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Balkan journal of medical genetics
| Balkan journal of medical genetics |
| Pubbl/distr/stampa | Warsaw, Poland : , : De Gruyter Open |
| Soggetto topico |
Medical genetics
Genetics, Medical Genètica mèdica |
| Soggetto genere / forma |
Periodical
Periodicals. Revistes electròniques. |
| ISSN | 2199-5761 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | BJMG |
| Record Nr. | UNISA-996321188003316 |
| Warsaw, Poland : , : De Gruyter Open | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Balkan journal of medical genetics
| Balkan journal of medical genetics |
| Pubbl/distr/stampa | Warsaw, Poland : , : De Gruyter Open |
| Soggetto topico |
Medical genetics
Genetics, Medical Genètica mèdica |
| Soggetto genere / forma |
Periodical
Periodicals. Revistes electròniques. |
| ISSN | 2199-5761 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | BJMG |
| Record Nr. | UNINA-9910145843203321 |
| Warsaw, Poland : , : De Gruyter Open | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The carbonic anhydrases : current and emerging therapeutic targets / / W. Richard Chegwidden, Nicholas D. Carter, editors
| The carbonic anhydrases : current and emerging therapeutic targets / / W. Richard Chegwidden, Nicholas D. Carter, editors |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (296 pages) |
| Disciplina | 615.1 |
| Collana | Progress in Drug Research |
| Soggetto topico |
Genètica mèdica
Pharmacology Clinical biochemistry Pharmacy |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-79511-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Dedication to Richard Tashian -- Preface -- Contents -- 1 The Carbonic Anhydrases in Health and Disease -- References -- 2 Carbonic Anhydrase Isozymes as Diagnostic Biomarkers and Therapeutic Targets -- 2.1 Short Introduction of Mammalian Carbonic Anhydrases -- 2.2 CA II as a Biomarker -- 2.3 CA IX as a Biomarker -- 2.4 CA IX Immunoassay Data -- 2.5 CA XII in Cancer -- 2.6 Carbonic Anhydrases as Therapeutic Targets -- 2.7 Concluding Remarks -- References -- 3 Targeting Carbonic Anhydrases in Cardiovascular and Pulmonary Disease -- 3.1 Introduction -- 3.2 Carbonic Anhydrase Isozymes and Activity in the Cardiopulmonary System -- 3.3 Effects of CA Inhibitors Independent of CA Inhibition -- 3.4 CA Functions in the Normal Heart -- 3.4.1 CO2 Elimination -- 3.4.2 Cardiac pH Homeostasis -- 3.4.3 Metabolism-Perfusion Matching -- 3.4.4 Fatty Acid/Lactate Uptake -- 3.4.5 Myocardial Contractility and Calcium Mobilization -- 3.5 CA Functions in the Normal Lung -- 3.5.1 Alveolar Carbon Dioxide Elimination -- 3.5.2 Lung Fluid Exchange and pH Regulation -- 3.5.3 Ventilation-Perfusion Matching -- 3.5.4 Pleural Fluid Composition and Turnover -- 3.6 Carbonic Anhydrase Inhibitors and Cardiovascular Disease -- 3.6.1 Systemic Hypertension -- 3.6.2 Cardiac Hypertrophy and Heart Failure -- 3.6.3 Coronary Artery Disease and Myocardial Infarction -- 3.7 Carbonic Anhydrase Inhibitors in Pulmonary Disease -- 3.7.1 Chronic Obstructive Pulmonary Disease (COPD) -- 3.7.2 Chronic Cough -- 3.7.3 Pulmonary Hypertension (PH) -- 3.7.4 Lung Ischemia-Reperfusion Injury -- 3.8 Conclusions -- References -- 4 Carbonic Anhydrase Inhibitors in Ophthalmology: Glaucoma and Macular Oedema -- 4.1 Introduction -- 4.2 Carbonic Anhydrase Inhibitors in Glaucoma -- 4.2.1 Systemic Carbonic Anhydrase Inhibitors -- 4.2.2 Topical Carbonic Anhydrase Inhibitors.
