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Endocrine disrupters [[electronic resource] ] : hazard testing and assessment methods / / edited by Peter Matthiessen
| Endocrine disrupters [[electronic resource] ] : hazard testing and assessment methods / / edited by Peter Matthiessen |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2013 |
| Descrizione fisica | 1 online resource (412 p.) |
| Disciplina | 615.3/6 |
| Altri autori (Persone) | MatthiessenPeter |
| Soggetto topico |
Endocrine disrupting chemicals - Toxicity testing
Endocrine disrupting chemicals - Environmental aspects Endocrine toxicology |
| ISBN |
1-118-35596-2
1-299-24236-7 1-118-35594-6 |
| Classificazione | SCI013060 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENDOCRINE DISRUPTERS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1 Ecotoxicity Test Methods for Endocrine-Disrupting Chemicals : AN INTRODUCTION; 1.1 BACKGROUND; 1.2 REGULATORY CONCERNS; 1.3 INVERTEBRATES; 1.4 VERTEBRATES; 1.5 TESTING SCHEMES FOR EDCs; REFERENCE; CHAPTER 2 Endocrine Disruption in Wildlife : BACKGROUND, EFFECTS, AND IMPLICATIONS; 2.1 BACKGROUND TO ENDOCRINE DISRUPTION; 2.1.1 Introduction; 2.1.2 Brief Account of the History of Endocrine Disruption; 2.1.3 What Are Endocrine-Disrupting Chemicals?; 2.1.4 Vertebrate Endocrine System; 2.1.5 Invertebrate Endocrine System
2.1.6 Mechanisms of Endocrine Disruption2.1.7 Endocrine Disrupters in the Environment; 2.2 EFFECTS OF EDCs ON WILDLIFE; 2.2.1 Mammals; 2.2.2 Birds; 2.2.3 Reptiles and Amphibians; 2.2.4 Fish; 2.2.5 Invertebrates; 2.3 WEIGHT OF EVIDENCE AND ECOLOGICAL SIGNIFICANCE OF ED EFFECTS; 2.4 IMPLICATIONS FOR EFFECT ASSESSMENT AND TOXICITY TESTING; 2.5 NEED FOR MORE FIELD STUDIES AND AN INTEGRATED APPROACH; 2.6 CONCLUDING POINTS; REFERENCES; CHAPTER 3 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards to Wildlife 3.1 EMERGING CONCERNS AND POLICY RESPONSES: FOCUSING ON EDCs AS A LARGE PSEUDO-UNIFORM GROUP OF SUBSTANCES3.1.1 Regulatory Action Among Public Concern, Policy, Stakeholder Interests, and Scientific Complexity: The Starting Point; 3.1.2 Policy Responses to the Initial General Concern: General Strategies; 3.2 GENERAL APPROACHES IN SUBSTANCE-RELATED REGULATORY FRAMEWORKS (EU); 3.2.1 Highlighted Role of ED Properties in General Parts of Regulatory Frameworks; 3.2.2 REACH: Authorization in Cases of "Very High Concern" 3.2.3 Plant Protection Products: Major Change from Directive 91/414 to New Regulation 1107/20093.2.4 Biocides; 3.2.5 Pharmaceuticals; 3.2.6 Other Regulatory Frameworks Not Primarily Related to Substances; 3.3 HOW TO MAKE EDC DEFINITIONS OPERATIONAL FOR SUBSTANCE-RELATED REGULATORY WORK; 3.4 FUTURE PERSPECTIVES; 3.5 CONCLUSIONS; REFERENCES; CHAPTER 4 Techniques for Measuring Endocrine Disruption in Insects; 4.1 INTRODUCTION; 4.1.1 Insects; 4.1.2 Insect Hormones; 4.1.3 Endocrine Disruption and Insects; 4.1.4 Development of Insecticides Targeting the Endocrine System; 4.2 METHODS 4.2.1 Mechanistic Assays4.2.2 Apical Assays; 4.3 DISCUSSION; 4.3.1 Mechanism and Effect; 4.3.2 Exposure Considerations; 4.4 CONCLUSION; 