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Fluorine in medicinal chemistry and chemical biology [[electronic resource] /] / edited by Iwao Ojima
| Fluorine in medicinal chemistry and chemical biology [[electronic resource] /] / edited by Iwao Ojima |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, : Wiley, 2009 |
| Descrizione fisica | 1 online resource (658 p.) |
| Disciplina |
615.19
615.27312 |
| Altri autori (Persone) | OjimaIwao <1945-> |
| Soggetto topico |
Organofluorine compounds
Fluorination - Physiological effect Bioorganic chemistry Pharmaceutical chemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-12347-5
9786612123474 1-4443-1209-X 0-470-74408-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Fluorine in Medicinal Chemistry and Chemical Biology; Contents; Preface; Contributors; Abbreviations; Introduction: Basic Aspects of Fluorine in Chemistry and Biology; 1: Unique Properties of Fluorine and Their Relevance to Medicinal Chemistry and Chemical Biology; Medicinal Chemistry; 2: Fluorinated Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent; 3: Fluorinated Conformationally Restricted Glutamate Analogues for CNS Drug Discovery and Development; 4: Fluorinated Inhibitors of Matrix Metalloproteinases; 5: Fluoro-Taxoid Anticancer Agents
6: Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stability7: Synthesis and Biological Activity of Fluorinated Nucleosides; Synthetic Methods for Medicinal Chemistry and Chemical Biology; 8: Synthesis of gem-Difluoromethylenated Nucleosides via gem-Difluoromethylene-containing Building Blocks; 9: Recent Advances in the Syntheses of Fluorinated Amino Acids; 10: Fluorinated Moieties for Replacement of Amide and Peptide Bonds; 11: Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery 12: gem-Difluorocyclopropanes as Key Building Blocks for Novel Biologically Active Molecules13: Fluorous Mixture Synthesis (FMS) of Drug-like Molecules and Enantiomers, Stereoisomers, and Analogues of Natural Products; 14: Fluorine-18 Radiopharmaceuticals; Applications of Fluorinated Amino Acids and Peptides to Chemical Biology and Pharmacology; 15: Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins; 16: Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology 17: Effects of Fluorination on the Bioorganic Properties of Methionine18: Structure Analysis of Membrane-Active Peptides Using 19F-labeled Amino Acids and Solid-State NMR; 19: Study of Metabolism of Fluorine-containing Drugs Using In Vivo Magnetic Resonance Spectroscopy; Appendix; Approved Active Pharmaceutical Ingredients Containing Fluorine; Section 1. Fluorine-containing Drugs for Human Use Approved by FDA in the United States; Section 2. Fluorine-containing Drugs for Veterinary Use Approved by FDA in the United States; Index; color plates |
| Record Nr. | UNINA-9910142970203321 |
| Chichester ; ; Hoboken, : Wiley, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Fluorine in medicinal chemistry and chemical biology [[electronic resource] /] / edited by Iwao Ojima
| Fluorine in medicinal chemistry and chemical biology [[electronic resource] /] / edited by Iwao Ojima |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, : Wiley, 2009 |
| Descrizione fisica | 1 online resource (658 p.) |
| Disciplina |
615.19
615.27312 |
| Altri autori (Persone) | OjimaIwao <1945-> |
| Soggetto topico |
Organofluorine compounds
Fluorination - Physiological effect Bioorganic chemistry Pharmaceutical chemistry |
| ISBN |
1-282-12347-5
9786612123474 1-4443-1209-X 0-470-74408-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Fluorine in Medicinal Chemistry and Chemical Biology; Contents; Preface; Contributors; Abbreviations; Introduction: Basic Aspects of Fluorine in Chemistry and Biology; 1: Unique Properties of Fluorine and Their Relevance to Medicinal Chemistry and Chemical Biology; Medicinal Chemistry; 2: Fluorinated Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent; 3: Fluorinated Conformationally Restricted Glutamate Analogues for CNS Drug Discovery and Development; 4: Fluorinated Inhibitors of Matrix Metalloproteinases; 5: Fluoro-Taxoid Anticancer Agents
6: Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stability7: Synthesis and Biological Activity of Fluorinated Nucleosides; Synthetic Methods for Medicinal Chemistry and Chemical Biology; 8: Synthesis of gem-Difluoromethylenated Nucleosides via gem-Difluoromethylene-containing Building Blocks; 9: Recent Advances in the Syntheses of Fluorinated Amino Acids; 10: Fluorinated Moieties for Replacement of Amide and Peptide Bonds; 11: Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery 12: gem-Difluorocyclopropanes as Key Building Blocks for Novel Biologically Active Molecules13: Fluorous Mixture Synthesis (FMS) of Drug-like Molecules and Enantiomers, Stereoisomers, and Analogues of Natural Products; 14: Fluorine-18 Radiopharmaceuticals; Applications of Fluorinated Amino Acids and Peptides to Chemical Biology and Pharmacology; 15: Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins; 16: Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology 17: Effects of Fluorination on the Bioorganic Properties of Methionine18: Structure Analysis of Membrane-Active Peptides Using 19F-labeled Amino Acids and Solid-State NMR; 19: Study of Metabolism of Fluorine-containing Drugs Using In Vivo Magnetic Resonance Spectroscopy; Appendix; Approved Active Pharmaceutical Ingredients Containing Fluorine; Section 1. Fluorine-containing Drugs for Human Use Approved by FDA in the United States; Section 2. Fluorine-containing Drugs for Veterinary Use Approved by FDA in the United States; Index; color plates |
| Record Nr. | UNINA-9910830686503321 |
| Chichester ; ; Hoboken, : Wiley, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Fluorine in medicinal chemistry and chemical biology / / edited by Iwao Ojima
| Fluorine in medicinal chemistry and chemical biology / / edited by Iwao Ojima |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, : Wiley, 2009 |
| Descrizione fisica | 1 online resource (658 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) | OjimaIwao <1945-> |
| Soggetto topico |
Organofluorine compounds
Fluorination - Physiological effect Bioorganic chemistry Pharmaceutical chemistry |
| ISBN |
1-282-12347-5
9786612123474 1-4443-1209-X 0-470-74408-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Fluorine in Medicinal Chemistry and Chemical Biology; Contents; Preface; Contributors; Abbreviations; Introduction: Basic Aspects of Fluorine in Chemistry and Biology; 1: Unique Properties of Fluorine and Their Relevance to Medicinal Chemistry and Chemical Biology; Medicinal Chemistry; 2: Fluorinated Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent; 3: Fluorinated Conformationally Restricted Glutamate Analogues for CNS Drug Discovery and Development; 4: Fluorinated Inhibitors of Matrix Metalloproteinases; 5: Fluoro-Taxoid Anticancer Agents
6: Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stability7: Synthesis and Biological Activity of Fluorinated Nucleosides; Synthetic Methods for Medicinal Chemistry and Chemical Biology; 8: Synthesis of gem-Difluoromethylenated Nucleosides via gem-Difluoromethylene-containing Building Blocks; 9: Recent Advances in the Syntheses of Fluorinated Amino Acids; 10: Fluorinated Moieties for Replacement of Amide and Peptide Bonds; 11: Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery 12: gem-Difluorocyclopropanes as Key Building Blocks for Novel Biologically Active Molecules13: Fluorous Mixture Synthesis (FMS) of Drug-like Molecules and Enantiomers, Stereoisomers, and Analogues of Natural Products; 14: Fluorine-18 Radiopharmaceuticals; Applications of Fluorinated Amino Acids and Peptides to Chemical Biology and Pharmacology; 15: Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins; 16: Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology 17: Effects of Fluorination on the Bioorganic Properties of Methionine18: Structure Analysis of Membrane-Active Peptides Using 19F-labeled Amino Acids and Solid-State NMR; 19: Study of Metabolism of Fluorine-containing Drugs Using In Vivo Magnetic Resonance Spectroscopy; Appendix; Approved Active Pharmaceutical Ingredients Containing Fluorine; Section 1. Fluorine-containing Drugs for Human Use Approved by FDA in the United States; Section 2. Fluorine-containing Drugs for Veterinary Use Approved by FDA in the United States; Index; color plates |
| Record Nr. | UNINA-9910877213103321 |
| Chichester ; ; Hoboken, : Wiley, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
