top

  Info

  • Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.

  Info

  • Utilizzare questo link per rimuovere la selezione effettuata.
21st century cures : modernizing clinical trials : hearing before the Subcommittee on Health of the Committee on Energy and Commerce, House of Representatives, One Hundred Thirteenth Congress, second session, July 9, 2014
21st century cures : modernizing clinical trials : hearing before the Subcommittee on Health of the Committee on Energy and Commerce, House of Representatives, One Hundred Thirteenth Congress, second session, July 9, 2014
Pubbl/distr/stampa Washington : , : U.S. Government Publishing Office, , 2015
Descrizione fisica 1 online resource (iv, 165 pages)
Soggetto topico Clinical trials - United States
Drugs - United States - Testing
Medical instruments and apparatus - United States - Testing
Clinical trials
Drugs - Testing
Medical instruments and apparatus - Testing
Soggetto genere / forma Legislative hearings.
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Altri titoli varianti 21st century cures
Record Nr. UNINA-9910703523803321
Washington : , : U.S. Government Publishing Office, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Accelerating the development of biomarkers for drug safety [[electronic resource] ] : workshop summary / / Steve Olson, Sally Robinson and Robert Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Accelerating the development of biomarkers for drug safety [[electronic resource] ] : workshop summary / / Steve Olson, Sally Robinson and Robert Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Pubbl/distr/stampa Washington, D.C., : National Academies Press, c2009
Descrizione fisica 1 online resource (99 p.)
Disciplina 616.075
Altri autori (Persone) GiffinRobert B
OlsonSteve <1956->
RobinsonSally
Soggetto topico Biochemical markers
Drugs - Safety measures
Drugs - Testing
Soggetto genere / forma Electronic books.
ISBN 1-282-27265-9
9786612272653
0-309-13125-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910454905103321
Washington, D.C., : National Academies Press, c2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Accelerating the development of biomarkers for drug safety [[electronic resource] ] : workshop summary / / Steve Olson, Sally Robinson and Robert Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Accelerating the development of biomarkers for drug safety [[electronic resource] ] : workshop summary / / Steve Olson, Sally Robinson and Robert Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Pubbl/distr/stampa Washington, D.C., : National Academies Press, c2009
Descrizione fisica 1 online resource (99 p.)
Disciplina 616.075
Altri autori (Persone) GiffinRobert B
OlsonSteve <1956->
RobinsonSally
Soggetto topico Biochemical markers
Drugs - Safety measures
Drugs - Testing
ISBN 0-309-14231-8
1-282-27265-9
9786612272653
0-309-13125-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Overview Of key issues -- Cardiac safety biomarkers -- Assessing and predicting kidney safety -- Biomarkers of acute idiosyncratic hepatocellular injury in clinical trials -- Future considerations.
Record Nr. UNINA-9910778330203321
Washington, D.C., : National Academies Press, c2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Accelerating the development of biomarkers for drug safety [[electronic resource] ] : workshop summary / / Steve Olson, Sally Robinson and Robert Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Accelerating the development of biomarkers for drug safety [[electronic resource] ] : workshop summary / / Steve Olson, Sally Robinson and Robert Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies
Edizione [1st ed.]
Pubbl/distr/stampa Washington, D.C., : National Academies Press, c2009
Descrizione fisica 1 online resource (99 p.)
Disciplina 616.075
Altri autori (Persone) GiffinRobert B
OlsonSteve <1956->
RobinsonSally
Soggetto topico Biochemical markers
Drugs - Safety measures
Drugs - Testing
ISBN 0-309-14231-8
1-282-27265-9
9786612272653
0-309-13125-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Overview Of key issues -- Cardiac safety biomarkers -- Assessing and predicting kidney safety -- Biomarkers of acute idiosyncratic hepatocellular injury in clinical trials -- Future considerations.
Record Nr. UNINA-9910828713903321
Washington, D.C., : National Academies Press, c2009
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Addendum to ICH S6 [[electronic resource] ] : preclinical safety evaluation of biotechnology-derived pharmaceuticals
Addendum to ICH S6 [[electronic resource] ] : preclinical safety evaluation of biotechnology-derived pharmaceuticals
Pubbl/distr/stampa [Rockville, Md.?] : , : [U.S. Dept. of Health and Human Services, Food and Drug Administration], , [2009]
Descrizione fisica 1 online resource (iv, 14 pages)
Soggetto topico Pharmaceutical biotechnology
Drugs - Testing
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Altri titoli varianti Addendum to ICH S6
Record Nr. UNINA-9910699222303321
[Rockville, Md.?] : , : [U.S. Dept. of Health and Human Services, Food and Drug Administration], , [2009]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
Autore Tsaioun Katya
Pubbl/distr/stampa Hoboken, : Wiley, 2012
Descrizione fisica 1 online resource (524 p.)
Disciplina 615.19
615/.19
Altri autori (Persone) KatesSteven A
Soggetto topico Drug Design
Drug Toxicity
Drugs - Testing
Drugs --Testing --Juvenile literature
Pharmaceutical Preparations - chemistry
Pharmacokinetics
Metabolic Phenomena
Drug Discovery
Pharmacological Phenomena
Natural Science Disciplines
Kinetics
Chemicals and Drugs
Poisoning
Biochemical Phenomena
Chemistry, Pharmaceutical
Substance-Related Disorders
Disciplines and Occupations
Investigative Techniques
Physiological Phenomena
Phenomena and Processes
Chemical Phenomena
Diseases
Pharmacology
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Chemistry
Pharmaceutical Preparations
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-280-59122-6
9786613621054
0-470-91509-9
0-470-91511-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs
2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods
2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution
4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools
4.5.7 Tools for Studying Drug Excretion
Record Nr. UNINA-9910133588303321
Tsaioun Katya  
Hoboken, : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
Autore Tsaioun Katya
Pubbl/distr/stampa Hoboken, : Wiley, 2012
Descrizione fisica 1 online resource (524 p.)
Disciplina 615.19
615/.19
Altri autori (Persone) KatesSteven A
Soggetto topico Drug Design
Drug Toxicity
Drugs - Testing
Drugs --Testing --Juvenile literature
Pharmaceutical Preparations - chemistry
Pharmacokinetics
Metabolic Phenomena
Drug Discovery
Pharmacological Phenomena
Natural Science Disciplines
Kinetics
Chemicals and Drugs
Poisoning
Biochemical Phenomena
Chemistry, Pharmaceutical
Substance-Related Disorders
Disciplines and Occupations
Investigative Techniques
Physiological Phenomena
Phenomena and Processes
Chemical Phenomena
Diseases
Pharmacology
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Chemistry
Pharmaceutical Preparations
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-280-59122-6
9786613621054
0-470-91509-9
0-470-91511-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs
2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods
2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution
4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools
4.5.7 Tools for Studying Drug Excretion
Record Nr. UNINA-9910830164603321
Tsaioun Katya  
Hoboken, : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
Autore Tsaioun Katya
Pubbl/distr/stampa Hoboken, : Wiley, 2012
Descrizione fisica 1 online resource (524 p.)
Disciplina 615.19
615/.19
Altri autori (Persone) KatesSteven A
Soggetto topico Drug Design
Drug Toxicity
Drugs - Testing
Drugs --Testing --Juvenile literature
Pharmaceutical Preparations - chemistry
Pharmacokinetics
Metabolic Phenomena
Drug Discovery
Pharmacological Phenomena
Natural Science Disciplines
Kinetics
Chemicals and Drugs
Poisoning
Biochemical Phenomena
Chemistry, Pharmaceutical
Substance-Related Disorders
Disciplines and Occupations
Investigative Techniques
Physiological Phenomena
Phenomena and Processes
Chemical Phenomena
Diseases
Pharmacology
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Chemistry
Pharmaceutical Preparations
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-280-59122-6
9786613621054
0-470-91509-9
0-470-91511-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs
2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods
2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution
4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools
4.5.7 Tools for Studying Drug Excretion
Record Nr. UNINA-9910841604803321
Tsaioun Katya  
Hoboken, : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances in collating and using trial data / / Sylvie Chevret, Matthieu Resche-Rigon, editors
Advances in collating and using trial data / / Sylvie Chevret, Matthieu Resche-Rigon, editors
Pubbl/distr/stampa London, England : , : Future Science Ltd, , 2014
Descrizione fisica 1 online resource (90 pages) : illustrations (some color)
Disciplina 615.1901
Soggetto topico Drugs - Testing
Drug development
Soggetto genere / forma Electronic books.
ISBN 1-909453-27-7
1-909453-28-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910464757503321
London, England : , : Future Science Ltd, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances in collating and using trial data / / Sylvie Chevret, Matthieu Resche-Rigon, editors
Advances in collating and using trial data / / Sylvie Chevret, Matthieu Resche-Rigon, editors
Pubbl/distr/stampa London, England : , : Future Science Ltd, , 2014
Descrizione fisica 1 online resource (90 pages) : illustrations (some color)
Disciplina 615.1901
Soggetto topico Drugs - Testing
Drug development
ISBN 1-909453-27-7
1-909453-28-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910789329703321
London, England : , : Future Science Ltd, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui