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Hereditary Breast and Ovarian Cancer : Molecular Mechanism and Clinical Practice / / edited by Seigo Nakamura, Daisuke Aoki, Yoshio Miki
| Hereditary Breast and Ovarian Cancer : Molecular Mechanism and Clinical Practice / / edited by Seigo Nakamura, Daisuke Aoki, Yoshio Miki |
| Edizione | [1st ed. 2021.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2021 |
| Descrizione fisica | 1 online resource (324 pages) : illustrations |
| Disciplina | 616.99449042 |
| Soggetto topico |
Internal medicine
Surgery Medicine - Research Biology - Research Medical genetics Internal Medicine Biomedical Research Medical Genetics Càncer d'ovari Càncer de mama Genètica molecular humana |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-16-4521-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1 History, Advancements, and Future Strategies -- 2 Molecular basis of BRCA1 and BRCA2 - Homologous recombination deficiency and tissue-specific carcinogenesis -- 3 Genetic Testing -- 4 Variants of uncertain significances in hereditary breast and ovarian cancer -- 5 Genetic counseling in Hereditary Breast and Ovarian Cancer -- 6 Hereditary Breast Cancer -- 7 Hereditary Ovarian Cancer -- 8 Risk-Based Breast Cancer Screening -- 9 Chemoprevention for Breast Cancer -- 10 Chemoprevention for Ovarian Cancer -- 11 Risk-Reducing Mastectomy (RRM) -- 12 Risk-reducing salpingo-oophorectomy (RRSO) -- 13 Panel Testing -- 14 Germline Findings through Precision Oncology for Ovarian Cancer -- 15 Germline Findings from Genetic Testing for Breast Cancer -- 16 Hereditary Breast and Ovarian Cancer (HBOC) Database -- 17 Ethical Issues: Overview in Genomic analysis and Clinical Context -- 18 PARP Inhibitors-Mechanism of action -- 19 PARPi - Efficacy in Hereditary Breast Cancer -- 20 Efficacy of Poly ADP-Ribose Polymerase Inhibitors for Hereditary Ovarian Cancer. |
| Record Nr. | UNINA-9910506401703321 |
| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular genetics & genomic medicine
| Molecular genetics & genomic medicine |
| Pubbl/distr/stampa | [Hoboken, NJ] : , : John Wiley & Sons, , [2013]- |
| Descrizione fisica | 1 online resource |
| Disciplina | 611 |
| Soggetto topico |
Medical genetics
Genomics Genetics, Medical Genètica mèdica Genètica molecular humana Genòmica |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. Revistes electròniques. |
| Soggetto non controllato | Pathology |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Molecular genetics and genomic medicine |
| Record Nr. | UNISA-996209075103316 |
| [Hoboken, NJ] : , : John Wiley & Sons, , [2013]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Molecular genetics & genomic medicine
| Molecular genetics & genomic medicine |
| Pubbl/distr/stampa | [Hoboken, NJ] : , : John Wiley & Sons, , [2013]- |
| Descrizione fisica | 1 online resource |
| Disciplina | 611 |
| Soggetto topico |
Medical genetics
Genomics Genetics, Medical Genètica mèdica Genètica molecular humana Genòmica |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. Revistes electròniques. |
| Soggetto non controllato | Pathology |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Molecular genetics and genomic medicine |
| Record Nr. | UNINA-9910139071003321 |
| [Hoboken, NJ] : , : John Wiley & Sons, , [2013]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Non-coding RNAs at the cross-road of cardiometabolic diseases and cancer / / Paul Holvoet
| Non-coding RNAs at the cross-road of cardiometabolic diseases and cancer / / Paul Holvoet |
| Autore | Holvoet Paul |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (xxx, 265 pages) : illustrations |
| Disciplina | 572.88 |
| Soggetto topico |
Non-coding RNA
Cardiovascular system - Diseases - Molecular aspects Metabolism - Disorders - Molecular aspects Cancer - Genetic aspects Càncer Malalties cardiovasculars Trastorns del metabolisme Genètica molecular humana |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-68844-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Acknowledgments -- Introduction -- The Move Towards Cellular Risk Markers -- Why Non-coding RNA? -- Objectives -- Approach -- Take Home Message -- References -- Contents -- Abbreviations -- 1 Biogenesis and Modes of Action of miRs and Circular and Long Non-coding RNAs -- 1.1 MiRs -- 1.1.1 Biogenesis of miRs -- 1.1.2 MiR Modes of Action -- 1.1.3 Naming of miRs -- 1.1.4 Useful Resources on miRs -- 1.2 Circular RNAs -- 1.2.1 Biogenesis of Circular RNAs -- 1.2.2 Circular RNAs Modes of Action -- 1.2.3 Useful Resources on Circ-RNAs -- 1.3 lncRNAs -- 1.3.1 Biogenesis of lncRNAs -- 1.3.2 Modes of Action of lncRNAs -- 1.4 piRs -- 1.4.1 Biogenesis of piRs -- 1.4.2 Modes of Action of piRs -- 1.4.3 Useful Resources on piRs -- References -- 2 Non-coding RNAs Related to Obesity -- 2.1 Mechanisms in White Adipogenesis -- 2.1.1 Role of Non-coding RNAs in White Adipogenesis -- 2.2 Inflammation and Insulin Resistance in Obese White Adipose Tissue -- 2.2.1 Role of Non-coding RNAs in Inflammation and Insulin Resistance in Obese White Adipose Tissue -- 2.3 Mechanisms in Brown Adipogenesis and Thermogenesis -- 2.3.1 Role of Non-coding RNAs in Brown Adipogenesis and Thermogenesis -- 2.4 Mechanisms in Browning of White Adipose Tissues -- 2.4.1 Role of Non-coding RNAs in Browning of White Adipose Tissue -- 2.5 Leptin and Insulin in the Hypothalamus -- 2.5.1 Non-coding RNAs Related to Leptin and Insulin in the Hypothalamus -- References -- 3 Non-coding RNAS Related to Type 2 Diabetes -- 3.1 Mechanisms in β Cell Maturation -- 3.1.1 Non-coding RNAs Related to β Cell Maturation -- 3.2 Mechanisms in Insulin Signaling in the Pancreas -- 3.2.1 Non-coding RNAs in Insulin Signaling in Type 2 Diabetes -- 3.3 Inflammation in the Pancreas, Insulin Resistance, and Type 2 Diabetes.
3.3.1 Non-coding RNAs Related to Inflammation in the Pancreas, with Insulin Resistance and Type 2 Diabetes -- References -- 4 Non-coding RNAs Related to Lipid Metabolism and Non-alcoholic Fatty Liver Disease -- 4.1 Cholesterol and Lipids in the Liver -- 4.1.1 Non-coding RNAs and Cholesterol in the Liver -- 4.2 Fatty Acids and Triglycerides -- 4.2.1 Non-coding RNAs and Fatty Acids and Triglycerides -- 4.3 Non-alcoholic Fatty Liver Disease -- 4.3.1 Non-coding RNAs Related to Non-alcoholic Fatty Liver Disease -- References -- 5 Non-coding RNAs Related to Atherosclerosis -- 5.1 Endothelial Injury, Inflammation, and Apoptosis -- 5.1.1 Non-coding RNAs in Endothelial Injury, Inflammation, and Apoptosis -- 5.2 Fibroproliferative Remodeling and Plaque Destabilization -- 5.2.1 Non-coding RNAs in Fibroproliferative Remodeling and Plaque Destabilization -- References -- 6 Non-coding RNAs in Cardiomyopathy and Heart Failure -- 6.1 Mechanisms in Cardiomyopathy and Heart Failure -- 6.2 Non-coding RNAs in Cardiomyopathy and Heart Failure -- 6.2.1 Non-coding RNAs in Cardiac Hypertrophy -- 6.2.2 Non-coding RNAs in Cardiac Fibrosis and ECM Deposition -- 6.2.3 Non-coding RNAs in Cardiac Inflammation -- 6.2.4 Non-coding RNAs in Cardiac Angiogenesis -- 6.2.5 Non-coding RNAs in Cardiac Apoptosis -- 6.3 Metabolic Syndrome: The Link Between Metabolic and Cardiovascular Diseases -- 6.3.1 Definition of Metabolic Syndrome -- 6.3.2 Oxidative Stress and Metabolic Syndrome -- 6.3.3 Metabolic Syndrome and Cardiovascular Risk -- 6.3.4 Non-coding RNAs and Metabolic Syndrome Components -- References -- 7 Non-coding RNAs Related to Cardiometabolic Diseases and Associated to Cancer -- 7.1 Mechanisms of Cancer Progression -- 7.1.1 Induction of Stemness -- 7.1.2 Induction of EMT -- 7.1.3 Induction of Insulin Sensitized State, Cancer Cell Proliferation, and Protection Against Apoptosis. 7.1.4 Induction of Glycolysis -- 7.1.5 Induction of Angiogenesis -- 7.1.6 Repression of Anti-tumor Immunity and Apoptosis -- 7.1.7 Cancer Cell Proliferation -- 7.1.8 EGFR Signaling and Cancer Progression -- 7.1.9 BMI1 and EZH2 in Cancer Progression -- 7.2 Non-coding RNAs Related to Metabolic and Cardiovascular Diseases Are also Involved in Cancer Progression -- 7.3 Comparison of the Role of Non-coding RNAs in Cardiometabolic Diseases and Cancer -- References -- 8 Regulation of Non-coding RNAs in Cardiometabolic Tissues and Tumors -- 8.1 Regulation of miRs -- 8.1.1 Hypoxia -- 8.1.2 Glucose -- 8.1.3 Oxidative Stress -- 8.1.4 Inflammation -- 8.1.5 TGF-β -- 8.1.6 MYC -- 8.1.7 Overview -- 8.2 Differences in miR-Profiles in Cardiometabolic Tissues and Tumors May be Due to the Typical Action of lncRNAs and circ-RNAs in Tumors -- 8.3 Action of piRs Particularly in Tumors -- References -- 9 Communication Between Tumor-Adjacent Tissues and Tumors with Emphasis on Role of Inflammatory Cells -- 9.1 Exchange of miR-Enriched Microvesicles -- 9.2 MiR-155 as a Link Between M1 Macrophage-Mediated Inflammation in Tumor-Adjacent Tissue and Tumor Growth and Metastasis -- References -- 10 The Impact of Non-coding RNA Networks on Disease Comorbidity: Cardiometabolic Diseases, Inflammatory Diseases, and Cancer -- 10.1 Identification of Non-coding RNAs at Cross-Road of Metabolic and Cardiovascular Diseases -- 10.2 Many Non-coding RNAs at Cross-Road of Metabolic and Cardiovascular Diseases are also Related to Inflammatory Diseases -- 10.3 Differences Between Non-coding RNAs in Cardiometabolic Tissues and Tumors -- 10.4 Expected Technical Developments Underlying the Use of Non-coding RNAs as Biomarkers -- 10.5 The Need for Measuring Fluctuation of Non-coding RNAs -- References. |
| Record Nr. | UNINA-9910483036503321 |
Holvoet Paul
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| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Omics Approaches to Understanding Muscle Biology / / edited by Jatin George Burniston, Yi-Wen Chen
| Omics Approaches to Understanding Muscle Biology / / edited by Jatin George Burniston, Yi-Wen Chen |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | New York, NY : , : Springer US : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (VII, 217 p. 35 illus., 32 illus. in color.) |
| Disciplina | 612 |
| Collana | Methods in Physiology |
| Soggetto topico |
Human physiology
Proteomics Metabolism Human genetics Systems biology Human Physiology Metabolomics Human Genetics Systems Biology Músculs Fisiologia humana Malalties musculars Genètica molecular humana |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 1-4939-9802-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I: Genomic and Epi-genomic -- 1) GWAS/muscle function and diseases (by Eric Hoffman) -- 2) Whole genome and whole exon sequencing/muscle disorders (by Silvère van der Maarel and Richard Lemmers) -- 3) Epi-genome approaches/muscle regeneration (by Vittorio Sartorelli) -- Part II: Transcriptomic -- 4) RNA profiling (by Yi-Wen Chen, confirmed) -- 5) miRNA profiling (by Alyson Fiorillo) -- 6) Single cell profiling in muscle (byPier Lorenzo Puri) -- 7) Statistics and bioinformatics (by Heather Gordish) -- Part III: Proteomic -- 8). Proteome profiling of human/ clinical samples – i.e. necessarily label-free techniques (by Lawrence Mandarino) -- 9) Proteome profiling of cell and animal models – i.e. label techniques such as SILAC (by Matthias Mann OR SILAM with JR Yates III) -- 10) Global analysis of post-translational modifications (by David E James) -- 11) Proteome dynamics – synthesis and degradation on a proteome wide scale (by Jatin Burniston, confirmed) -- Part IV: Metabolomic -- 12) Non-targeted metabolomics using mass spectrometry (by Charles Burant). |
| Record Nr. | UNINA-9910373921103321 |
| New York, NY : , : Springer US : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
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Genètica molecular humana
(5)
- Medical genetics (3)
- Genetics, Medical (2)
- Genomics (2)
- Genètica mèdica (2)