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MARC Lista (tabellare)
Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]]
Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]]
Pubbl/distr/stampa Cambridge : , : Cambridge University Press, , 2013
Descrizione fisica 1 online resource (xv, 481 pages) : digital, PDF file(s)
Disciplina 572.80285
Soggetto topico Bioinformatics - Statistical methods
Biometry
Genetics - Technique
ISBN 1-139-89118-9
1-107-24941-4
1-107-24858-2
1-299-70751-3
1-107-25107-9
1-107-25024-2
1-139-22644-4
1-107-24775-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Contents""; ""List of Contributors""; ""Preface""; ""1 An Introduction to Next-Generation Biological Platforms""; ""Virginia Mohlere, Wenting Wang, and Ganiraju Manyam""; ""1.1 Introduction""; ""1.2 The Biology of Gene Silencing""; ""1.2.1 DNA Methylation""; ""1.2.2 RNA Interference""; ""1.3 High-Throughput Profiling""; ""1.3.1 Molecular Inversion Probe Arrays""; ""1.3.2 Array Comparative Genomic Hybridization (aCGH)""; ""1.3.3 Genome-Wide Association Studies""; ""1.3.4 Reverse-Phase Protein Array""; ""1.4 Next-Generation Sequencing""; ""1.4.1 Whole-Genome and Whole-Exome Sequencing""
""1.4.2 ChIP-Seq""""1.4.3 RNA-Seq""; ""1.4.4 BS-seq""; ""1.5 NGS Data Management and Analysis""; ""1.6 Platform Integration""; ""Acknowledgments""; ""References""; ""References""; ""2 An Introduction to The Cancer Genome Atlas""; ""Bradley M. Broom and Rehan Akbani""; ""2.1 Introduction""; ""2.2 History and Goals of the TCGA Project""; ""2.3 Sample Collection and Processing""; ""2.3.1 Step 1: Tissue Collection""; ""2.3.2 Step 2: Quality Control and DNA/RNA Extraction""; ""2.3.3 Step 3: Molecular Profiling and Sequencing""; ""2.3.4 Step 4: Data Collection and Public Distribution""
""2.3.5 Step 5: Data Analysis""""2.4 Data Processing, Storage, and Access""; ""2.4.1 TCGA Barcodes and UUIDs""; ""2.4.2 The Data Coordinating Center""; ""2.4.3 Data Access Matrix""; ""2.4.4 Bulk Download""; ""2.4.5 HTTP""; ""2.4.6 CGHub""; ""2.4.7 Sample and Data Relationship Format (SDRF) and Investigation Description Format (IDF) Files""; ""2.4.8 File Format""; ""2.4.9 Version""; ""2.5 Tools for Visualizing and Analyzing TCGA Data""; ""2.5.1 cBio Cancer Genomics Portal""; ""2.5.2 MBatch Portal""; ""2.5.3 Next-Generation Clustered Heat Maps""; ""2.5.4 Regulome Explorer""
""2.5.5 Integrative Genome Viewer""""2.5.6 Cancer Genomics Browser""; ""2.6 Summary""; ""Acknowledgments""; ""References""; ""References""; ""3 DNA Variant Calling in Targeted Sequencing Data""; ""Wenyi Wang, Yu Fan, and Terence P. Speed""; ""3.1 Introduction""; ""3.2 Background""; ""3.2.1 Single-Nucleotide Variation""; ""3.2.2 Long Padlock Probes""; ""3.2.3 Array-Based Resequencing""; ""3.3 Sequence Robust Multiarray Analysis""; ""3.3.1 Quality Control""; ""3.3.2 Variant Calling""; ""3.4 Application of SRMA""; ""3.4.1 Candidate Gene Study for Mitochondrial Diseases""
""3.4.2 Validation Results""""3.4.3 Biological Findings""; ""3.5 Conclusion""; ""Appendix""; ""References""; ""References""; ""4 Statistical Analysis of Mapped Reads from mRNA-Seq Data""; ""Ernest Turro and Alex Lewin""; ""4.1 Background""; ""4.1.1 RNA Biology""; ""4.1.2 RNA Technology""; ""4.2 Mapping and Assembly Strategies""; ""4.2.1 De Novo Assembly of the Transcriptome""; ""4.2.2 Genome-Guided Assembly of the Transcriptome""; ""4.2.3 Alignment to a Reference Transcriptome""; ""4.3 Modeling Expression Levels""; ""4.3.1 Poisson Model for Expression Quantification""; ""4.4 Normalization""
""4.4.1 RPKM Normalization""
Record Nr. UNINA-9910464935503321
Cambridge : , : Cambridge University Press, , 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]]
Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]]
Pubbl/distr/stampa Cambridge : , : Cambridge University Press, , 2013
Descrizione fisica 1 online resource (xv, 481 pages) : digital, PDF file(s)
Disciplina 572.80285
Soggetto topico Bioinformatics - Statistical methods
Biometry
Genetics - Technique
ISBN 1-139-89118-9
1-107-24941-4
1-107-24858-2
1-299-70751-3
1-107-25107-9
1-107-25024-2
1-139-22644-4
1-107-24775-6
Classificazione MED090000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Contents""; ""List of Contributors""; ""Preface""; ""1 An Introduction to Next-Generation Biological Platforms""; ""Virginia Mohlere, Wenting Wang, and Ganiraju Manyam""; ""1.1 Introduction""; ""1.2 The Biology of Gene Silencing""; ""1.2.1 DNA Methylation""; ""1.2.2 RNA Interference""; ""1.3 High-Throughput Profiling""; ""1.3.1 Molecular Inversion Probe Arrays""; ""1.3.2 Array Comparative Genomic Hybridization (aCGH)""; ""1.3.3 Genome-Wide Association Studies""; ""1.3.4 Reverse-Phase Protein Array""; ""1.4 Next-Generation Sequencing""; ""1.4.1 Whole-Genome and Whole-Exome Sequencing""
""1.4.2 ChIP-Seq""""1.4.3 RNA-Seq""; ""1.4.4 BS-seq""; ""1.5 NGS Data Management and Analysis""; ""1.6 Platform Integration""; ""Acknowledgments""; ""References""; ""References""; ""2 An Introduction to The Cancer Genome Atlas""; ""Bradley M. Broom and Rehan Akbani""; ""2.1 Introduction""; ""2.2 History and Goals of the TCGA Project""; ""2.3 Sample Collection and Processing""; ""2.3.1 Step 1: Tissue Collection""; ""2.3.2 Step 2: Quality Control and DNA/RNA Extraction""; ""2.3.3 Step 3: Molecular Profiling and Sequencing""; ""2.3.4 Step 4: Data Collection and Public Distribution""
""2.3.5 Step 5: Data Analysis""""2.4 Data Processing, Storage, and Access""; ""2.4.1 TCGA Barcodes and UUIDs""; ""2.4.2 The Data Coordinating Center""; ""2.4.3 Data Access Matrix""; ""2.4.4 Bulk Download""; ""2.4.5 HTTP""; ""2.4.6 CGHub""; ""2.4.7 Sample and Data Relationship Format (SDRF) and Investigation Description Format (IDF) Files""; ""2.4.8 File Format""; ""2.4.9 Version""; ""2.5 Tools for Visualizing and Analyzing TCGA Data""; ""2.5.1 cBio Cancer Genomics Portal""; ""2.5.2 MBatch Portal""; ""2.5.3 Next-Generation Clustered Heat Maps""; ""2.5.4 Regulome Explorer""
""2.5.5 Integrative Genome Viewer""""2.5.6 Cancer Genomics Browser""; ""2.6 Summary""; ""Acknowledgments""; ""References""; ""References""; ""3 DNA Variant Calling in Targeted Sequencing Data""; ""Wenyi Wang, Yu Fan, and Terence P. Speed""; ""3.1 Introduction""; ""3.2 Background""; ""3.2.1 Single-Nucleotide Variation""; ""3.2.2 Long Padlock Probes""; ""3.2.3 Array-Based Resequencing""; ""3.3 Sequence Robust Multiarray Analysis""; ""3.3.1 Quality Control""; ""3.3.2 Variant Calling""; ""3.4 Application of SRMA""; ""3.4.1 Candidate Gene Study for Mitochondrial Diseases""
""3.4.2 Validation Results""""3.4.3 Biological Findings""; ""3.5 Conclusion""; ""Appendix""; ""References""; ""References""; ""4 Statistical Analysis of Mapped Reads from mRNA-Seq Data""; ""Ernest Turro and Alex Lewin""; ""4.1 Background""; ""4.1.1 RNA Biology""; ""4.1.2 RNA Technology""; ""4.2 Mapping and Assembly Strategies""; ""4.2.1 De Novo Assembly of the Transcriptome""; ""4.2.2 Genome-Guided Assembly of the Transcriptome""; ""4.2.3 Alignment to a Reference Transcriptome""; ""4.3 Modeling Expression Levels""; ""4.3.1 Poisson Model for Expression Quantification""; ""4.4 Normalization""
""4.4.1 RPKM Normalization""
Record Nr. UNINA-9910789313903321
Cambridge : , : Cambridge University Press, , 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]]
Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]]
Pubbl/distr/stampa Cambridge : , : Cambridge University Press, , 2013
Descrizione fisica 1 online resource (xv, 481 pages) : digital, PDF file(s)
Disciplina 572.80285
Soggetto topico Bioinformatics - Statistical methods
