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MARC Lista (tabellare)
Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen
Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen
Pubbl/distr/stampa Hoboken : , : Wiley, , 2011
Descrizione fisica 1 online resource (xxii, 462 pages) : illustrations
Disciplina 615.1
615/.1
Altri autori (Persone) PramanikBirendra N. <1944->
LeeMike S. <1960->
ChenGuodong
Collana Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
Soggetto topico Drugs - Analysis
Drugs - Spectra
Mass spectrometry
Contamination (Technology)
Public Health
Chemistry Techniques, Analytical
Investigative Techniques
Environment and Public Health
Health Care
Pharmaceutical Preparations
Mass Spectrometry
Drug Contamination
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-283-23943-4
9786613239433
0-470-92136-6
0-470-92137-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CHARACTERIZATION OF IMPURITIES AND DEGRADANTS USING MASS SPECTROMETRY; CONTENTS; PREFACE; CONTRIBUTORS; ACRONYMS; PART I: METHODOLOGY; 1. Introduction to Mass Spectrometry; 1.1. History; 1.1.1. Atomic Physics; 1.1.2. Early Applications; 1.1.3. Organic Structural Analysis; 1.1.4. The Biological Mass Spectrometry Revolution; 1.2. Ionization Methods; 1.3. Mass Spectrometer Types; 1.3.1. Magnetic Sector Mass Spectrometers; 1.3.2. Quadrupole Mass Filter and Quadrupole Ion Trap Mass Spectrometers; 1.3.3. Time-of-Flight Mass Spectrometers
1.3.4. Fourier Transform Ion Cyclotron Resonance Mass Spectrometers; 1.3.5. Orbitrap Mass Spectrometers; 1.4. Tandem Mass Spectrometry; 1.4.1. Ion Isolation; 1.4.2. Ion-Molecule Collisions and Collision-Induced Dissociation; 1.4.3. Electron Capture Dissociation and Electron Transfer Dissociation; 1.5. Separation Techniques Coupled to Mass Spectrometry; 1.5.1. Gas Chromatography-Mass Spectrometry; 1.5.2. Liquid Chromatography-Mass Spectrometry; 1.5.3. Capillary Electrophoresis-Mass Spectrometry; 1.5.4. Ion Mobility Spectrometry-Mass Spectrometry; 1.6. Prospects for Mass Spectrometry; References
2. LC Method Development and Strategies; 2.1. Introduction; 2.2. Column, pH, and Solvent Screening; 2.2.1. Resolution: Goal of Separation; 2.2.2. Screening: Systematic Approach to Seeking Selectivity; 2.2.3. Screening Instrumentation and Controlling Software; 2.3. Gradient and Temperature Optimization; 2.4. Orthogonal Screening; 2.4.1. Method Orthogonality; 2.4.2. Selection of Orthogonal Methods; 2.4.3. Impurity Orthogonal Screening; 2.5. High-Efficiency Separation; 2.6. Conclusions; References
3. Rapid Analysis of Drug-Related Substances using Desorption Electrospray Ionization and Direct Analysis in Real Time Ionization Mass Spectrometry; 3.1. Introduction; 3.2. Ionization Apparatus, Mechanisms, and General Performance; 3.2.1. Desorption Electrospray Ionization (DESI); 3.2.2. Direct Analysis in Real Time (DART); 3.3. Drug Analysis in Biological Matrices using DESI and DART; 3.3.1. DESI Application; 3.3.2. DART Application; 3.4. High-Throughput Analysis; 3.5. Chemical Imaging and Profiling; 3.6. Future Perspectives; References; 4. Orbitrap High-Resolution Applications
4.1. Historical Anecdote; 4.2. General Description of Orbitrap Operating Principles; 4.3. The Orbitrap is a "Fourier Transform" Device; 4.4. Performing Experiments in Trapping Devices; 4.4.1. "Raw" HPLC Data Look Like Infusion Data; 4.4.2. How Much Mass Resolution Should Be Used During HPLC; 4.5. Determining Elemental Compositions of "Unknowns" Using an Orbitrap; 4.6. Orbitrap Figures of Merit in Mass Measurement; 4.6.1. Accuracy; 4.6.2. Precision; 4.6.3. Discussion; 4.7. HPLC Orbitrap MS: Accurate Mass Demonstration and Differentiation of Small Molecule Formulas Very Proximate in Mass/Charge Ratio Space
Record Nr. UNINA-9910132377503321
Hoboken : , : Wiley, , 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen
Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen
Pubbl/distr/stampa Hoboken : , : Wiley, , 2011
