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Advanced genetic analysis [[electronic resource] ] : finding meaning in a genome / / R. Scott Hawley and Michelle Y. Walker
| Advanced genetic analysis [[electronic resource] ] : finding meaning in a genome / / R. Scott Hawley and Michelle Y. Walker |
| Autore | Hawley R. Scott |
| Pubbl/distr/stampa | Malden, Mass., : Blackwell Pub., c2003 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina | 576.5/072 |
| Altri autori (Persone) | WalkerMichelle Y |
| Soggetto topico | Genetics - Research - Methodology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-11830-7
9786612118302 1-4443-1308-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Advanced Genetic Analysis; Contents; Preface; Introduction; 1: Mutation; 1.1 Types of mutations; 1.1.1 Muller's classification of mutants; 1.1.2 Modern mutant terminology; 1.1.3 DNA-level terminology; 1.2 Dominance and recessivity; 1.2.1 Dominance and recessivity at the level of the cell; 1.2.2 Difficulties in applying the terms ""dominant"" and ""recessive"" to sex-linked mutants; 1.3 The genetic utility of dominant and recessive mutants; Summary; Gallery of model organisms; 1.1 Our favorite organism: Drosophila melanogaster; 1.2 Our second favorite organism: Saccharomyces cerevisiae
1.3 Our third favorite organism: Caenorhabditis elegans1.4 Our new favorite organism: zebrafish; 1.5 Phage lambda; 1.6 Phage T4; 1.7 Arabidopsis thaliana; 1.8 Mus musculus (the mouse); 2: Mutant hunts; 2.1 Why look for new mutant?; 2.1.1 Reason 1: To identify genes required for a specific biological process; Box 2.1 A screen for embryonic lethal mutations in Drosophila; Box 2.2 The balancer chromosome; 2.1.2 Reason 2: To isolate more mutations in a specific gene of interest; Box 2.3 A screen for sex-linked lethal mutations in Drosophila 2.1.3 Reason 3: To obtain mutation tools for structure-function analysis2.1.4 Reason 4: To isolate mutations in a gene so far identified only by molecular approaches; 2.2 Mutagenesis and mutational mechanisms; 2.2.1 Method 1: Ionizing radiation (usually X-rays and gamma-rays); 2.2.2 Method 2: Chemical mutagens; 2.2.3 Method 3: Transposons as mutagens; 2.2.4 Method 4: Targeted gene disruption (a variant on transposon mutagenesis); Box 2.4 Making phenocopies by RNAi and co-suppression; 2.3 What phenotype should you screen (or select) for?; 2.4 Actually getting started 2.4.1 Your starting material2.4.2 Pilot screens; 2.4.3 Keeping too many, keeping too few; 2.4.4 How many mutants is enough?; Summary; Box 2.5 Reviews of mutant isolation schemes and techniques in various organisms; 3: The complementation test; 3.1 The essence of the complementation test; Box 3.1 A more rigorous definition of the complementation test; Box 3.2 An example of using the complementation test in yeast; 3.2 Rules for using the complementation test; Box 3.3 Transformation rescue is a variant of the complementation test Box 3.4 One method for determining whether or not a dominant mutation is an allele of a given gene, or how to make dominants into recessives by pseudo-reversion3.3 How might the complementation test lie to you?; 3.4 Second-site non-complementation (SSNC) (non-allelic non-complementation); 3.4.1 Type I SSNC (poisonous interactions): the interaction is allele-specific at both loci; Box 3.5 Pairing-dependent complementation: transvection; Box 3.6 Synthetic lethality and genetic buffering; 3.4.2 Type 2 SSNC (sequestration): the interaction is allele-specific at one locus 3.4.3 Type 3 SSNC (combined haplo-insufficiency): the interaction is allele-independent at both loci |
| Record Nr. | UNINA-9910455297903321 |
Hawley R. Scott
|
||
| Malden, Mass., : Blackwell Pub., c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advanced genetic analysis [[electronic resource] ] : finding meaning in a genome / / R. Scott Hawley and Michelle Y. Walker
| Advanced genetic analysis [[electronic resource] ] : finding meaning in a genome / / R. Scott Hawley and Michelle Y. Walker |