4.2.3 Carbonic Anhydrase Inhibitors in Ocular Perfusion -- 4.3 Carbonic Anhydrase Inhibitors in Macular Oedema -- 4.3.1 Systemic Carbonic Anhydrase Inhibitors -- 4.3.2 Topical Carbonic Anhydrase Inhibitors -- References -- 5 Targeting Carbonic Anhydrase Isozymes in the Treatment of Neurological Disorders -- 5.1 Expression and Function of Enzymatically Active Carbonic Anhydrases in the Nervous System -- 5.2 CA Inhibitors in the Treatment of Neurological Diseases -- 5.3 CA Inhibitors in the Treatment of Acute High-Altitude Illness -- 5.4 CA Inhibitors in the Treatment of Pseudotumor Cerebri -- 5.5 CA Inhibitors in the Treatment of Brain Edema -- 5.6 CA Inhibitors in the Treatment of Epilepsy -- 5.7 Carbonic Anhydrase-Related Proteins (CARPs) -- 5.8 Localization and Role of CARP VIII -- 5.9 Distribution and Role of CARP X -- 5.10 Distribution and Role of CARP XI -- 5.11 Concluding Remarks -- References -- 6 Potential of Carbonic Anhydrase Inhibitors in the Treatment of Oxidative Stress and Diabetes -- 6.1 Introduction -- 6.2 Oxidative Stress and Diabetes -- 6.3 Retinal Pericytes and Metabolic Activity -- 6.4 Metabolic Activity, Oxidative Stress, and Diabetic Retinopathy -- 6.5 Carbonic Anhydrases -- 6.6 Mitochondrial Carbonic Anhydrases and Oxidative Stress -- 6.7 Carbonic Anhydrase Inhibitors and Prevention of Diabetic Retinopathy -- 6.8 Conclusions -- References -- 7 An Overview of Carbonic Anhydrase-Related Neoplasms -- 7.1 Introduction -- 7.2 Expression of Cytoplasmic CA Isoforms in Neoplasms -- 7.3 Expression of Mitochondrial CA Isoforms in Cancer -- 7.4 Expression of Membrane-Bound and Secreted CA Isoforms in Cancer -- 7.5 Expression of Inactive CA Isoforms in Cancer -- 7.6 Carbonic Anhydrase-Related Neoplasms -- 7.7 Conclusions -- References -- 8 Carbonic Anhydrase IX Interactome and the Regulation of Cancer Progression. 8.1 Tumour Microenvironment and Hypoxia -- 8.2 CAIX-regulation, Protein and Function -- 8.3 Overview of the CAIX Interactome -- 8.4 CAIX in Metastasis -- 8.4.1 CAIX and Cell-cell De-Adhesion -- 8.4.2 CAIX and Cell Migration -- 8.4.3 Invadopodia-Mediated Cell Invasion -- 8.5 Amino Acid Transporters and CAIX -- 8.6 CAIX and Unfolded Protein Response -- 8.7 Summary and Therapeutic Implications -- References -- 9 Carbonic Anhydrase IX: Current and Emerging Therapies -- 9.1 Introduction -- 9.2 Carbonic Anhydrase IX Imaging -- 9.2.1 CAIX Imaging in RCC -- 9.2.2 CAIX Imaging in Non-RCC -- 9.3 Intraoperative Imaging -- 9.4 CAIX-Directed Radioimmunotherapy -- 9.5 Carbonic Anhydrase IX Immunotherapy -- 9.6 Conclusion and Future Perspectives -- References -- 10 Carbonic Anhydrase Inhibitors: Designing Isozyme-Specific Inhibitors as Therapeutic Agents -- 10.1 Introduction: Classical CA Inhibitors (CAIs) -- 10.2 CA Inhibition Mechanisms and the Drug Design -- 10.3 Strategies for Obtaining Isoform-Selective CAIs -- 10.4 Conclusions -- References -- 11 Carbonic Anhydrase Inhibitors: Identifying Therapeutic Cancer Agents Through Virtual Screening -- 11.1 Virtual Screening in Drug Discovery -- 11.2 Virtual Screening Studies Identifying Novel Carbonic Anhydrase Inhibitors -- 11.3 Retrospective Virtual Screening Studies Using Carbonic Anhydrases as Target Receptors -- References -- 12 Targeting Carbonic Anhydrase IX in Tumor Imaging and Theranostic Cancer Therapy -- 12.1 Introduction -- 12.2 Targeting CA-IX as a Biomarker of Tumor Hypoxia -- 12.3 Methods for Detecting Tumor Hypoxia -- 12.4 CA-IX Expression in Clear Cell Renal Cell Carcinoma -- 12.5 Monoclonal Antibodies -- 12.5.1 Imaging with G250/cG250 -- 12.5.2 Radioimmunotherapy with G250/cG250 -- 12.5.3 Dual Modality Imaging with cG250 -- 12.6 Peptides and Affibodies -- 12.7 Small Molecule Inhibitors. 12.7.1 Net Charge -- 12.7.2 Multivalence and Size -- 12.7.3 Radiometal Chelator Complex -- 12.8 Perspectives and Conclusion -- References -- Index. |
| Record Nr. | UNINA-9910508477203321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Clinical genetics
| Clinical genetics |
| Pubbl/distr/stampa | Copenhagen, : Munksgaard |
| Descrizione fisica | 1 online resource |
| Disciplina | 616/.042/05 |
| Soggetto topico |
Medical genetics
Genetics, Medical Génétique médicale Medische genetica Genètica mèdica |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1399-0004 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996214087903316 |
| Copenhagen, : Munksgaard | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Clinical genetics
| Clinical genetics |
| Pubbl/distr/stampa | Copenhagen, : Munksgaard |
| Descrizione fisica | 1 online resource |
| Disciplina | 616/.042/05 |
| Soggetto topico |
Medical genetics
Genetics, Medical Génétique médicale Medische genetica Genètica mèdica |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1399-0004 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910135936603321 |
| Copenhagen, : Munksgaard | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The hereditary basis of childhood cancer / / David Malkin, editor
| The hereditary basis of childhood cancer / / David Malkin, editor |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (495 pages) |
| Disciplina | 618.92994 |
| Soggetto topico |
Cancer in children - Genetic aspects
Cancer in children - Molecular aspects Càncer en els infants Genètica mèdica Malalties hereditàries |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-74448-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910502993803321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Human mutation
| Human mutation |
| Pubbl/distr/stampa | [New York, N.Y.], : Wiley-Liss, Inc., ©1992- |
| Disciplina | 616 |
| Soggetto topico |
Human chromosome abnormalities
Mutation (Biology) Medical genetics - Periodicals Medical genetics Mutation - genetics Genetics, Medical Génétique médicale - Périodiques Chromosomes humains - Anomalies Mutation (Biologie) Génétique médicale Cromosomes humans Mutació (Biologia) Genètica mèdica |
| Soggetto genere / forma |
Periodicals.
Revistes electròniques. |
| ISSN | 1098-1004 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996198572203316 |
| [New York, N.Y.], : Wiley-Liss, Inc., ©1992- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Human mutation
| Human mutation |
| Pubbl/distr/stampa | [New York, N.Y.], : Wiley-Liss, Inc., ©1992- |
| Disciplina | 616 |
| Soggetto topico |
Human chromosome abnormalities
Mutation (Biology) Medical genetics - Periodicals Medical genetics Mutation - genetics Genetics, Medical Génétique médicale - Périodiques Chromosomes humains - Anomalies Mutation (Biologie) Génétique médicale Cromosomes humans Mutació (Biologia) Genètica mèdica |
| Soggetto genere / forma |
Periodicals.
Revistes electròniques. |
| ISSN | 1098-1004 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910144004103321 |
| [New York, N.Y.], : Wiley-Liss, Inc., ©1992- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Molecular genetics & genomic medicine
| Molecular genetics & genomic medicine |
| Pubbl/distr/stampa | [Hoboken, NJ] : , : John Wiley & Sons, , [2013]- |
| Descrizione fisica | 1 online resource |
| Disciplina | 611 |
| Soggetto topico |
Medical genetics
Genomics Genetics, Medical Genètica mèdica Genètica molecular humana Genòmica |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. Revistes electròniques. |
| Soggetto non controllato | Pathology |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Molecular genetics and genomic medicine |
| Record Nr. | UNISA-996209075103316 |
| [Hoboken, NJ] : , : John Wiley & Sons, , [2013]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Molecular genetics & genomic medicine
| Molecular genetics & genomic medicine |
| Pubbl/distr/stampa | [Hoboken, NJ] : , : John Wiley & Sons, , [2013]- |
| Descrizione fisica | 1 online resource |
| Disciplina | 611 |
| Soggetto topico |
Medical genetics
Genomics Genetics, Medical Genètica mèdica Genètica molecular humana Genòmica |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. Revistes electròniques. |
| Soggetto non controllato | Pathology |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Molecular genetics and genomic medicine |
| Record Nr. | UNINA-9910139071003321 |
| [Hoboken, NJ] : , : John Wiley & Sons, , [2013]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