Descrizione fisica 1 online resource (xxii, 462 pages) : illustrations
Disciplina 615.1
615/.1
Altri autori (Persone) PramanikBirendra N. <1944->
LeeMike S. <1960->
ChenGuodong
Collana Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
Soggetto topico Drugs - Analysis
Drugs - Spectra
Mass spectrometry
Contamination (Technology)
Public Health
Chemistry Techniques, Analytical
Investigative Techniques
Environment and Public Health
Health Care
Pharmaceutical Preparations
Mass Spectrometry
Drug Contamination
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-283-23943-4
9786613239433
0-470-92136-6
0-470-92137-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CHARACTERIZATION OF IMPURITIES AND DEGRADANTS USING MASS SPECTROMETRY; CONTENTS; PREFACE; CONTRIBUTORS; ACRONYMS; PART I: METHODOLOGY; 1. Introduction to Mass Spectrometry; 1.1. History; 1.1.1. Atomic Physics; 1.1.2. Early Applications; 1.1.3. Organic Structural Analysis; 1.1.4. The Biological Mass Spectrometry Revolution; 1.2. Ionization Methods; 1.3. Mass Spectrometer Types; 1.3.1. Magnetic Sector Mass Spectrometers; 1.3.2. Quadrupole Mass Filter and Quadrupole Ion Trap Mass Spectrometers; 1.3.3. Time-of-Flight Mass Spectrometers
1.3.4. Fourier Transform Ion Cyclotron Resonance Mass Spectrometers; 1.3.5. Orbitrap Mass Spectrometers; 1.4. Tandem Mass Spectrometry; 1.4.1. Ion Isolation; 1.4.2. Ion-Molecule Collisions and Collision-Induced Dissociation; 1.4.3. Electron Capture Dissociation and Electron Transfer Dissociation; 1.5. Separation Techniques Coupled to Mass Spectrometry; 1.5.1. Gas Chromatography-Mass Spectrometry; 1.5.2. Liquid Chromatography-Mass Spectrometry; 1.5.3. Capillary Electrophoresis-Mass Spectrometry; 1.5.4. Ion Mobility Spectrometry-Mass Spectrometry; 1.6. Prospects for Mass Spectrometry; References
2. LC Method Development and Strategies; 2.1. Introduction; 2.2. Column, pH, and Solvent Screening; 2.2.1. Resolution: Goal of Separation; 2.2.2. Screening: Systematic Approach to Seeking Selectivity; 2.2.3. Screening Instrumentation and Controlling Software; 2.3. Gradient and Temperature Optimization; 2.4. Orthogonal Screening; 2.4.1. Method Orthogonality; 2.4.2. Selection of Orthogonal Methods; 2.4.3. Impurity Orthogonal Screening; 2.5. High-Efficiency Separation; 2.6. Conclusions; References
3. Rapid Analysis of Drug-Related Substances using Desorption Electrospray Ionization and Direct Analysis in Real Time Ionization Mass Spectrometry; 3.1. Introduction; 3.2. Ionization Apparatus, Mechanisms, and General Performance; 3.2.1. Desorption Electrospray Ionization (DESI); 3.2.2. Direct Analysis in Real Time (DART); 3.3. Drug Analysis in Biological Matrices using DESI and DART; 3.3.1. DESI Application; 3.3.2. DART Application; 3.4. High-Throughput Analysis; 3.5. Chemical Imaging and Profiling; 3.6. Future Perspectives; References; 4. Orbitrap High-Resolution Applications
4.1. Historical Anecdote; 4.2. General Description of Orbitrap Operating Principles; 4.3. The Orbitrap is a "Fourier Transform" Device; 4.4. Performing Experiments in Trapping Devices; 4.4.1. "Raw" HPLC Data Look Like Infusion Data; 4.4.2. How Much Mass Resolution Should Be Used During HPLC; 4.5. Determining Elemental Compositions of "Unknowns" Using an Orbitrap; 4.6. Orbitrap Figures of Merit in Mass Measurement; 4.6.1. Accuracy; 4.6.2. Precision; 4.6.3. Discussion; 4.7. HPLC Orbitrap MS: Accurate Mass Demonstration and Differentiation of Small Molecule Formulas Very Proximate in Mass/Charge Ratio Space
Record Nr. UNINA-9910810569103321
Hoboken : , : Wiley, , 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Drug-DNA interactions [[electronic resource] ] : structures and spectra / / Kazuo Nakamoto, Masamichi Tsuboi, Gary D. Strahan
Drug-DNA interactions [[electronic resource] ] : structures and spectra / / Kazuo Nakamoto, Masamichi Tsuboi, Gary D. Strahan
Autore Nakamoto Kazuo <1922->
Pubbl/distr/stampa Hoboken, N.J., : John Wiley & Sons, c2008
Descrizione fisica 1 online resource (396 p.)
Disciplina 572.8/6
Altri autori (Persone) TsuboiMasamichi <1925->
StrahanGary D
Soggetto topico DNA-drug interactions - Research - Methodology
DNA - Spectra
Drugs - Spectra
ISBN 1-281-81450-4
9786611814502
0-470-37061-0
0-470-36916-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto DNA structures and spectra -- Intercalating drugs -- Groove-binding drugs -- Covalent bonding drugs -- Strand-breaking drugs -- Metal-containing drugs.
Record Nr. UNINA-9910144118403321
Nakamoto Kazuo <1922->  
Hoboken, N.J., : John Wiley & Sons, c2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Drug-DNA interactions [[electronic resource] ] : structures and spectra / / Kazuo Nakamoto, Masamichi Tsuboi, Gary D. Strahan
Drug-DNA interactions [[electronic resource] ] : structures and spectra / / Kazuo Nakamoto, Masamichi Tsuboi, Gary D. Strahan
Autore Nakamoto Kazuo <1922->
Pubbl/distr/stampa Hoboken, N.J., : John Wiley & Sons, c2008
Descrizione fisica 1 online resource (396 p.)
Disciplina 572.8/6
Altri autori (Persone) TsuboiMasamichi <1925->
StrahanGary D
Soggetto topico DNA-drug interactions - Research - Methodology
DNA - Spectra
Drugs - Spectra
ISBN 1-281-81450-4
9786611814502
0-470-37061-0
0-470-36916-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto DNA structures and spectra -- Intercalating drugs -- Groove-binding drugs -- Covalent bonding drugs -- Strand-breaking drugs -- Metal-containing drugs.
Record Nr. UNINA-9910830403903321
Nakamoto Kazuo <1922->  
Hoboken, N.J., : John Wiley & Sons, c2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Drug-DNA interactions [[electronic resource] ] : structures and spectra / / Kazuo Nakamoto, Masamichi Tsuboi, Gary D. Strahan
Drug-DNA interactions [[electronic resource] ] : structures and spectra / / Kazuo Nakamoto, Masamichi Tsuboi, Gary D. Strahan
Autore Nakamoto Kazuo <1922->
Pubbl/distr/stampa Hoboken, N.J., : John Wiley & Sons, c2008
Descrizione fisica 1 online resource (396 p.)
Disciplina 572.8/6
Altri autori (Persone) TsuboiMasamichi <1925->
StrahanGary D
Soggetto topico DNA-drug interactions - Research - Methodology
DNA - Spectra
Drugs - Spectra
ISBN 1-281-81450-4
9786611814502
0-470-37061-0
0-470-36916-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto DNA structures and spectra -- Intercalating drugs -- Groove-binding drugs -- Covalent bonding drugs -- Strand-breaking drugs -- Metal-containing drugs.
Record Nr. UNINA-9910840808703321
Nakamoto Kazuo <1922->  
Hoboken, N.J., : John Wiley & Sons, c2008
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Handbook of LC-MS bioanalysis [[electronic resource] ] : best practices, experimental protocols, and regulations / / edited by Wenkui Li, Jie Zhang, Francis L.S. Tse
Handbook of LC-MS bioanalysis [[electronic resource] ] : best practices, experimental protocols, and regulations / / edited by Wenkui Li, Jie Zhang, Francis L.S. Tse
Pubbl/distr/stampa Hoboken, N.J., : John Wiley & Sons, 2013
Descrizione fisica 1 online resource (706 p.)
Disciplina 615.1/901
Altri autori (Persone) LiWenkui <1964->
ZhangJie <1962->
TseFrancis L. S
Soggetto topico Drugs - Spectra
Drugs - Analysis
Mass spectrometry
Liquid chromatography
ISBN 1-118-67135-X
1-118-67127-9
1-118-67134-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto pt. I. Overview of LC-MS bioanalysis -- pt. II. Current understanding of LC-MS bioanalysis-related regulations -- pt. III. Best practice in LC-MS bioanalysis -- pt. IV. Representative guidelines and/or experimental protocols of LC-MS bioanalysis.
Record Nr. UNINA-9910139023203321
Hoboken, N.J., : John Wiley & Sons, 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui