Applications of toxicogenomic technologies to predictive toxicology and risk assessment [[electronic resource] /] / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies |
Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2007 |
Descrizione fisica | 1 online resource (299 p.) |
Disciplina | 616/.042 |
Soggetto topico |
Genetic toxicology
DNA microarrays - Statistical methods Health risk assessment Carcinogenesis |
Soggetto genere / forma | Electronic books. |
ISBN |
1-281-10990-8
9786611109905 0-309-11299-0 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910452115503321 |
Washington, D.C., : National Academies Press, c2007 | ||
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Lo trovi qui: Univ. Federico II | ||
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Applications of toxicogenomic technologies to predictive toxicology and risk assessment [[electronic resource] /] / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies |
Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2007 |
Descrizione fisica | 1 online resource (299 p.) |
Disciplina | 616/.042 |
Soggetto topico |
Genetic toxicology
DNA microarrays - Statistical methods Health risk assessment Carcinogenesis |
ISBN |
0-309-17889-4
1-281-10990-8 9786611109905 0-309-11299-0 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Introduction -- Toxicogenomic technologies -- Experimental design and data analysis -- Application to exposure assessment -- Application to hazard screening -- Application to analyzing variation in human susceptibility -- Application to the study of mechanisms of action -- Other potential applications of toxicogenomic technologies to risk assessment -- Validation -- Sample and data collection and analysis -- Ethical, legal, and social issues -- Conculsions and recommendations. |
Record Nr. | UNINA-9910778274603321 |
Washington, D.C., : National Academies Press, c2007 | ||
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Lo trovi qui: Univ. Federico II | ||
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Applications of toxicogenomic technologies to predictive toxicology and risk assessment / / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies |
Edizione | [1st ed.] |
Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2007 |
Descrizione fisica | 1 online resource (299 p.) |
Disciplina | 616/.042 |
Soggetto topico |
Genetic toxicology
DNA microarrays - Statistical methods Health risk assessment Carcinogenesis |
ISBN |
0-309-17889-4
1-281-10990-8 9786611109905 0-309-11299-0 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Introduction -- Toxicogenomic technologies -- Experimental design and data analysis -- Application to exposure assessment -- Application to hazard screening -- Application to analyzing variation in human susceptibility -- Application to the study of mechanisms of action -- Other potential applications of toxicogenomic technologies to risk assessment -- Validation -- Sample and data collection and analysis -- Ethical, legal, and social issues -- Conculsions and recommendations. |
Record Nr. | UNINA-9910824330703321 |
Washington, D.C., : National Academies Press, c2007 | ||
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Lo trovi qui: Univ. Federico II | ||
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Applications of Toxicogenomics in Safety Evaluation and Risk Assessment [[electronic resource]] |
Autore | Boverhof Darrell R |
Pubbl/distr/stampa | Hoboken, : Wiley, 2011 |
Descrizione fisica | 1 online resource (402 p.) |
Disciplina |
616.042
616/.042 |
Altri autori (Persone) | GollapudiB. Bhaskar |
Soggetto topico |
Genetic toxicology
Health risk assessment Risk Assessment Toxicity testing Toxicogenetics Toxicology Pharmacogenetics Risk Risk Management Epidemiologic Measurements Organization and Administration Pharmacology Probability Genetics Public Health Health Occupations Statistics as Topic Biological Science Disciplines Biology Health Services Administration Environment and Public Health Natural Science Disciplines Health Care Health Care Evaluation Mechanisms Epidemiologic Methods Quality of Health Care Investigative Techniques Health Care Quality, Access, and Evaluation Health & Biological Sciences Toxicology & Public Health |
Soggetto genere / forma | Electronic books. |
ISBN |
1-283-23966-3
9786613239662 1-118-00104-4 1-118-00103-6 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Contents; Preface; Contributors; 1 Toxicology, ""Omics"" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity
8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan 16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; Index |
Record Nr. | UNINA-9910139607903321 |
Boverhof Darrell R
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Hoboken, : Wiley, 2011 | ||
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Lo trovi qui: Univ. Federico II | ||
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Applications of Toxicogenomics in Safety Evaluation and Risk Assessment |
Autore | Boverhof Darrell R |
Edizione | [First edition.] |
Pubbl/distr/stampa | Hoboken : , : Wiley, , 2011 |
Descrizione fisica | 1 online resource (402 pages) |
Disciplina |
616.042
616/.042 |
Altri autori (Persone) | GollapudiB. Bhaskar |
Soggetto topico |
Genetic toxicology
Health risk assessment Risk Assessment Toxicity testing Toxicogenetics Toxicology Pharmacogenetics Risk Risk Management Epidemiologic Measurements Organization and Administration Pharmacology Probability Genetics Public Health Health Occupations Statistics as Topic Biological Science Disciplines Biology Health Services Administration Environment and Public Health Natural Science Disciplines Health Care Health Care Evaluation Mechanisms Epidemiologic Methods Quality of Health Care Investigative Techniques Health Care Quality, Access, and Evaluation Health & Biological Sciences Toxicology & Public Health |
ISBN |
1-283-23966-3
9786613239662 1-118-00104-4 1-118-00103-6 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Contents; Preface; Contributors; 1 Toxicology, ""Omics"" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity
8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan 16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; Index |
Record Nr. | UNINA-9910824275603321 |
Boverhof Darrell R
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Hoboken : , : Wiley, , 2011 | ||
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Lo trovi qui: Univ. Federico II | ||
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Chemical consequences [[electronic resource] ] : environmental mutagens, scientist activism, and the rise of genetic toxicology / / Scott Frickel |
Autore | Frickel Scott |
Pubbl/distr/stampa | New Brunswick, N.J., : Rutgers University Press, c2004 |
Descrizione fisica | 1 online resource (213 p.) |
Disciplina | 616/.042 |
Soggetto topico |
Genetic toxicology
Chemical mutagenesis Mutagens |
Soggetto genere / forma | Electronic books. |
ISBN |
0-8135-5565-5
0-8135-3708-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910450192403321 |
Frickel Scott
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New Brunswick, N.J., : Rutgers University Press, c2004 | ||
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Lo trovi qui: Univ. Federico II | ||
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Chemical consequences [[electronic resource] ] : environmental mutagens, scientist activism, and the rise of genetic toxicology / / Scott Frickel |
Autore | Frickel Scott <1965-> |
Pubbl/distr/stampa | New Brunswick, N.J., : Rutgers University Press, c2004 |
Descrizione fisica | 1 online resource (213 p.) |
Disciplina | 616/.042 |
Soggetto topico |
Genetic toxicology
Chemical mutagenesis Mutagens |
ISBN |
0-8135-5565-5
0-8135-3708-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910783309503321 |
Frickel Scott <1965->
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New Brunswick, N.J., : Rutgers University Press, c2004 | ||
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Lo trovi qui: Univ. Federico II | ||
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Chemical consequences [[electronic resource] ] : environmental mutagens, scientist activism, and the rise of genetic toxicology / / Scott Frickel |
