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Arachidonate metabolism in immunologic systems
| Arachidonate metabolism in immunologic systems |
| Pubbl/distr/stampa | [Place of publication not identified], : Karger, 1988 |
| Descrizione fisica | 1 online resource (VIII + 216 pages) : : 23 figures, 12 tables |
| Soggetto topico |
Eicosanoids
Fatty Acids, Unsaturated Hemic and Immune Systems Immune System Diseases Fatty Acids, Essential Anatomy Diseases Fatty Acids Lipids Chemicals and Drugs Arachidonic Acids Hypersensitivity Immune System |
| ISBN | 3-318-01525-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910155293003321 |
| [Place of publication not identified], : Karger, 1988 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The eicosanoids [[electronic resource] /] / edited by Peter Curtis-Prior
| The eicosanoids [[electronic resource] /] / edited by Peter Curtis-Prior |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2004 |
| Descrizione fisica | 1 online resource (656 p.) |
| Disciplina |
572.57
572/.57 |
| Altri autori (Persone) | Curtis-PriorP. B |
| Collana | FAO/Wiley Series on Food Agriculture |
| Soggetto topico |
Eicosanoids
Eicosanoids - Physiological effect Eicosanoids - Therapeutic use |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-54158-X
9786610541584 0-470-02061-X 0-470-02062-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Eicosanoids; Contents; List of Contributors; Preface; Preface from Prostaglandins; Acknowledgements; Foreword; SECTION ONE BIOSYNTHESIS AND METABOLISM; 1 Perspectives on the Biosynthesis and Metabolism of Eicosanoids; 2 Control of Eicosanoid Production by Cellular and Secreted Phospholipase A(2); 3 Mechanisms of PGH Synthase-1 (COX-1) Activity and Role of Radical States; 4 Regulation and Function of Prostaglandin Synthase-2/Cyclooxygenase II; 5 Mammalian Lipoxygenases; 6 Biosynthesis and Biological Effects of 5-oxo-ETE and Other Oxoeicosatetraenoic Acids; 7 Synthetic Eicosanoids
SECTION TWO ANALYTICAL METHODS8 Perspectives of Analytical Methods for Eicosanoids; 9 Enzyme Immunoassays of Metabolites and Enzymes Using Acetylcholinesterase as Label; 10 Bioassay of Eicosanoids; 11 Gas Chromatography and Mass Spectrometry in Eicosanoid Analysis; 12 Time-resolved Fluoroimmunoassay in Eicosanoid Analysis; SECTION THREE BIOCHEMICAL AND MOLECULAR PHARMACOLOGY; 13 Perspectives and Clinical Significance of the Biochemical and Molecular Pharmacology of Eicosanoids; 14 Eicosanoid Antagonists 15 Biosynthesis and Degradation of Anandamide, an Endogenous Ligand of Cannabinoid Receptors16 Inhibitors of Eicosanoids; 17 Biology and Chemistry of Products of the Isoprostane Pathway; 18 Insight into Prostanoid Functions: Lessons from Receptor-knockout Mice; SECTION FOUR IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC REGULATION; 19 Perspectives and Clinical Significance of Eicosanoids in Immunology, Endocrinology and Metabolic Regulation; 20 Prostaglandins and the Immune Response; 21 Leukotrienes in Aspirin-intolerant Asthma; 22 Essential Fatty Acids 23 Endothelial Secretory Function and Atherothrombosis24 Molecular Regulation of Pancreatic Islet Prostaglandin Synthesis and its Relevance to Diabetes Mellitus; 25 Prostaglandins, Leukotrienes and Bone; 26 Ageing and Prostaglandins; SECTION FIVE INFLAMMATION; 27 Perspectives and Clinical Significance of Eicosanoids in Pain and Inflammation; 28 Antiinflammatory Steroids; 29 Eicosanoids and Algesia in Inflammation; 30 Cyclooxygenase-2 in Cancer; 31 Cytokines and Eicosanoids in Arthritis; SECTION SIX CIRCULATORY SYSTEM 32 Perspectives and Clinical Significance of Eicosanoids in the Circulatory System33 Aspirin and Activated Platelets; 34 Generation of Vasoactive Prostanoids by the Cyclooxygenase-2 Pathway in the Cardiovascular System of the Rat; 35 Eicosanoid Generation and Effects in Cardiac Muscle and Coronary Vessels; SECTION SEVEN DIGESTIVE SYSTEM; 36 Perspectives and Clinical Significance of Eicosanoids in the Digestive System; 37 Eicosanoids and Liver Regeneration; 38 Eicosanoids and the Intestine; 39 Eicosanoids and Stomach Physiology; SECTION EIGHT NERVOUS SYSTEM 40 Perspectives and Clinical Significance of Arachidonic Acid Release, Action and Metabolism in the Nervous System |
