apical uptake by CACO-2 Cells -- Effect of Pufas and Bile Acids on 14C-BT Apical uptake by IEC-6 Cells -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 7 ANALYSIS OF BOTULINUM TOXIN: INTESTINAL EPITHELIAL BARRIER INTERACTION USING EPITHELIAL MONOLAYER CULTURE SYSTEMS -- ABSTRACT -- INTRODUCTION -- 1. TRANSCYTOSIS OF BONT ACROSS CULTURED INTESTINAL EPITHELIAL MONOLAYERS -- 2. ADHESION OF HA TO INTESTINAL EPITHELIAL CELLS -- 3. DISRUPTION OF THE INTERCELLULAR EPITHELIAL BARRIER BY HA -- 4. POSSIBLE MECHANISMS OF BONT COMPLEX TRANSPORT ACROSS THE INTESTINAL EPITHELIAL MONOLAYER -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 8 CACO-2 CELLS AND GENOTOXICITY STUDIES OF FOOD CONTAMINANTS -- ABSTRACT -- INTRODUCTION ON IN VITRO GENOTOXICITY TESTING. IN VITRO HUMAN INTESTINAL CELLS: PERTINENCE FOR GENOTOXICITY TESTING OF FOOD CONTAMINANTS -- USE OF CACO-2 CELLS IN GENOTOXICITY TESTS -- Comet Assay -- Others -- CYTOKINESIS-BLOCK MICRONUCLEUS ASSAY -- On Undifferentiated Cells -- On Differentiated Cells: Development and Application -- IMPROVEMENT OF THIS CELL MODEL TO PREDICT TOXICITY AND MECHANISTIC ENDPOINTS -- Co-Cultures CACO-2/TK6 -- Metabolism Regulation -- CONCLUSIONS -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 9 CACO-2 CELLS FOR STUDYING INTESTINAL ABSORPTION MECHANISMS: COMPARISON AND CORRELATIONS WITH RAT MODEL -- ABSTRACT -- INTRODUCTION: IN VITRO MODELS OF INTESTINAL PERMEATION -- ABSORPTION IN THE GASTROINTESTINAL TRACT: ROUTES OF PERMEATION ACROSS INTESTINAL CELLS. -- IN VITRO MODELS OF THE INTESTINAL BARRIER: CELL MODELS -- CACO-2 -- Other Cell Lines -- HT29 Cells -- CACO-2 CELLS FOR PREDICTING ORAL FRACTION ABSORBED: COMPARISON WITH HUMAN, RAT AND PAMPA MODELS -- CACO-2 CELLS FOR THE STUDY OF DRUG ABSORPTION MECHANISMS: MODELING APPROACHES FOR PARAMETER ESTIMATION -- Apparent Permeability Estimation (Sink versus Non Sink Conditions) -- Mathematical Modeling of CACO-2 Data for Parameter Estimation -- P versus C -- Amounts versus Time -- CORRELATION BETWEEN CACO-2 CELLS DATA AND IN SITU RAT DATA FOR THE STUDY OF P-GP MEDIATED SECRETION -- CONCLUSIONS -- REFERENCES -- Chapter 10 NANOCARRIER ABSORPTION STUDIES WITH CACO-2 CELLS -- ABSTRACT -- INTRODUCTION -- I. METHOD -- a. Absorption Study -- b. Mechanistic Studies -- II. RESULTS -- a. Absorption Study -- b. Mechanistics Study -- III. DISADVANTAGE/ LIMIT OF CACO-2 TO STUDY DRUG TRANSPORT / OTHER METHOD -- a. Parallel Artificial Membrane Permeation Assay (PAMPA) -- b. Alternative Cell Culture Models -- c. In Vivo or Ex Vivo Studies -- CONCLUSION -- ACKNOWLEDGMENT -- BIBLIOGRAPHY. Chapter 11 CACO-2 CELLS AS A MODEL TO STUDY THE INTESTINAL EFFECTS OF NON-ABSORBABLE PHYTOCHEMICALS -- ABSTRACT -- ABBREVIATIONS -- 1. INTRODUCTION -- 2. PROCYANIDINS:STRUCTURE AND METABOLISM -- 3. PROCYANIDINS AND THE HEALTH OF THE GASTROINTESTINAL TRACT -- 4. INTERACTIONS OF PROCYANIDINS WITH CACO-2 CELL MEMBRANES -- 5. PROCYANIDINS PROTECTCACO-2 CELLSFROM OXIDATION AND PERMEABILIZATION -- 6. PROCYANIDINS PROTECTCACO-2 CELLS FROM INFLAMMATION -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- INDEX. |
| Record Nr. | UNINA-9910822031303321 |
| Hauppauge, N.Y., : Nova Science Publishers, Inc., c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Development of mammalian absorptive processes / / [editors, Katherine Elliott (organizer), Julie Whelan]
| Development of mammalian absorptive processes / / [editors, Katherine Elliott (organizer), Julie Whelan] |
| Pubbl/distr/stampa | Amsterdam ; ; New York : , : Excerpta Medica, , 1979 |
| Descrizione fisica | 1 online resource (352 pages) : illustrations, charts |
| Disciplina | 599/.01/32 |
| Altri autori (Persone) |
ElliottKatherine May
WhelanJulie |
| Collana | Ciba Foundation symposium (new series) |
| Soggetto topico |
Digestion
Intestinal absorption Mammals - Physiology |
| ISBN |
1-280-78388-5
9786613694270 0-470-72053-0 0-470-71821-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Development of Mammalian Absorptive Processes; Contents; Introduction; Morphogenesis of the small intestine during fetal development; Discussion; The differentiation and redifferentiation of the intestinal epithelium and its brush border membrane; Discussion; Cell surface components of intestinal epithelial cells and their relationship to cellular differentiation; Discussion; The role of lingual lipase in neonatal fat digestion; Discussion; Bile acid metabolism in the fetus and newborn; Discussion; Sucrase and cellular development; Discussion
Mode of insertion of the sucrase-isomaltase complex in the in testinal brush border membrane: implications for the biosynthe; Discussion; Development of sucrase activity: effect of maternal hormonal status and fetal programming of jejuno-ileal differences; Discussion; The role of enteropeptidase in the digestion of protein and its development in human fetal small intestine; Discussion; Absorption of di- and tripeptides by the intestine of the guinea-pig; Discussion; Gastrointestinal host defence: importance of gut closure in control of macromolecular transport; Discussion Membrane digestion and nutrient assimilation in early development; Discussion; Perinatal changes in the absorption of trace elements; Discussion; The influence of gestational age and size on the absorption of D-xylose and D-glucose from the small intestine of the human n; Discussion; Absorption of biological amines of bacterial origin in normal and sick infants; Discussion; The immature intestine: implications for nutrition of the neonate; Discussion; General Discussion; Future morphological studies; Hormonal mediation of gastrointestinal maturation; Sodium-dependent active transport; Nutritional needs of the premature infant; Lipid digestion in the newborn; Antigen uptake and immunity transfer; Index of contributors; Subject index |
| Record Nr. | UNISA-996206965403316 |
| Amsterdam ; ; New York : , : Excerpta Medica, , 1979 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Development of mammalian absorptive processes / / [editors, Katherine Elliott (organizer), Julie Whelan]
| Development of mammalian absorptive processes / / [editors, Katherine Elliott (organizer), Julie Whelan] |
| Pubbl/distr/stampa | Amsterdam ; ; New York : , : Excerpta Medica, , 1979 |
| Descrizione fisica | 1 online resource (352 pages) : illustrations, charts |
| Disciplina | 599/.01/32 |
| Altri autori (Persone) |
ElliottKatherine May
WhelanJulie |
| Collana | Ciba Foundation symposium (new series) |
| Soggetto topico |
Digestion
Intestinal absorption Mammals - Physiology |
| ISBN |
1-280-78388-5
9786613694270 0-470-72053-0 0-470-71821-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Development of Mammalian Absorptive Processes; Contents; Introduction; Morphogenesis of the small intestine during fetal development; Discussion; The differentiation and redifferentiation of the intestinal epithelium and its brush border membrane; Discussion; Cell surface components of intestinal epithelial cells and their relationship to cellular differentiation; Discussion; The role of lingual lipase in neonatal fat digestion; Discussion; Bile acid metabolism in the fetus and newborn; Discussion; Sucrase and cellular development; Discussion
Mode of insertion of the sucrase-isomaltase complex in the in testinal brush border membrane: implications for the biosynthe; Discussion; Development of sucrase activity: effect of maternal hormonal status and fetal programming of jejuno-ileal differences; Discussion; The role of enteropeptidase in the digestion of protein and its development in human fetal small intestine; Discussion; Absorption of di- and tripeptides by the intestine of the guinea-pig; Discussion; Gastrointestinal host defence: importance of gut closure in control of macromolecular transport; Discussion Membrane digestion and nutrient assimilation in early development; Discussion; Perinatal changes in the