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Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
Autore Mozzarelli Andrea
Pubbl/distr/stampa Hoboken, : Wiley, 2011
Descrizione fisica 1 online resource (476 p.)
Disciplina 615.8/36
615.836
Altri autori (Persone) BettatiStefano
Soggetto topico Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use
Nitric oxide - Physiological effect
Nitric oxide -- Physiological effect
Oxigen - Physiological effect
Oxigen -- Physiological effect
Oxygen - blood
Oxygen -- blood
Oxygen Consumption
Oxygen Inhalation Therapy - methods
Oxygen Inhalation Therapy -- methods
Oxygen therapy
SCIENCE / Life Sciences / Biochemistry
Oxygen therapy - Physiological effect
Oxygen - Physiological effect
Nitric oxide
Metabolic Phenomena
Respiratory Therapy
Investigative Techniques
Body Fluids
Globins
Chalcogens
Blood Proteins
Gases
Therapeutics
Fluids and Secretions
Elements
Hemeproteins
Inorganic Chemicals
Proteins
Amino Acids, Peptides, and Proteins
Anatomy
Oxygen
Blood
Hemoglobins
Methods
Oxygen Inhalation Therapy
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-283-17785-4
9786613177858
1-119-97542-5
1-119-97543-3
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis
4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway
4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction
5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma
6.2.1 Massive Transfusion
Record Nr. UNINA-9910139631203321
Mozzarelli Andrea  
Hoboken, : Wiley, 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
Autore Mozzarelli Andrea
Pubbl/distr/stampa Hoboken, : Wiley, 2011
Descrizione fisica 1 online resource (476 p.)
Disciplina 615.8/36
615.836
Altri autori (Persone) BettatiStefano
Soggetto topico Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use
Nitric oxide - Physiological effect
Nitric oxide -- Physiological effect
Oxigen - Physiological effect
Oxigen -- Physiological effect
Oxygen - blood
Oxygen -- blood
Oxygen Consumption
Oxygen Inhalation Therapy - methods
Oxygen Inhalation Therapy -- methods
Oxygen therapy
SCIENCE / Life Sciences / Biochemistry
Oxygen therapy - Physiological effect
Oxygen - Physiological effect
Nitric oxide
Metabolic Phenomena
Respiratory Therapy
Investigative Techniques
Body Fluids
Globins
Chalcogens
Blood Proteins
Gases
Therapeutics
Fluids and Secretions
Elements
Hemeproteins
Inorganic Chemicals
Proteins
Amino Acids, Peptides, and Proteins
Anatomy
Oxygen
Blood
Hemoglobins
Methods
Oxygen Inhalation Therapy
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-283-17785-4
9786613177858
1-119-97542-5
1-119-97543-3
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis
4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway
4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction
5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma
6.2.1 Massive Transfusion
Record Nr. UNINA-9910806996303321
Mozzarelli Andrea  
Hoboken, : Wiley, 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Hemoglobin : molecular, genetic, and clinical aspects
Hemoglobin : molecular, genetic, and clinical aspects
Autore Bunn, H. Franklin
Pubbl/distr/stampa Philadelphia : W. B. Saunders Co., c1986
Descrizione fisica vii, 690 p. : ill. (some col.) ; 27 cm
Disciplina 616.15
Altri autori (Persone) Forget, Bernard G.
Soggetto topico Hemoglobinopathies
Hemoglobins
ISBN 0721621813
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNISALENTO-991003490169707536
Bunn, H. Franklin  
Philadelphia : W. B. Saunders Co., c1986
Materiale a stampa
Lo trovi qui: Univ. del Salento
Opac: Controlla la disponibilità qui
Hemoglobin
Hemoglobin
Pubbl/distr/stampa [New York, NY], : Marcel Dekker
Disciplina 616.151
Soggetto topico Hemoglobinopathy
Hemoglobin
Hemoglobins
Hematology
Thalassemia
Hematologic Diseases
Vascular Medicine
Soggetto genere / forma Periodical
Periodicals.
ISSN 1532-432X
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNINA-9910154532203321
[New York, NY], : Marcel Dekker
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui