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The epigenome [[electronic resource] ] : molecular hide and seek / / edited by S. Beck and A. Olek
| The epigenome [[electronic resource] ] : molecular hide and seek / / edited by S. Beck and A. Olek |
| Pubbl/distr/stampa | Weinheim ; ; [Cambridge], : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (190 p.) |
| Disciplina |
599.935
611.01816 |
| Altri autori (Persone) |
OlekA (Alexander)
BeckStephan (Stephan G.) |
| Soggetto topico |
Human genome
Medical genetics Nature and nurture Genome, Human Genomics - methods Cytosine - physiology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-52085-X
9786610520855 3-527-60597-5 3-527-60151-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Epigenome Molecular Hide and Seek; Preface; Contents; 1 Five Not Four: History and Significance of the Fifth Base; Summary; 1.1 Historical Introduction; 1.2 Sequencing 5-methylcytosine (5-mC) Residues in Genomic DNA; The Bisulfite Method; 1.3 Gene Silencing; 1.4 Development; 1.5 Abnormal DNA Methylation in Cancer Cells; 1.6 Nuclear Transfer; 1.7 Aging; 1.8 The Future; References; 2 (Epi)genetic Signals: Towards a Human Genome Sequence of All Five Nucleotides; Summary; 2.1 A Linguistic Prologue; 2.2 Towards the Complete Sequence of the Human Genome with Five Nucleotides
2.3 Patterns of DNA Methylation - the Scaffold for Building a Functional Genome2.4 DNA Methylation Patterns in Segments of the Human Genome and in Viral Genomes; 2.4.1 On Viral Genomes and Foreign DNA Integrates (Table 2.1); 2.4.2 DNA Methylation Patterns in the Human Genome (Table 2.1); 2.5 Insertions of Foreign DNA into Established Mammalian Genomes; 2.6 De Novo Methylation of Integrated Foreign DNA; 2.6.1 Ad12 Genomes in Hamster Tumor Cells; 2.6.2 De Novo Methylation of Foreign DNA Integrated into the Mouse Genome by Homologous or Heterologous Recombination [23] 2.7 Genome-wide Perturbations in the Mammalian Genome upon Foreign DNA Insertion2.8 Outlook and Recommendations; References; 3 Epi Meets Genomics: Technologies for Finding and Reading the 5(th) Base; Summary; 3.1 The Development of 5(th)-Base Technologies; 3.1.1 Unusual DNA-cutting Enzymes; 3.1.2 A Unique Chemical Reaction that Modifies Methylated DNA; 3.1.3 The Advance of 5(th) Base Technologies in Epigenomic Research; 3.2 Restriction Landmark Genomic Scanning (RLGS): Finding the 5(th)-base Signposts in the Genomic Atlas; 3.2.1 Principle; 3.2.2 How Does RLGS Work?; 3.2.3 Applications 3.3 Methylation-sensitive Arbitrarily Primed (AP) PCR: Fishing for the 5(th) Bases in Genomic Ponds3.3.1 Principle; 3.3.2 How Does MS AP-PCR Work?; 3.3.3 Applications; 3.4 Differential Methylation Hybridization (DMH): Identifying the 5(th) Bases in the Genomic Crossword Puzzle; 3.4.1 Principle; 3.4.2 How Does DMH Work?; 3.4.3 Applications; 3.5 MethyLight: Finding 5(th)-base Patterns in Genomic Shadows; 3.5.1 Principle; 3.5.2 How Does MethyLight Work?; 3.5.3 Applications; 3.6 Exploring the Epigenome; References; 4 Mammalian Epigenomics: Reprogramming the Genome for Development and Therapy Summary4.1 Introduction; 4.2 DNA Methylation; 4.3 Histone Modifications; 4.4 Imprinting; 4.5 Reprogramming and Cloning; 4.6 Epimutations and Epigenetic Inheritance; 4.7 Epigenomics: The Future; 4.7 Conclusions; References; 5 At the Controls: Genomic Imprinting and the Epigenetic Regulation of Gene Expression; Summary; 5.1 Introduction; 5.2 Genomic Imprinting; 5.2.1 The Role of DNA Methylation in Imprinted Gene Expression; 5.2.3 Organization of Imprinted Genes 5.2.4 The Mechanism of Imprinting at the Mouse Igf2r Imprinted Domain Requires a Cis-acting Noncoding Antisense Transcript Regulated by DNA Methylation (Fig. 5.2 a) |
| Record Nr. | UNINA-9910146241703321 |
| Weinheim ; ; [Cambridge], : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The epigenome [[electronic resource] ] : molecular hide and seek / / edited by S. Beck and A. Olek
| The epigenome [[electronic resource] ] : molecular hide and seek / / edited by S. Beck and A. Olek |
| Pubbl/distr/stampa | Weinheim ; ; [Cambridge], : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (190 p.) |
| Disciplina |
599.935
611.01816 |
| Altri autori (Persone) |
OlekA (Alexander)
BeckStephan (Stephan G.) |
| Soggetto topico |
Human genome
Medical genetics Nature and nurture Genome, Human Genomics - methods Cytosine - physiology |
| ISBN |
1-280-52085-X
9786610520855 3-527-60597-5 3-527-60151-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Epigenome Molecular Hide and Seek; Preface; Contents; 1 Five Not Four: History and Significance of the Fifth Base; Summary; 1.1 Historical Introduction; 1.2 Sequencing 5-methylcytosine (5-mC) Residues in Genomic DNA; The Bisulfite Method; 1.3 Gene Silencing; 1.4 Development; 1.5 Abnormal DNA Methylation in Cancer Cells; 1.6 Nuclear Transfer; 1.7 Aging; 1.8 The Future; References; 2 (Epi)genetic Signals: Towards a Human Genome Sequence of All Five Nucleotides; Summary; 2.1 A Linguistic Prologue; 2.2 Towards the Complete Sequence of the Human Genome with Five Nucleotides
2.3 Patterns of DNA Methylation - the Scaffold for Building a Functional Genome2.4 DNA Methylation Patterns in Segments of the Human Genome and in Viral Genomes; 2.4.1 On Viral Genomes and Foreign DNA Integrates (Table 2.1); 2.4.2 DNA Methylation Patterns in the Human Genome (Table 2.1); 2.5 Insertions of Foreign DNA into Established Mammalian Genomes; 2.6 De Novo Methylation of Integrated Foreign DNA; 2.6.1 Ad12 Genomes in Hamster Tumor Cells; 2.6.2 De Novo Methylation of Foreign DNA Integrated into the Mouse Genome by Homologous or Heterologous Recombination [23] 2.7 Genome-wide Perturbations in the Mammalian Genome upon Foreign DNA Insertion2.8 Outlook and Recommendations; References; 3 Epi Meets Genomics: Technologies for Finding and Reading the 5(th) Base; Summary; 3.1 The Development of 5(th)-Base Technologies; 3.1.1 Unusual DNA-cutting Enzymes; 3.1.2 A Unique Chemical Reaction that Modifies Methylated DNA; 3.1.3 The Advance of 5(th) Base Technologies in Epigenomic Research; 3.2 Restriction Landmark Genomic Scanning (RLGS): Finding the 5(th)-base Signposts in the Genomic Atlas; 3.2.1 Principle; 3.2.2 How Does RLGS Work?; 3.2.3 Applications 3.3 Methylation-sensitive Arbitrarily Primed (AP) PCR: Fishing for the 5(th) Bases in Genomic Ponds3.3.1 Principle; 3.3.2 How Does MS AP-PCR Work?; 3.3.3 Applications; 3.4 Differential Methylation Hybridization (DMH): Identifying the 5(th) Bases in the Genomic Crossword Puzzle; 3.4.1 Principle; 3.4.2 How Does DMH Work?; 3.4.3 Applications; 3.5 MethyLight: Finding 5(th)-base Patterns in Genomic Shadows; 3.5.1 Principle; 3.5.2 How Does MethyLight Work?; 3.5.3 Applications; 3.6 Exploring the Epigenome; References; 4 Mammalian Epigenomics: Reprogramming the Genome for Development and Therapy Summary4.1 Introduction; 4.2 DNA Methylation; 4.3 Histone Modifications; 4.4 Imprinting; 4.5 Reprogramming and Cloning; 4.6 Epimutations and Epigenetic Inheritance; 4.7 Epigenomics: The Future; 4.7 Conclusions; References; 5 At the Controls: Genomic Imprinting and the Epigenetic Regulation of Gene Expression; Summary; 5.1 Introduction; 5.2 Genomic Imprinting; 5.2.1 The Role of DNA Methylation in Imprinted Gene Expression; 5.2.3 Organization of Imprinted Genes 5.2.4 The Mechanism of Imprinting at the Mouse Igf2r Imprinted Domain Requires a Cis-acting Noncoding Antisense Transcript Regulated by DNA Methylation (Fig. 5.2 a) |
| Record Nr. | UNINA-9910831192003321 |
| Weinheim ; ; [Cambridge], : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomic tests for ovarian cancer detection and management
| Genomic tests for ovarian cancer detection and management |
| Pubbl/distr/stampa | [Place of publication not identified], : Agency for Healthcare Research and Quality U S Department of Health and Human Services, 2006 |
| Descrizione fisica | 1 online resource |
| Disciplina | 616.99/465042 |
| Collana | Evidence report/technology assessment Genomic tests for ovarian cancer detection and management |
| Soggetto topico |
Genetic screening
Ovarian Neoplasms - diagnosis Ovarian Neoplasms - genetics Genetic Testing - methods Genomics - methods Models, Genetic |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910698255403321 |
| [Place of publication not identified], : Agency for Healthcare Research and Quality U S Department of Health and Human Services, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Genomics of lung cancer / / Ramaswamy Govindan
| Genomics of lung cancer / / Ramaswamy Govindan |
| Autore | Govindan Ramaswamy |
| Pubbl/distr/stampa | London, : Henry Stewart Talks, 2016 |
| Descrizione fisica | 1 online resource (1 streaming video file (40 min.) : color, sound) |
| Collana | Cancer genetics |
| Soggetto topico |
Antineoplastic agents
Lungs - Cancer - Chemotherapy Lungs - Cancer - Genetic aspects Lungs - Cancer - Molecular aspects Antineoplastic Agents - therapeutic use Genome, Human Genomics - methods Genomics - trends Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - physiology Molecular Targeted Therapy Molecular Typing Receptor, Epidermal Growth Factor - physiology |
| Formato | Videoregistrazioni  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Contents: Complexity of the lung cancer genome -- Molecular classification of subtypes -- Pathways of activation in tumors -- Intratumoral heterogeneity -- Targetable alterations in patients -- Emerging areas in genomics of lung cancer. |
| Record Nr. | UNINA-9910887857403321 |
Govindan Ramaswamy
|
||
| London, : Henry Stewart Talks, 2016 | ||
| Videoregistrazioni | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Targets
| Targets |
| Pubbl/distr/stampa | London, : Elsevier Science Ltd |
| Collana | Drug discovery today publications |
| Soggetto topico |
Genomics - Research
Proteomics - Research Drug development Drug Delivery Systems Drug Design Genomics - methods Proteomics - methods Technology, Pharmaceutical |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1878-0989 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996199377803316 |
| London, : Elsevier Science Ltd | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Targets
| Targets |
| Pubbl/distr/stampa | London, : Elsevier Science Ltd |
| Collana | Drug discovery today publications |
| Soggetto topico |
Genomics - Research
Proteomics - Research Drug development Drug Delivery Systems Drug Design Genomics - methods Proteomics - methods Technology, Pharmaceutical Médicaments - Conception Thérapie génique Génétique médicale Génomique Protéomique Techniques pharmaceutiques |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1878-0989 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910333257903321 |
| London, : Elsevier Science Ltd | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
