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Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg
| Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene silencing
RNA |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-908230-67-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Preface; Current books of interest; 1: Overview of Biogenesis and Applications of MicroRNA; Introduction; Mammalian microRNA biogenesis; Regulation during normal and potentially pathogenic microRNA biogenesis; Harnessing the RNAi pathway for gene silencing; Augmenting and antagonizing microRNA function; MicroRNA targets as gene regulators and sensors; MicroRNAs as prognostic and diagnostic markers; Conclusion; 2: Non-canonical MicroRNA Biogenesis and Function; Canonical microRNA biogenesis and function; Other small RNA biogenesis pathways
Non-canonical microRNA biogenesisOther RNA modifications; Non-canonical microRNA function; Concluding remarks; 3: Non-coding RNAs and the Epigenetic Control of Gene Expression; Long non-coding RNAs epigenetic regulators in human cells; Disruption of long antisense ncRNA networks; The therapeutic potential of targeting antisense ncRNAs; Issues with using small antisense ncRNAs therapeutically; 4: From Mice to Men: Towards the Clinical Translation of MicroRNA Technologies for Somatic Cell Reprogramming; Introduction; General evidence for a role of miRNAs in pluripotency and differentiation Strategies for the identification of pluripotency-associated miRNAsDelivery or expression of miRNAs as novel tools to improve reprogramming; MiRNA-based systems to monitor or control pluripotency and differentiation; Outlook: the road towards clinical translation of human iPSC technologies; 5: Systems Biology Tools to Understand the Role of Host MicroRNAs in Infection: a Closer Look at HIV; Background information; Systems biology tools to investigate differential miRNA expression in HIV infection; A high-content screening approach to evaluate the role of host miRNAs in HIV infection Conclusions and future prospects6: Synthetic MicroRNA Blocking Agents; Introduction; Anti-miR chemistries; Mechanisms of action and delivery of anti-miRs into cells; Validation of anti-miR activity in cells and assays; Therapeutic anti-miRs and in vivo delivery; MicroRNA sponges for suppression of microRNA activity; Target protectors for inhibition of microRNA-induced mRNA degradation; MicroRNA mimics; Prospects; 7: Exploiting MicroRNAs to Regulate Transgene Expression; Introduction; Using microRNAs avoid immune response to transgene product after gene transfer Using microRNA to improve cell specificity and escape side-effect of gene transferNovel type of expression system using microRNAs; Conclusion; 8: Use of Artificial MicroRNAs for Gene Silencing; Introduction; Evolution of artificial miRNA as therapeutic agents; Application of amiRNA; Challenges using amiRNAs as therapeutic agents; amiRNA progress to clinic; Conclusions; 9: Harnessing RNAi for the Treatment of Viral Infections; Introduction; RNAi to treat viral hepatitis; RNAi for respiratory viruses; RNAi for haemorrhagic fever viruses; Other viruses targeted by RNAi RNAi for the treatment of non-viral infections |
| Record Nr. | UNINA-9910464383103321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg
| Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene silencing
RNA |
| ISBN | 1-908230-67-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Preface; Current books of interest; 1: Overview of Biogenesis and Applications of MicroRNA; Introduction; Mammalian microRNA biogenesis; Regulation during normal and potentially pathogenic microRNA biogenesis; Harnessing the RNAi pathway for gene silencing; Augmenting and antagonizing microRNA function; MicroRNA targets as gene regulators and sensors; MicroRNAs as prognostic and diagnostic markers; Conclusion; 2: Non-canonical MicroRNA Biogenesis and Function; Canonical microRNA biogenesis and function; Other small RNA biogenesis pathways
Non-canonical microRNA biogenesisOther RNA modifications; Non-canonical microRNA function; Concluding remarks; 3: Non-coding RNAs and the Epigenetic Control of Gene Expression; Long non-coding RNAs epigenetic regulators in human cells; Disruption of long antisense ncRNA networks; The therapeutic potential of targeting antisense ncRNAs; Issues with using small antisense ncRNAs therapeutically; 4: From Mice to Men: Towards the Clinical Translation of MicroRNA Technologies for Somatic Cell Reprogramming; Introduction; General evidence for a role of miRNAs in pluripotency and differentiation Strategies for the identification of pluripotency-associated miRNAsDelivery or expression of miRNAs as novel tools to improve reprogramming; MiRNA-based systems to monitor or control pluripotency and differentiation; Outlook: the road towards clinical translation of human iPSC technologies; 5: Systems Biology Tools to Understand the Role of Host MicroRNAs in Infection: a Closer Look at HIV; Background information; Systems biology tools to investigate differential miRNA expression in HIV infection; A high-content screening approach to evaluate the role of host miRNAs in HIV infection Conclusions and future prospects6: Synthetic MicroRNA Blocking Agents; Introduction; Anti-miR chemistries; Mechanisms of action and delivery of anti-miRs into cells; Validation of anti-miR activity in cells and assays; Therapeutic anti-miRs and in vivo delivery; MicroRNA sponges for suppression of microRNA activity; Target protectors for inhibition of microRNA-induced mRNA degradation; MicroRNA mimics; Prospects; 7: Exploiting MicroRNAs to Regulate Transgene Expression; Introduction; Using microRNAs avoid immune response to transgene product after gene transfer Using microRNA to improve cell specificity and escape side-effect of gene transferNovel type of expression system using microRNAs; Conclusion; 8: Use of Artificial MicroRNAs for Gene Silencing; Introduction; Evolution of artificial miRNA as therapeutic agents; Application of amiRNA; Challenges using amiRNAs as therapeutic agents; amiRNA progress to clinic; Conclusions; 9: Harnessing RNAi for the Treatment of Viral Infections; Introduction; RNAi to treat viral hepatitis; RNAi for respiratory viruses; RNAi for haemorrhagic fever viruses; Other viruses targeted by RNAi RNAi for the treatment of non-viral infections |
| Record Nr. | UNINA-9910786928003321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg
| Applied RNAi : from fundamental research to therapeutic applications / / Edited by Patrick Arbuthnot and Marc S. Weinberg |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2014] |
| Descrizione fisica | 1 online resource (266 p.) |
| Disciplina | 572.865 |
| Soggetto topico |
Gene silencing
RNA |
| ISBN | 1-908230-67-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; Preface; Current books of interest; 1: Overview of Biogenesis and Applications of MicroRNA; Introduction; Mammalian microRNA biogenesis; Regulation during normal and potentially pathogenic microRNA biogenesis; Harnessing the RNAi pathway for gene silencing; Augmenting and antagonizing microRNA function; MicroRNA targets as gene regulators and sensors; MicroRNAs as prognostic and diagnostic markers; Conclusion; 2: Non-canonical MicroRNA Biogenesis and Function; Canonical microRNA biogenesis and function; Other small RNA biogenesis pathways
Non-canonical microRNA biogenesisOther RNA modifications; Non-canonical microRNA function; Concluding remarks; 3: Non-coding RNAs and the Epigenetic Control of Gene Expression; Long non-coding RNAs epigenetic regulators in human cells; Disruption of long antisense ncRNA networks; The therapeutic potential of targeting antisense ncRNAs; Issues with using small antisense ncRNAs therapeutically; 4: From Mice to Men: Towards the Clinical Translation of MicroRNA Technologies for Somatic Cell Reprogramming; Introduction; General evidence for a role of miRNAs in pluripotency and differentiation Strategies for the identification of pluripotency-associated miRNAsDelivery or expression of miRNAs as novel tools to improve reprogramming; MiRNA-based systems to monitor or control pluripotency and differentiation; Outlook: the road towards clinical translation of human iPSC technologies; 5: Systems Biology Tools to Understand the Role of Host MicroRNAs in Infection: a Closer Look at HIV; Background information; Systems biology tools to investigate differential miRNA expression in HIV infection; A high-content screening approach to evaluate the role of host miRNAs in HIV infection Conclusions and future prospects6: Synthetic MicroRNA Blocking Agents; Introduction; Anti-miR chemistries; Mechanisms of action and delivery of anti-miRs into cells; Validation of anti-miR activity in cells and assays; Therapeutic anti-miRs and in vivo delivery; MicroRNA sponges for suppression of microRNA activity; Target protectors for inhibition of microRNA-induced mRNA degradation; MicroRNA mimics; Prospects; 7: Exploiting MicroRNAs to Regulate Transgene Expression; Introduction; Using microRNAs avoid immune response to transgene product after gene transfer Using microRNA to improve cell specificity and escape side-effect of gene transferNovel type of expression system using microRNAs; Conclusion; 8: Use of Artificial MicroRNAs for Gene Silencing; Introduction; Evolution of artificial miRNA as therapeutic agents; Application of amiRNA; Challenges using amiRNAs as therapeutic agents; amiRNA progress to clinic; Conclusions; 9: Harnessing RNAi for the Treatment of Viral Infections; Introduction; RNAi to treat viral hepatitis; RNAi for respiratory viruses; RNAi for haemorrhagic fever viruses; Other viruses targeted by RNAi RNAi for the treatment of non-viral infections |
| Record Nr. | UNINA-9910817216603321 |
| Norfolk, England : , : Caister Academic Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Gene silencing in ectomycorrhiza / / Minna J. Kemppainen and Alejandro G. Pardo
| Gene silencing in ectomycorrhiza / / Minna J. Kemppainen and Alejandro G. Pardo |
| Autore | Kemppainen Minna J. |
| Pubbl/distr/stampa | New York, [New York] : , : Novinka, , 2010 |
| Descrizione fisica | 1 online resource (69 pages) : color illustrations |
| Disciplina | 631.4/6 |
| Collana |
Genetics - Research and Issues
Botanical Research and Practices |
| Soggetto topico |
Ectomycorrhizas - Biotechnology
Ectomycorrhizas - Genetics Ectomycorrhizal fungi Gene silencing Fungal proteins Genomics |
| ISBN | 1-61761-344-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Ectomycorrhiza -- The molecular revolution of ECM research -- Laccaria bicolor and the first genome of an ECM fungus -- RNA silencing in Laccaria bicolor -- Development of the pHg/pSILBA?-vector system for efficient RNA silencing via AMT in Laccaria bicolor. |
| Record Nr. | UNINA-9910160274703321 |
Kemppainen Minna J.
|
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| New York, [New York] : , : Novinka, , 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research
| Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research |
| Pubbl/distr/stampa | Oxford, UK, : Library Pub. Media, [2005]- |
| Soggetto topico |
Gene silencing
RNA Gene Silencing RNA Interference |
| Soggetto genere / forma | Periodicals. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
RNAi j
JRGS |
| Record Nr. | UNINA-9910147082603321 |
| Oxford, UK, : Library Pub. Media, [2005]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research
| Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research |
| Pubbl/distr/stampa | Oxford, UK, : Library Pub. Media, [2005]- |
| Soggetto topico |
Gene silencing
RNA Gene Silencing RNA Interference |
| Soggetto genere / forma | Periodicals. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
RNAi j
JRGS |
| Record Nr. | UNISA-996209541903316 |
| Oxford, UK, : Library Pub. Media, [2005]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Polycomb group proteins / / edited by Vincenzo Pirrotta
| Polycomb group proteins / / edited by Vincenzo Pirrotta |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Elsevier, , 2017 |
| Descrizione fisica | 1 online resource (374 pages) : illustrations (some color), tables |
| Disciplina | 572.865 |
| Collana | Translational Epigenetics Series |
| Soggetto topico |
Epigenetics
Gene silencing |
| ISBN |
0-12-809822-8
0-12-809737-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Introduction to polycomb group mechanisms / V. Pirrotta -- The role of RAWUL and SAM in polycomb repression complex 1 assembly and function / C.A. Kim -- The chromodomain of polycomb : methylation reader and beyond / S. Qin, L. Li and J. Min -- Unraveling the roles of canonical and noncanonical PRC1 complexes / E.M. Conway and A.P. Bracken -- Structure and biochemistry of the polycomb repressive complex 1 ubiquitin ligase module / A.G. Cochran -- Cooperative recruitment of polycomb complexes by polycomb response elements / Y.B. Schwartz -- Polycomb function and nuclear organization / F. Bantignies and G. Cavalli -- Molecular architecture of the polycomb repressive complex 2 / C.S. Huang, E. Nogales and C. Ciferri -- Polycomb repressive complex 2 structure and function / D. Holoch and R. Margueron -- Regulation of PRC2 activity / N. Liu and B. Zhu -- Activating mutations of the EZH2 histone methyltransferase in cancer / R.G. Kruger, A.P. Graves and M.T. McCabe -- PcG proteins in Caenorhabditis elegans / B. Tursun -- Global functions of PRC2 complexes / V. Pirrotta. |
| Record Nr. | UNINA-9910583381203321 |
| Amsterdam, [Netherlands] : , : Elsevier, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
RNA interference [[electronic resource] /] / Patrick J. Paddison, Peter K. Vogt, editors
| RNA interference [[electronic resource] /] / Patrick J. Paddison, Peter K. Vogt, editors |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | Berlin, : Springer, c2008 |
| Descrizione fisica | 1 online resource (282 p.) |
| Disciplina | 615.7924 |
| Altri autori (Persone) |
VogtP. K <1932-> (Peter K.)
