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Chiral pollutants [[electronic resource] ] : distribution, toxicity, and analysis by chromatography and capillary electrophoresis / / Imran Ali and Hassan Y. Aboul-Enein
Chiral pollutants [[electronic resource] ] : distribution, toxicity, and analysis by chromatography and capillary electrophoresis / / Imran Ali and Hassan Y. Aboul-Enein
Autore Ali Imran
Pubbl/distr/stampa Chichester, West Sussex, Eng. ; ; Hoboken, NJ, : J. Wiley, c2004
Descrizione fisica 1 online resource (366 p.)
Disciplina 615.902
Altri autori (Persone) Aboul-EneinHassan Y
Soggetto topico Environmental toxicology
Enantiomers - Toxicology
Enantiomers - Separation
Chromatographic analysis
Capillary electrophoresis
Soggetto genere / forma Electronic books.
ISBN 1-280-27616-9
9786610276165
0-470-30051-5
0-470-86781-7
0-470-86782-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chiral Pollutants: Distribution, Toxicity and Analysis by Chromatography and Capillary Electrophoresis; Dedication; Contents; Preface; Acknowledgements; About the Book; About the Authors; 1 Introduction; 1.1 The Importance of the Environment; 1.2 Environmental Pollutants; 1.3 Chirality and its Occurrence; 1.4 The Chemical Evolution of Chirality; 1.5 The Electronic Theory of Chirality; 1.6 The Importance of Chirality; 1.7 Nomenclature for Chiral Pollutants; 1.8 Chirality in Environmental Pollutants; 1.9 Chirality and its Consequences in the Environment
1.10 The Enantiomeric Ratio and Fractions of Chiral Pollutants1.11 Methods for the Separation of Chiral Pollutants; 1.11.1 Chromatographic Methods; 1.11.2 The Capillary Electrophoretic Method; 1.12 Chiral Selectors in Chromatography and Capillary Electrophoresis; 1.13 Detection in Chromatography and Capillary Electrophoresis; 1.14 Other Methods of Separation of Chiral Pollutants; References; 2 Chiral Pollutants: Sources and Distribution; 2.1 Introduction; 2.2 Sources of Contamination; 2.3 The Distribution of Chiral Pollutants; 2.3.1 Distribution in Water; 2.3.2 Distribution in Sediment
2.3.3 Distribution in Soil2.3.4 Distribution in Air; 2.3.5 Distribution in Aquatic and Amphibian Biota; 2.3.6 Distribution in Terrestrial Biota; 2.3.7 Distribution in Food Products; 2.4 Conclusions; References; 3 Chiral Pollutants: Biotransformation, Biodegradation and Metabolism; 3.1 Introduction; 3.2 The Mechanisms of the Interactions of Chiral Xenobiotics in Biological Systems; 3.3 The Fate of Chiral Pollutants in the Ecosystem; 3.3.1 Biotransformation; 3.4 Photochemical Conversion; 3.5 Metabolism; 3.6 Conclusions; References; 4 The Enantioselective Toxicities of Chiral Pollutants
4.1 Introduction4.2 The Enantioselective Toxicities of PCBs; 4.3 The Enantioselective Toxicities of HCH; 4.4 The Enantioselective Toxicities of Other Chlorinated Pesticides; 4.5 The Enantioselective Toxicities of Phosphorous Pesticides; 4.6 The Enantioselective Toxicities of Polyaromatic Hydrocarbons (PAHs); 4.7 The Enantioselective Toxicities of Other Xenobiotics; 4.8 The Enantioselective Toxicities of Drugs and Pharmaceuticals; 4.9 Conclusions; References; 5 Sample Preparation; 5.1 Introduction; 5.2 Sampling; 5.3 Filtration; 5.4 Homogenization; 5.5 Extraction
5.5.1 The Extraction of Solid Samples5.5.2 The Extraction of Liquid Samples; 5.6 Membrane Methods in Sample Preparation; 5.7 Clean-up; 5.8 Pre-concentration; 5.9 Conclusions; References; 6 The Analysis of Chiral Pollutants by Gas Chromatography; 6.1 Introduction; 6.2 Chiral Selectors; 6.2.1 Structures and Properties; 6.2.2 Preparation and Commercialization; 6.2.3 Other Chiral GC CSPs; 6.3 Applications; 6.4 The Optimization of GC Conditions; 6.4.1 Mobile Phases; 6.4.2 Temperature; 6.4.3 The Column Dimensions; 6.4.4 Structures and Types of Chiral Selectors
6.4.5 The Structures of Chiral Pollutants
Record Nr. UNINA-9910145904403321
Ali Imran  
Chichester, West Sussex, Eng. ; ; Hoboken, NJ, : J. Wiley, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chiral pollutants [[electronic resource] ] : distribution, toxicity, and analysis by chromatography and capillary electrophoresis / / Imran Ali and Hassan Y. Aboul-Enein
Chiral pollutants [[electronic resource] ] : distribution, toxicity, and analysis by chromatography and capillary electrophoresis / / Imran Ali and Hassan Y. Aboul-Enein
Autore Ali Imran
Pubbl/distr/stampa Chichester, West Sussex, Eng. ; ; Hoboken, NJ, : J. Wiley, c2004
Descrizione fisica 1 online resource (366 p.)
Disciplina 615.902
Altri autori (Persone) Aboul-EneinHassan Y
Soggetto topico Environmental toxicology
Enantiomers - Toxicology
Enantiomers - Separation
Chromatographic analysis
Capillary electrophoresis
ISBN 1-280-27616-9
9786610276165
0-470-30051-5
0-470-86781-7
0-470-86782-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chiral Pollutants: Distribution, Toxicity and Analysis by Chromatography and Capillary Electrophoresis; Dedication; Contents; Preface; Acknowledgements; About the Book; About the Authors; 1 Introduction; 1.1 The Importance of the Environment; 1.2 Environmental Pollutants; 1.3 Chirality and its Occurrence; 1.4 The Chemical Evolution of Chirality; 1.5 The Electronic Theory of Chirality; 1.6 The Importance of Chirality; 1.7 Nomenclature for Chiral Pollutants; 1.8 Chirality in Environmental Pollutants; 1.9 Chirality and its Consequences in the Environment
1.10 The Enantiomeric Ratio and Fractions of Chiral Pollutants1.11 Methods for the Separation of Chiral Pollutants; 1.11.1 Chromatographic Methods; 1.11.2 The Capillary Electrophoretic Method; 1.12 Chiral Selectors in Chromatography and Capillary Electrophoresis; 1.13 Detection in Chromatography and Capillary Electrophoresis; 1.14 Other Methods of Separation of Chiral Pollutants; References; 2 Chiral Pollutants: Sources and Distribution; 2.1 Introduction; 2.2 Sources of Contamination; 2.3 The Distribution of Chiral Pollutants; 2.3.1 Distribution in Water; 2.3.2 Distribution in Sediment
2.3.3 Distribution in Soil2.3.4 Distribution in Air; 2.3.5 Distribution in Aquatic and Amphibian Biota; 2.3.6 Distribution in Terrestrial Biota; 2.3.7 Distribution in Food Products; 2.4 Conclusions; References; 3 Chiral Pollutants: Biotransformation, Biodegradation and Metabolism; 3.1 Introduction; 3.2 The Mechanisms of the Interactions of Chiral Xenobiotics in Biological Systems; 3.3 The Fate of Chiral Pollutants in the Ecosystem; 3.3.1 Biotransformation; 3.4 Photochemical Conversion; 3.5 Metabolism; 3.6 Conclusions; References; 4 The Enantioselective Toxicities of Chiral Pollutants
4.1 Introduction4.2 The Enantioselective Toxicities of PCBs; 4.3 The Enantioselective Toxicities of HCH; 4.4 The Enantioselective Toxicities of Other Chlorinated Pesticides; 4.5 The Enantioselective Toxicities of Phosphorous Pesticides; 4.6 The Enantioselective Toxicities of Polyaromatic Hydrocarbons (PAHs); 4.7 The Enantioselective Toxicities of Other Xenobiotics; 4.8 The Enantioselective Toxicities of Drugs and Pharmaceuticals; 4.9 Conclusions; References; 5 Sample Preparation; 5.1 Introduction; 5.2 Sampling; 5.3 Filtration; 5.4 Homogenization; 5.5 Extraction
5.5.1 The Extraction of Solid Samples5.5.2 The Extraction of Liquid Samples; 5.6 Membrane Methods in Sample Preparation; 5.7 Clean-up; 5.8 Pre-concentration; 5.9 Conclusions; References; 6 The Analysis of Chiral Pollutants by Gas Chromatography; 6.1 Introduction; 6.2 Chiral Selectors; 6.2.1 Structures and Properties; 6.2.2 Preparation and Commercialization; 6.2.3 Other Chiral GC CSPs; 6.3 Applications; 6.4 The Optimization of GC Conditions; 6.4.1 Mobile Phases; 6.4.2 Temperature; 6.4.3 The Column Dimensions; 6.4.4 Structures and Types of Chiral Selectors
6.4.5 The Structures of Chiral Pollutants
Record Nr. UNINA-9910830621503321
Ali Imran  
Chichester, West Sussex, Eng. ; ; Hoboken, NJ, : J. Wiley, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chiral pollutants : distribution, toxicity, and analysis by chromatography and capillary electrophoresis / / Imran Ali and Hassan Y. Aboul-Enein
Chiral pollutants : distribution, toxicity, and analysis by chromatography and capillary electrophoresis / / Imran Ali and Hassan Y. Aboul-Enein
Autore Ali Imran
Pubbl/distr/stampa Chichester, West Sussex, Eng. ; ; Hoboken, NJ, : J. Wiley, c2004
Descrizione fisica 1 online resource (366 p.)
Disciplina 615.9/02
Altri autori (Persone) Aboul-EneinHassan Y
Soggetto topico Environmental toxicology
Enantiomers - Toxicology
Enantiomers - Separation
Chromatographic analysis
Capillary electrophoresis
ISBN 9786610276165
9781280276163
1280276169
9780470300510
0470300515
9780470867815
0470867817
9780470867822
0470867825
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chiral Pollutants: Distribution, Toxicity and Analysis by Chromatography and Capillary Electrophoresis; Dedication; Contents; Preface; Acknowledgements; About the Book; About the Authors; 1 Introduction; 1.1 The Importance of the Environment; 1.2 Environmental Pollutants; 1.3 Chirality and its Occurrence; 1.4 The Chemical Evolution of Chirality; 1.5 The Electronic Theory of Chirality; 1.6 The Importance of Chirality; 1.7 Nomenclature for Chiral Pollutants; 1.8 Chirality in Environmental Pollutants; 1.9 Chirality and its Consequences in the Environment
1.10 The Enantiomeric Ratio and Fractions of Chiral Pollutants1.11 Methods for the Separation of Chiral Pollutants; 1.11.1 Chromatographic Methods; 1.11.2 The Capillary Electrophoretic Method; 1.12 Chiral Selectors in Chromatography and Capillary Electrophoresis; 1.13 Detection in Chromatography and Capillary Electrophoresis; 1.14 Other Methods of Separation of Chiral Pollutants; References; 2 Chiral Pollutants: Sources and Distribution; 2.1 Introduction; 2.2 Sources of Contamination; 2.3 The Distribution of Chiral Pollutants; 2.3.1 Distribution in Water; 2.3.2 Distribution in Sediment
2.3.3 Distribution in Soil2.3.4 Distribution in Air; 2.3.5 Distribution in Aquatic and Amphibian Biota; 2.3.6 Distribution in Terrestrial Biota; 2.3.7 Distribution in Food Products; 2.4 Conclusions; References; 3 Chiral Pollutants: Biotransformation, Biodegradation and Metabolism; 3.1 Introduction; 3.2 The Mechanisms of the Interactions of Chiral Xenobiotics in Biological Systems; 3.3 The Fate of Chiral Pollutants in the Ecosystem; 3.3.1 Biotransformation; 3.4 Photochemical Conversion; 3.5 Metabolism; 3.6 Conclusions; References; 4 The Enantioselective Toxicities of Chiral Pollutants
4.1 Introduction4.2 The Enantioselective Toxicities of PCBs; 4.3 The Enantioselective Toxicities of HCH; 4.4 The Enantioselective Toxicities of Other Chlorinated Pesticides; 4.5 The Enantioselective Toxicities of Phosphorous Pesticides; 4.6 The Enantioselective Toxicities of Polyaromatic Hydrocarbons (PAHs); 4.7 The Enantioselective Toxicities of Other Xenobiotics; 4.8 The Enantioselective Toxicities of Drugs and Pharmaceuticals; 4.9 Conclusions; References; 5 Sample Preparation; 5.1 Introduction; 5.2 Sampling; 5.3 Filtration; 5.4 Homogenization; 5.5 Extraction
5.5.1 The Extraction of Solid Samples5.5.2 The Extraction of Liquid Samples; 5.6 Membrane Methods in Sample Preparation; 5.7 Clean-up; 5.8 Pre-concentration; 5.9 Conclusions; References; 6 The Analysis of Chiral Pollutants by Gas Chromatography; 6.1 Introduction; 6.2 Chiral Selectors; 6.2.1 Structures and Properties; 6.2.2 Preparation and Commercialization; 6.2.3 Other Chiral GC CSPs; 6.3 Applications; 6.4 The Optimization of GC Conditions; 6.4.1 Mobile Phases; 6.4.2 Temperature; 6.4.3 The Column Dimensions; 6.4.4 Structures and Types of Chiral Selectors
6.4.5 The Structures of Chiral Pollutants
Record Nr. UNINA-9911019943403321
Ali Imran  
Chichester, West Sussex, Eng. ; ; Hoboken, NJ, : J. Wiley, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chiral separation methods for pharmaceutical and biotechnological products [[electronic resource] /] / Satinder Ahuja
Chiral separation methods for pharmaceutical and biotechnological products [[electronic resource] /] / Satinder Ahuja
Autore Ahuja Satinder <1933->
Pubbl/distr/stampa Hoboken, N.J., : Wiley, c2011
Descrizione fisica 1 online resource (508 p.)
Disciplina 615.19
615/.19
Soggetto topico Chiral drugs - Separation
Enantiomers - Separation
Soggetto genere / forma Electronic books.
ISBN 1-118-09775-0
1-282-88343-7
9786612883439
0-470-60866-8
0-470-60865-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CHIRAL SEPARATION METHODS FOR PHARMACEUTICAL AND BIOTECHNOLOGICAL PRODUCTS; CONTENTS; Contributors; Preface; 1 Overview of Chiral Separations; 2 Regulatory and Development Considerations of Chiral Compounds; 3 Basic Considerations in HPLC Method Development of Chiral Compounds; 4 Separation of Chiral Compounds on Polysaccharide Columns; 5 Chiral Separations by Various Techniques; 6 Chiral Discrimination Study for Polysaccharide-Based Chiral Stationary Phases; 7 Comparison of Chiral Chromatography Columns for Pharmaceutical Method Development
8 Chiral Screening Methods for Pharmaceutical Analysis and Purification in an Industrial Laboratory9 Separation of Enantiomers by Gas Chromatography on Chiral Stationary Phases; 10 Separations of Chiral Compounds by SFC; 11 Chiral Separations by Capillary Electrophoresis; 12 High-Throughput Screening and Method Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE; 13 Use of Enantioselective Synthesis and Preparative Chiral Chromatography to Access a Challenging Enantiopure Pharmaceutical Candidate from a Mixture of Four Stereoisomers
14 A Look into the Future: Chiral Analysis Using Chemical Sensor Technology15 Chirality of Biomolecules and Biotechnology Products; Index
Record Nr. UNINA-9910140905303321
Ahuja Satinder <1933->  
Hoboken, N.J., : Wiley, c2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chiral separation methods for pharmaceutical and biotechnological products [[electronic resource] /] / Satinder Ahuja
Chiral separation methods for pharmaceutical and biotechnological products [[electronic resource] /] / Satinder Ahuja
Autore Ahuja Satinder <1933->
Pubbl/distr/stampa Hoboken, N.J., : Wiley, c2011
Descrizione fisica 1 online resource (508 p.)
Disciplina 615.19
615/.19
Soggetto topico Chiral drugs - Separation
Enantiomers - Separation
ISBN 1-118-09775-0
1-282-88343-7
9786612883439
0-470-60866-8
0-470-60865-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CHIRAL SEPARATION METHODS FOR PHARMACEUTICAL AND BIOTECHNOLOGICAL PRODUCTS; CONTENTS; Contributors; Preface; 1 Overview of Chiral Separations; 2 Regulatory and Development Considerations of Chiral Compounds; 3 Basic Considerations in HPLC Method Development of Chiral Compounds; 4 Separation of Chiral Compounds on Polysaccharide Columns; 5 Chiral Separations by Various Techniques; 6 Chiral Discrimination Study for Polysaccharide-Based Chiral Stationary Phases; 7 Comparison of Chiral Chromatography Columns for Pharmaceutical Method Development
8 Chiral Screening Methods for Pharmaceutical Analysis and Purification in an Industrial Laboratory9 Separation of Enantiomers by Gas Chromatography on Chiral Stationary Phases; 10 Separations of Chiral Compounds by SFC; 11 Chiral Separations by Capillary Electrophoresis; 12 High-Throughput Screening and Method Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE; 13 Use of Enantioselective Synthesis and Preparative Chiral Chromatography to Access a Challenging Enantiopure Pharmaceutical Candidate from a Mixture of Four Stereoisomers
14 A Look into the Future: Chiral Analysis Using Chemical Sensor Technology15 Chirality of Biomolecules and Biotechnology Products; Index
Record Nr. UNINA-9910830060103321
Ahuja Satinder <1933->  
Hoboken, N.J., : Wiley, c2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chiral separation methods for pharmaceutical and biotechnological products / / Satinder Ahuja
Chiral separation methods for pharmaceutical and biotechnological products / / Satinder Ahuja
Autore Ahuja Satinder <1933->
Pubbl/distr/stampa Hoboken, N.J., : Wiley, c2011
Descrizione fisica 1 online resource (508 p.)
Disciplina 615/.19
Soggetto topico Chiral drugs - Separation
Enantiomers - Separation
ISBN 9786612883439
9781118097755
1118097750
9781282883437
1282883437
9780470608661
0470608668
9780470608654
047060865X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CHIRAL SEPARATION METHODS FOR PHARMACEUTICAL AND BIOTECHNOLOGICAL PRODUCTS; CONTENTS; Contributors; Preface; 1 Overview of Chiral Separations; 2 Regulatory and Development Considerations of Chiral Compounds; 3 Basic Considerations in HPLC Method Development of Chiral Compounds; 4 Separation of Chiral Compounds on Polysaccharide Columns; 5 Chiral Separations by Various Techniques; 6 Chiral Discrimination Study for Polysaccharide-Based Chiral Stationary Phases; 7 Comparison of Chiral Chromatography Columns for Pharmaceutical Method Development
8 Chiral Screening Methods for Pharmaceutical Analysis and Purification in an Industrial Laboratory9 Separation of Enantiomers by Gas Chromatography on Chiral Stationary Phases; 10 Separations of Chiral Compounds by SFC; 11 Chiral Separations by Capillary Electrophoresis; 12 High-Throughput Screening and Method Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE; 13 Use of Enantioselective Synthesis and Preparative Chiral Chromatography to Access a Challenging Enantiopure Pharmaceutical Candidate from a Mixture of Four Stereoisomers
14 A Look into the Future: Chiral Analysis Using Chemical Sensor Technology15 Chirality of Biomolecules and Biotechnology Products; Index
Record Nr. UNINA-9911019426703321
Ahuja Satinder <1933->  
Hoboken, N.J., : Wiley, c2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Preparative enantioselective chromatography [[electronic resource] /] / edited by Geoffrey B Cox
Preparative enantioselective chromatography [[electronic resource] /] / edited by Geoffrey B Cox
Edizione [1st ed.]
Pubbl/distr/stampa Ames, Iowa, : Blackwell Pub., 2005
Descrizione fisica 1 online resource (346 p.)
Disciplina 543.089
543.84
543/.84
Altri autori (Persone) CoxGeoffrey J. <1952->
Soggetto topico Liquid chromatography
Enantiomers - Separation
Soggetto genere / forma Electronic books.
ISBN 1-280-19691-2
9786610196913
0-470-98842-8
1-4051-4471-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preparative Enantioselective Chromatography; Contents; Contributors; Preface; 1. Chiral chromatography in support of pharmaceutical process research; 1.1 Introduction; 1.2 A brief introduction to chirality; 1.3 Why chirality is important; 1.4 Accessing enantiopurity: a brief overview of approaches; 1.4.1 Enantiopure starting materials: the chiral pool; 1.4.2 Removable enantioenriched auxiliaries; 1.4.3 Enantioselective catalysis; 1.4.4 Resolution technologies: introduction; 1.4.5 Chromatographic productivity is the key metric for preparative chromatography
1.4.6 Stationary phases for preparative chiral chromatography1.4.7 Advantages of preparative chiral chromatography over other approaches for accessing enantiopure materials; 1.4.8 Simulated moving bed enantioseparation; 1.5 Green enantioseparation; 1.6 What is the appropriate role of preparative chromatography in organic synthesis?; 1.7 Fording the river at the easiest point: some observations on the appropriate placement of a chromatographic resolution within a chiral synthesis; 1.8 Origins of preparative chiral chromatography
1.9 Practical tips for preparative chromatographic enantioseparation1.10 Conclusion; 2. Introduction to preparative chromatography; 2.1 Introduction; 2.2 Adsorption isotherms; 2.2.1 The simple case - the Langmuir isotherm; 2.2.2 Other isotherms; 2.2.3 Competitive isotherms; 2.3 Kinetics; 2.4 Metrics for preparative operations; 2.4.1 Throughput; 2.4.2 Production rate; 2.4.3 Productivity; 2.4.4 Specific productivity; 2.4.5 Cost; 2.5 The influence of chromatographic parameters on preparative chromatography; 2.5.1 Effect of particle size on preparative performance; 2.5.2 Effects of pressure
2.5.3 Effects of column efficiency2.5.4 Effect of column length; 2.5.5 The effects of selectivity; 2.6 Economics of preparative separations; 2.6.1 Point of insertion of the chromatographic resolution in the synthetic route; 3 Chiral stationary phases for preparative enantioselective chromatography; 3.1 Summary; 3.2 Introduction; 3.3 Historical development of CSPs for preparative chromatography; 3.4 Preparative CSPs; 3.4.1 Classification of CSPs; 3.4.2 Polymeric phases; 3.4.3 Brush-type CSPs; 3.4.4 Chiral phases for ligand-exchange chromatography; 3.4.5 Imprinted phases
3.5 Chemical and physical properties of CSPs3.5.1 Loading capacity; 3.5.2 Chemical and physical stability; 3.5.3 Solubility of the chiral solute; 3.6 New and future developments in the field of preparative CSPs; 3.6.1 CSPs with improved loading capacity; 3.6.2 CSPs with improved selectivity; 3.6.3 Immobilised polysaccharide-based CSPs; 3.7 Conclusion; 4 Method development for preparative enantioselective chromatography; 4.1 Introduction; 4.2 Chiral stationary phases for enantioselective chromatography; 4.3 Screening and optimisation strategy for preparative chiral chromatography
4.3.1 Choice of the stationary phase
Record Nr. UNINA-9910143298903321
Ames, Iowa, : Blackwell Pub., 2005
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Preparative enantioselective chromatography [[electronic resource] /] / edited by Geoffrey B Cox
Preparative enantioselective chromatography [[electronic resource] /] / edited by Geoffrey B Cox
Edizione [1st ed.]
Pubbl/distr/stampa Ames, Iowa, : Blackwell Pub., 2005
Descrizione fisica 1 online resource (346 p.)
Disciplina 543.089
543.84
543/.84
Altri autori (Persone) CoxGeoffrey J. <1952->
Soggetto topico Liquid chromatography
Enantiomers - Separation
ISBN 1-280-19691-2
9786610196913
0-470-98842-8
1-4051-4471-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preparative Enantioselective Chromatography; Contents; Contributors; Preface; 1. Chiral chromatography in support of pharmaceutical process research; 1.1 Introduction; 1.2 A brief introduction to chirality; 1.3 Why chirality is important; 1.4 Accessing enantiopurity: a brief overview of approaches; 1.4.1 Enantiopure starting materials: the chiral pool; 1.4.2 Removable enantioenriched auxiliaries; 1.4.3 Enantioselective catalysis; 1.4.4 Resolution technologies: introduction; 1.4.5 Chromatographic productivity is the key metric for preparative chromatography
1.4.6 Stationary phases for preparative chiral chromatography1.4.7 Advantages of preparative chiral chromatography over other approaches for accessing enantiopure materials; 1.4.8 Simulated moving bed enantioseparation; 1.5 Green enantioseparation; 1.6 What is the appropriate role of preparative chromatography in organic synthesis?; 1.7 Fording the river at the easiest point: some observations on the appropriate placement of a chromatographic resolution within a chiral synthesis; 1.8 Origins of preparative chiral chromatography
1.9 Practical tips for preparative chromatographic enantioseparation1.10 Conclusion; 2. Introduction to preparative chromatography; 2.1 Introduction; 2.2 Adsorption isotherms; 2.2.1 The simple case - the Langmuir isotherm; 2.2.2 Other isotherms; 2.2.3 Competitive isotherms; 2.3 Kinetics; 2.4 Metrics for preparative operations; 2.4.1 Throughput; 2.4.2 Production rate; 2.4.3 Productivity; 2.4.4 Specific productivity; 2.4.5 Cost; 2.5 The influence of chromatographic parameters on preparative chromatography; 2.5.1 Effect of particle size on preparative performance; 2.5.2 Effects of pressure
2.5.3 Effects of column efficiency2.5.4 Effect of column length; 2.5.5 The effects of selectivity; 2.6 Economics of preparative separations; 2.6.1 Point of insertion of the chromatographic resolution in the synthetic route; 3 Chiral stationary phases for preparative enantioselective chromatography; 3.1 Summary; 3.2 Introduction; 3.3 Historical development of CSPs for preparative chromatography; 3.4 Preparative CSPs; 3.4.1 Classification of CSPs; 3.4.2 Polymeric phases; 3.4.3 Brush-type CSPs; 3.4.4 Chiral phases for ligand-exchange chromatography; 3.4.5 Imprinted phases
3.5 Chemical and physical properties of CSPs3.5.1 Loading capacity; 3.5.2 Chemical and physical stability; 3.5.3 Solubility of the chiral solute; 3.6 New and future developments in the field of preparative CSPs; 3.6.1 CSPs with improved loading capacity; 3.6.2 CSPs with improved selectivity; 3.6.3 Immobilised polysaccharide-based CSPs; 3.7 Conclusion; 4 Method development for preparative enantioselective chromatography; 4.1 Introduction; 4.2 Chiral stationary phases for enantioselective chromatography; 4.3 Screening and optimisation strategy for preparative chiral chromatography
4.3.1 Choice of the stationary phase
Record Nr. UNISA-996214620903316
Ames, Iowa, : Blackwell Pub., 2005
Materiale a stampa
Lo trovi qui: Univ. di Salerno
Opac: Controlla la disponibilità qui
Preparative enantioselective chromatography [[electronic resource] /] / edited by Geoffrey B Cox
Preparative enantioselective chromatography [[electronic resource] /] / edited by Geoffrey B Cox
Edizione [1st ed.]
Pubbl/distr/stampa Ames, Iowa, : Blackwell Pub., 2005
Descrizione fisica 1 online resource (346 p.)
Disciplina 543.089
543.84
543/.84
Altri autori (Persone) CoxGeoffrey J. <1952->
Soggetto topico Liquid chromatography
Enantiomers - Separation
ISBN 1-280-19691-2
9786610196913
0-470-98842-8
1-4051-4471-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preparative Enantioselective Chromatography; Contents; Contributors; Preface; 1. Chiral chromatography in support of pharmaceutical process research; 1.1 Introduction; 1.2 A brief introduction to chirality; 1.3 Why chirality is important; 1.4 Accessing enantiopurity: a brief overview of approaches; 1.4.1 Enantiopure starting materials: the chiral pool; 1.4.2 Removable enantioenriched auxiliaries; 1.4.3 Enantioselective catalysis; 1.4.4 Resolution technologies: introduction; 1.4.5 Chromatographic productivity is the key metric for preparative chromatography
1.4.6 Stationary phases for preparative chiral chromatography1.4.7 Advantages of preparative chiral chromatography over other approaches for accessing enantiopure materials; 1.4.8 Simulated moving bed enantioseparation; 1.5 Green enantioseparation; 1.6 What is the appropriate role of preparative chromatography in organic synthesis?; 1.7 Fording the river at the easiest point: some observations on the appropriate placement of a chromatographic resolution within a chiral synthesis; 1.8 Origins of preparative chiral chromatography
1.9 Practical tips for preparative chromatographic enantioseparation1.10 Conclusion; 2. Introduction to preparative chromatography; 2.1 Introduction; 2.2 Adsorption isotherms; 2.2.1 The simple case - the Langmuir isotherm; 2.2.2 Other isotherms; 2.2.3 Competitive isotherms; 2.3 Kinetics; 2.4 Metrics for preparative operations; 2.4.1 Throughput; 2.4.2 Production rate; 2.4.3 Productivity; 2.4.4 Specific productivity; 2.4.5 Cost; 2.5 The influence of chromatographic parameters on preparative chromatography; 2.5.1 Effect of particle size on preparative performance; 2.5.2 Effects of pressure
2.5.3 Effects of column efficiency2.5.4 Effect of column length; 2.5.5 The effects of selectivity; 2.6 Economics of preparative separations; 2.6.1 Point of insertion of the chromatographic resolution in the synthetic route; 3 Chiral stationary phases for preparative enantioselective chromatography; 3.1 Summary; 3.2 Introduction; 3.3 Historical development of CSPs for preparative chromatography; 3.4 Preparative CSPs; 3.4.1 Classification of CSPs; 3.4.2 Polymeric phases; 3.4.3 Brush-type CSPs; 3.4.4 Chiral phases for ligand-exchange chromatography; 3.4.5 Imprinted phases
3.5 Chemical and physical properties of CSPs3.5.1 Loading capacity; 3.5.2 Chemical and physical stability; 3.5.3 Solubility of the chiral solute; 3.6 New and future developments in the field of preparative CSPs; 3.6.1 CSPs with improved loading capacity; 3.6.2 CSPs with improved selectivity; 3.6.3 Immobilised polysaccharide-based CSPs; 3.7 Conclusion; 4 Method development for preparative enantioselective chromatography; 4.1 Introduction; 4.2 Chiral stationary phases for enantioselective chromatography; 4.3 Screening and optimisation strategy for preparative chiral chromatography
4.3.1 Choice of the stationary phase
Record Nr. UNINA-9910831095603321
Ames, Iowa, : Blackwell Pub., 2005
Materiale a stampa
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Preparative enantioselective chromatography / / edited by Geoffrey B Cox
Preparative enantioselective chromatography / / edited by Geoffrey B Cox
Edizione [1st ed.]
