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Asymmetric catalysis on industrial scale : challenges, approaches and solutions / / edited by Hans-Ulrich Blaser and Hans-Jürgen Federsel
| Asymmetric catalysis on industrial scale : challenges, approaches and solutions / / edited by Hans-Ulrich Blaser and Hans-Jürgen Federsel |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim : , : Wiley-VCH, , [2010] |
| Descrizione fisica | 1 online resource (582 p.) |
| Disciplina | 547.1395 |
| Soggetto topico |
Enantioselective catalysis
Asymmetric synthesis Enantioselective catalysis - Industrial applications |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-78388-2
9786612783883 3-527-64216-1 3-527-63064-3 3-527-63063-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Asymmetric Catalysis on Industrial Scale; Contents; List of Contributors; Introduction; Part I New processes for Existing Active Compounds (APIs); 1 Some Recent Examples in Developing Biocatalytic Pharmaceutical Processes; 2 Enantioselective Hydrogenation: Applications in Process R&D of Pharmaceuticals; 3 Chiral Lactones by Asymmetric Hydrogenation - a Step Forward in (+)-Biotin Production; 4 Biocatalytic Asymmetric Oxidation for the Production of Bicyclic Proline Peptidomimetics
10 Development of Efficient Technical Processes for the Production of Enantiopure Amino Alcohols in the Pharmaceutical Industry11 The Asymmetric Hydrogenation of Enones - Access to a New L-Menthol Synthesis; 12 Eliminating Barriers in Large-Scale Asymmetric Synthesis; 13 Catalytic Asymmetric Ring Opening: A Transfer from Academia to Industry; 14 Asymmetric Baeyer-Villiger Reactions Using Whole-Cell Biocatalysts; 15 Large-Scale Applications of Hydrolases in Biocatalytic Asymmetric Synthesis; 16 Scale-Up Studies in Asymmetric Transfer Hydrogenation 17 2,2 ,5,5 -Tetramethyl-4,4 -bis(diphenylphoshino)-3,3 -bithiophene: A Very Efficient Chiral Ligand for Ru-Catalyzed Asymmetric Hydrogenations on the Multi-Kilograms Scale18 The Power of Whole-Cell Reaction: Efficient Production of Hydroxyproline, Sugar Nucleotides, Oligosaccharides, and Dipeptides; 19 Enantioselective Ketone Hydrogenation: from Research to Pilot Scale with Industrially Viable Ru-(Phosphine-Oxazoline) Complexes; Part III Processes for New Chemical Entities (NCEs); 20 Enabling Asymmetric Hydrogenation for the Design of Ef.cient Synthesis of Drug Substances 21 Scale-up of a Telescoped Enzymatic Hydrolysis Process for an Intermediate in the Synthesis of a Factor Xa Inhibitor22 An Efficient, Asymmetric Synthesis of Odanacatib, a Selective Inhibitor of Cathepsin K for the Treatment of Osteoporosis, Using an Enzyme-Mediated Dynamic Kinetic Resolution; 23 Biocatalytic Routes to the GPIIb/IIIa Antagonist Lotrafiban, SB 214857; 24 Discovery and Development of a Catalytic Asymmetric Conjugate Addition of Ketoesters to Nitroalkenes and Its Use in the Large-Scale Preparation of ABT-546 25 The Kagan Oxidation - Industrial-Scale Asymmetric Sulfoxidations in the Synthesis of Two Related NK1/NK2 Antagonists |
| Record Nr. | UNINA-9910140344403321 |
| Weinheim : , : Wiley-VCH, , [2010] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Asymmetric catalysis on industrial scale : challenges, approaches and solutions / / edited by Hans-Ulrich Blaser and Hans-Jürgen Federsel
| Asymmetric catalysis on industrial scale : challenges, approaches and solutions / / edited by Hans-Ulrich Blaser and Hans-Jürgen Federsel |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim : , : Wiley-VCH, , [2010] |
| Descrizione fisica | 1 online resource (582 p.) |
| Disciplina | 547.1395 |
| Soggetto topico |
Enantioselective catalysis
Asymmetric synthesis Enantioselective catalysis - Industrial applications |
| ISBN |
1-282-78388-2
9786612783883 3-527-64216-1 3-527-63064-3 3-527-63063-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Asymmetric Catalysis on Industrial Scale; Contents; List of Contributors; Introduction; Part I New processes for Existing Active Compounds (APIs); 1 Some Recent Examples in Developing Biocatalytic Pharmaceutical Processes; 2 Enantioselective Hydrogenation: Applications in Process R&D of Pharmaceuticals; 3 Chiral Lactones by Asymmetric Hydrogenation - a Step Forward in (+)-Biotin Production; 4 Biocatalytic Asymmetric Oxidation for the Production of Bicyclic Proline Peptidomimetics
10 Development of Efficient Technical Processes for the Production of Enantiopure Amino Alcohols in the Pharmaceutical Industry11 The Asymmetric Hydrogenation of Enones - Access to a New L-Menthol Synthesis; 12 Eliminating Barriers in Large-Scale Asymmetric Synthesis; 13 Catalytic Asymmetric Ring Opening: A Transfer from Academia to Industry; 14 Asymmetric Baeyer-Villiger Reactions Using Whole-Cell Biocatalysts; 15 Large-Scale Applications of Hydrolases in Biocatalytic Asymmetric Synthesis; 16 Scale-Up Studies in Asymmetric Transfer Hydrogenation 17 2,2 ,5,5 -Tetramethyl-4,4 -bis(diphenylphoshino)-3,3 -bithiophene: A Very Efficient Chiral Ligand for Ru-Catalyzed Asymmetric Hydrogenations on the Multi-Kilograms Scale18 The Power of Whole-Cell Reaction: Efficient Production of Hydroxyproline, Sugar Nucleotides, Oligosaccharides, and Dipeptides; 19 Enantioselective Ketone Hydrogenation: from Research to Pilot Scale with Industrially Viable Ru-(Phosphine-Oxazoline) Complexes; Part III Processes for New Chemical Entities (NCEs); 20 Enabling Asymmetric Hydrogenation for the Design of Ef.cient Synthesis of Drug Substances 21 Scale-up of a Telescoped Enzymatic Hydrolysis Process for an Intermediate in the Synthesis of a Factor Xa Inhibitor22 An Efficient, Asymmetric Synthesis of Odanacatib, a Selective Inhibitor of Cathepsin K for the Treatment of Osteoporosis, Using an Enzyme-Mediated Dynamic Kinetic Resolution; 23 Biocatalytic Routes to the GPIIb/IIIa Antagonist Lotrafiban, SB 214857; 24 Discovery and Development of a Catalytic Asymmetric Conjugate Addition of Ketoesters to Nitroalkenes and Its Use in the Large-Scale Preparation of ABT-546 25 The Kagan Oxidation - Industrial-Scale Asymmetric Sulfoxidations in the Synthesis of Two Related NK1/NK2 Antagonists |
| Record Nr. | UNINA-9910830875203321 |
| Weinheim : , : Wiley-VCH, , [2010] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