| Autore | Hawley R. Scott |
| Pubbl/distr/stampa | Malden, Mass., : Blackwell Pub., c2003 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina | 576.5/072 |
| Altri autori (Persone) | WalkerMichelle Y |
| Soggetto topico | Genetics - Research - Methodology |
| ISBN |
1-282-11830-7
9786612118302 1-4443-1308-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Advanced Genetic Analysis; Contents; Preface; Introduction; 1: Mutation; 1.1 Types of mutations; 1.1.1 Muller's classification of mutants; 1.1.2 Modern mutant terminology; 1.1.3 DNA-level terminology; 1.2 Dominance and recessivity; 1.2.1 Dominance and recessivity at the level of the cell; 1.2.2 Difficulties in applying the terms ""dominant"" and ""recessive"" to sex-linked mutants; 1.3 The genetic utility of dominant and recessive mutants; Summary; Gallery of model organisms; 1.1 Our favorite organism: Drosophila melanogaster; 1.2 Our second favorite organism: Saccharomyces cerevisiae
1.3 Our third favorite organism: Caenorhabditis elegans1.4 Our new favorite organism: zebrafish; 1.5 Phage lambda; 1.6 Phage T4; 1.7 Arabidopsis thaliana; 1.8 Mus musculus (the mouse); 2: Mutant hunts; 2.1 Why look for new mutant?; 2.1.1 Reason 1: To identify genes required for a specific biological process; Box 2.1 A screen for embryonic lethal mutations in Drosophila; Box 2.2 The balancer chromosome; 2.1.2 Reason 2: To isolate more mutations in a specific gene of interest; Box 2.3 A screen for sex-linked lethal mutations in Drosophila 2.1.3 Reason 3: To obtain mutation tools for structure-function analysis2.1.4 Reason 4: To isolate mutations in a gene so far identified only by molecular approaches; 2.2 Mutagenesis and mutational mechanisms; 2.2.1 Method 1: Ionizing radiation (usually X-rays and gamma-rays); 2.2.2 Method 2: Chemical mutagens; 2.2.3 Method 3: Transposons as mutagens; 2.2.4 Method 4: Targeted gene disruption (a variant on transposon mutagenesis); Box 2.4 Making phenocopies by RNAi and co-suppression; 2.3 What phenotype should you screen (or select) for?; 2.4 Actually getting started 2.4.1 Your starting material2.4.2 Pilot screens; 2.4.3 Keeping too many, keeping too few; 2.4.4 How many mutants is enough?; Summary; Box 2.5 Reviews of mutant isolation schemes and techniques in various organisms; 3: The complementation test; 3.1 The essence of the complementation test; Box 3.1 A more rigorous definition of the complementation test; Box 3.2 An example of using the complementation test in yeast; 3.2 Rules for using the complementation test; Box 3.3 Transformation rescue is a variant of the complementation test Box 3.4 One method for determining whether or not a dominant mutation is an allele of a given gene, or how to make dominants into recessives by pseudo-reversion3.3 How might the complementation test lie to you?; 3.4 Second-site non-complementation (SSNC) (non-allelic non-complementation); 3.4.1 Type I SSNC (poisonous interactions): the interaction is allele-specific at both loci; Box 3.5 Pairing-dependent complementation: transvection; Box 3.6 Synthetic lethality and genetic buffering; 3.4.2 Type 2 SSNC (sequestration): the interaction is allele-specific at one locus 3.4.3 Type 3 SSNC (combined haplo-insufficiency): the interaction is allele-independent at both loci |
| Record Nr. | UNINA-9910777940803321 |
|
Hawley R. Scott
|
||
| Malden, Mass., : Blackwell Pub., c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advanced genetic analysis : finding meaning in a genome / / R. Scott Hawley and Michelle Y. Walker
| Advanced genetic analysis : finding meaning in a genome / / R. Scott Hawley and Michelle Y. Walker |
| Autore | Hawley R. Scott |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Malden, Mass., : Blackwell Pub., c2003 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina | 576.5/072 |
| Altri autori (Persone) | WalkerMichelle Y |
| Soggetto topico | Genetics - Research - Methodology |
| ISBN |
9786612118302
9781282118300 1282118307 9781444313086 1444313088 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Advanced Genetic Analysis; Contents; Preface; Introduction; 1: Mutation; 1.1 Types of mutations; 1.1.1 Muller's classification of mutants; 1.1.2 Modern mutant terminology; 1.1.3 DNA-level terminology; 1.2 Dominance and recessivity; 1.2.1 Dominance and recessivity at the level of the cell; 1.2.2 Difficulties in applying the terms ""dominant"" and ""recessive"" to sex-linked mutants; 1.3 The genetic utility of dominant and recessive mutants; Summary; Gallery of model organisms; 1.1 Our favorite organism: Drosophila melanogaster; 1.2 Our second favorite organism: Saccharomyces cerevisiae
1.3 Our third favorite organism: Caenorhabditis elegans1.4 Our new favorite organism: zebrafish; 1.5 Phage lambda; 1.6 Phage T4; 1.7 Arabidopsis thaliana; 1.8 Mus musculus (the mouse); 2: Mutant hunts; 2.1 Why look for new mutant?; 2.1.1 Reason 1: To identify genes required for a specific biological process; Box 2.1 A screen for embryonic lethal mutations in Drosophila; Box 2.2 The balancer chromosome; 2.1.2 Reason 2: To isolate more mutations in a specific gene of interest; Box 2.3 A screen for sex-linked lethal mutations in Drosophila 2.1.3 Reason 3: To obtain mutation tools for structure-function analysis2.1.4 Reason 4: To isolate mutations in a gene so far identified only by molecular approaches; 2.2 Mutagenesis and mutational mechanisms; 2.2.1 Method 1: Ionizing radiation (usually X-rays and gamma-rays); 2.2.2 Method 2: Chemical mutagens; 2.2.3 Method 3: Transposons as mutagens; 2.2.4 Method 4: Targeted gene disruption (a variant on transposon mutagenesis); Box 2.4 Making phenocopies by RNAi and co-suppression; 2.3 What phenotype should you screen (or select) for?; 2.4 Actually getting started 2.4.1 Your starting material2.4.2 Pilot screens; 2.4.3 Keeping too many, keeping too few; 2.4.4 How many mutants is enough?; Summary; Box 2.5 Reviews of mutant isolation schemes and techniques in various organisms; 3: The complementation test; 3.1 The essence of the complementation test; Box 3.1 A more rigorous definition of the complementation test; Box 3.2 An example of using the complementation test in yeast; 3.2 Rules for using the complementation test; Box 3.3 Transformation rescue is a variant of the complementation test Box 3.4 One method for determining whether or not a dominant mutation is an allele of a given gene, or how to make dominants into recessives by pseudo-reversion3.3 How might the complementation test lie to you?; 3.4 Second-site non-complementation (SSNC) (non-allelic non-complementation); 3.4.1 Type I SSNC (poisonous interactions): the interaction is allele-specific at both loci; Box 3.5 Pairing-dependent complementation: transvection; Box 3.6 Synthetic lethality and genetic buffering; 3.4.2 Type 2 SSNC (sequestration): the interaction is allele-specific at one locus 3.4.3 Type 3 SSNC (combined haplo-insufficiency): the interaction is allele-independent at both loci |
| Record Nr. | UNINA-9910954523603321 |
|
Hawley R. Scott
|
||
| Malden, Mass., : Blackwell Pub., c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Quantitative genetics / / Shizhong Xu
| Quantitative genetics / / Shizhong Xu |
| Autore | Xu Shizhong |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (419 pages) |
| Disciplina | 576.5072 |
| Soggetto topico |
Quantitative research
Genetics - Research - Methodology |
| ISBN |
9783030839406
9783030839390 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910522931803321 |
|
Xu Shizhong
|
||
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Quantitative genetics / / Shizhong Xu
| Quantitative genetics / / Shizhong Xu |
| Autore | Xu Shizhong |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (419 pages) |
| Disciplina | 576.5072 |
| Soggetto topico |
Quantitative research
Genetics - Research - Methodology |
| ISBN |
9783030839406
9783030839390 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996464539803316 |
|
Xu Shizhong
|
||
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