4.5 ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 Crustaceans; 5.1 INTRODUCTION; 5.2 BACKGROUND TO CRUSTACEAN ENDOCRINOLOGY; 5.2.1 General; 5.2.2 Overview of the Crustacean Endocrine System; 5.3 STATE OF THE ART: WHAT DO WE KNOW ABOUT ENDOCRINE DISRUPTION IN CRUSTACEANS?; 5.3.1 General; 5.3.2 Daphnia sp.; 5.3.3 Barnacles; 5.3.4 Copepods; 5.3.5 Amphipods; 5.3.6 Mysids; 5.3.7 Other Studies Using Larger Crustaceans 5.4 AVAILABLE SUBCHRONIC/CHRONIC STANDARD TEST PROTOCOLS |
| Record Nr. | UNINA-9910141610703321 |
| Hoboken, N.J., : Wiley, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Endocrine disrupters [[electronic resource] ] : hazard testing and assessment methods / / edited by Peter Matthiessen
| Endocrine disrupters [[electronic resource] ] : hazard testing and assessment methods / / edited by Peter Matthiessen |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2013 |
| Descrizione fisica | 1 online resource (412 p.) |
| Disciplina | 615.3/6 |
| Altri autori (Persone) | MatthiessenPeter |
| Soggetto topico |
Endocrine disrupting chemicals - Toxicity testing
Endocrine disrupting chemicals - Environmental aspects Endocrine toxicology |
| ISBN |
1-118-35596-2
1-299-24236-7 1-118-35594-6 |
| Classificazione | SCI013060 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENDOCRINE DISRUPTERS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1 Ecotoxicity Test Methods for Endocrine-Disrupting Chemicals : AN INTRODUCTION; 1.1 BACKGROUND; 1.2 REGULATORY CONCERNS; 1.3 INVERTEBRATES; 1.4 VERTEBRATES; 1.5 TESTING SCHEMES FOR EDCs; REFERENCE; CHAPTER 2 Endocrine Disruption in Wildlife : BACKGROUND, EFFECTS, AND IMPLICATIONS; 2.1 BACKGROUND TO ENDOCRINE DISRUPTION; 2.1.1 Introduction; 2.1.2 Brief Account of the History of Endocrine Disruption; 2.1.3 What Are Endocrine-Disrupting Chemicals?; 2.1.4 Vertebrate Endocrine System; 2.1.5 Invertebrate Endocrine System
2.1.6 Mechanisms of Endocrine Disruption2.1.7 Endocrine Disrupters in the Environment; 2.2 EFFECTS OF EDCs ON WILDLIFE; 2.2.1 Mammals; 2.2.2 Birds; 2.2.3 Reptiles and Amphibians; 2.2.4 Fish; 2.2.5 Invertebrates; 2.3 WEIGHT OF EVIDENCE AND ECOLOGICAL SIGNIFICANCE OF ED EFFECTS; 2.4 IMPLICATIONS FOR EFFECT ASSESSMENT AND TOXICITY TESTING; 2.5 NEED FOR MORE FIELD STUDIES AND AN INTEGRATED APPROACH; 2.6 CONCLUDING POINTS; REFERENCES; CHAPTER 3 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards to Wildlife 3.1 EMERGING CONCERNS AND POLICY RESPONSES: FOCUSING ON EDCs AS A LARGE PSEUDO-UNIFORM GROUP OF SUBSTANCES3.1.1 Regulatory Action Among Public Concern, Policy, Stakeholder Interests, and Scientific Complexity: The Starting Point; 3.1.2 Policy Responses to the Initial General Concern: General Strategies; 3.2 GENERAL APPROACHES IN SUBSTANCE-RELATED REGULATORY FRAMEWORKS (EU); 3.2.1 Highlighted Role of ED Properties in General Parts of Regulatory Frameworks; 3.2.2 REACH: Authorization in Cases of "Very High Concern" 3.2.3 Plant Protection Products: Major Change from Directive 91/414 to New Regulation 1107/20093.2.4 Biocides; 3.2.5 Pharmaceuticals; 3.2.6 Other Regulatory Frameworks Not Primarily Related to Substances; 3.3 HOW TO MAKE EDC DEFINITIONS OPERATIONAL FOR SUBSTANCE-RELATED REGULATORY WORK; 3.4 FUTURE PERSPECTIVES; 3.5 CONCLUSIONS; REFERENCES; CHAPTER 4 Techniques for Measuring Endocrine Disruption in Insects; 4.1 INTRODUCTION; 4.1.1 Insects; 4.1.2 Insect Hormones; 4.1.3 Endocrine Disruption and Insects; 4.1.4 Development of Insecticides Targeting the Endocrine System; 4.2 METHODS 4.2.1 Mechanistic Assays4.2.2 Apical Assays; 4.3 DISCUSSION; 4.3.1 Mechanism and Effect; 4.3.2 Exposure Considerations; 4.4 CONCLUSION; 4.5 ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 Crustaceans; 5.1 INTRODUCTION; 5.2 BACKGROUND TO CRUSTACEAN ENDOCRINOLOGY; 5.2.1 General; 5.2.2 Overview of the Crustacean Endocrine System; 5.3 STATE OF THE ART: WHAT DO WE KNOW ABOUT ENDOCRINE DISRUPTION IN CRUSTACEANS?; 5.3.1 General; 5.3.2 Daphnia sp.; 5.3.3 Barnacles; 5.3.4 Copepods; 5.3.5 Amphipods; 5.3.6 Mysids; 5.3.7 Other Studies Using Larger Crustaceans 5.4 AVAILABLE SUBCHRONIC/CHRONIC STANDARD TEST PROTOCOLS |
| Record Nr. | UNINA-9910809347503321 |
| Hoboken, N.J., : Wiley, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Endocrine disrupting chemicals [[electronic resource] /] / editors, R.E. Hester and R.M. Harrison
| Endocrine disrupting chemicals [[electronic resource] /] / editors, R.E. Hester and R.M. Harrison |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cambridge, : RSC, 1999 |
| Descrizione fisica | 1 online resource (167 p.) |
| Disciplina | 363.7384 |
| Altri autori (Persone) |
HesterR. E
HarrisonR. M |
| Collana | Issues in environmental science and technology |
| Soggetto topico |
Endocrine toxicology
Endocrine glands - Effect of chemicals on |
| ISBN |
1-59124-413-7
1-84755-074-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Front cover; BK9780854042555-FP001; BK9780854042555-FP005; BK9780854042555-FP007; BK9780854042555-FP011; BK9780854042555-FP013; BK9780854042555-00001; BK9780854042555-00027; BK9780854042555-00049; BK9780854042555-00061; BK9780854042555-00083; BK9780854042555-00109; BK9780854042555-00135; BK9780854042555-00147 |
| Record Nr. | UNINA-9910142517103321 |
| Cambridge, : RSC, 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Endocrine disruption : biological bases for health effects in wildlife and humans / / edited by David O. Norris and James A. Carr
| Endocrine disruption : biological bases for health effects in wildlife and humans / / edited by David O. Norris and James A. Carr |
| Autore | Norris David O |
| Pubbl/distr/stampa | Oxford, England : , : Oxford University Press, , 2006 |
| Descrizione fisica | 1 online resource (492 p.) |
| Disciplina | 571.9/51 |
| Soggetto topico |
Endocrine toxicology
Reproductive toxicology Environmental toxicolo |
| ISBN |
0-19-770085-3
1-280-47374-6 1-4237-4560-4 0-19-535026-X 1-4337-0100-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; 1. Introduction to Endocrinology; 2. Hormone Action on Receptors; 3. The Hypothalamus-Pituitary Axis; 4. The Thyroid Gland; 5. The Adrenal Glands; 6. The Gonads; Introduction to Part II; 7. Introduction to the Science of Toxicology; 8. Probabilistic Risk Assessment; 9. Fish and Wildlife as Sentinels of Environmental Contamination; Introduction to Part III; 10. Polychlorinated Dibenzo-p-Dioxins: Potential Mechanisms and Risk as Endocrine Disruptors; 11. Toxicology of PCBs and Related Compounds