PaddisonPatrick J |
| Collana | Current topics in microbiology and immunology |
| Soggetto topico |
Gene silencing
RNA |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-17949-3
9786611179496 3-540-75157-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | RNA Interference in Mammalian Cell Systems -- RNAi Pathway in C. elegans: The Argonautes and Collaborators -- Genetics and Biochemistry of RNAi in Drosophila -- Role of Dicer in Posttranscriptional RNA Silencing -- The Mechanism of RNase III Action: How Dicer Dices -- MicroRNA Metabolism in Plants -- Structure-Function Relationships Among RNA-Dependent RNA Polymerases -- RNAi-Mediated Chromatin Silencing in Fission Yeast -- A Role for RNAi in Heterochromatin Formation in Drosophila -- RNA-Mediated Transcriptional Gene Silencing in Human Cells -- RNA Silencing in Mammalian Oocytes and Early Embryos -- Identifying Human MicroRNAs. |
| Record Nr. | UNINA-9910458389503321 |
| Berlin, : Springer, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
RNA interference [[electronic resource] /] / Patrick J. Paddison, Peter K. Vogt, editors
| RNA interference [[electronic resource] /] / Patrick J. Paddison, Peter K. Vogt, editors |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | Berlin, : Springer, c2008 |
| Descrizione fisica | 1 online resource (282 p.) |
| Disciplina | 615.7924 |
| Altri autori (Persone) |
VogtP. K <1932-> (Peter K.)
PaddisonPatrick J |
| Collana | Current topics in microbiology and immunology |
| Soggetto topico |
Gene silencing
RNA |
| ISBN |
1-281-17949-3
9786611179496 3-540-75157-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | RNA Interference in Mammalian Cell Systems -- RNAi Pathway in C. elegans: The Argonautes and Collaborators -- Genetics and Biochemistry of RNAi in Drosophila -- Role of Dicer in Posttranscriptional RNA Silencing -- The Mechanism of RNase III Action: How Dicer Dices -- MicroRNA Metabolism in Plants -- Structure-Function Relationships Among RNA-Dependent RNA Polymerases -- RNAi-Mediated Chromatin Silencing in Fission Yeast -- A Role for RNAi in Heterochromatin Formation in Drosophila -- RNA-Mediated Transcriptional Gene Silencing in Human Cells -- RNA Silencing in Mammalian Oocytes and Early Embryos -- Identifying Human MicroRNAs. |
| Record Nr. | UNINA-9910784875503321 |
| Berlin, : Springer, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
RNA interference / / Patrick J. Paddison, Peter K. Vogt, editors
| RNA interference / / Patrick J. Paddison, Peter K. Vogt, editors |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | Berlin, : Springer, c2008 |
| Descrizione fisica | 1 online resource (282 p.) |
| Disciplina | 615.7924 |
| Altri autori (Persone) |
VogtP. K <1932-> (Peter K.)
PaddisonPatrick J |
| Collana | Current topics in microbiology and immunology |
| Soggetto topico |
Gene silencing
RNA |
| ISBN |
1-281-17949-3
9786611179496 3-540-75157-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | RNA Interference in Mammalian Cell Systems -- RNAi Pathway in C. elegans: The Argonautes and Collaborators -- Genetics and Biochemistry of RNAi in Drosophila -- Role of Dicer in Posttranscriptional RNA Silencing -- The Mechanism of RNase III Action: How Dicer Dices -- MicroRNA Metabolism in Plants -- Structure-Function Relationships Among RNA-Dependent RNA Polymerases -- RNAi-Mediated Chromatin Silencing in Fission Yeast -- A Role for RNAi in Heterochromatin Formation in Drosophila -- RNA-Mediated Transcriptional Gene Silencing in Human Cells -- RNA Silencing in Mammalian Oocytes and Early Embryos -- Identifying Human MicroRNAs. |
| Record Nr. | UNINA-9910818062803321 |
| Berlin, : Springer, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Gene silencing
(10)
- RNA (8)
- Gene Silencing (2)
- RNA Interference (2)
- Ectomycorrhizal fungi (1)