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LC/MS applications in drug development [[electronic resource] /] / Mike S. Lee
| LC/MS applications in drug development [[electronic resource] /] / Mike S. Lee |
| Autore | Lee Mike S. <1960-> |
| Pubbl/distr/stampa | New York, : J. Wiley & Sons, c2002 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina |
615.19
615/.19 |
| Collana | Wiley-Interscience series on mass spectrometry |
| Soggetto topico |
Drug development - Methodology
Drugs - Analysis Liquid chromatography Mass spectrometry Combinatorial chemistry Gel permeation chromatography Drugs - Testing - Methodology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-36642-7
9786610366422 0-470-35636-7 0-471-45930-5 0-471-21881-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
LC/MS APPLICATIONS IN DRUG DEVELOPMENT; CONTENTS; Preface; Acknowledgments; 1. Introduction; Emerging Analytical Needs; Integration of LC/MS into Drug Development; Partnerships and Acceptance; Overview; 2. Drug Development Overview; Analysis Perspectives; The Four Stages of Drug Development; Drug Discovery; Preclinical Development; Clinical Development; Manufacturing; 3. Accelerated Drug Development; Accelerated Development Strategies; Quantitative and Qualitative Process Elements; Quantitative Process Pipeline; Qualitative Process Pipeline; Motivating Factors
Analysis Opportunities for Accelerated DevelopmentFull-Time Equivalent; Sample Throughput Model; Elimination Model; Rate-Determining Event Model; Accelerated Development Perspectives; 4. LC/MS Development; The Elements of LC/MS Application; HPLC; Mass Spectrometry; LC/MS Interface; LC/MS Growth; 5. Strategies; Standard Methods; Template Structure Identification; Databases; Screening; Integration; Miniaturization; Parallel Processing; Visualization; Automation; Summary; 6. LC/MS Applications; Drug Discovery; Proteomics; Protein Expression Profiling; Quantitation; Glycoprotein Mapping Natural Products DereplicationLead Identification Screening; Bioaffinity Screening; Combinatorial Library Screening; Open-Access LC/MS; Structure Confirmation; High Throughput; Purification; Combinatorial Mixture Screening; In Vivo Drug Screening; Pharmacokinetics; In Vitro Drug Screening; Metabolic Stability Screening; Membrane Permeability; Drug-Drug Interaction; Metabolite Identification; Preclinical Development; Metabolite Identification; Impurity Identification; Degradant Identification; Clinical Development; Quantitative Bioanalysis-Selected Ion Monitoring Quantitative Bioanalysis-Selected Reaction MonitoringQuantitative Bioanalysis-Automated Solid-Phase Extraction; Quantitative Bioanalysis-Automated On-Line Extraction; Metabolite Identification; Degradant Identification; Manufacturing; Impurity Identification Using Data-Dependent Analysis; Peptide Mapping in Quality Control; Patent Protection; 7. Future Applications and Prospects; Workstations; Multidimensional Analysis; Miniaturization; Information Management; Strategic Outsourcing; Summary; 8. Perspectives on the Future Growth of LC/MS; 9. Conclusions; Glossary; References; Index |
| Record Nr. | UNINA-9910143176103321 |
Lee Mike S. <1960->
|
||
| New York, : J. Wiley & Sons, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
LC/MS applications in drug development [[electronic resource] /] / Mike S. Lee
| LC/MS applications in drug development [[electronic resource] /] / Mike S. Lee |
| Autore | Lee Mike S. <1960-> |
| Pubbl/distr/stampa | New York, : J. Wiley & Sons, c2002 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina |
615.19
615/.19 |
| Collana | Wiley-Interscience series on mass spectrometry |
| Soggetto topico |
Drug development - Methodology
Drugs - Analysis Liquid chromatography Mass spectrometry Combinatorial chemistry Gel permeation chromatography Drugs - Testing - Methodology |
| ISBN |
1-280-36642-7
9786610366422 0-470-35636-7 0-471-45930-5 0-471-21881-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
LC/MS APPLICATIONS IN DRUG DEVELOPMENT; CONTENTS; Preface; Acknowledgments; 1. Introduction; Emerging Analytical Needs; Integration of LC/MS into Drug Development; Partnerships and Acceptance; Overview; 2. Drug Development Overview; Analysis Perspectives; The Four Stages of Drug Development; Drug Discovery; Preclinical Development; Clinical Development; Manufacturing; 3. Accelerated Drug Development; Accelerated Development Strategies; Quantitative and Qualitative Process Elements; Quantitative Process Pipeline; Qualitative Process Pipeline; Motivating Factors
Analysis Opportunities for Accelerated DevelopmentFull-Time Equivalent; Sample Throughput Model; Elimination Model; Rate-Determining Event Model; Accelerated Development Perspectives; 4. LC/MS Development; The Elements of LC/MS Application; HPLC; Mass Spectrometry; LC/MS Interface; LC/MS Growth; 5. Strategies; Standard Methods; Template Structure Identification; Databases; Screening; Integration; Miniaturization; Parallel Processing; Visualization; Automation; Summary; 6. LC/MS Applications; Drug Discovery; Proteomics; Protein Expression Profiling; Quantitation; Glycoprotein Mapping Natural Products DereplicationLead Identification Screening; Bioaffinity Screening; Combinatorial Library Screening; Open-Access LC/MS; Structure Confirmation; High Throughput; Purification; Combinatorial Mixture Screening; In Vivo Drug Screening; Pharmacokinetics; In Vitro Drug Screening; Metabolic Stability Screening; Membrane Permeability; Drug-Drug Interaction; Metabolite Identification; Preclinical Development; Metabolite Identification; Impurity Identification; Degradant Identification; Clinical Development; Quantitative Bioanalysis-Selected Ion Monitoring Quantitative Bioanalysis-Selected Reaction MonitoringQuantitative Bioanalysis-Automated Solid-Phase Extraction; Quantitative Bioanalysis-Automated On-Line Extraction; Metabolite Identification; Degradant Identification; Manufacturing; Impurity Identification Using Data-Dependent Analysis; Peptide Mapping in Quality Control; Patent Protection; 7. Future Applications and Prospects; Workstations; Multidimensional Analysis; Miniaturization; Information Management; Strategic Outsourcing; Summary; 8. Perspectives on the Future Growth of LC/MS; 9. Conclusions; Glossary; References; Index |
| Record Nr. | UNINA-9910830729403321 |
|
Lee Mike S. <1960->
|
||
| New York, : J. Wiley & Sons, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
LC/MS applications in drug development / / Mike S. Lee
| LC/MS applications in drug development / / Mike S. Lee |
| Autore | Lee Mike S. <1960-> |
| Pubbl/distr/stampa | New York, : J. Wiley & Sons, c2002 |
| Descrizione fisica | 1 online resource (257 p.) |
| Disciplina |
615.19
615/.19 |
| Collana | Wiley-Interscience series on mass spectrometry |
| Soggetto topico |
Drug development - Methodology
Drugs - Analysis Liquid chromatography Mass spectrometry Combinatorial chemistry Gel permeation chromatography Drugs - Testing - Methodology |
| ISBN |
9786610366422
9781280366420 1280366427 9780470356364 0470356367 9780471459309 0471459305 9780471218814 0471218812 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
LC/MS APPLICATIONS IN DRUG DEVELOPMENT; CONTENTS; Preface; Acknowledgments; 1. Introduction; Emerging Analytical Needs; Integration of LC/MS into Drug Development; Partnerships and Acceptance; Overview; 2. Drug Development Overview; Analysis Perspectives; The Four Stages of Drug Development; Drug Discovery; Preclinical Development; Clinical Development; Manufacturing; 3. Accelerated Drug Development; Accelerated Development Strategies; Quantitative and Qualitative Process Elements; Quantitative Process Pipeline; Qualitative Process Pipeline; Motivating Factors
Analysis Opportunities for Accelerated DevelopmentFull-Time Equivalent; Sample Throughput Model; Elimination Model; Rate-Determining Event Model; Accelerated Development Perspectives; 4. LC/MS Development; The Elements of LC/MS Application; HPLC; Mass Spectrometry; LC/MS Interface; LC/MS Growth; 5. Strategies; Standard Methods; Template Structure Identification; Databases; Screening; Integration; Miniaturization; Parallel Processing; Visualization; Automation; Summary; 6. LC/MS Applications; Drug Discovery; Proteomics; Protein Expression Profiling; Quantitation; Glycoprotein Mapping Natural Products DereplicationLead Identification Screening; Bioaffinity Screening; Combinatorial Library Screening; Open-Access LC/MS; Structure Confirmation; High Throughput; Purification; Combinatorial Mixture Screening; In Vivo Drug Screening; Pharmacokinetics; In Vitro Drug Screening; Metabolic Stability Screening; Membrane Permeability; Drug-Drug Interaction; Metabolite Identification; Preclinical Development; Metabolite Identification; Impurity Identification; Degradant Identification; Clinical Development; Quantitative Bioanalysis-Selected Ion Monitoring Quantitative Bioanalysis-Selected Reaction MonitoringQuantitative Bioanalysis-Automated Solid-Phase Extraction; Quantitative Bioanalysis-Automated On-Line Extraction; Metabolite Identification; Degradant Identification; Manufacturing; Impurity Identification Using Data-Dependent Analysis; Peptide Mapping in Quality Control; Patent Protection; 7. Future Applications and Prospects; Workstations; Multidimensional Analysis; Miniaturization; Information Management; Strategic Outsourcing; Summary; 8. Perspectives on the Future Growth of LC/MS; 9. Conclusions; Glossary; References; Index |
| Record Nr. | UNINA-9911019790603321 |
|
Lee Mike S. <1960->
|
||
| New York, : J. Wiley & Sons, c2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
