Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton
| Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
| Descrizione fisica | 1 online resource (156 pages) : color illustrations |
| Disciplina | 362.29 |
| Soggetto topico |
Brain - Effect of drugs on
Neuropharmacology Drugs - Physiological transport Blood-brain barrier |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-909453-97-8
1-909453-93-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910467801803321 |
| London, England : , : Future Science Ltd, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton
| Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
| Descrizione fisica | 1 online resource (156 pages) : color illustrations |
| Disciplina | 362.29 |
| Soggetto topico |
Brain - Effect of drugs on
Neuropharmacology Drugs - Physiological transport Blood-brain barrier |
| ISBN |
1-909453-97-8
1-909453-93-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910794873603321 |
| London, England : , : Future Science Ltd, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton
| Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
| Descrizione fisica | 1 online resource (156 pages) : color illustrations |
| Disciplina | 362.29 |
| Soggetto topico |
Brain - Effect of drugs on
Neuropharmacology Drugs - Physiological transport Blood-brain barrier |
| ISBN |
1-909453-97-8
1-909453-93-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910814283703321 |
| London, England : , : Future Science Ltd, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba
| Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2009 |
| Descrizione fisica | 1 online resource (451 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
EckerGerhard
ChibaPeter |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug carriers (Pharmacy)
Drugs - Physiological transport Drug resistance |
| ISBN |
1-282-30246-9
9786612302466 3-527-62742-1 3-527-62743-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Transporters as Drug Carriers: Structure, Function, Substrates; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Human Transporter Families - Structure, Function, Physiology; 1 The ABC Transporters: Structural Insights into Drug Transport; 1.1 ABC Proteins - Structure and Function; 1.1.1 ABC Proteins; 1.1.2 Predicted Topology of ABC Proteins; 1.1.3 Nucleotide Binding Domains; 1.1.3.1 Conserved Motifs of NBDs; 1.1.4 Transmembrane Domains; 1.1.5 Mechanisms of Transport; 1.1.6 Energy for Translocation; 1.1.7 Coupling of ATP Hydrolysis to Transport
1.2 Structures of ABC Transporters1.2.1 Tertiary Structure; 1.2.2 Quaternary Structure of ABC Proteins; 1.3 Multidrug Resistance and ABC Transporters; 1.3.1 P-Glycoprotein; 1.3.1.1 Historical Background; 1.3.1.2 The Role of P-gp in Drug Resistance; 1.3.1.3 Tissue Distribution and Physiological Roles; 1.3.2 Conformational Changes in the Mechanism of P-gp; 1.3.3 Comparison of Sav1866 and P-gp Structures; 1.3.4 Drug Binding Sites in P-Glycoprotein; 1.3.5 Structural Interpretation of Drug Binding; 1.3.6 Inhibitors of P-gp 1.3.7 What Properties Are Shared by Drugs that Interact with P-Glycoprotein?1.3.8 Postscript: Further X-Ray Crystallographic Studies and a Structure for the Nucleotide-Free State of P-Glycoprotein; 1.4 Summary; References; 2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters; 2.1 Nucleoside and Nucleobase Transporters; 2.1.1 Equilibrative Nucleoside Transporters; 2.1.2 Concentrative Nucleoside Transporters; 2.2 ENT and CNT Tissue Distribution, Regulation, and Physiological Roles; 2.2.1 ENT Tissue Distribution and Regulation 2.2.2 CNT Tissue Distribution and Regulation2.2.2.1 CNTs in Absorptive Epithelia; 2.2.2.2 CNTs in Liver Parenchymal Cells; 2.2.2.3 CNTs in Immune System Cells; 2.2.2.4 CNTs in CNS; 2.2.2.5 CNTs in Other Specialized Tissues; 2.2.3 NTs as ""Transceptors""; 2.3 Nucleoside- and Nucleobase-Derived Drug Transport into Cells; 2.3.1 Transport of Anticancer Drugs; 2.3.2 Transport of Antiviral Drugs; 2.4 Drug Transport and Responsiveness to Treatment; 2.4.1 Analysis of the Role of NTs in Sensitivity to Nucleoside Anticancer Drugs in Cultured Cell Models 2.4.2 Studies Linking NT Function to Drug Sensitivity and Clinical Outcome in Cancer Patients2.5 Future Perspectives; References; 3 Organic Anion Transporting Polypeptides (Oatps/OATPs); 3.1 Introduction; 3.2 Nomenclature and Classification; 3.3 Tissue Distribution, Structure, and Functions; 3.4 Substrate Spectrum; 3.5 Members of the Rodent Oatp Family; 3.5.1 Oatp1a1; 3.5.2 Oatp1a3-v1/v2; 3.5.3 Oatp1a4; 3.5.4 Oatp1a5; 3.5.5 Oatp1a6; 3.5.6 Oatp1b2; 3.5.7 Oatp1c1; 3.5.8 Oatp2a1; 3.5.9 Oatp2b1; 3.5.10 Oatp3a1; 3.5.11 Oatp4a1; 3.5.12 Oatp4c1; 3.5.13 Oatp6b1/Oatp6c1; 3.5.14 PGT-2 3.5.15 TST-1 and TST-2 |
| Record Nr. | UNINA-9910139773003321 |
| Weinheim, : Wiley-VCH, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba
| Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2009 |
| Descrizione fisica | 1 online resource (451 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
EckerGerhard
ChibaPeter |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug carriers (Pharmacy)
Drugs - Physiological transport Drug resistance |
| ISBN |
1-282-30246-9
9786612302466 3-527-62742-1 3-527-62743-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Transporters as Drug Carriers: Structure, Function, Substrates; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Human Transporter Families - Structure, Function, Physiology; 1 The ABC Transporters: Structural Insights into Drug Transport; 1.1 ABC Proteins - Structure and Function; 1.1.1 ABC Proteins; 1.1.2 Predicted Topology of ABC Proteins; 1.1.3 Nucleotide Binding Domains; 1.1.3.1 Conserved Motifs of NBDs; 1.1.4 Transmembrane Domains; 1.1.5 Mechanisms of Transport; 1.1.6 Energy for Translocation; 1.1.7 Coupling of ATP Hydrolysis to Transport
1.2 Structures of ABC Transporters1.2.1 Tertiary Structure; 1.2.2 Quaternary Structure of ABC Proteins; 1.3 Multidrug Resistance and ABC Transporters; 1.3.1 P-Glycoprotein; 1.3.1.1 Historical Background; 1.3.1.2 The Role of P-gp in Drug Resistance; 1.3.1.3 Tissue Distribution and Physiological Roles; 1.3.2 Conformational Changes in the Mechanism of P-gp; 1.3.3 Comparison of Sav1866 and P-gp Structures; 1.3.4 Drug Binding Sites in P-Glycoprotein; 1.3.5 Structural Interpretation of Drug Binding; 1.3.6 Inhibitors of P-gp 1.3.7 What Properties Are Shared by Drugs that Interact with P-Glycoprotein?1.3.8 Postscript: Further X-Ray Crystallographic Studies and a Structure for the Nucleotide-Free State of P-Glycoprotein; 1.4 Summary; References; 2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters; 2.1 Nucleoside and Nucleobase Transporters; 2.1.1 Equilibrative Nucleoside Transporters; 2.1.2 Concentrative Nucleoside Transporters; 2.2 ENT and CNT Tissue Distribution, Regulation, and Physiological Roles; 2.2.1 ENT Tissue Distribution and Regulation 2.2.2 CNT Tissue Distribution and Regulation2.2.2.1 CNTs in Absorptive Epithelia; 2.2.2.2 CNTs in Liver Parenchymal Cells; 2.2.2.3 CNTs in Immune System Cells; 2.2.2.4 CNTs in CNS; 2.2.2.5 CNTs in Other Specialized Tissues; 2.2.3 NTs as ""Transceptors""; 2.3 Nucleoside- and Nucleobase-Derived Drug Transport into Cells; 2.3.1 Transport of Anticancer Drugs; 2.3.2 Transport of Antiviral Drugs; 2.4 Drug Transport and Responsiveness to Treatment; 2.4.1 Analysis of the Role of NTs in Sensitivity to Nucleoside Anticancer Drugs in Cultured Cell Models 2.4.2 Studies Linking NT Function to Drug Sensitivity and Clinical Outcome in Cancer Patients2.5 Future Perspectives; References; 3 Organic Anion Transporting Polypeptides (Oatps/OATPs); 3.1 Introduction; 3.2 Nomenclature and Classification; 3.3 Tissue Distribution, Structure, and Functions; 3.4 Substrate Spectrum; 3.5 Members of the Rodent Oatp Family; 3.5.1 Oatp1a1; 3.5.2 Oatp1a3-v1/v2; 3.5.3 Oatp1a4; 3.5.4 Oatp1a5; 3.5.5 Oatp1a6; 3.5.6 Oatp1b2; 3.5.7 Oatp1c1; 3.5.8 Oatp2a1; 3.5.9 Oatp2b1; 3.5.10 Oatp3a1; 3.5.11 Oatp4a1; 3.5.12 Oatp4c1; 3.5.13 Oatp6b1/Oatp6c1; 3.5.14 PGT-2 3.5.15 TST-1 and TST-2 |
| Record Nr. | UNINA-9910830216303321 |
| Weinheim, : Wiley-VCH, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba
| Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2009 |
| Descrizione fisica | 1 online resource (451 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
EckerGerhard
ChibaPeter |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug carriers (Pharmacy)
Drugs - Physiological transport Drug resistance |
| ISBN |
1-282-30246-9
9786612302466 3-527-62742-1 3-527-62743-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Transporters as Drug Carriers: Structure, Function, Substrates; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Human Transporter Families - Structure, Function, Physiology; 1 The ABC Transporters: Structural Insights into Drug Transport; 1.1 ABC Proteins - Structure and Function; 1.1.1 ABC Proteins; 1.1.2 Predicted Topology of ABC Proteins; 1.1.3 Nucleotide Binding Domains; 1.1.3.1 Conserved Motifs of NBDs; 1.1.4 Transmembrane Domains; 1.1.5 Mechanisms of Transport; 1.1.6 Energy for Translocation; 1.1.7 Coupling of ATP Hydrolysis to Transport
1.2 Structures of ABC Transporters1.2.1 Tertiary Structure; 1.2.2 Quaternary Structure of ABC Proteins; 1.3 Multidrug Resistance and ABC Transporters; 1.3.1 P-Glycoprotein; 1.3.1.1 Historical Background; 1.3.1.2 The Role of P-gp in Drug Resistance; 1.3.1.3 Tissue Distribution and Physiological Roles; 1.3.2 Conformational Changes in the Mechanism of P-gp; 1.3.3 Comparison of Sav1866 and P-gp Structures; 1.3.4 Drug Binding Sites in P-Glycoprotein; 1.3.5 Structural Interpretation of Drug Binding; 1.3.6 Inhibitors of P-gp 1.3.7 What Properties Are Shared by Drugs that Interact with P-Glycoprotein?1.3.8 Postscript: Further X-Ray Crystallographic Studies and a Structure for the Nucleotide-Free State of P-Glycoprotein; 1.4 Summary; References; 2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters; 2.1 Nucleoside and Nucleobase Transporters; 2.1.1 Equilibrative Nucleoside Transporters; 2.1.2 Concentrative Nucleoside Transporters; 2.2 ENT and CNT Tissue Distribution, Regulation, and Physiological Roles; 2.2.1 ENT Tissue Distribution and Regulation 2.2.2 CNT Tissue Distribution and Regulation2.2.2.1 CNTs in Absorptive Epithelia; 2.2.2.2 CNTs in Liver Parenchymal Cells; 2.2.2.3 CNTs in Immune System Cells; 2.2.2.4 CNTs in CNS; 2.2.2.5 CNTs in Other Specialized Tissues; 2.2.3 NTs as ""Transceptors""; 2.3 Nucleoside- and Nucleobase-Derived Drug Transport into Cells; 2.3.1 Transport of Anticancer Drugs; 2.3.2 Transport of Antiviral Drugs; 2.4 Drug Transport and Responsiveness to Treatment; 2.4.1 Analysis of the Role of NTs in Sensitivity to Nucleoside Anticancer Drugs in Cultured Cell Models 2.4.2 Studies Linking NT Function to Drug Sensitivity and Clinical Outcome in Cancer Patients2.5 Future Perspectives; References; 3 Organic Anion Transporting Polypeptides (Oatps/OATPs); 3.1 Introduction; 3.2 Nomenclature and Classification; 3.3 Tissue Distribution, Structure, and Functions; 3.4 Substrate Spectrum; 3.5 Members of the Rodent Oatp Family; 3.5.1 Oatp1a1; 3.5.2 Oatp1a3-v1/v2; 3.5.3 Oatp1a4; 3.5.4 Oatp1a5; 3.5.5 Oatp1a6; 3.5.6 Oatp1b2; 3.5.7 Oatp1c1; 3.5.8 Oatp2a1; 3.5.9 Oatp2b1; 3.5.10 Oatp3a1; 3.5.11 Oatp4a1; 3.5.12 Oatp4c1; 3.5.13 Oatp6b1/Oatp6c1; 3.5.14 PGT-2 3.5.15 TST-1 and TST-2 |
| Record Nr. | UNINA-9910840619203321 |
| Weinheim, : Wiley-VCH, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
