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The Andean wonder drug : cinchona bark and imperial science in the Spanish Atlantic, 1630-1800 / / Matthew James Crawford
The Andean wonder drug : cinchona bark and imperial science in the Spanish Atlantic, 1630-1800 / / Matthew James Crawford
Autore Crawford Matthew James
Pubbl/distr/stampa Pittsburgh, Pennsylvania : , : University of Pittsburgh Press, , 2016
Descrizione fisica 1 online resource (297 p.)
Disciplina 615.1
Soggetto topico Cinchona bark - Therapeutic use
Drugs - History
Medicine - History
Science - Social aspects
Soggetto genere / forma Electronic books.
ISBN 0-8229-8139-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Contents; Acknowledgements; Introduction: The Power and Fragility of European Science in the Spanish Atlantic World; Part I. Andean, Atlantic, and Imperial Networks of Knowledge; 1. Quina as a Medicament from the Andean World; 2. Quina as a Product of the Atlantic World; 3. Quina as a Natural Resource for the Spanish Empire; Part II. The Rule of the Local and the Rise of the Botanists; 4. Loja's Bark Collectors, the King's Pharmacists, and the Search for the Best Bark; 5. Botanists as the Empire's New Experts in Madrid
6. Imperial Reform, Local Knowledge, and the Limits of Botany in the Andean World7. Regalist and Mercantilist Visions of Empire in the "War of the Quinas"; Conclusion: The Natures of Empire before the "Drapery" of Modern Science; Notes; Bibliography; Index
Record Nr. UNINA-9910466442203321
Crawford Matthew James  
Pittsburgh, Pennsylvania : , : University of Pittsburgh Press, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
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The Andean wonder drug : cinchona bark and imperial science in the Spanish Atlantic, 1630-1800 / / Matthew James Crawford
The Andean wonder drug : cinchona bark and imperial science in the Spanish Atlantic, 1630-1800 / / Matthew James Crawford
Autore Crawford Matthew James
Pubbl/distr/stampa Pittsburgh, Pennsylvania : , : University of Pittsburgh Press, , 2016
Descrizione fisica 1 online resource (297 p.)
Disciplina 615.1
Soggetto topico Cinchona bark - Therapeutic use
Drugs - History
Medicine - History
Science - Social aspects
ISBN 0-8229-8139-4
Classificazione SCI034000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Contents; Acknowledgements; Introduction: The Power and Fragility of European Science in the Spanish Atlantic World; Part I. Andean, Atlantic, and Imperial Networks of Knowledge; 1. Quina as a Medicament from the Andean World; 2. Quina as a Product of the Atlantic World; 3. Quina as a Natural Resource for the Spanish Empire; Part II. The Rule of the Local and the Rise of the Botanists; 4. Loja's Bark Collectors, the King's Pharmacists, and the Search for the Best Bark; 5. Botanists as the Empire's New Experts in Madrid
6. Imperial Reform, Local Knowledge, and the Limits of Botany in the Andean World7. Regalist and Mercantilist Visions of Empire in the "War of the Quinas"; Conclusion: The Natures of Empire before the "Drapery" of Modern Science; Notes; Bibliography; Index
Record Nr. UNINA-9910796325203321
Crawford Matthew James  
Pittsburgh, Pennsylvania : , : University of Pittsburgh Press, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
The Andean wonder drug : cinchona bark and imperial science in the Spanish Atlantic, 1630-1800 / / Matthew James Crawford
The Andean wonder drug : cinchona bark and imperial science in the Spanish Atlantic, 1630-1800 / / Matthew James Crawford
Autore Crawford Matthew James
Pubbl/distr/stampa Pittsburgh, Pennsylvania : , : University of Pittsburgh Press, , 2016
Descrizione fisica 1 online resource (297 p.)
Disciplina 615.1
Soggetto topico Cinchona bark - Therapeutic use
Drugs - History
Medicine - History
Science - Social aspects
ISBN 0-8229-8139-4
Classificazione SCI034000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Contents; Acknowledgements; Introduction: The Power and Fragility of European Science in the Spanish Atlantic World; Part I. Andean, Atlantic, and Imperial Networks of Knowledge; 1. Quina as a Medicament from the Andean World; 2. Quina as a Product of the Atlantic World; 3. Quina as a Natural Resource for the Spanish Empire; Part II. The Rule of the Local and the Rise of the Botanists; 4. Loja's Bark Collectors, the King's Pharmacists, and the Search for the Best Bark; 5. Botanists as the Empire's New Experts in Madrid
6. Imperial Reform, Local Knowledge, and the Limits of Botany in the Andean World7. Regalist and Mercantilist Visions of Empire in the "War of the Quinas"; Conclusion: The Natures of Empire before the "Drapery" of Modern Science; Notes; Bibliography; Index
Record Nr. UNINA-9910812989803321
Crawford Matthew James  
Pittsburgh, Pennsylvania : , : University of Pittsburgh Press, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Life saving drugs [[electronic resource] ] : the elusive magic bullet / / John Mann
Life saving drugs [[electronic resource] ] : the elusive magic bullet / / John Mann
Autore Mann J
Pubbl/distr/stampa Cambridge, U.K., : Royal Society of Chemistry, c2004
Descrizione fisica 1 online resource (257 p.)
