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Applications of toxicogenomic technologies to predictive toxicology and risk assessment [[electronic resource] /] / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies
Applications of toxicogenomic technologies to predictive toxicology and risk assessment [[electronic resource] /] / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies
Pubbl/distr/stampa Washington, D.C., : National Academies Press, c2007
Descrizione fisica 1 online resource (299 p.)
Disciplina 616/.042
Soggetto topico Genetic toxicology
DNA microarrays - Statistical methods
Health risk assessment
Carcinogenesis
Soggetto genere / forma Electronic books.
ISBN 1-281-10990-8
9786611109905
0-309-11299-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910452115503321
Washington, D.C., : National Academies Press, c2007
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Applications of toxicogenomic technologies to predictive toxicology and risk assessment [[electronic resource] /] / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies
Applications of toxicogenomic technologies to predictive toxicology and risk assessment [[electronic resource] /] / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies
Pubbl/distr/stampa Washington, D.C., : National Academies Press, c2007
Descrizione fisica 1 online resource (299 p.)
Disciplina 616/.042
Soggetto topico Genetic toxicology
DNA microarrays - Statistical methods
Health risk assessment
Carcinogenesis
ISBN 0-309-17889-4
1-281-10990-8
9786611109905
0-309-11299-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- Toxicogenomic technologies -- Experimental design and data analysis -- Application to exposure assessment -- Application to hazard screening -- Application to analyzing variation in human susceptibility -- Application to the study of mechanisms of action -- Other potential applications of toxicogenomic technologies to risk assessment -- Validation -- Sample and data collection and analysis -- Ethical, legal, and social issues -- Conculsions and recommendations.
Record Nr. UNINA-9910778274603321
Washington, D.C., : National Academies Press, c2007
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Applications of toxicogenomic technologies to predictive toxicology and risk assessment / / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies
Applications of toxicogenomic technologies to predictive toxicology and risk assessment / / Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology ; Board on Environmental Studies and Toxicology ; Board on Life Studies ; Division on Earth and Life Studies ; National Research Council of the National Academies
Edizione [1st ed.]
Pubbl/distr/stampa Washington, D.C., : National Academies Press, c2007
Descrizione fisica 1 online resource (299 p.)
Disciplina 616/.042
Soggetto topico Genetic toxicology
DNA microarrays - Statistical methods
Health risk assessment
Carcinogenesis
ISBN 0-309-17889-4
1-281-10990-8
9786611109905
0-309-11299-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- Toxicogenomic technologies -- Experimental design and data analysis -- Application to exposure assessment -- Application to hazard screening -- Application to analyzing variation in human susceptibility -- Application to the study of mechanisms of action -- Other potential applications of toxicogenomic technologies to risk assessment -- Validation -- Sample and data collection and analysis -- Ethical, legal, and social issues -- Conculsions and recommendations.
Record Nr. UNINA-9910824330703321
Washington, D.C., : National Academies Press, c2007
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Applications of Toxicogenomics in Safety Evaluation and Risk Assessment [[electronic resource]]
Applications of Toxicogenomics in Safety Evaluation and Risk Assessment [[electronic resource]]
Autore Boverhof Darrell R
Pubbl/distr/stampa Hoboken, : Wiley, 2011
Descrizione fisica 1 online resource (402 p.)
Disciplina 616.042
616/.042
Altri autori (Persone) GollapudiB. Bhaskar
Soggetto topico Genetic toxicology
Health risk assessment
Risk Assessment
Toxicity testing
Toxicogenetics
Toxicology
Pharmacogenetics
Risk
Risk Management
Epidemiologic Measurements
Organization and Administration
Pharmacology
Probability
Genetics
Public Health
Health Occupations
Statistics as Topic
Biological Science Disciplines
Biology
Health Services Administration
Environment and Public Health
Natural Science Disciplines
Health Care
Health Care Evaluation Mechanisms
Epidemiologic Methods
Quality of Health Care
Investigative Techniques
Health Care Quality, Access, and Evaluation
Health & Biological Sciences
Toxicology & Public Health
Soggetto genere / forma Electronic books.
ISBN 1-283-23966-3
9786613239662
1-118-00104-4
1-118-00103-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Contents; Preface; Contributors; 1 Toxicology, ""Omics"" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity
8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan
16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; Index
Record Nr. UNINA-9910139607903321
Boverhof Darrell R  
Hoboken, : Wiley, 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
Autore Boverhof Darrell R
Edizione [First edition.]