Autore | Frickel Scott <1965-> |
Pubbl/distr/stampa | New Brunswick, N.J., : Rutgers University Press, c2004 |
Descrizione fisica | 1 online resource (213 p.) |
Disciplina | 616/.042 |
Soggetto topico |
Genetic toxicology
Chemical mutagenesis Mutagens |
ISBN |
0-8135-5565-5
0-8135-3708-8 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910816825403321 |
Frickel Scott <1965->
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New Brunswick, N.J., : Rutgers University Press, c2004 | ||
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Lo trovi qui: Univ. Federico II | ||
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The Children of atomic bomb survivors [[electronic resource] ] : a genetic study / / edited by James V. Neel and William J. Schull |
Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1991 |
Descrizione fisica | 1 online resource (524 p.) |
Disciplina | 614.5/99 |
Altri autori (Persone) |
NeelJames V <1915-2000.> (James Van Gundia)
SchullWilliam J |
Soggetto topico |
Children of atomic bomb victims - Health and hygiene - Japan - Hiroshima-shi
Children of atomic bomb victims - Health and hygiene - Japan - Nagasaki-shi Radiation - Toxicology Genetic toxicology |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-20376-5
9786610203765 0-309-59318-2 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
""THE CHILDREN OF ATOMIC BOMB SURVIVORS""; ""Copyright""; ""Preface""; ""Contents""; ""Orientation""; ""BEGINNINGS""; ""THE THREE PHASES OF THE STUDY""; ""Phase I (1948�1954)""; ""Phase II (1955�1968)""; ""Phase III (1969�1990)""; ""AN ESTIMATE OF THE GENETIC DOUBLING DOSE OF RADIATION""; ""REFERENCES""; ""Genetic Effects of the Atomic Bombs in Hiroshima and Nagasaki""; ""THE EFFECT OF EXPOSURE TO THE ATOMIC BOMBS ON PREGNANCY TERMINATION IN HIROSHIMA AND NAGASAKI""; ""TABLE OF CONTENTS""; ""LIST OF TABLES""; ""LIST OF FIGURES""; ""CHAPTER I BACKGROUND""; ""CHAPTER II THE PLAN""
""CHAPTER III A COMPARISON OF HIROSHIMA AND NAGASAKI""""CHAPTER IV THE CRITERIA OF RADIATION EMPLOYED IN THE STUDY""; ""CHAPTER V THE COMPARABILITY OF IRRADIATION SUBCLASSES""; ""CHAPTER VI STATISTICAL METHODS""; ""CHAPTER VII ANALYSIS OF THE SEX RATIO DATA""; ""CHAPTER VIII ANALYSIS OF THE MALFORMATION DATA""; ""CHAPTER IX ANALYSIS OF THE STILLBIRTH DATA""; ""CHAPTER X THE ANALYSIS OF THE BIRTHWEIGHT DATA""; ""CHAPTER XI ANALYSIS OF THE DATA CONCERNING DEATH DURING THE NINE-MONTH PERIOD FOLLOWING DELIVERY""; ""CHAPTER XII THE ANALYSIS OF THE ANTHROPOMETRIC DATA"" ""CHAPTER XIII THE AUTOPSY FINDINGS""""CHAPTER XIV RECAPITULATION""; ""CHAPTER XV PERMISSIBLE INFERENCES""; ""APPENDIX""; ""PROCEDURE FOR CODING GENETICS SHORT-FORM QUESTIONNAIRES""; ""CODING INSTRUCTIONS FOR GENETICS FOLLOW-UP QUESTIONNAIRES""; ""CODING INSTRUCTIONS FOR PEDIATRICS FOLLOW-UP QUESTIONNAIRE""; ""REFERENCES""; ""SUBJECT INDEX ""; ""NAME INDEX ""; ""ATOMIC BOMB EXPOSURE AND THE PREGNANCIES OF BIOLOGICALLY RELATED PARENTS A PROSPECTIVE STUDY OFGENETIC EFFECTS OF IONIZING�""; ""REFERENCES"" ""Some Further Observations on the Sex Ratio Among Infants Born to Survivors of the Atomic Bombings of Hiroshima and Nagasaki""""STUDIES OF THE SEX RATIO IN HIROSHIMA AND NAGASAKI""; ""DISCUSSION""; ""Other Studies of the Effect of Radiation on the Sex Ratio in Man""; ""On an Interpretation of the Present Studies""; ""SUMMARY""; ""REFERENCES""; ""A Cohort-Type Study of Survival in the Children of Parents Exposed to Atomic Bombings""; ""Factors Determining the Design of the Study""; ""DESCRIPTION OF STUDY PROCEDURES""; ""SOURCES OF VARIATION IN MORTALITY OTHER THAN RADIATION"" ""THE RELATIONSHIP OF MORTALITY TO EXPOSURE""""DISCUSSION""; ""EPILOGUE""; ""SUMMARY""; ""REFERENCES""; ""MORTALITY IN THE CHILDREN OF ATOMIC BOMB SURVIVORS AND CONTROLS""; ""ABSTRACT""; ""THE STUDY POPULATION""; ""STATISTICAL CONSIDERATIONS""; ""THE DATA""; ""DISCUSSION""; ""LITERATURE CITED""; ""8 Cytogenetic Study of the Offspring of Atomic Bomb Survivors, Hiroshima and Nagasaki""; ""1 INTRODUCTION""; ""2 MATERIALS AND METHODS""; ""3 RESULTS""; ""3.1 Characteristics of the Study Sample""; ""3.2 Types and Frequencies of Chromosome Abnormalities""; ""3.2.1 Sex Chromosome Abnormalities"" ""3.2.2 Autosomal Structural Rearrangements"" |
