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Generation and effector functions of regulatory lymphocytes [[electronic resource] /] / [editors, Gregory Bock and Jamie Goode]
| Generation and effector functions of regulatory lymphocytes [[electronic resource] /] / [editors, Gregory Bock and Jamie Goode] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2003 |
| Descrizione fisica | 1 online resource (327 p.) |
| Disciplina | 571.96 |
| Altri autori (Persone) |
BockGregory
GoodeJamie |
| Collana | Novartis Foundation symposium |
| Soggetto topico |
Lymphocytes
T cells Immune response - Regulation |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-27406-9
9786610274062 0-470-87161-X 0-470-87162-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
GENERATION AND EFFECTOR FUNCTIONS OF REGULATORY LYMPHOCYTES; Contents; Participants; Chair's introduction; Thymic generation and selection of CD25(+)CD4(+) regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance; Discussion; Control of T cell activation by CD4(+)CD25(+) suppressor T cells; Discussion; Regulation of experimental autoimmune encephalomyelitis (EAE) by CD4(+)CD25(+) regulatory T cells; Discussion; The role of CD28 and CTLA4 in the function and homeostasis of CD4(+)CD25(+) regulatory T cells
DiscussionCD4(+)CD25(+) regulatory cells from human peripheral blood express very high levels of CD25 ex vivo; Discussion; Control of immune pathology by regulatory T cells; Discussion; General discussion I TGFB; Type 1 T regulatory cells and their relationship with CD4(+)CD25(+) T regulatory cells; Discussion; (PRO)insulin-specific regulatory T cells; Discussion; CD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into the mechanisms of protection against Type 1 diabetes; Discussion Seven surprises in the TCR-centred regulation of immune responsiveness in an autoimmune systemDiscussion; Regulatory cells in transplantation; Discussion; CD4(+) regulatory T cells in chronic viral infection; Discussion; General discussion II; Modulation of T cell responses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship; Discussion; Dendritic cells: controllers of the immune system and a new promise for immunotherapy; Discussion; Regulation of viral and autoimmune responses; Discussion; General discussion III Active immune regulation Notch signalling in the peripheral immune systemDiscussion; CD3 antibody treatment stimulates the functional capability of regulatory T cells; Discussion; The role of dendritic cells in regulating mucosal immunity and tolerance; Discussion; Index of contributors; Subject index |
| Record Nr. | UNINA-9910143227103321 |
| Hoboken, N.J., : Wiley, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Generation and effector functions of regulatory lymphocytes [[electronic resource] /] / [editors, Gregory Bock and Jamie Goode]
| Generation and effector functions of regulatory lymphocytes [[electronic resource] /] / [editors, Gregory Bock and Jamie Goode] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2003 |
| Descrizione fisica | 1 online resource (327 p.) |
| Disciplina | 571.96 |
| Altri autori (Persone) |
BockGregory
GoodeJamie |
| Collana | Novartis Foundation symposium |
| Soggetto topico |
Lymphocytes
T cells Immune response - Regulation |
| ISBN |
1-280-27406-9
9786610274062 0-470-87161-X 0-470-87162-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
GENERATION AND EFFECTOR FUNCTIONS OF REGULATORY LYMPHOCYTES; Contents; Participants; Chair's introduction; Thymic generation and selection of CD25(+)CD4(+) regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance; Discussion; Control of T cell activation by CD4(+)CD25(+) suppressor T cells; Discussion; Regulation of experimental autoimmune encephalomyelitis (EAE) by CD4(+)CD25(+) regulatory T cells; Discussion; The role of CD28 and CTLA4 in the function and homeostasis of CD4(+)CD25(+) regulatory T cells