Biometry
Genetics - Technique
ISBN 1-139-89118-9
1-107-24941-4
1-107-24858-2
1-299-70751-3
1-107-25107-9
1-107-25024-2
1-139-22644-4
1-107-24775-6
Classificazione MED090000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""Contents""; ""List of Contributors""; ""Preface""; ""1 An Introduction to Next-Generation Biological Platforms""; ""Virginia Mohlere, Wenting Wang, and Ganiraju Manyam""; ""1.1 Introduction""; ""1.2 The Biology of Gene Silencing""; ""1.2.1 DNA Methylation""; ""1.2.2 RNA Interference""; ""1.3 High-Throughput Profiling""; ""1.3.1 Molecular Inversion Probe Arrays""; ""1.3.2 Array Comparative Genomic Hybridization (aCGH)""; ""1.3.3 Genome-Wide Association Studies""; ""1.3.4 Reverse-Phase Protein Array""; ""1.4 Next-Generation Sequencing""; ""1.4.1 Whole-Genome and Whole-Exome Sequencing""
""1.4.2 ChIP-Seq""""1.4.3 RNA-Seq""; ""1.4.4 BS-seq""; ""1.5 NGS Data Management and Analysis""; ""1.6 Platform Integration""; ""Acknowledgments""; ""References""; ""References""; ""2 An Introduction to The Cancer Genome Atlas""; ""Bradley M. Broom and Rehan Akbani""; ""2.1 Introduction""; ""2.2 History and Goals of the TCGA Project""; ""2.3 Sample Collection and Processing""; ""2.3.1 Step 1: Tissue Collection""; ""2.3.2 Step 2: Quality Control and DNA/RNA Extraction""; ""2.3.3 Step 3: Molecular Profiling and Sequencing""; ""2.3.4 Step 4: Data Collection and Public Distribution""
""2.3.5 Step 5: Data Analysis""""2.4 Data Processing, Storage, and Access""; ""2.4.1 TCGA Barcodes and UUIDs""; ""2.4.2 The Data Coordinating Center""; ""2.4.3 Data Access Matrix""; ""2.4.4 Bulk Download""; ""2.4.5 HTTP""; ""2.4.6 CGHub""; ""2.4.7 Sample and Data Relationship Format (SDRF) and Investigation Description Format (IDF) Files""; ""2.4.8 File Format""; ""2.4.9 Version""; ""2.5 Tools for Visualizing and Analyzing TCGA Data""; ""2.5.1 cBio Cancer Genomics Portal""; ""2.5.2 MBatch Portal""; ""2.5.3 Next-Generation Clustered Heat Maps""; ""2.5.4 Regulome Explorer""
""2.5.5 Integrative Genome Viewer""""2.5.6 Cancer Genomics Browser""; ""2.6 Summary""; ""Acknowledgments""; ""References""; ""References""; ""3 DNA Variant Calling in Targeted Sequencing Data""; ""Wenyi Wang, Yu Fan, and Terence P. Speed""; ""3.1 Introduction""; ""3.2 Background""; ""3.2.1 Single-Nucleotide Variation""; ""3.2.2 Long Padlock Probes""; ""3.2.3 Array-Based Resequencing""; ""3.3 Sequence Robust Multiarray Analysis""; ""3.3.1 Quality Control""; ""3.3.2 Variant Calling""; ""3.4 Application of SRMA""; ""3.4.1 Candidate Gene Study for Mitochondrial Diseases""
""3.4.2 Validation Results""""3.4.3 Biological Findings""; ""3.5 Conclusion""; ""Appendix""; ""References""; ""References""; ""4 Statistical Analysis of Mapped Reads from mRNA-Seq Data""; ""Ernest Turro and Alex Lewin""; ""4.1 Background""; ""4.1.1 RNA Biology""; ""4.1.2 RNA Technology""; ""4.2 Mapping and Assembly Strategies""; ""4.2.1 De Novo Assembly of the Transcriptome""; ""4.2.2 Genome-Guided Assembly of the Transcriptome""; ""4.2.3 Alignment to a Reference Transcriptome""; ""4.3 Modeling Expression Levels""; ""4.3.1 Poisson Model for Expression Quantification""; ""4.4 Normalization""
""4.4.1 RPKM Normalization""
Record Nr. UNINA-9910810575303321
Cambridge : , : Cambridge University Press, , 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Cellular oncology
Cellular oncology
Pubbl/distr/stampa Amsterdam, : IOS Press, ©2004-
Disciplina 616.994
Soggetto topico Oncology
Cancer - Cytopathology
Cytology - Technique
Genetics - Technique
Cancer
Cells - pathology
Cell Transformation, Neoplastic
Cytological Techniques
Genetic Techniques
Medical Oncology
Neoplasms
Cancérologie
Cytologie - Technique
Cancer - Cytopathologie
Génétique - Technique
Soggetto genere / forma Periodical
periodicals.
Periodicals.
Périodiques.
ISSN 1875-8606
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNISA-996203540603316
Amsterdam, : IOS Press, ©2004-
Materiale a stampa
Lo trovi qui: Univ. di Salerno
Opac: Controlla la disponibilità qui
Cellular oncology
Cellular oncology
Pubbl/distr/stampa Amsterdam, : IOS Press, ©2004-
Disciplina 616.994
Soggetto topico Oncology
Cancer - Cytopathology
Cytology - Technique
Genetics - Technique
Cancer
Cells - pathology
Cell Transformation, Neoplastic
Cytological Techniques
Genetic Techniques
Medical Oncology
Neoplasms
Cancérologie
Cytologie - Technique
Cancer - Cytopathologie
Génétique - Technique
Soggetto genere / forma Periodical
periodicals.
Periodicals.
Périodiques.
ISSN 1875-8606
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNINA-9910143634503321
Amsterdam, : IOS Press, ©2004-
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
DNA
DNA
Pubbl/distr/stampa New Rochelle, New York, : Mary Ann Liebert, ©1981-1989
Disciplina 572.8
574.87/3282/05
Soggetto topico DNA
Nucleic acids
Genetic engineering - Technique
Recombinant DNA
Genetics - Technique
DNA, Recombinant
Genetic Techniques
ADN recombinant
ADN
Génétique - Technique
Celbiologie
Soggetto genere / forma Periodical
Periodicals.
ISSN 2331-4672
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Altri titoli varianti D.N.A.
DNA -- a journal of molecular and cellular biology
Record Nr. UNINA-9910388593803321
New Rochelle, New York, : Mary Ann Liebert, ©1981-1989
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
DNA
DNA
Pubbl/distr/stampa New Rochelle, New York, : Mary Ann Liebert, ©1981-1989
Disciplina 572.8
574.87/3282/05
Soggetto topico DNA
Nucleic acids
Genetic engineering - Technique
Recombinant DNA
Genetics - Technique
DNA, Recombinant
Genetic Techniques
ADN recombinant
ADN
Génétique - Technique
Celbiologie
Soggetto genere / forma Periodical
Periodicals.
ISSN 2331-4672
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Altri titoli varianti D.N.A.
DNA -- a journal of molecular and cellular biology
Record Nr. UNISA-996418329303316
New Rochelle, New York, : Mary Ann Liebert, ©1981-1989
Materiale a stampa
Lo trovi qui: Univ. di Salerno
Opac: Controlla la disponibilità qui
DNA and cell biology
DNA and cell biology
Pubbl/distr/stampa [Larchmont, N.Y.], : Mary Ann Liebert, 1990-
Disciplina 574
Soggetto topico DNA
Cytology
Genes
Genetics - Technique
Nucleic acids
Recombinant DNA
Genetic Techniques
Nucleic Acids
ADN recombinant
ADN
Cytologie
Gènes
Génétique - Technique
Acides nucléiques
Histology
Zeitschrift
Celbiologie
DNS
Soggetto genere / forma Periodical
Periodicals.