absorption of trace elements; Discussion; The influence of gestational age and size on the absorption of D-xylose and D-glucose from the small intestine of the human n; Discussion; Absorption of biological amines of bacterial origin in normal and sick infants; Discussion; The immature intestine: implications for nutrition of the neonate; Discussion; General Discussion; Future morphological studies; Hormonal mediation of gastrointestinal maturation; Sodium-dependent active transport; Nutritional needs of the premature infant; Lipid digestion in the newborn; Antigen uptake and immunity transfer; Index of contributors; Subject index |
| Record Nr. | UNINA-9910144657603321 |
| Amsterdam ; ; New York : , : Excerpta Medica, , 1979 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Development of mammalian absorptive processes / / [editors, Katherine Elliott (organizer), Julie Whelan]
| Development of mammalian absorptive processes / / [editors, Katherine Elliott (organizer), Julie Whelan] |
| Pubbl/distr/stampa | Amsterdam ; ; New York : , : Excerpta Medica, , 1979 |
| Descrizione fisica | 1 online resource (352 pages) : illustrations, charts |
| Disciplina | 599/.01/32 |
| Altri autori (Persone) |
ElliottKatherine May
WhelanJulie |
| Collana | Ciba Foundation symposium (new series) |
| Soggetto topico |
Digestion
Intestinal absorption Mammals - Physiology |
| ISBN |
1-280-78388-5
9786613694270 0-470-72053-0 0-470-71821-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Development of Mammalian Absorptive Processes; Contents; Introduction; Morphogenesis of the small intestine during fetal development; Discussion; The differentiation and redifferentiation of the intestinal epithelium and its brush border membrane; Discussion; Cell surface components of intestinal epithelial cells and their relationship to cellular differentiation; Discussion; The role of lingual lipase in neonatal fat digestion; Discussion; Bile acid metabolism in the fetus and newborn; Discussion; Sucrase and cellular development; Discussion
Mode of insertion of the sucrase-isomaltase complex in the in testinal brush border membrane: implications for the biosynthe; Discussion; Development of sucrase activity: effect of maternal hormonal status and fetal programming of jejuno-ileal differences; Discussion; The role of enteropeptidase in the digestion of protein and its development in human fetal small intestine; Discussion; Absorption of di- and tripeptides by the intestine of the guinea-pig; Discussion; Gastrointestinal host defence: importance of gut closure in control of macromolecular transport; Discussion Membrane digestion and nutrient assimilation in early development; Discussion; Perinatal changes in the absorption of trace elements; Discussion; The influence of gestational age and size on the absorption of D-xylose and D-glucose from the small intestine of the human n; Discussion; Absorption of biological amines of bacterial origin in normal and sick infants; Discussion; The immature intestine: implications for nutrition of the neonate; Discussion; General Discussion; Future morphological studies; Hormonal mediation of gastrointestinal maturation; Sodium-dependent active transport; Nutritional needs of the premature infant; Lipid digestion in the newborn; Antigen uptake and immunity transfer; Index of contributors; Subject index |
| Record Nr. | UNINA-9910827880803321 |
| Amsterdam ; ; New York : , : Excerpta Medica, , 1979 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Oral bioavailability [[electronic resource] ] : basic principles, advanced concepts, and applications / / edited by Ming Hu, Xiaoling Li
| Oral bioavailability [[electronic resource] ] : basic principles, advanced concepts, and applications / / edited by Ming Hu, Xiaoling Li |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2011 |
| Descrizione fisica | 1 online resource (570 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
HuMing, Ph. D.
LiXiaoling <1957-> |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Drugs - Bioavailability
Drug development Intestinal absorption |
| ISBN |
1-283-25776-9
9786613257765 1-118-06758-4 1-118-06759-2 1-118-06752-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ORAL BIOAVAILABILITY; CONTENTS; Foreword; Preface; Contributors; 1 Barriers to Oral Bioavailability-An Overview; 2 Physicochemical Characterization of Pharmaceutical Solids; 3 Solubility of Pharmaceutical Solids; 4 In Vitro Dissolution of Pharmaceutical Solids; 5 Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption; 6 Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways; 7 In Vitro-In Vivo Correlations of Pharmaceutical Dosage Forms; 8 Drug Metabolism in Gastrointestinal Tract
9 Efflux of Drugs via Transporters-The Antiabsorption Pathway 10 Liver Drug Metabolism; 11 Protein Binding of Drugs; 12 Urinary Excretion of Drugs and Drug Reabsorption; 13 Pharmacokinetic Behaviors of Orally Administered Drugs; 14 Effects of Food on Drug Absorption; 15 Drug-Drug Interactions and Drug-Dietary Chemical Interactions; 16 Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans; 17 Amino Acid Drug Transporters; 18 Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide-Based Pharmaceuticals 19 Organic Anion and Cation Drug Transporters 20 Gastric Retentive Drug Delivery Systems; 21 Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems; 22 Prodrug Strategies to Enhance Oral Drug Absorption; 23 Oral Delivery of Protein/Peptide Therapeutics; 24 ABC Transporters in Intestinal and Liver Efflux; 25 Interplay Between Efflux Transporters and Metabolic Enzymes; 26 Regulatory Considerations in Metabolism- and Transporter-Based Drug Interactions; 27 Caco-2 Cell Culture Model for Oral Drug Absorption; 28 MDCK Cells and Other Cell-Culture Models of Oral Drug Absorption 29 Intestinal Perfusion Methods for Oral Drug Absorptions 30 Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion; 31 In vivo Methods for Oral Bioavailability Studies; 32 Determination of Regulation of Drug-Metabolizing Enzymes and Transporters; 33 Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction; Index |
| Record Nr. | UNINA-9910139611803321 |
| Hoboken, NJ, : John Wiley & Sons, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Oral bioavailability : basic principles, advanced concepts, and applications / / edited by Ming Hu, Xiaoling Li
| Oral bioavailability : basic principles, advanced concepts, and applications / / edited by Ming Hu, Xiaoling Li |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2011 |
| Descrizione fisica | 1 online resource (570 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
HuMing, Ph. D.
LiXiaoling <1957-> |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Drugs - Bioavailability
Drug development Intestinal absorption |
| ISBN |
1-283-25776-9
9786613257765 1-118-06758-4 1-118-06759-2 1-118-06752-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ORAL BIOAVAILABILITY; CONTENTS; Foreword; Preface; Contributors; 1 Barriers to Oral Bioavailability-An Overview; 2 Physicochemical Characterization of Pharmaceutical Solids; 3 Solubility of Pharmaceutical Solids; 4 In Vitro Dissolution of Pharmaceutical Solids; 5 Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption; 6 Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways; 7 In Vitro-In Vivo Correlations of Pharmaceutical Dosage Forms; 8 Drug Metabolism in Gastrointestinal Tract
9 Efflux of Drugs via Transporters-The Antiabsorption Pathway 10 Liver Drug Metabolism; 11 Protein Binding of Drugs; 12 Urinary Excretion of Drugs and Drug Reabsorption; 13 Pharmacokinetic Behaviors of Orally Administered Drugs; 14 Effects of Food on Drug Absorption; 15 Drug-Drug Interactions and Drug-Dietary Chemical Interactions; 16 Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans; 17 Amino Acid Drug Transporters; 18 Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide-Based Pharmaceuticals 19 Organic Anion and Cation Drug Transporters 20 Gastric Retentive Drug Delivery Systems; 21 Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems; 22 Prodrug Strategies to Enhance Oral Drug Absorption; 23 Oral Delivery of Protein/Peptide Therapeutics; 24 ABC Transporters in Intestinal and Liver Efflux; 25 Interplay Between Efflux Transporters and Metabolic Enzymes; 26 Regulatory Considerations in Metabolism- and Transporter-Based Drug Interactions; 27 Caco-2 Cell Culture Model for Oral Drug Absorption; 28 MDCK Cells and Other Cell-Culture Models of Oral Drug Absorption 29 Intestinal Perfusion Methods for Oral Drug Absorptions 30 Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion; 31 In vivo Methods for Oral Bioavailability Studies; 32 Determination of Regulation of Drug-Metabolizing Enzymes and Transporters; 33 Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction; Index |
| Record Nr. | UNINA-9910808327803321 |
| Hoboken, NJ, : John Wiley & Sons, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptide transport and hydrolysis / / editors, Katherine Elliott, Maeve O'Connor
| Peptide transport and hydrolysis / / editors, Katherine Elliott, Maeve O'Connor |
| Pubbl/distr/stampa | Amsterdam ; ; New York : , : Elsevier/Excerpta Medica/North Holland, , 1977 |
| Descrizione fisica | 1 online resource (ix, 385 pages) : illustrations |
| Disciplina | 574.1/9256 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Peptides
Peptidase Biological transport Intestinal absorption |
| ISBN |
0-444-15272-5
1-280-78366-4 0-470-71800-5 9786613694058 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Peptide Transport and Hydrolysis; Contents; Chairman's opening remarks; Introduction; Amino acid and peptide absorption in man; Discussion of the two preceding papers; Intestinal dipeptidases and dipeptide transport in the monkey and in man; Discussion; Dipeptide transport in the intestinal mucosa of developing rabbits; Discussion; Mechanisms of peptide transport; Discussion; A brush-border-bound peptidase and amino acid transport; Discussion; The function of the γ-glutamyl cycle in the transport of amino acids and peptides; Discussion; General Discussion I
Intestinal mucosal hydrolysis of proteins and peptides; Discussion; Intestinal brush border peptidases; Discussion; Intracellular hydrolysis of peptides; Endopeptidases in the brush border of the kidney proximal tubule; Discussion of the two preceding papers; Membrane and intracellular hydrolysis of peptides : differentiation, role and interrelations with transport; Discussion; Intestinal hydrolysis of disaccharides and peptides : comparison of hydrolases and perfusion studies; Discussion; Clearance of dipeptides from plasma: role of kidney and intestine; Discussion Peptiduria in the Fanconi syndrome; Discussion; General Discussion II; Coeliac disease; Transport and hydrolysis of peptides by microorganisms; Discussion; Peptidases in germinating barley grain: properties, localization and possible functions; Discussion; Final Discussion; Site of peptide hydrolysis; Peptide transport through membranes; Membrane digestion of peptides; Epithelial transport of peptides; Rate-limiting steps : hydrolysis or transport?; Closing remarks; Index of contributors; Subject index |
| Record Nr. | UNINA-9910144659803321 |
| Amsterdam ; ; New York : , : Elsevier/Excerpta Medica/North Holland, , 1977 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Peptide transport and hydrolysis / / editors, Katherine Elliott, Maeve O'Connor
| Peptide transport and hydrolysis / / editors, Katherine Elliott, Maeve O'Connor |
| Pubbl/distr/stampa | Amsterdam ; ; New York : , : Elsevier/Excerpta Medica/North Holland, , 1977 |
| Descrizione fisica | 1 online resource (ix, 385 pages) : illustrations |
| Disciplina | 574.1/9256 |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Peptides
Peptidase Biological transport Intestinal absorption |
| ISBN |
0-444-15272-5
1-280-78366-4 0-470-71800-5 9786613694058 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Peptide Transport and Hydrolysis; Contents; Chairman's opening remarks; Introduction; Amino acid and peptide absorption in man; Discussion of the two preceding papers; Intestinal dipeptidases and dipeptide transport in the monkey and in man; Discussion; Dipeptide transport in the intestinal mucosa of developing rabbits; Discussion; Mechanisms of peptide transport; Discussion; A brush-border-bound peptidase and amino acid transport; Discussion; The function of the γ-glutamyl cycle in the transport of amino acids and peptides; Discussion; General Discussion I
Intestinal mucosal hydrolysis of proteins and peptides; Discussion; Intestinal brush border peptidases; Discussion; Intracellular hydrolysis of peptides; Endopeptidases in the brush border of the kidney proximal tubule; Discussion of the two preceding papers; Membrane and intracellular hydrolysis of peptides : differentiation, role and interrelations with transport; Discussion; Intestinal hydrolysis of disaccharides and peptides : comparison of hydrolases and perfusion studies; Discussion; Clearance of dipeptides from plasma: role of kidney and intestine; Discussion Peptiduria in the Fanconi syndrome; Discussion; General Discussion II; Coeliac disease; Transport and hydrolysis of peptides by microorganisms; Discussion; Peptidases in germinating barley grain: properties, localization and possible functions; Discussion; Final Discussion; Site of peptide hydrolysis; Peptide transport through membranes; Membrane digestion of peptides; Epithelial transport of peptides; Rate-limiting steps : hydrolysis or transport?; Closing remarks; Index of contributors; Subject index |
| Record Nr. | UNISA-996202076403316 |
| Amsterdam ; ; New York : , : Elsevier/Excerpta Medica/North Holland, , 1977 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