DiscussionCD4(+)CD25(+) regulatory cells from human peripheral blood express very high levels of CD25 ex vivo; Discussion; Control of immune pathology by regulatory T cells; Discussion; General discussion I TGFB; Type 1 T regulatory cells and their relationship with CD4(+)CD25(+) T regulatory cells; Discussion; (PRO)insulin-specific regulatory T cells; Discussion; CD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into the mechanisms of protection against Type 1 diabetes; Discussion Seven surprises in the TCR-centred regulation of immune responsiveness in an autoimmune systemDiscussion; Regulatory cells in transplantation; Discussion; CD4(+) regulatory T cells in chronic viral infection; Discussion; General discussion II; Modulation of T cell responses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship; Discussion; Dendritic cells: controllers of the immune system and a new promise for immunotherapy; Discussion; Regulation of viral and autoimmune responses; Discussion; General discussion III Active immune regulation Notch signalling in the peripheral immune systemDiscussion; CD3 antibody treatment stimulates the functional capability of regulatory T cells; Discussion; The role of dendritic cells in regulating mucosal immunity and tolerance; Discussion; Index of contributors; Subject index |
| Record Nr. | UNINA-9910830549003321 |
| Hoboken, N.J., : Wiley, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Generation and effector functions of regulatory lymphocytes / / [editors, Gregory Bock and Jamie Goode]
| Generation and effector functions of regulatory lymphocytes / / [editors, Gregory Bock and Jamie Goode] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2003 |
| Descrizione fisica | 1 online resource (327 p.) |
| Disciplina | 571.9/6 |
| Altri autori (Persone) |
BockGregory
GoodeJamie |
| Collana | Novartis Foundation symposium |
| Soggetto topico |
Lymphocytes
T cells Immune response - Regulation |
| ISBN |
9786610274062
9781280274060 1280274069 9780470871614 047087161X 9780470871621 0470871628 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
GENERATION AND EFFECTOR FUNCTIONS OF REGULATORY LYMPHOCYTES; Contents; Participants; Chair's introduction; Thymic generation and selection of CD25(+)CD4(+) regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance; Discussion; Control of T cell activation by CD4(+)CD25(+) suppressor T cells; Discussion; Regulation of experimental autoimmune encephalomyelitis (EAE) by CD4(+)CD25(+) regulatory T cells; Discussion; The role of CD28 and CTLA4 in the function and homeostasis of CD4(+)CD25(+) regulatory T cells
DiscussionCD4(+)CD25(+) regulatory cells from human peripheral blood express very high levels of CD25 ex vivo; Discussion; Control of immune pathology by regulatory T cells; Discussion; General discussion I TGFB; Type 1 T regulatory cells and their relationship with CD4(+)CD25(+) T regulatory cells; Discussion; (PRO)insulin-specific regulatory T cells; Discussion; CD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into the mechanisms of protection against Type 1 diabetes; Discussion Seven surprises in the TCR-centred regulation of immune responsiveness in an autoimmune systemDiscussion; Regulatory cells in transplantation; Discussion; CD4(+) regulatory T cells in chronic viral infection; Discussion; General discussion II; Modulation of T cell responses after cross-talk between antigen presenting cells and T cells: a give-and-take relationship; Discussion; Dendritic cells: controllers of the immune system and a new promise for immunotherapy; Discussion; Regulation of viral and autoimmune responses; Discussion; General discussion III Active immune regulation Notch signalling in the peripheral immune systemDiscussion; CD3 antibody treatment stimulates the functional capability of regulatory T cells; Discussion; The role of dendritic cells in regulating mucosal immunity and tolerance; Discussion; Index of contributors; Subject index |
| Record Nr. | UNINA-9911019704803321 |
| Hoboken, N.J., : Wiley, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Human immunology
| Human immunology |
| Pubbl/distr/stampa | New York, NY, : Elsevier Science Pub. Co |
| Disciplina | 616.07/9/05 |
| Soggetto topico |
Immunology
Immune response - Regulation HLA histocompatibility antigens Histocompatibility Immunology - Periodicals Allergy and Immunology Immunologie - Périodiques Réaction immunitaire - Régulation Antigènes HLA Immunologie Histocompatibilité |
| Soggetto genere / forma |
Periodical
periodicals. Periodicals. Périodiques. |
| ISSN | 1879-1166 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996218517603316 |
| New York, NY, : Elsevier Science Pub. Co | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Human immunology
| Human immunology |
| Pubbl/distr/stampa | New York, NY, : Elsevier Science Pub. Co |
| Disciplina | 616.07/9/05 |
| Soggetto topico |
Immunology
Immune response - Regulation HLA histocompatibility antigens Histocompatibility Allergy and Immunology Immunologie - Périodiques Réaction immunitaire - Régulation Antigènes HLA Immunologie Histocompatibilité |
| Soggetto genere / forma |
Periodical
periodicals. Periodicals. Périodiques. |
| ISSN | 1879-1166 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910146786803321 |
| New York, NY, : Elsevier Science Pub. Co | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Immune modulating agents / / edited by Thomas F. Kresina
| Immune modulating agents / / edited by Thomas F. Kresina |
| Edizione | [1st.] |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , 2020 |
| Descrizione fisica | 1 online resource (xiv, 557 pages) : illustrations |
| Disciplina | 616.079 |
| Soggetto topico |
Immune response - Regulation
Biological response modifiers |
| ISBN |
1-00-306467-1
1-000-14597-2 1-000-11012-5 1-003-06467-1 0-585-38885-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. Immunomodulation -- pt. II. Immunomodulating agents in disease -- pt. III. Immunomodulating agents in therapy. |
| Record Nr. | UNINA-9910585983003321 |
| Boca Raton : , : CRC Press, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Immune Response Activation and Immunomodulation / / Rajeev K. Tyagi, Prakash S. Bisen, editors
| Immune Response Activation and Immunomodulation / / Rajeev K. Tyagi, Prakash S. Bisen, editors |
| Autore | Prakash S. Bisen |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | IntechOpen, 2019 |
| Descrizione fisica | 1 online resource (xii, 165 pages) : illustrations |
| Disciplina | 616.079 |
| Soggetto topico |
Immune response - Regulation
Immune system |
| Soggetto non controllato |
Life Sciences
Immunology and Microbiology Pure Immunology |
| ISBN |
1-83962-135-4
1-78985-152-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910326250903321 |
Prakash S. Bisen
|
||
| IntechOpen, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The immune synapse as a novel target for therapy [[electronic resource] /] / Luis Graca, editor
| The immune synapse as a novel target for therapy [[electronic resource] /] / Luis Graca, editor |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | Basel, : Birkhäuser, c2008 |
| Descrizione fisica | 1 online resource (203 p.) |
| Disciplina | 616.079 |
| Altri autori (Persone) | GracaLuis, MD. |
| Collana | PIR (Series) |
| Soggetto topico |
Immune response - Molecular aspects
Immune response - Regulation Synapses |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-14091-0