ISSN 1557-7430
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNISA-996213086803316
[Larchmont, N.Y.], : Mary Ann Liebert, 1990-
Materiale a stampa
Lo trovi qui: Univ. di Salerno
Opac: Controlla la disponibilità qui
DNA and cell biology
DNA and cell biology
Pubbl/distr/stampa [Larchmont, N.Y.], : Mary Ann Liebert, 1990-
Disciplina 574
Soggetto topico DNA
Cytology
Genes
Genetics - Technique
Nucleic acids
Recombinant DNA
Genetic Techniques
Nucleic Acids
ADN recombinant
ADN
Cytologie
Gènes
Génétique - Technique
Acides nucléiques
Histology
Zeitschrift
Celbiologie
DNS
Soggetto genere / forma Periodical
Periodicals.
ISSN 1557-7430
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNINA-9910137791603321
[Larchmont, N.Y.], : Mary Ann Liebert, 1990-
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Genetic analysis [[electronic resource] ] : principles, scope, and objectives / / John R.S. Fincham
Genetic analysis [[electronic resource] ] : principles, scope, and objectives / / John R.S. Fincham
Autore Fincham J. R. S
Pubbl/distr/stampa Oxford ; ; Boston, : Blackwell Scientific Publications, 1994
Descrizione fisica 1 online resource (241 p.)
Disciplina 574.87/322
Soggetto topico Genetics - Technique
Nucleotide sequence
Gene mapping
ISBN 1-282-18905-0
9786612189050
1-4443-1383-5
1-4443-1382-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto GENETIC ANALYSIS; CONTENTS; PREFACE; INTRODUCTION: THE EXPANDING SCOPE OF GENETICS; 1: DISSECTING THE GENOME USING NATURAL GENETIC SYSTEMS; The eukaryotic system; Eukaryotes distinguished from prokaryotes; Mitosis and chromosome structure; Alternation of haploid and diploid phases in the sexual cycle; Meiosis and the rules of classical genetics; Meiosis; Single-factor genetic ratios and their explanation; Independent assortment of different allele-pairs; Testing data for fit to theoretical ratios; Linkage groups and the nature of crossovers; Map units and map distance
Placing Linked genes in sequenceDistinguishing between independent assorment and distant linkage; Mapping centromeres using tetrads; Sex linkage; Segregation and linkage in human genetics; Assigning linkage groups to chromosomes; Genetic analysis of bacteria and bacteriophage; Three modes of gene transfer in bacteria; Time-of-entry mapping in E. coli; Analogy with sexual recombination and segregation; Stable partial diploids - F' plasmids; Bacteriophage lambda - a virus in the chromosome; Bacteriophage T4 - a model recombinational system; Eukaryotic organelle genetics
Exceptions to the rule of equal results from reciprocal crossesChloroplast variants; Mitochondrial variants; Summary and perspective; Further reading; References; 2: FROM MUTATIONS TO GENES; Defining the gene by mutation and complementation; What is it that the markers mark?; The collection of mutants; Sorting of mutants into complementation groups; An interim definition of the gene; Mapping within the gene; The detection of recombination within genes; Mapping by reference to flanking markers; Recombination frequency; Deletion mapping; The determination by genes of protein structure
Colinearity of the gene and its encoded protein productBiochemistry of polypeptide synthesis; Not all genes encode proteins; Conclusions; References; 3: THE GENE AS DNA SEQUENCE; Characterization of DNA fragments; Restriction endonucleases; Separating aod sizing DNA fragments; Probing for specific sequences; Making restriction-site maps; Cloning and cloning vectors; Making recombinant DNA molecules; Escherichia coli plasmid vectors; Yeast 2-um plasmid and shuttle vectors; Lambda (l) bacteriophage and cosmid vectors; Yeast artificial chromosomes (YACs)
Screening DNA libraries for functional genesGenomic libraries and cDNA libraries; Gene identification by complementation of mutants; Screening gene libraries with DNA probes; Designing gene-specific probes; Use of cDNA probes; Screening for gene expression; Probing across species or group boundaries; Positional cloning; Confirming the identity of cloned sequences; DNA sequence and open reading frames; Using the clone to disrupt the corresponding gene; Hybridization back to chromosomes; Simultaneous mutagenesis and gene tagging; The principle; Transposon tags; Conclusion; References
4: THE EVOLVING CONCEPT OF THE GENE
Record Nr. UNISA-996206293403316
Fincham J. R. S  
Oxford ; ; Boston, : Blackwell Scientific Publications, 1994
Materiale a stampa
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