Record Nr. | UNINA-9910455962903321 |
Washington, D.C., : National Academy Press, 1991 | ||
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Lo trovi qui: Univ. Federico II | ||
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The Children of atomic bomb survivors [[electronic resource] ] : a genetic study / / edited by James V. Neel and William J. Schull |
Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1991 |
Descrizione fisica | 1 online resource (524 p.) |
Disciplina | 614.5/99 |
Altri autori (Persone) |
NeelJames V <1915-2000.> (James Van Gundia)
SchullWilliam J |
Soggetto topico |
Children of atomic bomb victims - Health and hygiene - Japan - Hiroshima-shi
Children of atomic bomb victims - Health and hygiene - Japan - Nagasaki-shi Radiation - Toxicology Genetic toxicology |
ISBN |
1-280-20376-5
9786610203765 0-309-59318-2 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
""THE CHILDREN OF ATOMIC BOMB SURVIVORS""; ""Copyright""; ""Preface""; ""Contents""; ""Orientation""; ""BEGINNINGS""; ""THE THREE PHASES OF THE STUDY""; ""Phase I (1948�1954)""; ""Phase II (1955�1968)""; ""Phase III (1969�1990)""; ""AN ESTIMATE OF THE GENETIC DOUBLING DOSE OF RADIATION""; ""REFERENCES""; ""Genetic Effects of the Atomic Bombs in Hiroshima and Nagasaki""; ""THE EFFECT OF EXPOSURE TO THE ATOMIC BOMBS ON PREGNANCY TERMINATION IN HIROSHIMA AND NAGASAKI""; ""TABLE OF CONTENTS""; ""LIST OF TABLES""; ""LIST OF FIGURES""; ""CHAPTER I BACKGROUND""; ""CHAPTER II THE PLAN""
""CHAPTER III A COMPARISON OF HIROSHIMA AND NAGASAKI""""CHAPTER IV THE CRITERIA OF RADIATION EMPLOYED IN THE STUDY""; ""CHAPTER V THE COMPARABILITY OF IRRADIATION SUBCLASSES""; ""CHAPTER VI STATISTICAL METHODS""; ""CHAPTER VII ANALYSIS OF THE SEX RATIO DATA""; ""CHAPTER VIII ANALYSIS OF THE MALFORMATION DATA""; ""CHAPTER IX ANALYSIS OF THE STILLBIRTH DATA""; ""CHAPTER X THE ANALYSIS OF THE BIRTHWEIGHT DATA""; ""CHAPTER XI ANALYSIS OF THE DATA CONCERNING DEATH DURING THE NINE-MONTH PERIOD FOLLOWING DELIVERY""; ""CHAPTER XII THE ANALYSIS OF THE ANTHROPOMETRIC DATA"" ""CHAPTER XIII THE AUTOPSY FINDINGS""""CHAPTER XIV RECAPITULATION""; ""CHAPTER XV PERMISSIBLE INFERENCES""; ""APPENDIX""; ""PROCEDURE FOR CODING GENETICS SHORT-FORM QUESTIONNAIRES""; ""CODING INSTRUCTIONS FOR GENETICS FOLLOW-UP QUESTIONNAIRES""; ""CODING INSTRUCTIONS FOR PEDIATRICS FOLLOW-UP QUESTIONNAIRE""; ""REFERENCES""; ""SUBJECT INDEX ""; ""NAME INDEX ""; ""ATOMIC BOMB EXPOSURE AND THE PREGNANCIES OF BIOLOGICALLY RELATED PARENTS A PROSPECTIVE STUDY OFGENETIC EFFECTS OF IONIZING�""; ""REFERENCES"" ""Some Further Observations on the Sex Ratio Among Infants Born to Survivors of the Atomic Bombings of Hiroshima and Nagasaki""""STUDIES OF THE SEX RATIO IN HIROSHIMA AND NAGASAKI""; ""DISCUSSION""; ""Other Studies of the Effect of Radiation on the Sex Ratio in Man""; ""On an Interpretation of the Present Studies""; ""SUMMARY""; ""REFERENCES""; ""A Cohort-Type Study of Survival in the Children of Parents Exposed to Atomic Bombings""; ""Factors Determining the Design of the Study""; ""DESCRIPTION OF STUDY PROCEDURES""; ""SOURCES OF VARIATION IN MORTALITY OTHER THAN RADIATION"" ""THE RELATIONSHIP OF MORTALITY TO EXPOSURE""""DISCUSSION""; ""EPILOGUE""; ""SUMMARY""; ""REFERENCES""; ""MORTALITY IN THE CHILDREN OF ATOMIC BOMB SURVIVORS AND CONTROLS""; ""ABSTRACT""; ""THE STUDY POPULATION""; ""STATISTICAL CONSIDERATIONS""; ""THE DATA""; ""DISCUSSION""; ""LITERATURE CITED""; ""8 Cytogenetic Study of the Offspring of Atomic Bomb Survivors, Hiroshima and Nagasaki""; ""1 INTRODUCTION""; ""2 MATERIALS AND METHODS""; ""3 RESULTS""; ""3.1 Characteristics of the Study Sample""; ""3.2 Types and Frequencies of Chromosome Abnormalities""; ""3.2.1 Sex Chromosome Abnormalities"" ""3.2.2 Autosomal Structural Rearrangements"" |
Record Nr. | UNINA-9910778503703321 |
Washington, D.C., : National Academy Press, 1991 | ||
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Lo trovi qui: Univ. Federico II | ||
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