Pubbl/distr/stampa Ames, Iowa, : Blackwell Pub., 2005
Descrizione fisica 1 online resource (346 p.)
Disciplina 543/.84
Altri autori (Persone) CoxGeoffrey J. <1952->
Soggetto topico Liquid chromatography
Enantiomers - Separation
ISBN 9786610196913
9781280196911
1280196912
9780470988428
0470988428
9781405144711
1405144718
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Preparative Enantioselective Chromatography; Contents; Contributors; Preface; 1. Chiral chromatography in support of pharmaceutical process research; 1.1 Introduction; 1.2 A brief introduction to chirality; 1.3 Why chirality is important; 1.4 Accessing enantiopurity: a brief overview of approaches; 1.4.1 Enantiopure starting materials: the chiral pool; 1.4.2 Removable enantioenriched auxiliaries; 1.4.3 Enantioselective catalysis; 1.4.4 Resolution technologies: introduction; 1.4.5 Chromatographic productivity is the key metric for preparative chromatography
1.4.6 Stationary phases for preparative chiral chromatography1.4.7 Advantages of preparative chiral chromatography over other approaches for accessing enantiopure materials; 1.4.8 Simulated moving bed enantioseparation; 1.5 Green enantioseparation; 1.6 What is the appropriate role of preparative chromatography in organic synthesis?; 1.7 Fording the river at the easiest point: some observations on the appropriate placement of a chromatographic resolution within a chiral synthesis; 1.8 Origins of preparative chiral chromatography
1.9 Practical tips for preparative chromatographic enantioseparation1.10 Conclusion; 2. Introduction to preparative chromatography; 2.1 Introduction; 2.2 Adsorption isotherms; 2.2.1 The simple case - the Langmuir isotherm; 2.2.2 Other isotherms; 2.2.3 Competitive isotherms; 2.3 Kinetics; 2.4 Metrics for preparative operations; 2.4.1 Throughput; 2.4.2 Production rate; 2.4.3 Productivity; 2.4.4 Specific productivity; 2.4.5 Cost; 2.5 The influence of chromatographic parameters on preparative chromatography; 2.5.1 Effect of particle size on preparative performance; 2.5.2 Effects of pressure
2.5.3 Effects of column efficiency2.5.4 Effect of column length; 2.5.5 The effects of selectivity; 2.6 Economics of preparative separations; 2.6.1 Point of insertion of the chromatographic resolution in the synthetic route; 3 Chiral stationary phases for preparative enantioselective chromatography; 3.1 Summary; 3.2 Introduction; 3.3 Historical development of CSPs for preparative chromatography; 3.4 Preparative CSPs; 3.4.1 Classification of CSPs; 3.4.2 Polymeric phases; 3.4.3 Brush-type CSPs; 3.4.4 Chiral phases for ligand-exchange chromatography; 3.4.5 Imprinted phases
3.5 Chemical and physical properties of CSPs3.5.1 Loading capacity; 3.5.2 Chemical and physical stability; 3.5.3 Solubility of the chiral solute; 3.6 New and future developments in the field of preparative CSPs; 3.6.1 CSPs with improved loading capacity; 3.6.2 CSPs with improved selectivity; 3.6.3 Immobilised polysaccharide-based CSPs; 3.7 Conclusion; 4 Method development for preparative enantioselective chromatography; 4.1 Introduction; 4.2 Chiral stationary phases for enantioselective chromatography; 4.3 Screening and optimisation strategy for preparative chiral chromatography
4.3.1 Choice of the stationary phase
Record Nr. UNINA-9911020193903321
Ames, Iowa, : Blackwell Pub., 2005
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui