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Medicinal chemistry approaches to personalized medicine / / edited by Karen Lackey and Bruce D. Roth
| Medicinal chemistry approaches to personalized medicine / / edited by Karen Lackey and Bruce D. Roth |
| Pubbl/distr/stampa | Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2014 |
| Descrizione fisica | 1 online resource (407 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
LackeyKaren
RothBruce D |
| Collana | Methods and Principles in Medicinal Chemistry |
| Soggetto topico |
Pharmaceutical chemistry
Drugs - Synthesis |
| ISBN |
3-527-67727-5
3-527-67725-9 3-527-67728-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Medicinal Chemistry Approaches to Personalized Medicine; Contents; List of Contributors; Foreword; Preface; A Personal Foreword; Acronyms; 1 Medicinal Chemistry Approaches to Creating Targeted Medicines; 1.1 Introduction; 1.2 Role of Medicinal Chemistry in Drug Discovery; 1.3 Evolution of Molecular Design for Subsets of Patients; 1.4 Combinations for Effective Therapies; 1.5 Biomarkers in Targeting Patients; 1.6 Emerging Field of Epigenetics; 1.7 Systems Chemical Biology; 1.8 Theranostics and Designing Drug Delivery Systems; 1.9 Rapid Progress in Further Personalizing Medicine Expected
References 2 Discovery of Predictive Biomarkers for Anticancer Drugs; 2.1 Introduction; 2.2 "Oncogene Addiction" as a Paradigm for Clinical Implementation of Predictive Biomarkers; 2.3 Cancer Cell Lines as a Model System for Discovery of Predictive Biomarkers; 2.3.1 Historical Application of Cell Lines in Cancer Research; 2.3.2 Biomarker Discovery Using Cell Line Models; 2.3.3 Cell Lines as Models of Human Cancer; 2.3.4 Challenges and Limitations of Cell Line Models; 2.4 Modeling Drug Resistance to Discover Predictive Biomarkers 2.5 Discovery of Predictive Biomarkers in the Context of Treatment Combinations 2.6 Discovery of Predictive Biomarkers for Antiangiogenic Agents; 2.6.1 Challenges; 2.6.2 Pathway Activity as a Predictor of Drug Efficacy; 2.6.3 Predicting Inherent Resistance; 2.6.4 On-Treatment Effects as a Surrogate of Drug Efficacy; 2.6.5 Summary; 2.7 Gene Expression Signatures as Predictive Biomarkers; 2.7.1 Signature Discovery: Unsupervised Clustering; 2.7.2 Diagnostic Development: Supervised Classification; 2.7.3 Summary; 2.8 Current Challenges in Discovering Predictive Biomarkers 2.8.1 Access to Tumor Cells Is Limited during Treatment 2.8.2 Drivers and Passengers; 2.8.3 Epigenetic Regulation Adds Another Layer of Complexity; 2.8.4 Many Oncoproteins and Tumor Suppressors Undergo Regulatory Posttranslational Modifications; 2.9 Future Perspective; References; 3 Crizotinib; 3.1 Introduction; 3.2 Discovery of Crizotinib (PF-02341066) [40]; 3.3 Kinase Selectivity of Crizotinib; 3.4 Pharmacology of Crizotinib [45,46]; 3.5 Human Clinical Efficacies of Crizotinib; 3.6 Summary; References 4 Discovery and Development of Vemurafenib: First-in-Class Inhibitor of Mutant BRAF for the Treatment of Cancer 4.1 Background; 4.2 Discovery and Development of Vemurafenib (PLX4032); 4.3 Pharmacology; 4.4 Clinical Efficacy and Safety; 4.5 Companion Diagnostic (cobas 4800) Development; 4.6 Synthesis; 4.6.1 Discovery Route(s); 4.6.2 Process Route; 4.7 Summary; References; 5 Targeting Basal-Cell Carcinoma: Discovery and Development of Vismodegib (GDC-0449), a First-in-Class Inhibitor of the Hedgehog Pathway; 5.1 Introduction; 5.2 Hedgehog and Basal-Cell Carcinoma 5.3 Cyclopamine as an SMO Antagonist |
| Record Nr. | UNINA-9910138987903321 |
| Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Medicinal chemistry approaches to personalized medicine / / edited by Karen Lackey and Bruce D. Roth
| Medicinal chemistry approaches to personalized medicine / / edited by Karen Lackey and Bruce D. Roth |
| Pubbl/distr/stampa | Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2014 |
| Descrizione fisica | 1 online resource (407 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
LackeyKaren
RothBruce D |
| Collana | Methods and Principles in Medicinal Chemistry |
| Soggetto topico |
Pharmaceutical chemistry
Drugs - Synthesis |
| ISBN |
3-527-67727-5
3-527-67725-9 3-527-67728-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Medicinal Chemistry Approaches to Personalized Medicine; Contents; List of Contributors; Foreword; Preface; A Personal Foreword; Acronyms; 1 Medicinal Chemistry Approaches to Creating Targeted Medicines; 1.1 Introduction; 1.2 Role of Medicinal Chemistry in Drug Discovery; 1.3 Evolution of Molecular Design for Subsets of Patients; 1.4 Combinations for Effective Therapies; 1.5 Biomarkers in Targeting Patients; 1.6 Emerging Field of Epigenetics; 1.7 Systems Chemical Biology; 1.8 Theranostics and Designing Drug Delivery Systems; 1.9 Rapid Progress in Further Personalizing Medicine Expected
References 2 Discovery of Predictive Biomarkers for Anticancer Drugs; 2.1 Introduction; 2.2 "Oncogene Addiction" as a Paradigm for Clinical Implementation of Predictive Biomarkers; 2.3 Cancer Cell Lines as a Model System for Discovery of Predictive Biomarkers; 2.3.1 Historical Application of Cell Lines in Cancer Research; 2.3.2 Biomarker Discovery Using Cell Line Models; 2.3.3 Cell Lines as Models of Human Cancer; 2.3.4 Challenges and Limitations of Cell Line Models; 2.4 Modeling Drug Resistance to Discover Predictive Biomarkers 2.5 Discovery of Predictive Biomarkers in the Context of Treatment Combinations 2.6 Discovery of Predictive Biomarkers for Antiangiogenic Agents; 2.6.1 Challenges; 2.6.2 Pathway Activity as a Predictor of Drug Efficacy; 2.6.3 Predicting Inherent Resistance; 2.6.4 On-Treatment Effects as a Surrogate of Drug Efficacy; 2.6.5 Summary; 2.7 Gene Expression Signatures as Predictive Biomarkers; 2.7.1 Signature Discovery: Unsupervised Clustering; 2.7.2 Diagnostic Development: Supervised Classification; 2.7.3 Summary; 2.8 Current Challenges in Discovering Predictive Biomarkers 2.8.1 Access to Tumor Cells Is Limited during Treatment 2.8.2 Drivers and Passengers; 2.8.3 Epigenetic Regulation Adds Another Layer of Complexity; 2.8.4 Many Oncoproteins and Tumor Suppressors Undergo Regulatory Posttranslational Modifications; 2.9 Future Perspective; References; 3 Crizotinib; 3.1 Introduction; 3.2 Discovery of Crizotinib (PF-02341066) [40]; 3.3 Kinase Selectivity of Crizotinib; 3.4 Pharmacology of Crizotinib [45,46]; 3.5 Human Clinical Efficacies of Crizotinib; 3.6 Summary; References 4 Discovery and Development of Vemurafenib: First-in-Class Inhibitor of Mutant BRAF for the Treatment of Cancer 4.1 Background; 4.2 Discovery and Development of Vemurafenib (PLX4032); 4.3 Pharmacology; 4.4 Clinical Efficacy and Safety; 4.5 Companion Diagnostic (cobas 4800) Development; 4.6 Synthesis; 4.6.1 Discovery Route(s); 4.6.2 Process Route; 4.7 Summary; References; 5 Targeting Basal-Cell Carcinoma: Discovery and Development of Vismodegib (GDC-0449), a First-in-Class Inhibitor of the Hedgehog Pathway; 5.1 Introduction; 5.2 Hedgehog and Basal-Cell Carcinoma 5.3 Cyclopamine as an SMO Antagonist |
| Record Nr. | UNINA-9910814431003321 |
| Weinheim an der Bergstrasse, Germany : , : Wiley-VCH, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
New trends in synthetic medicinal chemistry [[electronic resource] /] / edited by Fulvio Gualtieri
| New trends in synthetic medicinal chemistry [[electronic resource] /] / edited by Fulvio Gualtieri |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, c2000 |
| Descrizione fisica | 1 online resource (372 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | GualtieriF |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Synthesis
Pharmaceutical chemistry |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-01040-9
9786612010408 3-527-61340-4 3-527-61341-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Methods and Principles in Medicinal Chemistry; Preface; List of Contributors; Contents; 1 Organic Synthesis and Medicinal Chemistry; 2 Series Design in Synthetic Chemistry; 3 Combinatorial Chemistry; 4 Tubes and Cubes. Chips and Tips: Tools for Solid-Phase Organic Synthesis; 5 Stereoselective Synthesis of Enantiomerically Pure Drugs; 6 Resolution of Enantiomers of Chiral Drugs; 7 Biocatalyzed Reactions; 8 Selective Glycosidation Reactions and their Use in Medicinal Chemistry; 9 Chemistry of Antisense Oligonucleotides; Index |
| Record Nr. | UNINA-9910144098203321 |
| Weinheim ; ; New York, : Wiley-VCH, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
New trends in synthetic medicinal chemistry [[electronic resource] /] / edited by Fulvio Gualtieri
| New trends in synthetic medicinal chemistry [[electronic resource] /] / edited by Fulvio Gualtieri |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, c2000 |
| Descrizione fisica | 1 online resource (372 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | GualtieriF |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Synthesis
Pharmaceutical chemistry |
| ISBN |
1-282-01040-9
9786612010408 3-527-61340-4 3-527-61341-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Methods and Principles in Medicinal Chemistry; Preface; List of Contributors; Contents; 1 Organic Synthesis and Medicinal Chemistry; 2 Series Design in Synthetic Chemistry; 3 Combinatorial Chemistry; 4 Tubes and Cubes. Chips and Tips: Tools for Solid-Phase Organic Synthesis; 5 Stereoselective Synthesis of Enantiomerically Pure Drugs; 6 Resolution of Enantiomers of Chiral Drugs; 7 Biocatalyzed Reactions; 8 Selective Glycosidation Reactions and their Use in Medicinal Chemistry; 9 Chemistry of Antisense Oligonucleotides; Index |
| Record Nr. | UNINA-9910830718303321 |
| Weinheim ; ; New York, : Wiley-VCH, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
New trends in synthetic medicinal chemistry / / edited by Fulvio Gualtieri
| New trends in synthetic medicinal chemistry / / edited by Fulvio Gualtieri |
| Pubbl/distr/stampa | Weinheim ; ; New York, : Wiley-VCH, c2000 |
| Descrizione fisica | 1 online resource (372 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | GualtieriF |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drugs - Synthesis
Pharmaceutical chemistry |
| ISBN |
1-282-01040-9
9786612010408 3-527-61340-4 3-527-61341-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Methods and Principles in Medicinal Chemistry; Preface; List of Contributors; Contents; 1 Organic Synthesis and Medicinal Chemistry; 2 Series Design in Synthetic Chemistry; 3 Combinatorial Chemistry; 4 Tubes and Cubes. Chips and Tips: Tools for Solid-Phase Organic Synthesis; 5 Stereoselective Synthesis of Enantiomerically Pure Drugs; 6 Resolution of Enantiomers of Chiral Drugs; 7 Biocatalyzed Reactions; 8 Selective Glycosidation Reactions and their Use in Medicinal Chemistry; 9 Chemistry of Antisense Oligonucleotides; Index |
| Record Nr. | UNINA-9910877656303321 |
| Weinheim ; ; New York, : Wiley-VCH, c2000 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Strategies for organic drug synthesis and design [[electronic resource] /] / Daniel Lednicer
| Strategies for organic drug synthesis and design [[electronic resource] /] / Daniel Lednicer |
| Autore | Lednicer Daniel <1929-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (702 p.) |
| Disciplina |
615.19
615/.19 |
| Soggetto topico |
Pharmaceutical chemistry
Drugs - Synthesis Drugs - Design Organic compounds - Synthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-03106-6
9786612031069 0-470-39961-9 0-470-39959-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Prostaglandins, peptidomimetic compounds, and retinoids -- Drugs based on a substituted benzene ring -- Indenes, naphthalenes, and other polycyclic aromatic compounds -- Steroids; pt. 1 : estranes, gonanes, and androstanes -- Steroids; pt. 2 : compounds related to progesterone, cortisone, and cholesterol -- Nonsteroidal sex hormones and their antagonists -- Opioid anagesics -- Drugs based on five-membered heterocycles -- Drugs based on six-membered heterocycles -- Five-membered heterocycles fused to a benzene ring -- Six-membered heterocycles fused to a benzene ring -- Seven-membered heterocycles fused to benzene -- Heterocyles fused to two aromatic rings -- Beta lactam antibiotics -- Heterocycles fused to other heterocyclic rings. |
| Record Nr. | UNINA-9910146150103321 |
Lednicer Daniel <1929->
|
||
| Hoboken, N.J., : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Strategies for organic drug synthesis and design [[electronic resource] /] / Daniel Lednicer
| Strategies for organic drug synthesis and design [[electronic resource] /] / Daniel Lednicer |
| Autore | Lednicer Daniel <1929-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (702 p.) |
| Disciplina |
615.19
615/.19 |
| Soggetto topico |
Pharmaceutical chemistry
Drugs - Synthesis Drugs - Design Organic compounds - Synthesis |
| ISBN |
1-282-03106-6
9786612031069 0-470-39961-9 0-470-39959-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Prostaglandins, peptidomimetic compounds, and retinoids -- Drugs based on a substituted benzene ring -- Indenes, naphthalenes, and other polycyclic aromatic compounds -- Steroids; pt. 1 : estranes, gonanes, and androstanes -- Steroids; pt. 2 : compounds related to progesterone, cortisone, and cholesterol -- Nonsteroidal sex hormones and their antagonists -- Opioid anagesics -- Drugs based on five-membered heterocycles -- Drugs based on six-membered heterocycles -- Five-membered heterocycles fused to a benzene ring -- Six-membered heterocycles fused to a benzene ring -- Seven-membered heterocycles fused to benzene -- Heterocyles fused to two aromatic rings -- Beta lactam antibiotics -- Heterocycles fused to other heterocyclic rings. |
| Record Nr. | UNINA-9910830339303321 |
|
Lednicer Daniel <1929->
|
||
| Hoboken, N.J., : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Strategies for organic drug synthesis and design / / Daniel Lednicer
| Strategies for organic drug synthesis and design / / Daniel Lednicer |
| Autore | Lednicer Daniel <1929-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2009 |
| Descrizione fisica | 1 online resource (702 p.) |
| Disciplina | 615/.19 |
| Soggetto topico |
Pharmaceutical chemistry
Drugs - Synthesis Drugs - Design Organic compounds - Synthesis |
| ISBN |
1-282-03106-6
9786612031069 0-470-39961-9 0-470-39959-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Prostaglandins, peptidomimetic compounds, and retinoids -- Drugs based on a substituted benzene ring -- Indenes, naphthalenes, and other polycyclic aromatic compounds -- Steroids; pt. 1 : estranes, gonanes, and androstanes -- Steroids; pt. 2 : compounds related to progesterone, cortisone, and cholesterol -- Nonsteroidal sex hormones and their antagonists -- Opioid anagesics -- Drugs based on five-membered heterocycles -- Drugs based on six-membered heterocycles -- Five-membered heterocycles fused to a benzene ring -- Six-membered heterocycles fused to a benzene ring -- Seven-membered heterocycles fused to benzene -- Heterocyles fused to two aromatic rings -- Beta lactam antibiotics -- Heterocycles fused to other heterocyclic rings. |
| Record Nr. | UNINA-9910877026303321 |
|
Lednicer Daniel <1929->
|
||
| Hoboken, N.J., : John Wiley & Sons, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
