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Gel filtration chromatography / L. Fischer
| Gel filtration chromatography / L. Fischer |
| Autore | Fischer, Lave |
| Edizione | [2nd. ed.] |
| Pubbl/distr/stampa | Amsterdam ; New York : Elsevier/North-Holland Biomedical Press, 1980 |
| Descrizione fisica | viii, 269 p. : ill. ; 20 cm |
| Disciplina | 572 |
| Collana | Laboratory techniques in biochemistry and molecular biology ; 1 Pt.2 |
| Soggetto topico |
Gel permeation chromatography
Biochemistry - Technique Molecular biology - Technique Chromatography - laboratory manuals Electrophoresis Gels - laboratory manuals |
| ISBN | 044480191X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISALENTO-991004051489707536 |
Fischer, Lave
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| Amsterdam ; New York : Elsevier/North-Holland Biomedical Press, 1980 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Salento | ||
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LC/MS applications in drug development [[electronic resource] /] / Mike S. Lee
| LC/MS applications in drug development [[electronic resource] /] / Mike S. Lee |
| Autore | Lee Mike S. <1960-> |
| Pubbl/distr/stampa | New York, : J. Wiley & Sons, c2002 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina |
615.19
615/.19 |
| Collana | Wiley-Interscience series on mass spectrometry |
| Soggetto topico |
Drug development - Methodology
Drugs - Analysis Liquid chromatography Mass spectrometry Combinatorial chemistry Gel permeation chromatography Drugs - Testing - Methodology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-36642-7
9786610366422 0-470-35636-7 0-471-45930-5 0-471-21881-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
LC/MS APPLICATIONS IN DRUG DEVELOPMENT; CONTENTS; Preface; Acknowledgments; 1. Introduction; Emerging Analytical Needs; Integration of LC/MS into Drug Development; Partnerships and Acceptance; Overview; 2. Drug Development Overview; Analysis Perspectives; The Four Stages of Drug Development; Drug Discovery; Preclinical Development; Clinical Development; Manufacturing; 3. Accelerated Drug Development; Accelerated Development Strategies; Quantitative and Qualitative Process Elements; Quantitative Process Pipeline; Qualitative Process Pipeline; Motivating Factors
Analysis Opportunities for Accelerated DevelopmentFull-Time Equivalent; Sample Throughput Model; Elimination Model; Rate-Determining Event Model; Accelerated Development Perspectives; 4. LC/MS Development; The Elements of LC/MS Application; HPLC; Mass Spectrometry; LC/MS Interface; LC/MS Growth; 5. Strategies; Standard Methods; Template Structure Identification; Databases; Screening; Integration; Miniaturization; Parallel Processing; Visualization; Automation; Summary; 6. LC/MS Applications; Drug Discovery; Proteomics; Protein Expression Profiling; Quantitation; Glycoprotein Mapping Natural Products DereplicationLead Identification Screening; Bioaffinity Screening; Combinatorial Library Screening; Open-Access LC/MS; Structure Confirmation; High Throughput; Purification; Combinatorial Mixture Screening; In Vivo Drug Screening; Pharmacokinetics; In Vitro Drug Screening; Metabolic Stability Screening; Membrane Permeability; Drug-Drug Interaction; Metabolite Identification; Preclinical Development; Metabolite Identification; Impurity Identification; Degradant Identification; Clinical Development; Quantitative Bioanalysis-Selected Ion Monitoring Quantitative Bioanalysis-Selected Reaction MonitoringQuantitative Bioanalysis-Automated Solid-Phase Extraction; Quantitative Bioanalysis-Automated On-Line Extraction; Metabolite Identification; Degradant Identification; Manufacturing; Impurity Identification Using Data-Dependent Analysis; Peptide Mapping in Quality Control; Patent Protection; 7. Future Applications and Prospects; Workstations; Multidimensional Analysis; Miniaturization; Information Management; Strategic Outsourcing; Summary; 8. Perspectives on the Future Growth of LC/MS; 9. Conclusions; Glossary; References; Index |
| Record Nr. | UNINA-9910143176103321 |
|
Lee Mike S. <1960->
|
||
| New York, : J. Wiley & Sons, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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LC/MS applications in drug development [[electronic resource] /] / Mike S. Lee
| LC/MS applications in drug development [[electronic resource] /] / Mike S. Lee |
| Autore | Lee Mike S. <1960-> |
| Pubbl/distr/stampa | New York, : J. Wiley & Sons, c2002 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina |
615.19
615/.19 |
| Collana | Wiley-Interscience series on mass spectrometry |
| Soggetto topico |
Drug development - Methodology
Drugs - Analysis Liquid chromatography Mass spectrometry Combinatorial chemistry Gel permeation chromatography Drugs - Testing - Methodology |
| ISBN |
1-280-36642-7
9786610366422 0-470-35636-7 0-471-45930-5 0-471-21881-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
LC/MS APPLICATIONS IN DRUG DEVELOPMENT; CONTENTS; Preface; Acknowledgments; 1. Introduction; Emerging Analytical Needs; Integration of LC/MS into Drug Development; Partnerships and Acceptance; Overview; 2. Drug Development Overview; Analysis Perspectives; The Four Stages of Drug Development; Drug Discovery; Preclinical Development; Clinical Development; Manufacturing; 3. Accelerated Drug Development; Accelerated Development Strategies; Quantitative and Qualitative Process Elements; Quantitative Process Pipeline; Qualitative Process Pipeline; Motivating Factors
Analysis Opportunities for Accelerated DevelopmentFull-Time Equivalent; Sample Throughput Model; Elimination Model; Rate-Determining Event Model; Accelerated Development Perspectives; 4. LC/MS Development; The Elements of LC/MS Application; HPLC; Mass Spectrometry; LC/MS Interface; LC/MS Growth; 5. Strategies; Standard Methods; Template Structure Identification; Databases; Screening; Integration; Miniaturization; Parallel Processing; Visualization; Automation; Summary; 6. LC/MS Applications; Drug Discovery; Proteomics; Protein Expression Profiling; Quantitation; Glycoprotein Mapping Natural Products DereplicationLead Identification Screening; Bioaffinity Screening; Combinatorial Library Screening; Open-Access LC/MS; Structure Confirmation; High Throughput; Purification; Combinatorial Mixture Screening; In Vivo Drug Screening; Pharmacokinetics; In Vitro Drug Screening; Metabolic Stability Screening; Membrane Permeability; Drug-Drug Interaction; Metabolite Identification; Preclinical Development; Metabolite Identification; Impurity Identification; Degradant Identification; Clinical Development; Quantitative Bioanalysis-Selected Ion Monitoring Quantitative Bioanalysis-Selected Reaction MonitoringQuantitative Bioanalysis-Automated Solid-Phase Extraction; Quantitative Bioanalysis-Automated On-Line Extraction; Metabolite Identification; Degradant Identification; Manufacturing; Impurity Identification Using Data-Dependent Analysis; Peptide Mapping in Quality Control; Patent Protection; 7. Future Applications and Prospects; Workstations; Multidimensional Analysis; Miniaturization; Information Management; Strategic Outsourcing; Summary; 8. Perspectives on the Future Growth of LC/MS; 9. Conclusions; Glossary; References; Index |
| Record Nr. | UNINA-9910830729403321 |
|
Lee Mike S. <1960->
|
||
| New York, : J. Wiley & Sons, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
LC/MS applications in drug development / / Mike S. Lee
| LC/MS applications in drug development / / Mike S. Lee |
| Autore | Lee Mike S. <1960-> |
| Pubbl/distr/stampa | New York, : J. Wiley & Sons, c2002 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina |
615.19
615/.19 |
| Collana | Wiley-Interscience series on mass spectrometry |
| Soggetto topico |
Drug development - Methodology
Drugs - Analysis Liquid chromatography Mass spectrometry Combinatorial chemistry Gel permeation chromatography Drugs - Testing - Methodology |
| ISBN |
1-280-36642-7
9786610366422 0-470-35636-7 0-471-45930-5 0-471-21881-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
LC/MS APPLICATIONS IN DRUG DEVELOPMENT; CONTENTS; Preface; Acknowledgments; 1. Introduction; Emerging Analytical Needs; Integration of LC/MS into Drug Development; Partnerships and Acceptance; Overview; 2. Drug Development Overview; Analysis Perspectives; The Four Stages of Drug Development; Drug Discovery; Preclinical Development; Clinical Development; Manufacturing; 3. Accelerated Drug Development; Accelerated Development Strategies; Quantitative and Qualitative Process Elements; Quantitative Process Pipeline; Qualitative Process Pipeline; Motivating Factors
Analysis Opportunities for Accelerated DevelopmentFull-Time Equivalent; Sample Throughput Model; Elimination Model; Rate-Determining Event Model; Accelerated Development Perspectives; 4. LC/MS Development; The Elements of LC/MS Application; HPLC; Mass Spectrometry; LC/MS Interface; LC/MS Growth; 5. Strategies; Standard Methods; Template Structure Identification; Databases; Screening; Integration; Miniaturization; Parallel Processing; Visualization; Automation; Summary; 6. LC/MS Applications; Drug Discovery; Proteomics; Protein Expression Profiling; Quantitation; Glycoprotein Mapping Natural Products DereplicationLead Identification Screening; Bioaffinity Screening; Combinatorial Library Screening; Open-Access LC/MS; Structure Confirmation; High Throughput; Purification; Combinatorial Mixture Screening; In Vivo Drug Screening; Pharmacokinetics; In Vitro Drug Screening; Metabolic Stability Screening; Membrane Permeability; Drug-Drug Interaction; Metabolite Identification; Preclinical Development; Metabolite Identification; Impurity Identification; Degradant Identification; Clinical Development; Quantitative Bioanalysis-Selected Ion Monitoring Quantitative Bioanalysis-Selected Reaction MonitoringQuantitative Bioanalysis-Automated Solid-Phase Extraction; Quantitative Bioanalysis-Automated On-Line Extraction; Metabolite Identification; Degradant Identification; Manufacturing; Impurity Identification Using Data-Dependent Analysis; Peptide Mapping in Quality Control; Patent Protection; 7. Future Applications and Prospects; Workstations; Multidimensional Analysis; Miniaturization; Information Management; Strategic Outsourcing; Summary; 8. Perspectives on the Future Growth of LC/MS; 9. Conclusions; Glossary; References; Index |
| Record Nr. | UNINA-9910877682203321 |
|
Lee Mike S. <1960->
|
||
| New York, : J. Wiley & Sons, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Modern size-exclusion liquid chromatography [[electronic resource] /] / André M. Striegel ... [et al.]
| Modern size-exclusion liquid chromatography [[electronic resource] /] / André M. Striegel ... [et al.] |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2009 |
| Descrizione fisica | 1 online resource (512 p.) |
| Disciplina | 543/.8 |
| Altri autori (Persone) | StriegelAndré M. <1967-> |
| Soggetto topico |
Gel permeation chromatography
Chromatographic analysis |
| ISBN |
1-282-27891-6
9786612278914 0-470-44287-5 0-470-44283-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
MODERN SIZE-EXCLUSION LIQUID CHROMATOGRAPHY; CONTENTS; Foreword; Preface; 1 Background; 1.1 Introduction; 1.2 History; 1.3 Utility of SEC; 1.4 Molar Mass Averages and Molar Mass Distribution; 1.5 Structure of The Book; References; 2 Retention; 2.1 Introduction; 2.2 Solute Retention in LC; 2.3 Solute Retention in SEC; 2.4 SEC Retention Mechanism; 2.5 Theoretical Models of SEC Separation; 2.5.1 Hard-Sphere Solute Model; 2.5.2 Rigid Molecules of Other Shapes; 2.5.3 Random-Coil Solute Model; 2.6 Other Considerations; 2.6.1 Factors Influencing SEC Retention
2.6.2 Failure to Define an Effective Polymer Radius2.6.3 Hydrodynamic Chromatography Effects in SEC; 2.6.4 Slalom Chromatography Effects in SEC; References; 3 Band Broadening; 3.1 Introduction; 3.1.1 Basic Column-Dispersion Processes; 3.1.2 Peak Variance; 3.2 LC Plate Theory; 3.2.1 Basic Plate Theory; 3.2.2 The van Deemter Equation; 3.2.3 Flow-Diffusion Coupling; 3.2.4 Reduced Plate Height; 3.3 Mechanism of SEC Band Broadening; 3.3.1 Experimental Verification; 3.3.2 Rate Theory; 3.3.3 Theoretical Inferences; 3.4 Influencing Factors; 3.4.1 Column Parameters; 3.4.2 Kinetic Factors 3.4.3 Experimental Factors3.5 Experimental Methods; 3.5.1 Plate Number; 3.5.2 Column-Dispersion Calibration; References; 4 Resolution; 4.1 Introduction; 4.1.1 Chromatographic Resolution; 4.1.2 Peak-Capacity Concept; 4.2 Resolution Concept in SEC of Polymers; 4.3 Molar Mass Accuracy Criterion; 4.4 Applications of Column Performance Criteria; 4.5 Pore Geometry and Operational Effects; 4.5.1 Connecting Columns; 4.5.2 Separation Capacity of Single Pores; 4.5.3 Effect of Packing Pore-Size Distribution; 4.5.4 Effect of Operating Parameters; References; 5 Equipment; 5.1 Introduction 5.2 Extra-Column Effects: General5.3 Mobile-Phase Reservoirs, Inlet Filters, and Degassers; 5.4 Solvent-Metering Systems (Pumps); 5.4.1 General Pump Specifications; 5.4.2 Reciprocating Pumps; 5.5 Sample Injectors and Autosamplers; 5.6 Miscellaneous Hardware; 5.7 Laboratory Safety; References; 6 The Column; 6.1 Introduction; 6.2 Column Packings; 6.2.1 Semirigid Organic Gels; 6.2.2 Rigid Inorganic Packings; 6.3 Column-Packing Methods; 6.3.1 Particle Technology; 6.3.2 Basis of Column-Packing Techniques; 6.4 Column Performance; References; 7 Experimental Variables and Techniques; 7.1 Introduction 7.2 Solvent Effects7.2.1 Sample Solubility; 7.2.2 Other Solvent Effects; 7.2.3 Flow-Rate Effects; 7.2.4 Temperature Effects; 7.3 Substrate Effects; 7.4 Sample Effects; 7.4.1 Sample Volume; 7.4.2 Sample Weight or Concentration; 7.5 Laboratory Techniques; 7.6 Solvent Selection and Preparation; 7.6.1 Convenience; 7.6.2 Sample Type; 7.6.3 Effect on Column Packing; 7.6.4 Operation; 7.6.5 Safety; 7.6.6 Solvent Purification and Modification; 7.7 Selection and Use of Standard Reference Materials; 7.8 Detector Selection; 7.9 Column Selection and Handling; 7.9.1 Optimum Single Pore-Size Separations 7.9.2 Bimodal Pore-Size Separations: Optimum Linearity and Range |
| Record Nr. | UNINA-9910139921903321 |
| Hoboken, N.J., : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Modern size-exclusion liquid chromatography / / Andre M. Striegel ... [et al.]
| Modern size-exclusion liquid chromatography / / Andre M. Striegel ... [et al.] |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2009 |
| Descrizione fisica | 1 online resource (512 p.) |
| Disciplina | 543/.8 |
| Altri autori (Persone) | StriegelAndre M. <1967-> |
| Soggetto topico |
Gel permeation chromatography
Chromatographic analysis |
| ISBN |
1-282-27891-6
9786612278914 0-470-44287-5 0-470-44283-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
MODERN SIZE-EXCLUSION LIQUID CHROMATOGRAPHY; CONTENTS; Foreword; Preface; 1 Background; 1.1 Introduction; 1.2 History; 1.3 Utility of SEC; 1.4 Molar Mass Averages and Molar Mass Distribution; 1.5 Structure of The Book; References; 2 Retention; 2.1 Introduction; 2.2 Solute Retention in LC; 2.3 Solute Retention in SEC; 2.4 SEC Retention Mechanism; 2.5 Theoretical Models of SEC Separation; 2.5.1 Hard-Sphere Solute Model; 2.5.2 Rigid Molecules of Other Shapes; 2.5.3 Random-Coil Solute Model; 2.6 Other Considerations; 2.6.1 Factors Influencing SEC Retention
2.6.2 Failure to Define an Effective Polymer Radius2.6.3 Hydrodynamic Chromatography Effects in SEC; 2.6.4 Slalom Chromatography Effects in SEC; References; 3 Band Broadening; 3.1 Introduction; 3.1.1 Basic Column-Dispersion Processes; 3.1.2 Peak Variance; 3.2 LC Plate Theory; 3.2.1 Basic Plate Theory; 3.2.2 The van Deemter Equation; 3.2.3 Flow-Diffusion Coupling; 3.2.4 Reduced Plate Height; 3.3 Mechanism of SEC Band Broadening; 3.3.1 Experimental Verification; 3.3.2 Rate Theory; 3.3.3 Theoretical Inferences; 3.4 Influencing Factors; 3.4.1 Column Parameters; 3.4.2 Kinetic Factors 3.4.3 Experimental Factors3.5 Experimental Methods; 3.5.1 Plate Number; 3.5.2 Column-Dispersion Calibration; References; 4 Resolution; 4.1 Introduction; 4.1.1 Chromatographic Resolution; 4.1.2 Peak-Capacity Concept; 4.2 Resolution Concept in SEC of Polymers; 4.3 Molar Mass Accuracy Criterion; 4.4 Applications of Column Performance Criteria; 4.5 Pore Geometry and Operational Effects; 4.5.1 Connecting Columns; 4.5.2 Separation Capacity of Single Pores; 4.5.3 Effect of Packing Pore-Size Distribution; 4.5.4 Effect of Operating Parameters; References; 5 Equipment; 5.1 Introduction 5.2 Extra-Column Effects: General5.3 Mobile-Phase Reservoirs, Inlet Filters, and Degassers; 5.4 Solvent-Metering Systems (Pumps); 5.4.1 General Pump Specifications; 5.4.2 Reciprocating Pumps; 5.5 Sample Injectors and Autosamplers; 5.6 Miscellaneous Hardware; 5.7 Laboratory Safety; References; 6 The Column; 6.1 Introduction; 6.2 Column Packings; 6.2.1 Semirigid Organic Gels; 6.2.2 Rigid Inorganic Packings; 6.3 Column-Packing Methods; 6.3.1 Particle Technology; 6.3.2 Basis of Column-Packing Techniques; 6.4 Column Performance; References; 7 Experimental Variables and Techniques; 7.1 Introduction 7.2 Solvent Effects7.2.1 Sample Solubility; 7.2.2 Other Solvent Effects; 7.2.3 Flow-Rate Effects; 7.2.4 Temperature Effects; 7.3 Substrate Effects; 7.4 Sample Effects; 7.4.1 Sample Volume; 7.4.2 Sample Weight or Concentration; 7.5 Laboratory Techniques; 7.6 Solvent Selection and Preparation; 7.6.1 Convenience; 7.6.2 Sample Type; 7.6.3 Effect on Column Packing; 7.6.4 Operation; 7.6.5 Safety; 7.6.6 Solvent Purification and Modification; 7.7 Selection and Use of Standard Reference Materials; 7.8 Detector Selection; 7.9 Column Selection and Handling; 7.9.1 Optimum Single Pore-Size Separations 7.9.2 Bimodal Pore-Size Separations: Optimum Linearity and Range |
| Record Nr. | UNINA-9910816845503321 |
| Hoboken, N.J., : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