Pubbl/distr/stampa Hoboken : , : Wiley, , 2011
Descrizione fisica 1 online resource (402 pages)
Disciplina 616.042
616/.042
Altri autori (Persone) GollapudiB. Bhaskar
Soggetto topico Genetic toxicology
Health risk assessment
Risk Assessment
Toxicity testing
Toxicogenetics
Toxicology
Pharmacogenetics
Risk
Risk Management
Epidemiologic Measurements
Organization and Administration
Pharmacology
Probability
Genetics
Public Health
Health Occupations
Statistics as Topic
Biological Science Disciplines
Biology
Health Services Administration
Environment and Public Health
Natural Science Disciplines
Health Care
Health Care Evaluation Mechanisms
Epidemiologic Methods
Quality of Health Care
Investigative Techniques
Health Care Quality, Access, and Evaluation
Health & Biological Sciences
Toxicology & Public Health
ISBN 1-283-23966-3
9786613239662
1-118-00104-4
1-118-00103-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Contents; Preface; Contributors; 1 Toxicology, ""Omics"" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity
8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan
16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; Index
Record Nr. UNINA-9910824275603321
Boverhof Darrell R  
Hoboken : , : Wiley, , 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemical consequences [[electronic resource] ] : environmental mutagens, scientist activism, and the rise of genetic toxicology / / Scott Frickel
Chemical consequences [[electronic resource] ] : environmental mutagens, scientist activism, and the rise of genetic toxicology / / Scott Frickel
Autore Frickel Scott
Pubbl/distr/stampa New Brunswick, N.J., : Rutgers University Press, c2004
Descrizione fisica 1 online resource (213 p.)
Disciplina 616/.042
Soggetto topico Genetic toxicology
Chemical mutagenesis
Mutagens
Soggetto genere / forma Electronic books.
ISBN 0-8135-5565-5
0-8135-3708-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910450192403321
Frickel Scott  
New Brunswick, N.J., : Rutgers University Press, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemical consequences [[electronic resource] ] : environmental mutagens, scientist activism, and the rise of genetic toxicology / / Scott Frickel
Chemical consequences [[electronic resource] ] : environmental mutagens, scientist activism, and the rise of genetic toxicology / / Scott Frickel
Autore Frickel Scott <1965->
Pubbl/distr/stampa New Brunswick, N.J., : Rutgers University Press, c2004
Descrizione fisica 1 online resource (213 p.)
Disciplina 616/.042
Soggetto topico Genetic toxicology
Chemical mutagenesis
Mutagens
ISBN 0-8135-5565-5
0-8135-3708-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910783309503321
Frickel Scott <1965->  
New Brunswick, N.J., : Rutgers University Press, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemical consequences [[electronic resource] ] : environmental mutagens, scientist activism, and the rise of genetic toxicology / / Scott Frickel
Chemical consequences [[electronic resource] ] : environmental mutagens, scientist activism, and the rise of genetic toxicology / / Scott Frickel
Autore Frickel Scott <1965->
Pubbl/distr/stampa New Brunswick, N.J., : Rutgers University Press, c2004
Descrizione fisica 1 online resource (213 p.)
Disciplina 616/.042
Soggetto topico Genetic toxicology
Chemical mutagenesis
Mutagens
ISBN 0-8135-5565-5
0-8135-3708-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910816825403321
Frickel Scott <1965->  
New Brunswick, N.J., : Rutgers University Press, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
The Children of atomic bomb survivors [[electronic resource] ] : a genetic study / / edited by James V. Neel and William J. Schull
The Children of atomic bomb survivors [[electronic resource] ] : a genetic study / / edited by James V. Neel and William J. Schull
Pubbl/distr/stampa Washington, D.C., : National Academy Press, 1991
Descrizione fisica 1 online resource (524 p.)
Disciplina 614.5/99
Altri autori (Persone) NeelJames V <1915-2000.> (James Van Gundia)
SchullWilliam J
Soggetto topico Children of atomic bomb victims - Health and hygiene - Japan - Hiroshima-shi
Children of atomic bomb victims - Health and hygiene - Japan - Nagasaki-shi
Radiation - Toxicology
Genetic toxicology
Soggetto genere / forma Electronic books.
ISBN 1-280-20376-5
9786610203765
0-309-59318-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""THE CHILDREN OF ATOMIC BOMB SURVIVORS""; ""Copyright""; ""Preface""; ""Contents""; ""Orientation""; ""BEGINNINGS""; ""THE THREE PHASES OF THE STUDY""; ""Phase I (1948�1954)""; ""Phase II (1955�1968)""; ""Phase III (1969�1990)""; ""AN ESTIMATE OF THE GENETIC DOUBLING DOSE OF RADIATION""; ""REFERENCES""; ""Genetic Effects of the Atomic Bombs in Hiroshima and Nagasaki""; ""THE EFFECT OF EXPOSURE TO THE ATOMIC BOMBS ON PREGNANCY TERMINATION IN HIROSHIMA AND NAGASAKI""; ""TABLE OF CONTENTS""; ""LIST OF TABLES""; ""LIST OF FIGURES""; ""CHAPTER I BACKGROUND""; ""CHAPTER II THE PLAN""
""CHAPTER III A COMPARISON OF HIROSHIMA AND NAGASAKI""""CHAPTER IV THE CRITERIA OF RADIATION EMPLOYED IN THE STUDY""; ""CHAPTER V THE COMPARABILITY OF IRRADIATION SUBCLASSES""; ""CHAPTER VI STATISTICAL METHODS""; ""CHAPTER VII ANALYSIS OF THE SEX RATIO DATA""; ""CHAPTER VIII ANALYSIS OF THE MALFORMATION DATA""; ""CHAPTER IX ANALYSIS OF THE STILLBIRTH DATA""; ""CHAPTER X THE ANALYSIS OF THE BIRTHWEIGHT DATA""; ""CHAPTER XI ANALYSIS OF THE DATA CONCERNING DEATH DURING THE NINE-MONTH PERIOD FOLLOWING DELIVERY""; ""CHAPTER XII THE ANALYSIS OF THE ANTHROPOMETRIC DATA""
""CHAPTER XIII THE AUTOPSY FINDINGS""""CHAPTER XIV RECAPITULATION""; ""CHAPTER XV PERMISSIBLE INFERENCES""; ""APPENDIX""; ""PROCEDURE FOR CODING GENETICS SHORT-FORM QUESTIONNAIRES""; ""CODING INSTRUCTIONS FOR GENETICS FOLLOW-UP QUESTIONNAIRES""; ""CODING INSTRUCTIONS FOR PEDIATRICS FOLLOW-UP QUESTIONNAIRE""; ""REFERENCES""; ""SUBJECT INDEX ""; ""NAME INDEX ""; ""ATOMIC BOMB EXPOSURE AND THE PREGNANCIES OF BIOLOGICALLY RELATED PARENTS A PROSPECTIVE STUDY OFGENETIC EFFECTS OF IONIZING�""; ""REFERENCES""
""Some Further Observations on the Sex Ratio Among Infants Born to Survivors of the Atomic Bombings of Hiroshima and Nagasaki""""STUDIES OF THE SEX RATIO IN HIROSHIMA AND NAGASAKI""; ""DISCUSSION""; ""Other Studies of the Effect of Radiation on the Sex Ratio in Man""; ""On an Interpretation of the Present Studies""; ""SUMMARY""; ""REFERENCES""; ""A Cohort-Type Study of Survival in the Children of Parents Exposed to Atomic Bombings""; ""Factors Determining the Design of the Study""; ""DESCRIPTION OF STUDY PROCEDURES""; ""SOURCES OF VARIATION IN MORTALITY OTHER THAN RADIATION""
""THE RELATIONSHIP OF MORTALITY TO EXPOSURE""""DISCUSSION""; ""EPILOGUE""; ""SUMMARY""; ""REFERENCES""; ""MORTALITY IN THE CHILDREN OF ATOMIC BOMB SURVIVORS AND CONTROLS""; ""ABSTRACT""; ""THE STUDY POPULATION""; ""STATISTICAL CONSIDERATIONS""; ""THE DATA""; ""DISCUSSION""; ""LITERATURE CITED""; ""8 Cytogenetic Study of the Offspring of Atomic Bomb Survivors, Hiroshima and Nagasaki""; ""1 INTRODUCTION""; ""2 MATERIALS AND METHODS""; ""3 RESULTS""; ""3.1 Characteristics of the Study Sample""; ""3.2 Types and Frequencies of Chromosome Abnormalities""; ""3.2.1 Sex Chromosome Abnormalities""
""3.2.2 Autosomal Structural Rearrangements""
Record Nr. UNINA-9910455962903321
Washington, D.C., : National Academy Press, 1991
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
The Children of atomic bomb survivors [[electronic resource] ] : a genetic study / / edited by James V. Neel and William J. Schull
The Children of atomic bomb survivors [[electronic resource] ] : a genetic study / / edited by James V. Neel and William J. Schull
Pubbl/distr/stampa Washington, D.C., : National Academy Press, 1991
Descrizione fisica 1 online resource (524 p.)
Disciplina 614.5/99
Altri autori (Persone) NeelJames V <1915-2000.> (James Van Gundia)
SchullWilliam J
Soggetto topico Children of atomic bomb victims - Health and hygiene - Japan - Hiroshima-shi
Children of atomic bomb victims - Health and hygiene - Japan - Nagasaki-shi
Radiation - Toxicology
Genetic toxicology
ISBN 1-280-20376-5
9786610203765
0-309-59318-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ""THE CHILDREN OF ATOMIC BOMB SURVIVORS""; ""Copyright""; ""Preface""; ""Contents""; ""Orientation""; ""BEGINNINGS""; ""THE THREE PHASES OF THE STUDY""; ""Phase I (1948�1954)""; ""Phase II (1955�1968)""; ""Phase III (1969�1990)""; ""AN ESTIMATE OF THE GENETIC DOUBLING DOSE OF RADIATION""; ""REFERENCES""; ""Genetic Effects of the Atomic Bombs in Hiroshima and Nagasaki""; ""THE EFFECT OF EXPOSURE TO THE ATOMIC BOMBS ON PREGNANCY TERMINATION IN HIROSHIMA AND NAGASAKI""; ""TABLE OF CONTENTS""; ""LIST OF TABLES""; ""LIST OF FIGURES""; ""CHAPTER I BACKGROUND""; ""CHAPTER II THE PLAN""
""CHAPTER III A COMPARISON OF HIROSHIMA AND NAGASAKI""""CHAPTER IV THE CRITERIA OF RADIATION EMPLOYED IN THE STUDY""; ""CHAPTER V THE COMPARABILITY OF IRRADIATION SUBCLASSES""; ""CHAPTER VI STATISTICAL METHODS""; ""CHAPTER VII ANALYSIS OF THE SEX RATIO DATA""; ""CHAPTER VIII ANALYSIS OF THE MALFORMATION DATA""; ""CHAPTER IX ANALYSIS OF THE STILLBIRTH DATA""; ""CHAPTER X THE ANALYSIS OF THE BIRTHWEIGHT DATA""; ""CHAPTER XI ANALYSIS OF THE DATA CONCERNING DEATH DURING THE NINE-MONTH PERIOD FOLLOWING DELIVERY""; ""CHAPTER XII THE ANALYSIS OF THE ANTHROPOMETRIC DATA""
""CHAPTER XIII THE AUTOPSY FINDINGS""""CHAPTER XIV RECAPITULATION""; ""CHAPTER XV PERMISSIBLE INFERENCES""; ""APPENDIX""; ""PROCEDURE FOR CODING GENETICS SHORT-FORM QUESTIONNAIRES""; ""CODING INSTRUCTIONS FOR GENETICS FOLLOW-UP QUESTIONNAIRES""; ""CODING INSTRUCTIONS FOR PEDIATRICS FOLLOW-UP QUESTIONNAIRE""; ""REFERENCES""; ""SUBJECT INDEX ""; ""NAME INDEX ""; ""ATOMIC BOMB EXPOSURE AND THE PREGNANCIES OF BIOLOGICALLY RELATED PARENTS A PROSPECTIVE STUDY OFGENETIC EFFECTS OF IONIZING�""; ""REFERENCES""
""Some Further Observations on the Sex Ratio Among Infants Born to Survivors of the Atomic Bombings of Hiroshima and Nagasaki""""STUDIES OF THE SEX RATIO IN HIROSHIMA AND NAGASAKI""; ""DISCUSSION""; ""Other Studies of the Effect of Radiation on the Sex Ratio in Man""; ""On an Interpretation of the Present Studies""; ""SUMMARY""; ""REFERENCES""; ""A Cohort-Type Study of Survival in the Children of Parents Exposed to Atomic Bombings""; ""Factors Determining the Design of the Study""; ""DESCRIPTION OF STUDY PROCEDURES""; ""SOURCES OF VARIATION IN MORTALITY OTHER THAN RADIATION""
""THE RELATIONSHIP OF MORTALITY TO EXPOSURE""""DISCUSSION""; ""EPILOGUE""; ""SUMMARY""; ""REFERENCES""; ""MORTALITY IN THE CHILDREN OF ATOMIC BOMB SURVIVORS AND CONTROLS""; ""ABSTRACT""; ""THE STUDY POPULATION""; ""STATISTICAL CONSIDERATIONS""; ""THE DATA""; ""DISCUSSION""; ""LITERATURE CITED""; ""8 Cytogenetic Study of the Offspring of Atomic Bomb Survivors, Hiroshima and Nagasaki""; ""1 INTRODUCTION""; ""2 MATERIALS AND METHODS""; ""3 RESULTS""; ""3.1 Characteristics of the Study Sample""; ""3.2 Types and Frequencies of Chromosome Abnormalities""; ""3.2.1 Sex Chromosome Abnormalities""
""3.2.2 Autosomal Structural Rearrangements""
Record Nr. UNINA-9910778503703321
Washington, D.C., : National Academy Press, 1991
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui