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Cancer Epigenetics / / edited by Rasime Kalkan
| Cancer Epigenetics / / edited by Rasime Kalkan |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer Nature Switzerland AG, , [2023] |
| Descrizione fisica | 1 online resource (389 pages) |
| Disciplina | 616.99/4042 |
| Collana | Epigenetics and Human Health Series |
| Soggetto topico |
Cancer - Genetic aspects
Epigenetics Neoplasms - genetics Epigenomics Epigenesis, Genetic |
| ISBN | 3-031-42365-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- About the Editor -- List of Contributors -- Abbreviations -- Part-I: Background -- Chapter 1: An Overview of Epigenetics Modifications in Normal and Cancer Cell -- 1.1 Introduction -- 1.1.1 DNA Methylation -- 1.1.2 DNA Hydroxymethylation -- 1.1.3 Histone Modifications -- 1.1.4 Nucleosome Remodeling -- 1.1.5 Non-coding RNAs -- 1.2 Epigenetics in Normal Cell -- 1.2.1 DNA Methylation in Normal Cell -- 1.2.2 DNA Hydroxymethylation in Normal Cell -- 1.2.3 Histone Modifications in Normal Cell -- 1.2.4 Nucleosome Remodeling in Normal Cell -- 1.2.5 Non-coding RNAs in Normal Cell -- 1.3 Epigenetics in Cancer Cell -- 1.3.1 DNA Methylation in Cancer Cell -- 1.3.2 DNA Hydroxymethylation in Cancer Cell -- 1.3.3 Histone Modifications in Cancer Cell -- 1.3.4 Nucleosome Remodeling in Cancer Cell -- 1.3.5 Non-coding RNAs in Cancer Cell -- 1.4 Conclusion -- References -- Chapter 2: Epigenetic Enzymes and Their Mutations in Cancer -- 2.1 Introduction -- 2.1.1 DNA Methylation -- 2.1.1.1 DNA Methyltransferase 1 -- 2.1.1.2 DNA Methyltransferase 3 -- 2.1.1.3 Mutations of DNA Methyltransferases -- 2.1.1.4 Ten Eleven Translocation Proteins -- 2.1.1.5 Mutations of Ten Eleven Translocation Proteins -- 2.1.2 Histone Modifications -- 2.1.2.1 Histone Acetyltransferases -- 2.1.2.2 Mutations of Histone Acetyltransferases -- 2.1.2.3 Histone Deacetylases -- 2.1.2.4 Mutations of Histone Deacetylases -- 2.1.2.5 Histone Methyltransferases -- 2.1.2.6 Mutations of Histone Methyltransferases -- 2.1.2.7 Histone Demethylases -- 2.1.2.8 Mutations of Histone Demethylases -- 2.2 Conclusion -- References -- Chapter 3: Introduction to Cancer Epigenetics -- 3.1 Introduction -- 3.1.1 History of Epigenetics -- 3.1.2 Epigenetics and Epigenome -- 3.2 Epigenetic Machinery -- 3.2.1 DNA Methylation -- 3.2.1.1 DNA Methyltransferases.
3.2.1.2 Methyl-CpG Recognition Proteins -- 3.2.1.3 5-Hydroxymethyl Cytosine and TET Enzymes -- 3.2.1.4 TET Proteins and DNA Demethylation -- 3.2.2 Abnormal Epigenomic Reprogramming in Cancer -- 3.2.2.1 Cancer-Specific DNA Methylation Alterations -- 3.2.2.2 Global DNA Hypomethylation -- 3.2.2.2.1 DNA Methyltransferases (DNMTs) and DNA Methylation -- 3.2.2.2.2 Focal DNA Hypermethylation and Tumor Suppressor Genes -- 3.2.2.2.3 Roles of DNA Methylation Aberrations in Cell Proliferation -- 3.2.2.2.4 Role of DNA Methylation Changes in Evasion of Apoptosis -- 3.2.2.2.5 Promotion of Genome Instability by DNA Methylation Alterations -- 3.2.3 Histon Modifications in Cancer -- 3.2.3.1 Histone Acetylation -- 3.2.3.2 Histone Methylation -- 3.2.3.3 Histone Ubiquitination -- 3.2.3.4 Histone Phosphorylation -- 3.2.3.5 Other Modifications -- 3.2.4 Chromatin Remodelers -- 3.2.5 miRNAs in Cancer -- 3.2.5.1 miRNA Biogenesis and Functions -- 3.2.5.1.1 Canonical miRNA Biogenesis -- 3.2.5.1.2 Non-canonical miRNA Biogenesis -- 3.2.6 The Role of miRNA in Cancer -- 3.2.6.1 Proliferation and miRNAs in Cancer -- 3.2.6.2 Apoptosis and miRNAs in Cancer -- 3.2.6.3 Invasion, Metastasis, and miRNAs in Cancer -- 3.2.6.4 Angiogenesis and miRNAs in Cancer -- 3.2.6.5 Non-canonical Function of miRNA in Cancer -- 3.2.6.6 Deregulation of miRNA Expression in Cancer -- 3.2.7 Circulating miRNA in Cancer -- 3.2.8 miRNA-based Biomarkers in Cancer -- 3.2.9 miRNA-Based Therapies in Cancer -- 3.2.9.1 Approaches for miRNA Therapeutic Delivery -- 3.3 Conclusion -- References -- Part II: Cancer Specific Epigenetic Alterations -- Chapter 4: Epigenetics in the Diagnosis, Prognosis, and Therapy of Cancer -- 4.1 Epigenetics and Cancer -- 4.1.1 Histone Modification -- 4.1.2 DNA Methylation -- 4.1.3 Noncoding RNAs -- 4.1.4 Chromatin Remodeling -- 4.2 Epigenetics in Cancer Diagnosis. 4.2.1 DNA Methylation as a Biomarker of Cancer Diagnosis -- 4.2.2 Histone Modification as a Biomarker of Cancer Diagnosis -- 4.2.3 Non-encoding RNAs as Biomarkers of Cancer Diagnosis -- 4.2.4 Imprinted Genes as Biomarkers of Cancer Diagnosis -- 4.3 Epigenetic in Cancer Prognosis -- 4.3.1 DNA Methylation in Cancer Prognosis -- 4.3.2 Histone Modifications in Cancer Prognosis -- 4.3.3 Histone Variants and Chromatin Remodeling in Cancer Prognosis -- 4.3.4 Noncoding RNAs in Cancer Prognosis -- 4.4 Epigenetics in Cancer Therapy -- 4.4.1 Targeting DNA Methylation-Related Enzymes in Cancer Treatment -- 4.4.2 Targeting Histone Acetylation-Related Enzymes in Cancer Treatment -- 4.4.3 Targeting Other Epigenetic Biomarkers in Cancer Treatment -- 4.5 Conclusions and Perspectives -- References -- Chapter 5: Clinical Studies and Epi-Drugs in Various Cancer Types -- 5.1 Introduction -- 5.2 Epigenetic Studies Regarding the Most Common Solid Tumor Types -- 5.2.1 Lung Cancer -- 5.2.2 Breast Cancer -- 5.2.3 Colorectal Cancer -- 5.2.4 Prostate Cancer -- 5.2.5 Cutaneous Melanoma -- 5.2.6 Epigenetic Studies Regarding the Most Common Hematological Malignancies -- 5.2.6.1 Myeloid Leukemias -- 5.2.6.2 Lymphoid Leukemias -- 5.2.6.3 Lymphomas -- 5.3 Conclusion -- References -- Chapter 6: Epigenetic Regulation in Breast Cancer Tumor Microenvironment -- 6.1 Introduction -- 6.2 Tumor Microenvironment in Breast Cancer -- 6.2.1 Tumor-Associated Macrophages (TAMs) -- 6.2.2 Helper T Cells and Cytotoxic T Cells -- 6.2.3 Natural Killer Cells (NK Cells) -- 6.2.4 Dendritic Cells (DCs) -- 6.2.5 Myeloid-Derived Suppressor Cells (MDSCs) -- 6.2.6 Cancer-Associated Fibroblasts (CAFs) -- 6.2.7 Endothelial Cells -- 6.2.8 Cytokines and Chemokines -- 6.3 Epigenetic Modifications in Breast Cancer Tumor Microenvironment -- 6.3.1 DNA Methylation -- 6.3.2 Histone Modifications. 6.3.3 NcRNA-mediated Gene Silencing -- 6.4 Epigenetic Modulators in the Tumor Microenvironment of Breast Cancer -- 6.5 Conclusion -- References -- Chapter 7: The Epigenetics of Brain Tumors: Fundamental Aspects of Epigenetics in Glioma -- 7.1 Introduction -- 7.2 Overview of Epigenetic Mechanisms -- 7.2.1 DNA Methylation -- 7.2.1.1 DNA Demethylation and Hypermethylated Phenotype -- 7.2.2 Posttranslational Modifications of Histones -- 7.2.3 Noncoding RNAs -- 7.3 Epigenetic Changes in Gliomas -- 7.3.1 Glioma CpG Island Methylator Phenotype (G-CIMP) -- 7.3.2 IDH1 Mutations and Relationship to Epigenetic Changes in Gliomas -- 7.3.2.1 IDH1 and IDH2 Genes -- 7.3.2.2 Classifying Marker 1p/19q Codeletion -- 7.3.2.3 MGMT Promoter Methylation -- 7.3.2.4 IDHs, G-CIMP Status, and MGMT Promoter Methylation Relations -- 7.4 Epigenetic Biomarkers Related with Chromatin Modifications -- 7.4.1 CTCF (CCCTC-Binding Factor) -- 7.4.2 Nuclear Alpha-Thalassemia/Mental Retardation X-Linked Syndrome (ATRX) Gene -- 7.5 Histone Modifications -- 7.5.1 Histone Acetylation -- 7.5.2 Histone Methylation and Pediatric Gliomas -- 7.6 Noncoding RNA and Glial Tumors -- 7.7 Conclusion -- References -- Chapter 8: Epigenetic Alterations in Pancreatic Cancer -- 8.1 Introduction -- 8.2 Genetic Alterations in Pancreatic Cancer -- 8.3 Epigenetic Events in Pancreatic Cancer -- 8.3.1 DNA Methylation -- 8.3.2 Histone Modification -- 8.3.2.1 Lysine Residue-Specific Methylation -- 8.3.2.2 Lysine-Specific Demethylation -- 8.3.2.3 Arginine-Specific Methylation -- 8.4 Conclusion -- References -- Chapter 9: Current Preclinical Applications of Pharmaco-Epigenetics in Cardiovascular Diseases -- 9.1 Cardiovascular Diseases: From Ischemic Injuries to Heart Repair -- 9.2 The Impact of Epigenetics on Cardiovascular Activity -- 9.3 Epigenetic Machinery in Cardiovascular Diseases. 9.3.1 DNA Methylation Role in CVD -- 9.3.2 Histone Modifications in CVD -- 9.3.3 Histone Deacetylases in CVD -- 9.3.4 Histone Methylation in CVD -- 9.3.5 Noncoding RNAS in CVD -- 9.4 Epigenetic Dysregulation and Cardiovascular Disease Susceptibility. -- 9.5 Epigenetic Biomarkers in Cardiovascular Diseases -- 9.5.1 Epigenetic Biomarkers in MI -- 9.5.2 Epigenetic Biomarkers in HF -- 9.5.3 Epi-Biomarkers in Arrhythmia -- 9.6 Preclinical Evidence of Pharmaco-Epigenetic Role in Cardiovascular Diseases -- 9.6.1 Histone Modifications -- 9.6.2 DNA Methylation -- 9.6.3 Noncoding RNA -- 9.7 Epigenetic-Based Therapies in Cardiovascular Diseases and Future Perspectives -- 9.8 Potential Effects of Existing Drugs on Epigenetic Modulators in Cardiovascular Disease -- References -- Chapter 10: Epigenetic Alterations in Colorectal Cancer -- 10.1 Introduction -- 10.2 Aberrant DNA Methylation -- 10.2.1 DNA Methylation Alterations in Colorectal Cancer (CRC) -- 10.2.1.1 Hypermethylation -- 10.2.1.2 Hypomethylation -- 10.2.2 DNA Methylation and the Pathogenesis of Colorectal Cancer: ``Traditional´´ and ``Serrated´´ Polyp Pathways -- 10.2.3 Clinical Applications of DNA methylation in Colorectal Cancer -- 10.2.3.1 Stool-Based Biomarkers -- 10.2.3.2 Blood-Based Biomarkers -- 10.2.3.3 Epigenetic Prognostic Biomarkers -- 10.2.3.4 Epigenetic Predictive Biomarkers for Response to Treatment -- 10.2.3.5 Colorectal Cancer and ``Field Cancerization´´ -- 10.2.4 Chromatin Alterations and Histone Modifications -- 10.2.4.1 Overview of Histone Biology -- 10.2.4.2 Histone Modification Alterations in Colorectal Cancer and Potential for Clinical Applications -- 10.2.5 microRNA and Colorectal Cancer -- 10.2.5.1 Overview of miRNA Biology -- 10.2.5.2 Dysregulation of miRNA Expression in ``Traditional´´ and ``Serrated´´ Pathways -- 10.2.6 miRNAs as Diagnostic Biomarkers in Colorectal Cancer. 10.2.6.1 Blood-Based Biomarkers. |
| Record Nr. | UNINA-9910768191303321 |
| Cham, Switzerland : , : Springer Nature Switzerland AG, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical epigenetics
| Clinical epigenetics |
| Pubbl/distr/stampa | Berlin, : Springer-Verlag, 2010- |
| Soggetto topico |
Epigenesis
Epigenesis, Genetic Genetics, Medical |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1868-7083 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Clin Epigenet |
| Record Nr. | UNISA-996210246303316 |
| Berlin, : Springer-Verlag, 2010- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Clinical epigenetics
| Clinical epigenetics |
| Pubbl/distr/stampa | Berlin, : Springer-Verlag, 2010- |
| Soggetto topico |
Epigenesis
Epigenesis, Genetic Genetics, Medical Epigènesi |
| Soggetto genere / forma |
Periodical
Periodicals. Revistes electròniques. |
| ISSN | 1868-7083 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Clin Epigenet |
| Record Nr. | UNINA-9910140000303321 |
| Berlin, : Springer-Verlag, 2010- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Epigenetic drug discovery / / edited by Wolfgang Sippl and Manfred Jung
| Epigenetic drug discovery / / edited by Wolfgang Sippl and Manfred Jung |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2019] |
| Descrizione fisica | 1 online resource (506 pages) |
| Disciplina | 615.7 |
| Collana | Methods and Principles in Medicinal Chemistry |
| Soggetto topico |
Pharmacogenomics
Epigenesis, Genetic Drug Discovery - methods Pharmacogenetics - methods |
| ISBN |
3-527-80928-7
3-527-80925-2 3-527-80926-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910555280203321 |
| Weinheim, Germany : , : Wiley-VCH, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Epigenetic drug discovery / / edited by Wolfgang Sippl and Manfred Jung
| Epigenetic drug discovery / / edited by Wolfgang Sippl and Manfred Jung |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2019] |
| Descrizione fisica | 1 online resource (506 pages) |
| Disciplina | 615.7 |
| Collana | Methods and Principles in Medicinal Chemistry |
| Soggetto topico |
Pharmacogenomics
Epigenesis, Genetic Drug Discovery - methods Pharmacogenetics - methods |
| ISBN |
3-527-80928-7
3-527-80925-2 3-527-80926-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910676614603321 |
| Weinheim, Germany : , : Wiley-VCH, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Epigenetic drug discovery / / edited by Wolfgang Sippl and Manfred Jung
| Epigenetic drug discovery / / edited by Wolfgang Sippl and Manfred Jung |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2019] |
| Descrizione fisica | 1 online resource (506 pages) |
| Disciplina | 615.7 |
| Collana | Methods and Principles in Medicinal Chemistry |
| Soggetto topico |
Pharmacogenomics
Epigenesis, Genetic Drug Discovery - methods Pharmacogenetics - methods |
| ISBN |
3-527-80928-7
3-527-80925-2 3-527-80926-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910807219403321 |
| Weinheim, Germany : , : Wiley-VCH, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Epigenetic mechanisms in cancer . Volume 3 / / edited by Sabita Saldanha
| Epigenetic mechanisms in cancer . Volume 3 / / edited by Sabita Saldanha |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2018 |
| Descrizione fisica | 1 online resource (381 pages) : color illustrations, tables |
| Disciplina | 616.994042 |
| Collana | Translational Epigenetics Series |
| Soggetto topico |
Cancer - Genetic aspects
Epigenetics Neoplasms - genetics Epigenesis, Genetic |
| ISBN |
0-12-813460-7
0-12-809552-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910583082003321 |
| London, England : , : Academic Press, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Epigenetic principles of evolution / / Nelson R. Cabej
| Epigenetic principles of evolution / / Nelson R. Cabej |
| Autore | Çabej Nelson |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2019 |
| Descrizione fisica | 1 online resource (1,060 pages) |
| Disciplina | 616.042 |
| Soggetto topico |
Epigenesis
Epigenomics Biological Evolution Epigenesis, Genetic |
| ISBN | 0-12-814068-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910583075303321 |
Çabej Nelson
|
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| London, England : , : Academic Press, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Epigenetic targets in drug discovery
| Epigenetic targets in drug discovery |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2009 |
| Disciplina | 615.7 |
| Collana | Methods and principles in medicinal chemistry Epigenetic targets in drug discovery |
| Soggetto topico |
Pharmacogenomics
Epigenesis, Genetic Drug Discovery - methods Pharmacogenetics - methods Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN | 3-527-62707-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910139416203321 |
| [Place of publication not identified], : Wiley VCH, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Epigenetic targets in drug discovery
| Epigenetic targets in drug discovery |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH, 2009 |
| Disciplina | 615.7 |
| Collana | Methods and principles in medicinal chemistry Epigenetic targets in drug discovery |
| Soggetto topico |
Pharmacogenomics
Epigenesis, Genetic Drug Discovery - methods Pharmacogenetics - methods Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN | 3-527-62707-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830297303321 |
| [Place of publication not identified], : Wiley VCH, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Epigenesis, Genetic
(30)
- Epigenetics (13)
- Epigenesis (11)
- Epigenomics (8)
- Drug Discovery - methods (6)