Disciplina 615.109
Collana RSC paperbacks
Soggetto topico Drugs - Research - History
Pharmacology - History
Drugs - History
Soggetto genere / forma Electronic books.
ISBN 1-84755-122-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Life Saving DrugsOFC; LSD_Pre-i-viii; LSD_Ch01_001_010; LSD_Ch02_011_084; LSD_Ch03_085_140; LSD_Ch04_141_222; LSD_Ch05_223_232; LSD_Further reading_233_240; LSD_Subject Index_241_248
Record Nr. UNINA-9910455222203321
Mann J  
Cambridge, U.K., : Royal Society of Chemistry, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Life saving drugs [[electronic resource] ] : the elusive magic bullet / / John Mann
Life saving drugs [[electronic resource] ] : the elusive magic bullet / / John Mann
Autore Mann J
Pubbl/distr/stampa Cambridge, U.K., : Royal Society of Chemistry, c2004
Descrizione fisica 1 online resource (257 p.)
Disciplina 615.109
Collana RSC paperbacks
Soggetto topico Drugs - Research - History
Pharmacology - History
Drugs - History
ISBN 1-84755-122-X
Classificazione 44.42
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Life Saving DrugsOFC; LSD_Pre-i-viii; LSD_Ch01_001_010; LSD_Ch02_011_084; LSD_Ch03_085_140; LSD_Ch04_141_222; LSD_Ch05_223_232; LSD_Further reading_233_240; LSD_Subject Index_241_248
Record Nr. UNINA-9910778311103321
Mann J  
Cambridge, U.K., : Royal Society of Chemistry, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Life saving drugs : the elusive magic bullet / / John Mann
Life saving drugs : the elusive magic bullet / / John Mann
Autore Mann J
Edizione [1st ed.]
Pubbl/distr/stampa Cambridge, U.K., : Royal Society of Chemistry, c2004
Descrizione fisica 1 online resource (257 p.)
Disciplina 615.109
Collana ISSN
RSC paperbacks
Soggetto topico Drugs - Research - History
Pharmacology - History
Drugs - History
ISBN 1-84755-122-X
Classificazione 44.42
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Life Saving DrugsOFC; LSD_Pre-i-viii; LSD_Ch01_001_010; LSD_Ch02_011_084; LSD_Ch03_085_140; LSD_Ch04_141_222; LSD_Ch05_223_232; LSD_Further reading_233_240; LSD_Subject Index_241_248
Record Nr. UNINA-9910817125403321
Mann J  
Cambridge, U.K., : Royal Society of Chemistry, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Top drugs : history, pharmacology, syntheses / / Jie Jack Li
Top drugs : history, pharmacology, syntheses / / Jie Jack Li
Autore Li Jie Jack
Pubbl/distr/stampa New York, New York : , : Oxford University Press, , 2015
Descrizione fisica 1 online resource (219 p.)
Disciplina 615.1
Collana Oxford scholarship online
Soggetto topico Drugs - History
Drugs - Design
Pharmaceutical chemistry
Soggetto genere / forma Electronic books.
ISBN 0-19-756291-4
0-19-936260-2
0-19-936259-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cover; Top Drugs History, Pharmacology, and Syntheses; Copyright; Dedication; Contents; Preface; Cardiovascular Drugs; Chapter 1: Atorvastatin Calcium (Lipitor); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 2: Clopidogrel Bisulfate (Plavix); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Bioavailability, Metabolism, and Toxicology; 2.2 Mechanism of Action; 2.3 Structure-Activity Relationship; 3 SYNTHESIS
3.1 Discovery Route3.2 Process Route; 3.3 Synthesis of Radio-labeled API; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 3: Amlodipine (Novasc); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Cancer Drugs; Chapter 4: Paclitaxel (Taxol); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 PROCESS SEMI-SYNTHESIS; 4 TOTAL SYNTHESIS
4.1 Holton's Synthesis4.2 Nicolaou's Synthesis; 4.3 Danishefsky's Synthesis; 4.4 Wender's Synthesis; 5 CONCLUDING REMARKS; 6 REFERENCES; Chapter 5: Imatinib Mesylate (Gleevec); 1 HISTORY; 1.1 A Brief History of Cancer Drugs; 1.2 Treatments of Chronic Myeloid Leukemia; 1.3 Protein Kinase Inhibitors; 1.4 Genesis of Gleevec; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Synthesis; 3.2 Process Synthesis; 4 CONCLUDING REMARKS; 5 REFERENCES; Drugs for Metabolic Diseases
Chapter 6: Sitagliptin (Januvia)1 HISTORY OF DIABETES AND DIABETIC DRUGS; 1.1 Sulfonylureas; 1.2. Biguanides; 1.3 PPARγ Agonists ; 2 PHARMACOLOGY; 2.1 Mechanism of Action ; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESES; 3.1 Discovery Synthesis; 3.2 Process/Manufacturing Synthesis; 4 CONCLUDING REMARKS; 5 REFERENCES; CNS Drugs; Chapter 7: Duloxetine Hydrochloride (Cymbalta) ; 1 HISTORY OF DEPRESSION AND ANTIDEPRESSANTS; 1.1 Monoamine Oxidase Inhibitors; 1.2 Tricyclic Antidepressants; 1.3 Selective Serotonin Reuptake Inhibitors
1.4 Serotonin and Norepinephrine Reuptake Inhibitors2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology ; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 8: Olanzapine (Zyprexa) ; 1 HISTORY OF SCHIZOPHRENIA AND ANTIPSYCHOTIC DRUGS ; 1.1 Typical Antipsychotics-The First Generation; 1.2 Atypical Antipsychotics-The Second Generation; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS
3.1 Discovery Route
Record Nr. UNINA-9910460278403321
Li Jie Jack  
New York, New York : , : Oxford University Press, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Top drugs : history, pharmacology, syntheses / / Jie Jack Li
Top drugs : history, pharmacology, syntheses / / Jie Jack Li
Autore Li Jie Jack
Pubbl/distr/stampa New York, New York : , : Oxford University Press, , 2015
Descrizione fisica 1 online resource (219 p.)
Disciplina 615.1
Collana Oxford scholarship online
Soggetto topico Drugs - History
Drugs - Design
Pharmaceutical chemistry
ISBN 0-19-756291-4
0-19-936260-2
0-19-936259-9
Classificazione MED071000SCI013060
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cover; Top Drugs History, Pharmacology, and Syntheses; Copyright; Dedication; Contents; Preface; Cardiovascular Drugs; Chapter 1: Atorvastatin Calcium (Lipitor); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 2: Clopidogrel Bisulfate (Plavix); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Bioavailability, Metabolism, and Toxicology; 2.2 Mechanism of Action; 2.3 Structure-Activity Relationship; 3 SYNTHESIS
3.1 Discovery Route3.2 Process Route; 3.3 Synthesis of Radio-labeled API; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 3: Amlodipine (Novasc); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Cancer Drugs; Chapter 4: Paclitaxel (Taxol); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 PROCESS SEMI-SYNTHESIS; 4 TOTAL SYNTHESIS
4.1 Holton's Synthesis4.2 Nicolaou's Synthesis; 4.3 Danishefsky's Synthesis; 4.4 Wender's Synthesis; 5 CONCLUDING REMARKS; 6 REFERENCES; Chapter 5: Imatinib Mesylate (Gleevec); 1 HISTORY; 1.1 A Brief History of Cancer Drugs; 1.2 Treatments of Chronic Myeloid Leukemia; 1.3 Protein Kinase Inhibitors; 1.4 Genesis of Gleevec; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Synthesis; 3.2 Process Synthesis; 4 CONCLUDING REMARKS; 5 REFERENCES; Drugs for Metabolic Diseases
Chapter 6: Sitagliptin (Januvia)1 HISTORY OF DIABETES AND DIABETIC DRUGS; 1.1 Sulfonylureas; 1.2. Biguanides; 1.3 PPARγ Agonists ; 2 PHARMACOLOGY; 2.1 Mechanism of Action ; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESES; 3.1 Discovery Synthesis; 3.2 Process/Manufacturing Synthesis; 4 CONCLUDING REMARKS; 5 REFERENCES; CNS Drugs; Chapter 7: Duloxetine Hydrochloride (Cymbalta) ; 1 HISTORY OF DEPRESSION AND ANTIDEPRESSANTS; 1.1 Monoamine Oxidase Inhibitors; 1.2 Tricyclic Antidepressants; 1.3 Selective Serotonin Reuptake Inhibitors
1.4 Serotonin and Norepinephrine Reuptake Inhibitors2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology ; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 8: Olanzapine (Zyprexa) ; 1 HISTORY OF SCHIZOPHRENIA AND ANTIPSYCHOTIC DRUGS ; 1.1 Typical Antipsychotics-The First Generation; 1.2 Atypical Antipsychotics-The Second Generation; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS
3.1 Discovery Route
Record Nr. UNINA-9910797122703321
Li Jie Jack  
New York, New York : , : Oxford University Press, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Top drugs : history, pharmacology, syntheses / / Jie Jack Li
Top drugs : history, pharmacology, syntheses / / Jie Jack Li
Autore Li Jie Jack
Pubbl/distr/stampa New York, New York : , : Oxford University Press, , 2015
Descrizione fisica 1 online resource (219 p.)
Disciplina 615.1
Collana Oxford scholarship online
Soggetto topico Drugs - History
Drugs - Design
Pharmaceutical chemistry
ISBN 0-19-756291-4
0-19-936260-2
0-19-936259-9
Classificazione MED071000SCI013060
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cover; Top Drugs History, Pharmacology, and Syntheses; Copyright; Dedication; Contents; Preface; Cardiovascular Drugs; Chapter 1: Atorvastatin Calcium (Lipitor); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 2: Clopidogrel Bisulfate (Plavix); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Bioavailability, Metabolism, and Toxicology; 2.2 Mechanism of Action; 2.3 Structure-Activity Relationship; 3 SYNTHESIS
3.1 Discovery Route3.2 Process Route; 3.3 Synthesis of Radio-labeled API; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 3: Amlodipine (Novasc); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Cancer Drugs; Chapter 4: Paclitaxel (Taxol); 1 HISTORY; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 PROCESS SEMI-SYNTHESIS; 4 TOTAL SYNTHESIS
4.1 Holton's Synthesis4.2 Nicolaou's Synthesis; 4.3 Danishefsky's Synthesis; 4.4 Wender's Synthesis; 5 CONCLUDING REMARKS; 6 REFERENCES; Chapter 5: Imatinib Mesylate (Gleevec); 1 HISTORY; 1.1 A Brief History of Cancer Drugs; 1.2 Treatments of Chronic Myeloid Leukemia; 1.3 Protein Kinase Inhibitors; 1.4 Genesis of Gleevec; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS; 3.1 Discovery Synthesis; 3.2 Process Synthesis; 4 CONCLUDING REMARKS; 5 REFERENCES; Drugs for Metabolic Diseases
Chapter 6: Sitagliptin (Januvia)1 HISTORY OF DIABETES AND DIABETIC DRUGS; 1.1 Sulfonylureas; 1.2. Biguanides; 1.3 PPARγ Agonists ; 2 PHARMACOLOGY; 2.1 Mechanism of Action ; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESES; 3.1 Discovery Synthesis; 3.2 Process/Manufacturing Synthesis; 4 CONCLUDING REMARKS; 5 REFERENCES; CNS Drugs; Chapter 7: Duloxetine Hydrochloride (Cymbalta) ; 1 HISTORY OF DEPRESSION AND ANTIDEPRESSANTS; 1.1 Monoamine Oxidase Inhibitors; 1.2 Tricyclic Antidepressants; 1.3 Selective Serotonin Reuptake Inhibitors
1.4 Serotonin and Norepinephrine Reuptake Inhibitors2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology ; 3 SYNTHESIS; 3.1 Discovery Route; 3.2 Process Route; 4 CONCLUDING REMARKS; 5 REFERENCES; Chapter 8: Olanzapine (Zyprexa) ; 1 HISTORY OF SCHIZOPHRENIA AND ANTIPSYCHOTIC DRUGS ; 1.1 Typical Antipsychotics-The First Generation; 1.2 Atypical Antipsychotics-The Second Generation; 2 PHARMACOLOGY; 2.1 Mechanism of Action; 2.2 Structure-Activity Relationship; 2.3 Bioavailability, Metabolism, and Toxicology; 3 SYNTHESIS
3.1 Discovery Route
Record Nr. UNINA-9910826031703321
Li Jie Jack  
New York, New York : , : Oxford University Press, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui