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Anoikis : how the extracellular matrix regulates life-or-death decisions / / edited by Steven M. Frisch
| Anoikis : how the extracellular matrix regulates life-or-death decisions / / edited by Steven M. Frisch |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (210 pages) |
| Disciplina | 571.936 |
| Soggetto topico |
Extracellular matrix
Apoptosis Apoptosi Histologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-73856-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Introduction -- Contents -- 1 Metabolic Contributions to Anoikis-Resistance in Metastatic Dissemination -- Abstract -- 1 Introduction -- 2 Bioenergetics -- 2.1 Glycolysis -- 2.2 Glutaminolysis -- 2.3 Autophagy -- 3 Redox Control -- 3.1 Restricted Glucose Oxidation -- 3.2 Antioxidant Defenses -- 3.3 ROS-Mediated Anti-apoptotic Signaling -- 4 Conclusion -- References -- 2 Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer -- Abstract -- 1 Metabolic Signal Integrators -- 1.1 The PI3K/Akt-mTOR Pathway -- 1.2 The Ras-MAPK Pathway -- 1.3 Myc and HIF-1 Transcription Factors -- 1.4 AMPK Pathway -- 2 ECM Attachment-Dependent Signaling Pathways that Regulate Cell Metabolism -- 3 An Overview of Model Systems Used to Study Anoikis -- 4 Metabolic Adaptations of Detached Cancer Cells-Roles in Anoikis-Resistance and Metastasis -- 4.1 Glucose Metabolism -- 4.2 Amino Acid Metabolism -- 4.3 Redox Homeostasis -- 4.3.1 Antioxidant Enzymes in Anoikis-Resistance -- 4.3.2 Mechanisms to Reduce ROS Generation -- 4.3.3 Synthesis of Reducing Equivalents -- 4.3.4 Mitochondrial ROS and Anoikis -- 4.4 Lipid Metabolism -- 5 HIF-1 and Anoikis-Resistance -- 6 Autophagy and Its Role in the Regulation of Metabolic Stress and Anoikis -- 7 Metabolic Switch in Detached Cells-The Tug of War Between AMPK and Akt -- Acknowledgement -- References -- 3 The Intersection of Anoikis Resistance and Fatty Acid Metabolism in Cancer -- Abstract -- 1 Introduction -- 2 Metabolic Plasticity -- 3 Fatty Acid Oxidation -- 4 Stemness and Fatty Acid Oxidation -- 5 FAO in Ovarian Cancer -- 6 FAO-Mediated Signaling and Anoikis Resistance -- 7 Receptor Tyrosine Kinase Contribution to Metabolic Reprogramming -- 8 Conclusions -- References -- 4 Shc and the Control of Small GTPase Dynamics in Cellular Anchorage -- Abstract.
1 Cellular Anchorage and the Importance of Shape Change -- 2 Regulation of Shape Change by Rho GTPases -- 3 Rho GTPases and Abnormal Matrix Signaling in Cancer -- 4 p52Shc and the Control of Mechanical Signals -- 5 Distinct Functional Roles for p66Shc -- 6 Control of RhoA and Anoikis by p66Shc -- 7 p66Shc and Metastatic Behavior -- 8 Epigenetic Control of SHC1 and Implications for Lineage Shifting -- 9 Summary -- References -- 5 Anoikis and the Human Gut Epithelium in Health and Disease -- Abstract -- 1 Anoikis: Back to (General) Basics -- 1.1 A Brief Word on Apoptosis -- 1.2 Cell-ECM and Cell-Cell Interactions -- 1.2.1 Integrins -- 1.2.2 E-cadherin -- 1.3 Enter Anoikis -- 1.3.1 Anoikis and Integrins -- 1.3.2 Anoikis and E-cadherin -- 2 Anoikis and the Human Gut Epithelium in Health -- 2.1 Anoikis and the Renewal of the Human Gut Epithelium -- 2.1.1 A Few Words on the Regulation of hIEC Survival -- 2.1.2 hIEC Anoikis: Sensitivity Versus State of Differentiation -- 2.2 hIEC Anoikis and Integrins -- 2.3 hIEC Anoikis and E-cadherin -- 3 Anoikis and the Human Gut Epithelium in Disease -- 3.1 Anoikis and CRC: Generalities -- 3.1.1 Anoikis, Integrins and CRC -- 3.1.2 Anoikis, E-cadherins and CRC -- 3.2 Anoikis and ... IBD? -- 4 Concluding Considerations -- Acknowledgements -- References -- 6 The Roles of Anoikis in Cervical Cancer -- Abstract -- 1 Introduction -- 2 The Role of Anoikis in Cervical Cancer -- 2.1 Molecular Mechanisms of Anoikis -- 2.2 The Role of Anoikis Resistance in Cervical Cancer Invasion and Metastasis -- 2.3 Molecular Mechanisms of Anoikis Resistance in Cervical Cancer Cells -- 2.4 The Role of Chronic Stress in Cervical Cancer Through Anoikis Resistance -- 3 The Role of YAP Proteins in Cervical Cancer -- 3.1 The Structure and Function of YAP-Related Proteins -- 3.2 Role of YAP Proteins in Cervical Caner. 