12. DDT and Its Analogues: New Insights into Their Endocrine-Disrupting Effects on Wildlife13. Heavy Metals; 14. Effects of Alkylphenolic Compounds on Wildlife; 15. Endocrine-Active Phytochemicals: Environmental Signaling Context and Mechanisms; 16. Triazines; Appendices; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Z |
| Record Nr. | UNINA-9910784660903321 |
Norris David O
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| Oxford, England : , : Oxford University Press, , 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Endocrine disruption : biological bases for health effects in wildlife and humans / / edited by David O. Norris and James A. Carr
| Endocrine disruption : biological bases for health effects in wildlife and humans / / edited by David O. Norris and James A. Carr |
| Autore | Norris David O |
| Pubbl/distr/stampa | Oxford, England : , : Oxford University Press, , 2006 |
| Descrizione fisica | 1 online resource (492 p.) |
| Disciplina | 571.9/51 |
| Soggetto topico |
Endocrine toxicology
Reproductive toxicology Environmental toxicolo |
| ISBN |
0-19-770085-3
1-280-47374-6 1-4237-4560-4 0-19-535026-X 1-4337-0100-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; 1. Introduction to Endocrinology; 2. Hormone Action on Receptors; 3. The Hypothalamus-Pituitary Axis; 4. The Thyroid Gland; 5. The Adrenal Glands; 6. The Gonads; Introduction to Part II; 7. Introduction to the Science of Toxicology; 8. Probabilistic Risk Assessment; 9. Fish and Wildlife as Sentinels of Environmental Contamination; Introduction to Part III; 10. Polychlorinated Dibenzo-p-Dioxins: Potential Mechanisms and Risk as Endocrine Disruptors; 11. Toxicology of PCBs and Related Compounds
12. DDT and Its Analogues: New Insights into Their Endocrine-Disrupting Effects on Wildlife13. Heavy Metals; 14. Effects of Alkylphenolic Compounds on Wildlife; 15. Endocrine-Active Phytochemicals: Environmental Signaling Context and Mechanisms; 16. Triazines; Appendices; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Z |
| Record Nr. | UNINA-9910815326603321 |
|
Norris David O
|
||
| Oxford, England : , : Oxford University Press, , 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Endocrine disruption : biological bases for health effects in wildlife and humans / / edited by David O. Norris and James A. Carr
| Endocrine disruption : biological bases for health effects in wildlife and humans / / edited by David O. Norris and James A. Carr |
| Pubbl/distr/stampa | Oxford, England : , : Oxford University Press, , 2006 |
| Descrizione fisica | 1 online resource (492 p.) |
| Disciplina | 571.9/51 |
| Soggetto topico |
Endocrine toxicology
Reproductive toxicology Environmental toxicolo |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-47374-6
1-4237-4560-4 0-19-535026-X 1-4337-0100-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Contributors; 1. Introduction to Endocrinology; 2. Hormone Action on Receptors; 3. The Hypothalamus-Pituitary Axis; 4. The Thyroid Gland; 5. The Adrenal Glands; 6. The Gonads; Introduction to Part II; 7. Introduction to the Science of Toxicology; 8. Probabilistic Risk Assessment; 9. Fish and Wildlife as Sentinels of Environmental Contamination; Introduction to Part III; 10. Polychlorinated Dibenzo-p-Dioxins: Potential Mechanisms and Risk as Endocrine Disruptors; 11. Toxicology of PCBs and Related Compounds
12. DDT and Its Analogues: New Insights into Their Endocrine-Disrupting Effects on Wildlife13. Heavy Metals; 14. Effects of Alkylphenolic Compounds on Wildlife; 15. Endocrine-Active Phytochemicals: Environmental Signaling Context and Mechanisms; 16. Triazines; Appendices; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Z |
| Record Nr. | UNINA-9910458227303321 |
| Oxford, England : , : Oxford University Press, , 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Endocrine disruption in fish [[electronic resource] ] : an assessment of recent research and results / / Anthony S. Pait, Judd O. Nelson
| Endocrine disruption in fish [[electronic resource] ] : an assessment of recent research and results / / Anthony S. Pait, Judd O. Nelson |
| Autore | Pait Anthony S |
| Pubbl/distr/stampa | Silver Spring, Md. : , : U.S. Dept. of Commerce, National Oceanic and Atmospheric Administration, National Ocean Service, National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment, , [2002] |
| Descrizione fisica | 1 online resource (iv, 55 pages) : illustrations (some color) |
| Altri autori (Persone) | NelsonJudd O |
| Collana | NOAA technical memorandum NOS NCCOS CCMA |
| Soggetto topico |
Fishes - Endocrinology
Fishes - Effect of water pollution on Endocrine toxicology Indicators (Biology) Sewage - Environmental aspects Wood-pulp industry - Environmental aspects Paper mills - Environmental aspects |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Endocrine disruption in fish |
| Record Nr. | UNINA-9910699747203321 |
Endocrine disruptors
| Endocrine disruptors |
| Pubbl/distr/stampa | Austin, Texas : , : Landes Bioscience, , [2013]- |
| Descrizione fisica | 1 online resource |
| Disciplina | 616.4 |
| Soggetto topico |
Endocrine disrupting chemicals
Endocrine toxicology Reproductive toxicology Environmental toxicology Endocrine System Diseases Endocrine Disruptors |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2327-3747 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910139231603321 |
| Austin, Texas : , : Landes Bioscience, , [2013]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Endocrine disruptors in the environment / / Sushil K. Khetan
| Endocrine disruptors in the environment / / Sushil K. Khetan |
| Autore | Khetan Sushil K. |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (410 p.) |
| Disciplina | 614.5/94 |
| Soggetto topico |
Endocrine disrupting chemicals - Environmental aspects
Endocrine disrupting chemicals - Toxicity testing Endocrine toxicology |
| ISBN |
1-5231-1066-X
1-118-89115-5 1-118-89109-0 1-118-89103-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Contents; Foreword; Preface; Acronyms; Glossary; Chapter 1 Environmental Endocrine Disruptors; 1.1 Introduction; 1.1.1 The Endocrine System; 1.1.2 Endocrine Disrupting Chemicals (EDCs); 1.1.3 Sources of EDCs in the Environment; 1.1.4 Deleterious Effects of EDCs on Wildlife and on Humans; 1.1.5 Endocrine Disruption Endpoints; 1.2 Salient Aspects about Endocrine Disruption; 1.2.1 Low-Dose Effects and Nonmonotonic Dose Responses; 1.2.2 Exposures during Periods of Heightened Susceptibility in Critical Life Stages; 1.2.3 Delayed Dysfunction; 1.2.4 Importance of Mixtures
1.2.5 Transgenerational, Epigenetic Effects1.3 Historical Perspective of Endocrine Disruption; 1.4 Scope and Layout of this Book; 1.5 Conclusion; References; Part I Mechanisms of Hormonal Action and Putative Endocrine Disruptors; Chapter 2 Mechanisms of Endocrine System Function; 2.1 Introduction; 2.2 Hormonal Axes; 2.2.1 Hypothalamus-Pituitary-Gonad (HPG) Axis; 2.2.2 The Hypothalamic-Pituitary-Thyroid (HPT) Axis; 2.2.3 The Hypothalamic-Pituitary-Adrenal (HPA) Axis; 2.3 Hormonal Cell Signaling; 2.3.1 Receptors and Hormone Action; 2.3.2 Genomic Signaling Pathway 2.3.3 Rapid-Response Pathway (Nongenomic Signaling)2.3.4 Receptor Agonists, Partial Agonists, and Antagonists; 2.4 Sex Steroids; 2.4.1 Physiologic Estrogens; 2.4.2 Androgens; 2.5 Thyroid Hormones; 2.6 Conclusions and Future Prospects; References; Chapter 3 Environmental Chemicals Targeting Estrogen Signaling Pathways; 3.1 Introduction; 3.1.1 Gonadal Estrogen Function Disruptors; 3.2 Steroidal Estrogens; 3.2.1 Physiologic Estrogens; 3.2.2 17alpha-Ethinylestradiol (EE2); 3.2.3 Phytoestrogens; 3.2.4 Mycoestrogen-Zearalenone (ZEN); 3.3 Nonsteroidal Estrogenic Chemicals 3.3.1 Diethylstilbestrol (DES)3.3.2 Organochlorine Insecticides; 3.3.3 Polychlorinated Biphenyls (PCBs); 3.3.4 Alkyphenols; 3.3.5 Parabens (Hydroxy Benzoates); 3.3.6 Sun Screens (Chemical UV Filters); 3.4 Metalloestrogens; 3.4.1 Cadmium (Cd); 3.4.2 Lead (Pb); 3.4.3 Mercury (Hg); 3.4.4 Arsenic (As); 3.5 Conclusion and Future Prospects; References; Chapter 4 Anti-Androgenic Chemicals; 4.1 Introduction; 4.2 Testosterone Synthesis Inhibitors; 4.2.1 Phthalates; 4.3 Androgen Receptor (AR) Antagonists; 4.3.1 Organochlorine (OC) Pesticides; 4.3.2 Organophosphorus (OP) Insecticides 4.3.3 Bisphenol A (BPA)4.3.4 Polybrominated Diphenyl Ethers (PBDEs); 4.3.5 Vinclozolin (VZ); 4.3.6 Procymidone; 4.4 AR Antagonists and Fetal Testosterone Synthesis Inhibitors; 4.4.1 Prochloraz; 4.4.2 Linuron; 4.5 Comparative Anti-Androgenic Effects of Pesticides to Androgen Agonist DHT; 4.6 Conclusions and Future Prospects; References; Chapter 5 Thyroid-Disrupting Chemicals; 5.1 Introduction; 5.2 Thyroid Synthesis Inhibition by Interference in Iodide Uptake; 5.2.1 Perchlorate; 5.3 TH Transport Disruptors and Estrogen Sulfotransferases Inhibitors; 5.3.1 Polychlorinated Biphenyls (PCBs) 5.3.2 Triclosan |
| Record Nr. | UNINA-9910132211703321 |
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Khetan Sushil K.
|
||
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Endocrine disruptors in the environment / / Sushil K. Khetan
| Endocrine disruptors in the environment / / Sushil K. Khetan |
| Autore | Khetan Sushil K. |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (410 p.) |
| Disciplina | 614.5/94 |
| Soggetto topico |
Endocrine disrupting chemicals - Environmental aspects
Endocrine disrupting chemicals - Toxicity testing Endocrine toxicology |
| ISBN |
1-5231-1066-X
1-118-89115-5 1-118-89109-0 1-118-89103-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Contents; Foreword; Preface; Acronyms; Glossary; Chapter 1 Environmental Endocrine Disruptors; 1.1 Introduction; 1.1.1 The Endocrine System; 1.1.2 Endocrine Disrupting Chemicals (EDCs); 1.1.3 Sources of EDCs in the Environment; 1.1.4 Deleterious Effects of EDCs on Wildlife and on Humans; 1.1.5 Endocrine Disruption Endpoints; 1.2 Salient Aspects about Endocrine Disruption; 1.2.1 Low-Dose Effects and Nonmonotonic Dose Responses; 1.2.2 Exposures during Periods of Heightened Susceptibility in Critical Life Stages; 1.2.3 Delayed Dysfunction; 1.2.4 Importance of Mixtures
1.2.5 Transgenerational, Epigenetic Effects1.3 Historical Perspective of Endocrine Disruption; 1.4 Scope and Layout of this Book; 1.5 Conclusion; References; Part I Mechanisms of Hormonal Action and Putative Endocrine Disruptors; Chapter 2 Mechanisms of Endocrine System Function; 2.1 Introduction; 2.2 Hormonal Axes; 2.2.1 Hypothalamus-Pituitary-Gonad (HPG) Axis; 2.2.2 The Hypothalamic-Pituitary-Thyroid (HPT) Axis; 2.2.3 The Hypothalamic-Pituitary-Adrenal (HPA) Axis; 2.3 Hormonal Cell Signaling; 2.3.1 Receptors and Hormone Action; 2.3.2 Genomic Signaling Pathway 2.3.3 Rapid-Response Pathway (Nongenomic Signaling)2.3.4 Receptor Agonists, Partial Agonists, and Antagonists; 2.4 Sex Steroids; 2.4.1 Physiologic Estrogens; 2.4.2 Androgens; 2.5 Thyroid Hormones; 2.6 Conclusions and Future Prospects; References; Chapter 3 Environmental Chemicals Targeting Estrogen Signaling Pathways; 3.1 Introduction; 3.1.1 Gonadal Estrogen Function Disruptors; 3.2 Steroidal Estrogens; 3.2.1 Physiologic Estrogens; 3.2.2 17alpha-Ethinylestradiol (EE2); 3.2.3 Phytoestrogens; 3.2.4 Mycoestrogen-Zearalenone (ZEN); 3.3 Nonsteroidal Estrogenic Chemicals 3.3.1 Diethylstilbestrol (DES)3.3.2 Organochlorine Insecticides; 3.3.3 Polychlorinated Biphenyls (PCBs); 3.3.4 Alkyphenols; 3.3.5 Parabens (Hydroxy Benzoates); 3.3.6 Sun Screens (Chemical UV Filters); 3.4 Metalloestrogens; 3.4.1 Cadmium (Cd); 3.4.2 Lead (Pb); 3.4.3 Mercury (Hg); 3.4.4 Arsenic (As); 3.5 Conclusion and Future Prospects; References; Chapter 4 Anti-Androgenic Chemicals; 4.1 Introduction; 4.2 Testosterone Synthesis Inhibitors; 4.2.1 Phthalates; 4.3 Androgen Receptor (AR) Antagonists; 4.3.1 Organochlorine (OC) Pesticides; 4.3.2 Organophosphorus (OP) Insecticides 4.3.3 Bisphenol A (BPA)4.3.4 Polybrominated Diphenyl Ethers (PBDEs); 4.3.5 Vinclozolin (VZ); 4.3.6 Procymidone; 4.4 AR Antagonists and Fetal Testosterone Synthesis Inhibitors; 4.4.1 Prochloraz; 4.4.2 Linuron; 4.5 Comparative Anti-Androgenic Effects of Pesticides to Androgen Agonist DHT; 4.6 Conclusions and Future Prospects; References; Chapter 5 Thyroid-Disrupting Chemicals; 5.1 Introduction; 5.2 Thyroid Synthesis Inhibition by Interference in Iodide Uptake; 5.2.1 Perchlorate; 5.3 TH Transport Disruptors and Estrogen Sulfotransferases Inhibitors; 5.3.1 Polychlorinated Biphenyls (PCBs) 5.3.2 Triclosan |
| Record Nr. | UNINA-9910826916503321 |
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Khetan Sushil K.
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| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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