9786611140915 3-7643-8296-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The immune synapse and T cell activation: regulation by chemokines -- The induction of regulatory T cells by targeting the immune synapse -- Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology -- Targeting CD4 for the induction of dominant tolerance -- Anti-CD3: from T cell depletion to tolerance induction -- Immune modulation by CD40L blockade -- CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance -- Adhesion molecules as therapeutic targets -- E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within? -- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells -- Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance -- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic. |
| Record Nr. | UNINA-9910458653103321 |
| Basel, : Birkhäuser, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Immunodominance [[electronic resource] ] : the choice of the immune system / / edited by Jeffrey A. Frelinger
| Immunodominance [[electronic resource] ] : the choice of the immune system / / edited by Jeffrey A. Frelinger |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (316 p.) |
| Disciplina | 616.079 |
| Altri autori (Persone) | FrelingerJeffrey A |
| Soggetto topico |
Immune response - Regulation
Antigenic determinants - Research |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-85434-0
9786610854349 3-527-60802-8 3-527-60737-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Immunodominance; Contents; Preface; List of Contributors; Color Plates; I Mechanics of Antigen Processing; 1 Class I MHC Antigen Processing; 1.1 Introduction; 1.2 Properties of MHC; 1.2.1 Structure of MHC; 1.2.2 Polymorphic Residues Generate Specificity Pockets; 1.3 Properties of Peptides; 1.3.1 Peptides That Bind Are Not Random Sequences; 1.3.2 Peptide-binding Motifs; 1.3.3 Peptide Length Is Limited in Class I MHC Peptides; 1.3.4 Binding Affinity; 1.3.5 Molecular Recognition; 1.3.6 Epitope Prediction; 1.4 Cytosolic Processing; 1.4.1 The Proteasome; 1.4.2 The Immunoproteasome
1.4.3 Opening the Immunoproteasome1.4.4 Peptide Trimming; 1.4.5 Association of the Proteasome with the Endoplasmic Reticulum; 1.5 Peptide Transport; 1.5.1 Transport via TAP; 1.5.2 TAP Selectivity; 1.5.3 TAP-independent Peptide Transport; 1.5.3.1 Endogenous Peptides; 1.5.3.2 Exogenous Peptides; 1.6 Class I MHC Maturation and Peptide Loading; 1.6.1 ER Chaperones: Calnexin, Calreticulin, ERp57, and Tapasin; 1.6.1.1 Calnexin; 1.6.1.2 Tapasin; 1.6.1.3 ERp57; 1.6.1.4 Calreticulin; 1.6.2 Peptide Loading; 1.7 Immunodominance and Class I MHC Peptide Processing 2 The Mechanics of Class II Processing: Establishment of a Peptide Class II Hierarchy2.1 General Overview; 2.1.1 Immunodominance and Crypticity; 2.1.2 The Impact of T-Cell Repertoire in the Experimental Analysis of Immunodominance; 2.1.3 Different Antigen-presenting Cells Have Different Functions; 2.1.4 The Phases of Antigen Processing; 2.2 Phase I: MHC Class II Biosynthesis and Delivery to Peptide-loading Compartments; 2.2.1 Invariant Chain Isoforms; 2.2.2 Effects of Cell Signaling on MHC Class II Transport; 2.3 Phase II: Antigen Internalization and Processing 2.3.1 BCR-mediated Antigen Internalization2.3.2 Dendritic Cells and Macrophages; 2.4 Phase III: Formation and Expression of Antigenic Peptide by MHC Class II Molecules; 2.4.1 Proteolytic Antigen Processing; 2.4.2 Class II Peptide Loading; 2.4.2.1 DM; 2.4.2.2 DO; 2.4.2.3 DO-, DM-, and BCR-Mediated Antigen Processing; 2.4.2.4 The Distribution of MHC Class II and Other Proteins Within MIIC; 2.4.3 Cell-surface Delivery of Peptide-Class II Complexes; 2.4.3.1 Exosomes; 2.4.3.2 Signaling Properties of Peptide-Class II Complexes; 2.5 Conclusions; Acknowledgments 3 The Phenomenon of Immunodomination: Speculations on the Nature of Immunodominance3.1 Introduction; 3.2 MHC Binding, Cellular Processing, and T-Cell Repertoire are Major Determinants of Immunodominance; 3.3 Previous Systematic Analysis of Immunodominance by Our Group; 3.4 Cellular and Molecular Events in Immunodomination; 3.5 Speculations on the Mechanism of Immunodomination; 3.5.1 Involvement of APCs; 3.5.2 Possible Involvement of the Immune Synapse in Immunodomination; 3.5.3 The Potential Role of MTOC in Immunodomination; 3.6 Significance of Studying Immunodominance for Vaccine Development 3.7 Conclusions |
| Record Nr. | UNINA-9910144556903321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Immunodominance : the choice of the immune system / / edited by Jeffrey A. Frelinger
| Immunodominance : the choice of the immune system / / edited by Jeffrey A. Frelinger |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (316 p.) |
| Disciplina | 616.079 |
| Altri autori (Persone) | FrelingerJeffrey A |
| Soggetto topico |
Immune response - Regulation
Antigenic determinants - Research |
| ISBN |
9786610854349
9781280854347 1280854340 9783527608027 3527608028 9783527607372 3527607374 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Immunodominance; Contents; Preface; List of Contributors; Color Plates; I Mechanics of Antigen Processing; 1 Class I MHC Antigen Processing; 1.1 Introduction; 1.2 Properties of MHC; 1.2.1 Structure of MHC; 1.2.2 Polymorphic Residues Generate Specificity Pockets; 1.3 Properties of Peptides; 1.3.1 Peptides That Bind Are Not Random Sequences; 1.3.2 Peptide-binding Motifs; 1.3.3 Peptide Length Is Limited in Class I MHC Peptides; 1.3.4 Binding Affinity; 1.3.5 Molecular Recognition; 1.3.6 Epitope Prediction; 1.4 Cytosolic Processing; 1.4.1 The Proteasome; 1.4.2 The Immunoproteasome
1.4.3 Opening the Immunoproteasome1.4.4 Peptide Trimming; 1.4.5 Association of the Proteasome with the Endoplasmic Reticulum; 1.5 Peptide Transport; 1.5.1 Transport via TAP; 1.5.2 TAP Selectivity; 1.5.3 TAP-independent Peptide Transport; 1.5.3.1 Endogenous Peptides; 1.5.3.2 Exogenous Peptides; 1.6 Class I MHC Maturation and Peptide Loading; 1.6.1 ER Chaperones: Calnexin, Calreticulin, ERp57, and Tapasin; 1.6.1.1 Calnexin; 1.6.1.2 Tapasin; 1.6.1.3 ERp57; 1.6.1.4 Calreticulin; 1.6.2 Peptide Loading; 1.7 Immunodominance and Class I MHC Peptide Processing 2 The Mechanics of Class II Processing: Establishment of a Peptide Class II Hierarchy2.1 General Overview; 2.1.1 Immunodominance and Crypticity; 2.1.2 The Impact of T-Cell Repertoire in the Experimental Analysis of Immunodominance; 2.1.3 Different Antigen-presenting Cells Have Different Functions; 2.1.4 The Phases of Antigen Processing; 2.2 Phase I: MHC Class II Biosynthesis and Delivery to Peptide-loading Compartments; 2.2.1 Invariant Chain Isoforms; 2.2.2 Effects of Cell Signaling on MHC Class II Transport; 2.3 Phase II: Antigen Internalization and Processing 2.3.1 BCR-mediated Antigen Internalization2.3.2 Dendritic Cells and Macrophages; 2.4 Phase III: Formation and Expression of Antigenic Peptide by MHC Class II Molecules; 2.4.1 Proteolytic Antigen Processing; 2.4.2 Class II Peptide Loading; 2.4.2.1 DM; 2.4.2.2 DO; 2.4.2.3 DO-, DM-, and BCR-Mediated Antigen Processing; 2.4.2.4 The Distribution of MHC Class II and Other Proteins Within MIIC; 2.4.3 Cell-surface Delivery of Peptide-Class II Complexes; 2.4.3.1 Exosomes; 2.4.3.2 Signaling Properties of Peptide-Class II Complexes; 2.5 Conclusions; Acknowledgments 3 The Phenomenon of Immunodomination: Speculations on the Nature of Immunodominance3.1 Introduction; 3.2 MHC Binding, Cellular Processing, and T-Cell Repertoire are Major Determinants of Immunodominance; 3.3 Previous Systematic Analysis of Immunodominance by Our Group; 3.4 Cellular and Molecular Events in Immunodomination; 3.5 Speculations on the Mechanism of Immunodomination; 3.5.1 Involvement of APCs; 3.5.2 Possible Involvement of the Immune Synapse in Immunodomination; 3.5.3 The Potential Role of MTOC in Immunodomination; 3.6 Significance of Studying Immunodominance for Vaccine Development 3.7 Conclusions |
| Record Nr. | UNINA-9910677191803321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Immune response - Regulation
(20)
- T cells (8)
- Diseases (3)
- Health (3)
- Immunology (3)