| Record Nr. | UNINA-9910143643103321 |
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The eicosanoids [[electronic resource] /] / edited by Peter Curtis-Prior
| The eicosanoids [[electronic resource] /] / edited by Peter Curtis-Prior |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2004 |
| Descrizione fisica | 1 online resource (656 p.) |
| Disciplina |
572.57
572/.57 |
| Altri autori (Persone) | Curtis-PriorP. B |
| Collana | FAO/Wiley Series on Food Agriculture |
| Soggetto topico |
Eicosanoids
Eicosanoids - Physiological effect Eicosanoids - Therapeutic use |
| ISBN |
1-280-54158-X
9786610541584 0-470-02061-X 0-470-02062-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Eicosanoids; Contents; List of Contributors; Preface; Preface from Prostaglandins; Acknowledgements; Foreword; SECTION ONE BIOSYNTHESIS AND METABOLISM; 1 Perspectives on the Biosynthesis and Metabolism of Eicosanoids; 2 Control of Eicosanoid Production by Cellular and Secreted Phospholipase A(2); 3 Mechanisms of PGH Synthase-1 (COX-1) Activity and Role of Radical States; 4 Regulation and Function of Prostaglandin Synthase-2/Cyclooxygenase II; 5 Mammalian Lipoxygenases; 6 Biosynthesis and Biological Effects of 5-oxo-ETE and Other Oxoeicosatetraenoic Acids; 7 Synthetic Eicosanoids
SECTION TWO ANALYTICAL METHODS8 Perspectives of Analytical Methods for Eicosanoids; 9 Enzyme Immunoassays of Metabolites and Enzymes Using Acetylcholinesterase as Label; 10 Bioassay of Eicosanoids; 11 Gas Chromatography and Mass Spectrometry in Eicosanoid Analysis; 12 Time-resolved Fluoroimmunoassay in Eicosanoid Analysis; SECTION THREE BIOCHEMICAL AND MOLECULAR PHARMACOLOGY; 13 Perspectives and Clinical Significance of the Biochemical and Molecular Pharmacology of Eicosanoids; 14 Eicosanoid Antagonists 15 Biosynthesis and Degradation of Anandamide, an Endogenous Ligand of Cannabinoid Receptors16 Inhibitors of Eicosanoids; 17 Biology and Chemistry of Products of the Isoprostane Pathway; 18 Insight into Prostanoid Functions: Lessons from Receptor-knockout Mice; SECTION FOUR IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC REGULATION; 19 Perspectives and Clinical Significance of Eicosanoids in Immunology, Endocrinology and Metabolic Regulation; 20 Prostaglandins and the Immune Response; 21 Leukotrienes in Aspirin-intolerant Asthma; 22 Essential Fatty Acids 23 Endothelial Secretory Function and Atherothrombosis24 Molecular Regulation of Pancreatic Islet Prostaglandin Synthesis and its Relevance to Diabetes Mellitus; 25 Prostaglandins, Leukotrienes and Bone; 26 Ageing and Prostaglandins; SECTION FIVE INFLAMMATION; 27 Perspectives and Clinical Significance of Eicosanoids in Pain and Inflammation; 28 Antiinflammatory Steroids; 29 Eicosanoids and Algesia in Inflammation; 30 Cyclooxygenase-2 in Cancer; 31 Cytokines and Eicosanoids in Arthritis; SECTION SIX CIRCULATORY SYSTEM 32 Perspectives and Clinical Significance of Eicosanoids in the Circulatory System33 Aspirin and Activated Platelets; 34 Generation of Vasoactive Prostanoids by the Cyclooxygenase-2 Pathway in the Cardiovascular System of the Rat; 35 Eicosanoid Generation and Effects in Cardiac Muscle and Coronary Vessels; SECTION SEVEN DIGESTIVE SYSTEM; 36 Perspectives and Clinical Significance of Eicosanoids in the Digestive System; 37 Eicosanoids and Liver Regeneration; 38 Eicosanoids and the Intestine; 39 Eicosanoids and Stomach Physiology; SECTION EIGHT NERVOUS SYSTEM 40 Perspectives and Clinical Significance of Arachidonic Acid Release, Action and Metabolism in the Nervous System |
| Record Nr. | UNINA-9910830436503321 |
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The eicosanoids [[electronic resource] /] / edited by Peter Curtis-Prior
| The eicosanoids [[electronic resource] /] / edited by Peter Curtis-Prior |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2004 |
| Descrizione fisica | 1 online resource (656 p.) |
| Disciplina |
572.57
572/.57 |
| Altri autori (Persone) | Curtis-PriorP. B |
| Collana | FAO/Wiley Series on Food Agriculture |
| Soggetto topico |
Eicosanoids
Eicosanoids - Physiological effect Eicosanoids - Therapeutic use |
| ISBN |
1-280-54158-X
9786610541584 0-470-02061-X 0-470-02062-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Eicosanoids; Contents; List of Contributors; Preface; Preface from Prostaglandins; Acknowledgements; Foreword; SECTION ONE BIOSYNTHESIS AND METABOLISM; 1 Perspectives on the Biosynthesis and Metabolism of Eicosanoids; 2 Control of Eicosanoid Production by Cellular and Secreted Phospholipase A(2); 3 Mechanisms of PGH Synthase-1 (COX-1) Activity and Role of Radical States; 4 Regulation and Function of Prostaglandin Synthase-2/Cyclooxygenase II; 5 Mammalian Lipoxygenases; 6 Biosynthesis and Biological Effects of 5-oxo-ETE and Other Oxoeicosatetraenoic Acids; 7 Synthetic Eicosanoids
SECTION TWO ANALYTICAL METHODS8 Perspectives of Analytical Methods for Eicosanoids; 9 Enzyme Immunoassays of Metabolites and Enzymes Using Acetylcholinesterase as Label; 10 Bioassay of Eicosanoids; 11 Gas Chromatography and Mass Spectrometry in Eicosanoid Analysis; 12 Time-resolved Fluoroimmunoassay in Eicosanoid Analysis; SECTION THREE BIOCHEMICAL AND MOLECULAR PHARMACOLOGY; 13 Perspectives and Clinical Significance of the Biochemical and Molecular Pharmacology of Eicosanoids; 14 Eicosanoid Antagonists 15 Biosynthesis and Degradation of Anandamide, an Endogenous Ligand of Cannabinoid Receptors16 Inhibitors of Eicosanoids; 17 Biology and Chemistry of Products of the Isoprostane Pathway; 18 Insight into Prostanoid Functions: Lessons from Receptor-knockout Mice; SECTION FOUR IMMUNOLOGY, ENDOCRINOLOGY AND METABOLIC REGULATION; 19 Perspectives and Clinical Significance of Eicosanoids in Immunology, Endocrinology and Metabolic Regulation; 20 Prostaglandins and the Immune Response; 21 Leukotrienes in Aspirin-intolerant Asthma; 22 Essential Fatty Acids 23 Endothelial Secretory Function and Atherothrombosis24 Molecular Regulation of Pancreatic Islet Prostaglandin Synthesis and its Relevance to Diabetes Mellitus; 25 Prostaglandins, Leukotrienes and Bone; 26 Ageing and Prostaglandins; SECTION FIVE INFLAMMATION; 27 Perspectives and Clinical Significance of Eicosanoids in Pain and Inflammation; 28 Antiinflammatory Steroids; 29 Eicosanoids and Algesia in Inflammation; 30 Cyclooxygenase-2 in Cancer; 31 Cytokines and Eicosanoids in Arthritis; SECTION SIX CIRCULATORY SYSTEM 32 Perspectives and Clinical Significance of Eicosanoids in the Circulatory System33 Aspirin and Activated Platelets; 34 Generation of Vasoactive Prostanoids by the Cyclooxygenase-2 Pathway in the Cardiovascular System of the Rat; 35 Eicosanoid Generation and Effects in Cardiac Muscle and Coronary Vessels; SECTION SEVEN DIGESTIVE SYSTEM; 36 Perspectives and Clinical Significance of Eicosanoids in the Digestive System; 37 Eicosanoids and Liver Regeneration; 38 Eicosanoids and the Intestine; 39 Eicosanoids and Stomach Physiology; SECTION EIGHT NERVOUS SYSTEM 40 Perspectives and Clinical Significance of Arachidonic Acid Release, Action and Metabolism in the Nervous System |
| Record Nr. | UNINA-9910840882903321 |
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Prostaglandins, leukotrienes, and other eicosanoids : from biogenesis to clinical application / / F. Marks, G. Fürstenberger (eds.)
| Prostaglandins, leukotrienes, and other eicosanoids : from biogenesis to clinical application / / F. Marks, G. Fürstenberger (eds.) |
| Pubbl/distr/stampa | Weinheim, [Germany] : , : Wiley-VCH, , 1999 |
| Descrizione fisica | 1 online resource (410 p.) |
| Disciplina |
572.57
572/.57 |
| Soggetto topico |
Eicosanoids
Leukotrienes Prostanoids |
| ISBN |
1-282-01043-3
9786612010439 3-527-61362-5 3-527-61363-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Prostaglandins, Leukotrienes and Other Eicosanoids; Contents; 1 Arachidonic acid and companions: an abundant source of biological signals; 1.1 The world of PUFAs; 1.2 The discovery of prostaglandins and related eicosanoids; 1.3 Mammalian eicosanoids; 1.3.1 Free arachidonic acid: a signaling compound?; 1.3.2 Prostanoids; 1.3.3 HPETEs, HETEs and leukotrienes; 1.3.4 Lipoxins; 1.3.5 15-Epi-lipoxins; 1.3.6 Hepoxilins; 1.3.7 Monooxygenase-derived eicosanoids; 1.3.8 Isoprostanes; 1.3.9 Anandammide; 1.4 Eicosanoids in invertebrates; 1.5 Eicosanoid-related signaling compounds in plants
1.6 The cellular functions of eicosanoids in mammals1.6.1 Eicosanoids as local mediators; 1.6.2 Specific membrane receptors mediate many biological effects of eicosanoids; 1.6.3 Nuclear eicosanoid receptors: a new frontier in research; 1.7 Addendum: Methods of eicosanoid research; 1.8 References; 2 The generation of free arachidonic acid; 2.1 Introduction; 2.2 (Re)Incorporartion of arachidonic acid into phospholipids; 2.3 Phospholipases A; 2.3.1 Phospholipase A1; 2.3.2 Phospholipases A2; 2.3.2.1 Secretory phospholipases A2; 2.3.2.2 Cytosolic phospholipase A2 2.3.2.3 Calciurn-independent phospholipases A22.4 DAG lipase and PLC or PLD/PA phosphohydrolase; 2.5 Cellular models; 2.5.1 P388D1 macrophages; 2.5.2 Rat liver macrophages; 2.6 Conclusions; 2.7 References; 3 Cyclooxygenases; 3.1 Introduction; 3.2 Cloning of cyclooxygenase isoforms; 3.3 Cyclooxygenase gene structures; 3.4 Regulation of cyclooxygenase isoenzyme expression; 3.5 Cyclooxygenase proteins; 3.5.1 Sequence comparisons; 3.5.2 Post-translational modification; 3.5.3 X-ray analysis of crystal structure; 3.5.4 Subcellular localization; 3.6 Coupling of COX isoenzymes with phospholipases A2 3.7 Substrate specificities3.8 Mechanism of enzyme catalysis; 3.9 Biological functions of COX isoforms; 3.10 Isoenzyme-specific inhibitors; 3.11 References; 4 Prostanoid synthases; 4.1 Introduction; 4.2. Thromboxane A2 synthase; 4.3 Prostacyclin synthase; 4.4 Prostaglandin D syntase; 4.5. Prostaglandin E synthase; 4.6 Prostaglandin F synthase; 4.7 Glutathione S-transferases; 4.8 Detection of prostaglandin synthases in various tissues; 4.9 Summary and outlook; 4.10 References; 5 Lipoxygenases; 5.1. lntroduction; 5.2. Lipoxygenase reaction; 5.3. Common properties of lipoxygenases 5.4. Classification of lipoxygenases5.5 Structural aspects of lipoxygenases; 5.5.1. X-ray crystallography; 5.5.2 Substrate alignment and determinants of positional specificity; 5.6 5-Lipoxygenases; 5.6.1 Enzymatic properties; 5.6.2 5-Lipoxygenase activating protein; 5.6.3 Molecular biology of 5-lipoxygenases; 5.6.4 Tissue distribution and regulation of 5-LOX expression; 5.6.5 Biological functions of 5-lipoxygenases; 5.7 12-Lipoxygenases; 5.7.1 Subclassification and enzymatic properties; 5.7.2 Molecular biology of 12-lipoxygenases; 5.7.3 Tissue distribution and regulation of 12-LOX expression 5.7.4 Biological functions of 12-lipoxygenases |
| Record Nr. | UNINA-9910144010303321 |
| Weinheim, [Germany] : , : Wiley-VCH, , 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