3.3 YAP Proteins in the Susceptibility to hrHPV Infection -- 3.4 The Role of Chronic Stress in Cervical Cancer Through the Hippo-YAP Pathway -- 4 Conclusions and Future Directions -- References -- 7 Anoikis Resistance in Melanoma -- Abstract -- 1 Introduction -- 2 Epithelial-Mesenchymal Transition (EMT) -- 3 Anoikis-Death Induced in Epithelial Cells upon Detachment from Extra Cellular Matrix (ECM) -- 4 General Pathways Leading to Anoikis Resistance in Epithelial Tissues -- 5 Melanocytes and Melanoma-Non-epithelial Lineage Origins -- 6 Cell Surface Molecules in Anoikis Resistance in Melanoma -- 6.1 Integrin Switch -- 6.2 Fibronectin -- 6.3 Cadherins -- 7 Activation of Receptor Tyrosine Kinases in Melanoma Anoikis Resistance -- 7.1 c-MET/HGF Axis -- 7.2 FGFR1/FGF2 Axis -- 8 Signaling Pathways in Melanoma Anoikis Resistance -- 8.1 Mitogen-Activated Protein Kinase (MAPK) Pathway -- 8.2 Phosphoinositide 3-Kinase (PI3K)/AKT Pathway -- 8.3 CDKN2A and p16INK4A -- 8.4 Focal Adhesion Kinase (FAK) Pathway -- 9 Transcription Factors in Melanoma Anoikis Resistance -- 9.1 STAT3 -- 9.2 FOSL1 -- 9.3 BRN2 -- 10 Anti-apoptotic Mechanisms in Melanoma Anoikis Resistance -- 11 Conclusion -- References -- 8 Anoikis Mediated by Stress-Activated MAPK Signaling Pathways -- Abstract -- 1 Stress-Activated MAPK Signaling Pathways -- 1.1 p38 MAPK -- 1.2 JNK -- 2 Stress-Activated MAPK and Cell Death -- 3 Stress-Activated MAPK and BCL2 Family Proteins -- 4 JNK and Anoikis -- 5 p38 MAPK and Anoikis -- 6 Conclusions -- References -- 9 The TGFβ and Androgen Receptor Signaling Pathways Converge to Support Anoikis Resistance in Triple Negative Breast Cancer -- Abstract -- 1 Introduction -- 2 Anoikis Resistance and Breast Cancer -- 3 The TGFβ Pathway -- 4 TGFβ Signaling in Breast Cancer -- 5 TGFβ Inhibitors in BC Clinical Trials. 6 Connections Between AR and TGFβ in Prostate and Breast Cancer -- 7 TGFβ and AR Pathways Converge to Support TNBC Anoikis Resistance -- References -- 10 Regulation of Homeostasis and Anoikis by Epithelial Cell Extrusion -- Abstract -- 1 Introduction -- 2 Sphingosine-1-Phosphate (S1P) and Collaborating Factors in Cell Extrusion -- 3 Specialized Mechanisms Pertaining to the Extrusion of Transformed Cells -- 4 Summary and Future Directions -- References. |
| Record Nr. | UNINA-9910495350303321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Composition and function of the extracellular matrix in the human body / / edited by Francesco Travascio
| Composition and function of the extracellular matrix in the human body / / edited by Francesco Travascio |
| Pubbl/distr/stampa | Rijeka, Croatia : , : IntechOpen, , [2016] |
| Descrizione fisica | 1 online resource (374 pages) : illustrations |
| Disciplina | 611.0182 |
| Soggetto topico | Extracellular matrix |
| ISBN |
953-51-5433-8
953-51-2416-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910317703303321 |
| Rijeka, Croatia : , : IntechOpen, , [2016] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Extracellular matrix : developments and therapeutics / / edited by Rama Sashank Madhurapantula, Joseph Orgel, Zvi Loewy
| Extracellular matrix : developments and therapeutics / / edited by Rama Sashank Madhurapantula, Joseph Orgel, Zvi Loewy |
| Pubbl/distr/stampa | London, England : , : IntechOpen, , [2021] |
| Descrizione fisica | 1 online resource (170 pages) : illustrations |
| Disciplina | 611.0182 |
| Soggetto topico | Extracellular matrix |
| ISBN | 1-83968-236-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Extracellular Matrix |
| Record Nr. | UNINA-9910586675803321 |
| London, England : , : IntechOpen, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Extracellular Matrix : developments and therapeutics / / Rama Sashank Madhurapantula, Joseph Orgel, Zvi Loewy, editor
| Extracellular Matrix : developments and therapeutics / / Rama Sashank Madhurapantula, Joseph Orgel, Zvi Loewy, editor |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2021 |
| Descrizione fisica | 1 online resource (xiii, 155 pages) |
| Disciplina | 611.0182 |
| Soggetto topico | Extracellular matrix |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Extracellular Matrix |
| Record Nr. | UNINA-9910688312303321 |
| London : , : IntechOpen, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Extracellular matrix [[electronic resource] ] : pathobiology and signaling / / edited by Nikos K. Karamanos
| Extracellular matrix [[electronic resource] ] : pathobiology and signaling / / edited by Nikos K. Karamanos |
| Pubbl/distr/stampa | Berlin, : Walter de Gruyter, c2012 |
| Descrizione fisica | 1 online resource (940 p.) |
| Disciplina | 611/.0182 |
| Altri autori (Persone) | KaramanosNikos K |
| Soggetto topico |
Extracellular matrix
Cellular signal transduction |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-62774-4
3-11-025877-3 9786613940193 |
| Classificazione | WE 3900 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling / Achilleas Theocharis ... [et al.] -- Insights into the function of glycans / Paraskevi Heldin -- Proteoglycans : structure, pathobiology, and signaling / Liliana Schaefer -- ECM cell surface receptors / Donald Gullberg -- Extracellular proteinases / Jan-Olof Winberg -- Collagen : not just mechanics, for the high degree of connectivity grounded on the apparently simple triple helix / Ruggero Tenni -- Emerging aspects in extracellular matrix pathobiology / Achilleas Theocharis -- Targeting tumor microenvironment at the ECM level / Nikos K. Karamanos. |
| Record Nr. | UNINA-9910464688803321 |
| Berlin, : Walter de Gruyter, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Extracellular matrix [[electronic resource] ] : pathobiology and signaling / / edited by Nikos K. Karamanos
| Extracellular matrix [[electronic resource] ] : pathobiology and signaling / / edited by Nikos K. Karamanos |
| Pubbl/distr/stampa | Berlin, : Walter de Gruyter, c2012 |
| Descrizione fisica | 1 online resource (940 p.) |
| Disciplina | 611/.0182 |
| Altri autori (Persone) | KaramanosNikos K |
| Soggetto topico |
Extracellular matrix
Cellular signal transduction |
| Soggetto non controllato |
Biochemistry
Collagens Glycans Matrix Metalloproteinases |
| ISBN |
1-283-62774-4
3-11-025877-3 9786613940193 |
| Classificazione | WE 3900 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | An introduction to the extracellular matrix molecules and their importance in pathobiology and signaling / Achilleas Theocharis ... [et al.] -- Insights into the function of glycans / Paraskevi Heldin -- Proteoglycans : structure, pathobiology, and signaling / Liliana Schaefer -- ECM cell surface receptors / Donald Gullberg -- Extracellular proteinases / Jan-Olof Winberg -- Collagen : not just mechanics, for the high degree of connectivity grounded on the apparently simple triple helix / Ruggero Tenni -- Emerging aspects in extracellular matrix pathobiology / Achilleas Theocharis -- Targeting tumor microenvironment at the ECM level / Nikos K. Karamanos. |
| Record Nr. | UNINA-9910788689203321 |
| Berlin, : Walter de Gruyter, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The extracellular matrix factsbook [[electronic resource] /] / Shirley Ayad ... [et al.]
| The extracellular matrix factsbook [[electronic resource] /] / Shirley Ayad ... [et al.] |
| Autore | Ayad Shirley |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | San Diego, : Academic Press, c1998 |
| Descrizione fisica | 1 online resource (313 p.) |
| Disciplina |
571.6
572/.6 21 |
| Collana | Factsbook series |
| Soggetto topico |
Extracellular matrix proteins
Extracellular matrix |
| ISBN |
1-281-79530-5
9786611795306 1-4356-9969-6 0-08-053151-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Extracellular Matrix; Copyright Page; Contents; Preface; Abbreviations; Section I: INTRODUCTORY MATERIAL; Chapter 1. Introduction; Chapter 2. Extracellular matrices; Section II: THE EXTRACELLULAR MATRIX PROTEINS; Chapter 3. Aggrecan; Chapter 4. Agrin; Chapter 5. Bamacan; Chapter 6. BEHAB; Chapter 7. Biglycan; Chapter 8. Bone sialoprotein; Chapter 9. Brevican; Chapter 10. Cartilage matrix protein; Chapter 11. Chondroadherin; Chapter 12. Collagen type I; Chapter 13. Collagen type II; Chapter 14. Collagen type III; Chapter 15. Collagen type IV; Chapter 16. Collagen type V
Chapter 17. Collagen type VIChapter 18. Collagen type VII; Chapter 19. Collagen type VIII; Chapter 20. Collagen type IX; Chapter 21. Collagen type X; Chapter 22. Collagen type XI; Chapter 23. Collagen type XII; Chapter 24. Collagen type XIII; Chapter 25. Collagen type XIV; Chapter 26. Collagen type XV; Chapter 27. Collagen type XVI; Chapter 28. Collagen type XVII; Chapter 29. Collagen type XVIII; Chapter 30. Collagen type XIX; Chapter 31. Decorin; Chapter 32. Dentine matrix protein; Chapter 33. Dentine sialoprotein; Chapter 34. Elastin; Chapter 35. Fibrillin-1; Chapter 36. Fibrillin-2 Chapter 37. FibrinogenChapter 38. Fibromodulin; Chapter 39. Fibronectin; Chapter 40. Fibulin-1; Chapter 41. Fibulin-2; Chapter 42. Keratocan; Chapter 43. Laminins; Chapter 44. Latent transforming growth factor-ß binding protein-1; Chapter 45. Latent transforming growth factor-ß binding protein-2; Chapter 46. Latent transforming growth factor-ß binding protein-3; Chapter 47. Link protein; Chapter 48. Lumican; Chapter 49. Lysyloxidase; Chapter 50. Matrix Gla protein; Chapter 51. Microfibril-associated glycoprotein-1; Chapter 52. Microfibril-associated glycoprotein-2 Chapter 53. Microfibril-associated protein-1Chapter 54. Microfibril-associated protein-3; Chapter 55. MMP1; Chapter 56. MMP2; Chapter 57. MMP3; Chapter 58. MMP7; Chapter 59. MMP8; Chapter 60. MMP9; Chapter 61. MMP10; Chapter 62. MMP11; Chapter 63. MMP12; Chapter 64. MMP13; Chapter 65. Neurocan; Chapter 66. Nidogen; Chapter 67. Osteocalcin; Chapter 68. Osteonectin; Chapter 69. Osteopontin; Chapter 70. Perlecan; Chapter 71. Phosphophoryn; Chapter 72. PRELP; Chapter 73. Procollagen C-proteinase; Chapter 74. Procollagen I N-proteinase; Chapter 75. Tenascin-C; Chapter 76. Tenascin-R Chapter 77. Tenascin-XChapter 78. Tenascin-Y; Chapter 79. Thrombospondin-l; Chapter 80. Thrombospondin-2; Chapter 81. Thrombospondin-3; Chapter 82. Thrombospondin-4; Chapter 83. Thrombospondin-5; Chapter 84. TIMPl; Chapter 85. TIMP2; Chapter 86. TIMP3; Chapter 87. TIMP4; Chapter 88. Versican; Chapter 89. Vitronectin; Chapter 90. von Willebrand factor; Index |
| Record Nr. | UNINA-9910784530603321 |
Ayad Shirley
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| San Diego, : Academic Press, c1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Journal of extracellular biology
| Journal of extracellular biology |
| Pubbl/distr/stampa | [Hoboken, New Jersey] : , : Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles, , [2022]- |
| Descrizione fisica | 1 online resource |
| Disciplina | 611.0182 |
| Soggetto topico |
Extracellular Vesicles
Extracellular Matrix Coated vesicles Cytology Extracellular matrix |
| Soggetto genere / forma |
Periodical
Periodicals. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Extracellular biology |
| Record Nr. | UNISA-996542771203316 |
| [Hoboken, New Jersey] : , : Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles, , [2022]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Journal of extracellular biology
| Journal of extracellular biology |
| Pubbl/distr/stampa | [Hoboken, New Jersey] : , : Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles, , [2022]- |
| Descrizione fisica | 1 online resource |
| Disciplina | 611.0182 |
| Soggetto topico |
Extracellular Vesicles
Extracellular Matrix Coated vesicles Cytology Extracellular matrix |
| Soggetto genere / forma |
Periodical
Periodicals. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Extracellular biology |
| Record Nr. | UNINA-9910555009903321 |
| [Hoboken, New Jersey] : , : Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles, , [2022]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Junctional complexes of epithelial cells [[electronic resource]]
| Junctional complexes of epithelial cells [[electronic resource]] |
| Pubbl/distr/stampa | Chichester ; ; New York, : Wiley, 1987 |
| Descrizione fisica | 1 online resource (284 p.) |
| Disciplina |
591.1
591.1858 591.87 |
| Altri autori (Persone) |
BockGregory
ClarkSarah |
| Collana | Ciba Foundation symposium |
| Soggetto topico |
Junctional complexes (Epithelium)
Cell adhesion Extracellular matrix |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-12233-9
9786612122330 0-470-51340-3 0-470-51341-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
JUNCTIONAL COMPLEXES OF EPITHELIAL CELLS; Contents; Participants; Chairman's introduction; On the molecular organization, diversity and functions of desmosomal proteins; The desmosomal plaque and the cytoskeleton; Recognition, calcium and the control of desmosome formation; General discussion I; Gap junction structure and the control of cell-to-cell communication; Molecular structure of the gap junctional channel; The use of antibodies to gap junction protein to explore the role of gap junctional communication during development
The role of uvomorulin in the formation of epithelial occluding junctionsGeneral discussion I I; Epigenetic rules for expression of cell adhesion molecules during morphogenesis; Factors affecting epithelial interactions; Cell junctions and the biological behaviour of cancer; Final general discussion; Index of contributors; Subject index |
| Record Nr. | UNINA-9910144748903321 |
| Chichester ; ; New York, : Wiley, 1987 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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