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Cancer biology : how science works / / Carsten Carlberg and Eunike Velleuer
| Cancer biology : how science works / / Carsten Carlberg and Eunike Velleuer |
| Autore | Carlberg Carsten |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (179 pages) |
| Disciplina | 616.994071 |
| Soggetto topico |
Carcinogenesis
Cancer - Etiology Càncer Etiologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-75699-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Acknowledgements -- Contents -- Abbreviations -- 1 Introduction to Cancer -- 1.1 The Global Burden of Cancer -- 1.2 Categorization and Diagnosis of Tumors -- 1.3 Crucial Transitions in Cancer -- 1.4 Causes of Cancer -- 1.5 Cancer Prevention -- Further Reading -- 2 Oncogenes and Signal Transduction -- 2.1 Cellular Transformation -- 2.2 Activating Oncogenes in Signal Transduction Pathways -- 2.3 Oncogenic Translocations and Amplifications -- 2.4 The Hallmarks of Cancer Concept -- Further Reading -- 3 Tumor Suppressor Genes and Cell Fate Control -- 3.1 p53 - A Master Example -- 3.2 Tumor Suppressors and Oncogenes in Cell Cycle Control -- 3.3 Tumor Suppressor Inhibition and Cancer Onset -- Further Reading -- 4 Multi-step Tumorigenesis and Genome Instability -- 4.1 Characteristics of Tumor Growth -- 4.2 Multi-step Tumorigenesis -- 4.3 Genome Instability -- 4.4 Cancer Driver Mutations and Genes -- Further Reading -- 5 Cancer Genomics -- 5.1 Human Genetic Variation and Cancer Susceptibility -- 5.2 The Cancer Genome -- 5.3 Cancer Genome Projects -- Further Reading -- 6 Cancer Epigenomics -- 6.1 Epigenetic Mechanisms of Cancer -- 6.2 DNA Methylation and Cancer -- 6.3 Chromatin Changes and Cancer -- 6.4 Epigenetic Reprogramming in Cancer -- Further Reading -- 7 Aging and Cancer -- 7.1 Central Role of Aging During Chronic Diseases -- 7.2 The Hallmarks of Aging -- 7.3 Epigenetics of Aging -- 7.4 Telomeres and Replicative Immortality -- Further Reading -- 8 Tumor Microenvironment -- 8.1 The Impact of the Wound Healing Program for Cancer -- 8.2 Cell Types of the Tumor Microenvironment -- 8.3 Inducing Angiogenesis -- 8.4 Tumor-Promoting Inflammation -- 8.5 Deregulating Cellular Energetics -- Further Reading -- 9 Metastasis and Cachexia -- 9.1 The Metastatic Cascade -- 9.2 Epithelial-Mesenchymal Transition -- 9.3 Metastatic Colonization.
9.4 Cachexia -- Further Reading -- 10 Cancer Immunity -- 10.1 Outline of Cancer Immunity -- 10.2 Recognition of Tumor Antigens -- 10.3 Monoclonal Antibodies in Cancer Immunotherapy -- 10.4 Immune Cell Therapies -- Further Reading -- 11 Architecture of Cancer Therapies -- 11.1 Classical Cancer Treatments -- 11.2 Targeted Therapies -- 11.3 Precision Oncology -- Further Reading -- Glossary. |
| Record Nr. | UNINA-9910490024603321 |
Carlberg Carsten
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| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Etiopathogenic theories and models in depression / / edited by Juan Pablo Jiménez, Alberto Botto, and Peter Fonagy
| Etiopathogenic theories and models in depression / / edited by Juan Pablo Jiménez, Alberto Botto, and Peter Fonagy |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (344 pages) |
| Disciplina | 616.8527 |
| Collana | Depression and Personality |
| Soggetto topico |
Depression, Mental - Etiology
Depressió psíquica Etiologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-77329-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910522565703321 |
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Inflammatory bowel disease : pathogenesis, diagnosis and management / / edited by Ramona Rajapakse
| Inflammatory bowel disease : pathogenesis, diagnosis and management / / edited by Ramona Rajapakse |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (368 pages) |
| Disciplina | 616.344 |
| Collana | Clinical Gastroenterology Ser. |
| Soggetto topico |
Inflammatory bowel diseases - Pathogenesis
Inflammatory bowel diseases - Diagnosis Malalties intestinals Etiologia Diagnòstic Terapèutica |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-81780-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- Contributors -- Chapter 1: Advances in Our Understanding of the Pathogenesis of Inflammatory Bowel Disease -- Introduction -- Genetic Factors -- Gut Microbiome -- Lifestyle -- Diet -- Smoking -- Physical and Emotional Stress and Mental Health -- Environmental Factors -- Pollution -- Low Vitamin D -- Hygiene Hypothesis -- Pharmacological Agents -- NSAIDs -- Antibiotics -- Oral Contraceptives -- Vaccines -- Surgeries -- Appendectomy -- Tonsillectomy -- Early Life Events -- Cesarean Delivery -- Breastfeeding -- Summary -- References -- Chapter 2: Diagnosis and Monitoring in Inflammatory Bowel Disease: Who, When, Where, and How -- Pathogenesis -- Genetics -- Microbiome -- Epidemiology -- Clinical Presentation of Inflammatory Bowel Disease -- Clinical Features of Crohn's Disease -- Small Bowel Crohn's -- Perianal Crohn's -- Colonic Crohn's -- Upper Tract Crohn's -- Extraintestinal Manifestations -- Clinical Features of Ulcerative Colitis -- Diagnostic Evaluation -- Imaging -- Unique Radiographic Findings in Inflammatory Bowel Disease -- Endoscopy -- Revised Montreal Classification -- References -- Chapter 3: Ulcerative Colitis Diagnosis and Management: Past, Present, and Future Directions -- Epidemiology and History of Ulcerative Colitis (UC) -- Early Medical Therapies: The Pre-Biologic Era -- Diagnosis of UC -- Clinical Presentation -- Laboratory Testing -- Endoscopic Examination -- Microscopic Examination -- Radiographic Imaging -- Management of Ulcerative Colitis -- Mild Disease -- ACG UC Activity Index -- Moderate to Severe Disease -- ACG UC Activity Index. -- Fulminant UC -- ACG UC Activity Index -- Goals of Therapy: The Evolution of Treat to Target (T2T) -- Colonic Dysplasia and Cancer Surveillance -- References -- Chapter 4: New Developments in the Management of Crohn's Disease -- Introduction.
Currently Available Therapies -- 5-Aminosalicylates (5ASAs), Antibiotics, and Steroids -- Immunomodulators -- 6-Mercaptopurine/Azathioprine (6-MP/AZA) -- Methotrexate (MTX) -- Biologics -- Anti-Tumor Necrosis Factor -- Biosimilars -- Integrin Inhibitors -- Ustekinumab (Stelara) -- Small Molecules -- Choice of Therapy -- Therapeutic Targets -- Health-Related Quality of Life (HRQOL) -- Therapeutic Drug Monitoring -- De-escalation of Therapy -- Prevention of Postoperative Recurrence -- Therapies Under Investigation for the Management of Crohn's Disease -- Nutrition -- Hematopoietic and Mesenchymal Stem Cell Transplantation -- Restoring the Microbiome: Fecal Microbiota Transplantation, Prebiotics, and Probiotics -- Hyperbaric Oxygen Therapy -- Leukapheresis and Extracorporeal Photopheresis -- Conclusion -- References -- Chapter 5: Extraintestinal Manifestations in Inflammatory Bowel Disease -- Introduction -- Epidemiology -- Pathogenesis -- Dermatologic Manifestations -- Erythema Nodosum -- Epidemiology and Diagnosis -- Clinical Presentation -- Pyoderma Gangrenosum -- Epidemiology -- Pathophysiology -- Clinical Presentation -- Treatment -- Sweet Syndrome -- Pathophysiology and Epidemiology -- Clinical Presentation and Diagnosis -- Oral Lesions -- Epidemiology -- Clinical Presentation and Pathophysiology -- Anti-TNF-Induced Skin Lesions -- Epidemiology and Pathophysiology -- Clinical Presentation and Diagnosis -- Treatment -- Metastatic Crohn's Disease -- Clinical Presentation and Diagnosis -- Treatment -- Ocular Manifestations -- Episcleritis -- Clinical Presentation -- Treatment -- Scleritis -- Epidemiology -- Clinical Presentation and Diagnosis -- Treatment -- Uveitis -- Epidemiology -- Clinical Presentation -- Rheumatologic Manifestations -- Peripheral Arthropathy/Arthritis -- Epidemiology -- Clinical Presentation -- Axial Arthropathy/Arthritis. Types, Epidemiology, and Clinical Presentation -- Treatment -- Hepatobiliary Manifestations -- Primary Sclerosing Cholangitis (PSC) -- Epidemiology -- Clinical Presentation -- Pathogenesis -- Diagnosis -- Small Duct PSC -- Treatment -- Other Organ Systems -- Primary Manifestations -- Secondary Manifestations -- Overlapping Conditions -- References -- Chapter 6: Infectious Complications in Inflammatory Bowel Disease -- Introduction -- Therapy for IBD and Infection Risk -- Specific Drugs and Drug Classes for the Treatment of IBD -- Anti-TNF Agents -- Vedolizumab -- Ustekinumab -- Janus Kinase (JAK) Inhibitor -- Infection Risk Based on Organism and Organism Type -- Bacterial -- Mycobacterium tuberculosis -- Nontuberculous Mycobacteria (NTM) -- Listeria monocytogenes -- Streptococcus pneumoniae -- Viral -- Herpes Zoster (HZ) -- Disseminated Herpes Zoster (DHZ) -- Chronic Hepatitis B Virus (HBV) -- Chronic Hepatitis C (HCV) -- Fungal -- Candidiasis -- Histoplasmosis -- Coccidioidomycosis -- Blastomycosis -- Aspergillosis -- Cryptococcosis -- Parasitic -- Leishmaniasis -- Strongyloides -- Preventing Infections in IBD -- Taking a History from an Infectious Disease (ID) Perspective -- Travel History and Future Plans -- Occupation -- Hobbies and Activities -- Diet -- Animal Exposures -- Sexual History -- Substance Use and Other Practices -- Screening Methods for Specific Infections -- Tuberculosis -- Histoplasmosis and Coccidioidomycosis -- Hepatitis B -- Strongyloides -- Vaccines -- Inactivated Vaccines -- Tetanus, Diphtheria, and Pertussis Vaccination -- Influenza -- Streptococcus pneumoniae -- Hepatitis A -- Hepatitis B -- Herpes Zoster -- Human Papillomavirus -- Meningococcal Disease -- Live Vaccines -- Measles, Mumps and Rubella (MMR) -- Varicella -- Herpes Zoster -- Conclusions -- References. Chapter 7: Healthcare Maintenance in the Patient with Inflammatory Bowel Disease: High-Yield Interventions -- Introduction -- Immunizations -- Immunizations: Influenza -- Immunizations: Pneumococcal Pneumonia -- Immunizations: Varicella and Herpes Zoster -- Immunizations: Hepatitis A, B, and C -- Immunizations: MMR, HPV, Meningococcal, and Tdap -- Screenings -- Screenings: Bone Health -- Screenings: Eye Health -- Screenings: Colon Cancer -- Screenings: Skin Cancer -- Screenings: Cervical Cancer -- Screenings: Depression -- Screenings: Fatigue -- Screenings: Tobacco -- Nutrition -- Nutrition: Diet Counseling -- Nutrition: Vitamin B12 -- Nutrition: Iron -- Nutrition: Vitamin D -- Special Considerations -- Special Considerations: Healthcare Maintenance in the Older Adult -- Special Considerations: Medication Adherence -- Special Considerations: Complementary Medicine -- Cannabis -- Conclusion -- References -- Chapter 8: The Woman with Inflammatory Bowel Disease: Fertility, Pregnancy, and beyond -- Overview -- Fertility -- Preconception -- Contraception -- Healthcare Maintenance -- Genetics -- Nutrition and Supplements -- Disease Control -- Medications -- Conception -- Disease in Remission -- Active Disease -- Medications -- Surgery -- Delivery and Postpartum Care -- Mode of Delivery -- Breastfeeding -- Infant Monitoring -- Summary -- References -- Chapter 9: Unique Challenges in the Diagnosis and Management of the Pediatric IBD Patient -- Overview -- Clinical Manifestations -- Differential Diagnosis -- Diagnosis -- Growth Failure and Poor Weight Gain in IBD -- Pathogenesis of Growth Failure -- Vitamin and Mineral Deficiencies -- Nutritional Assessment -- Treatment -- Medical -- Nutritional -- Surgical -- Health Maintenance Issues -- Immunizations -- Psychological Support -- Transitioning to Adult Care. Very Early-Onset Inflammatory Bowel Disease (VEO-IBD) -- Overview -- Clinical Features -- Genetics -- Treatment -- References -- Chapter 10: Colon Cancer Screening and Surveillance in the IBD Patient -- Epidemiology and Risk Factors -- Common Considerations for Ulcerative Colitis (UC) and Crohn's Disease (CD) -- Epidemiology and Risk Factors for Colorectal Cancer in Crohn's Disease -- Epidemiology and Risk Factors for Colorectal Cancer in Ulcerative Colitis -- Carcinogenesis in IBD -- Role of Inflammation -- Genetic Alteration -- Free Radical and Immune-Mediated -- Microbiome -- Surveillance and Intervals -- Goals and Considerations of Surveillance -- Endoscopic and Histological Considerations Dictating Intervals of Surveillance -- Method of Surveillance -- Intervals -- Future Trends in Surveillance -- Chemoprevention -- Conclusion -- References -- Chapter 11: The Utility of Endoscopy in Inflammatory Bowel Disease -- Introduction -- Screening Guidelines -- Typical Endoscopic Findings -- Crohn's Disease -- Ulcerative Colitis -- Post-op Endoscopic Evaluation in Crohn's Disease and Ulcerative Colitis -- Specialized Endoscopic Evaluations -- Therapeutic Endoscopy in IBD -- References -- Chapter 12: Changing Paradigms in the Management of the Elderly IBD Patient -- Introduction -- Elderly-Onset vs. Adult-Onset Elderly -- Genetics and Pathophysiology -- Treatment Considerations -- Overview -- 5-ASA -- Steroids -- Immunomodulators -- Biologic Agents -- TNF-Alpha Antagonists -- Vedolizumab -- Ustekinumab -- Tofacitinib -- Surgery -- Frailty -- Cancer and Mortality -- COVID-19 and the Elderly IBD Patient -- Conclusion -- Bibliography -- Chapter 13: Surgical Management of the Complex Crohn's and Ulcerative Colitis Patient: When to Redo a Pouch -- Role of the IBD Surgeon -- Operative Management of Crohn's Disease. Surgical Management of UC: Restorative Proctocolectomy with Pelvic Pouch. |
| Record Nr. | UNINA-9910502973303321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Integrated omics approaches to infectious diseases / / Saif Hameed and Zeeshan Fatima (editors)
| Integrated omics approaches to infectious diseases / / Saif Hameed and Zeeshan Fatima (editors) |
| Pubbl/distr/stampa | Gateway East, Singapore : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (538 pages) |
| Disciplina | 616.9 |
| Soggetto topico |
Parasitology
Communicable diseases - Etiology Malalties infeccioses Etiologia Biologia molecular Nanomedicina |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-16-0691-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910495232703321 |
| Gateway East, Singapore : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Major depressive disorder : rethinking and understanding recent discoveries / / Yong-Ku Kim, editor
| Major depressive disorder : rethinking and understanding recent discoveries / / Yong-Ku Kim, editor |
| Pubbl/distr/stampa | Singapore : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (555 pages) |
| Disciplina | 616.8527 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Depression, Mental
Depression, Mental - Pathogenesis Depression, Mental - Treatment Depressió psíquica Etiologia Terapèutica |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 981-336-044-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910483674603321 |
| Singapore : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Parkinsonism and the Environment [[electronic resource] /] / edited by Nikolay M. Filipov
| Parkinsonism and the Environment [[electronic resource] /] / edited by Nikolay M. Filipov |
| Autore | Filipov Nikolay M. |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (162 pages) |
| Disciplina | 616.833 |
| Collana | Molecular and Integrative Toxicology |
| Soggetto topico |
Pharmacology
Neurosciences Neuroscience Malaltia de Parkinson Etiologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN |
9783030874513
9783030874506 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Experimental evidence for pesticide contribution in the pathogenesis of Parkinsonism: an update -- Epidemiological evidence for pesticide involvement in the etiology of Parkinson’s Disease: current state of affairs?” -- Manganese induced Parkinsonism: cellular and molecular mechanisms -- Manganese overexposures in occupational and environmental settings and Parkinsonism: where do we stand -- Aberrant dopamine metabolism as a focal point in the mechanism of environmental contaminant-induced dopaminergic dysfunction -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Protein kinase C-delta (PKC-delta): a major molecular target for disparate dopaminergic toxicants -- Environmental contribution to redox dyshomeostasis in Parkinsonism. |
| Record Nr. | UNINA-9910547297003321 |
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Filipov Nikolay M.
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
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Etiologia
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