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ADVERSE DRUG INTERACTIONS : a handbook for prescribers
ADVERSE DRUG INTERACTIONS : a handbook for prescribers
Edizione [Second edition.]
Pubbl/distr/stampa [Place of publication not identified], : CRC Press, 2017
Descrizione fisica 1 online resource (1,214 pages)
Disciplina 615.7/045
Soggetto topico Drugs - Side effects
Drug interactions
ISBN 0-429-58633-7
0-429-16002-X
1-4822-3622-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Acknowledgments -- Abbreviations -- Preface -- Easy Reference Guide to Drugs -- Introduction -- Drug Metabolism and Elimination -- Individual Variability of Adverse Drug Interactions -- Pathological States That Are Associated with Increased Risk of Adverse Drug Interactions -- Special Populations at Higher Risk of Adverse Drug Interactions -- Specific Clinical Problems -- Editors -- Contributors -- Part 1: Drugs Acting on the Cardiovascular System -- Part 2: Drugs Acting on the Central Nervous System -- Part 3: Anticancer and Immunomodulating Drugs -- Part 4: Anticoagulants -- Part 5: Antidiabetic Drugs -- Part 6: Other Endocrine Drugs -- Part 7: Analgesics -- Part 8: Musculoskeletal Drugs -- Part 9: Anesthetic Drugs -- Part 10: Drugs to Treat Infections -- Part 11: Drugs Acting on the Gastrointestinal Tract -- Part 12: Respiratory Drugs -- Part 13: Metabolic Drugs -- Part 14: Obstetrics and Gynecology -- Part 15: Drugs Used to Treat the Urinary System -- Part 16: Drugs of Abuse -- Part 17: Miscellaneous -- Part 18: Over-the-Counter/Online Drugs and Remedies -- Appendix A: Factors Associated with Drug Effects -- Appendix B: Factors Associated with Interactions -- Appendix C: Foods Implicated in Potentially Severe Interactions -- Appendix D: Clinical Drug Development -- Appendix E: Assessments of Manifestations of DDIs -- Appendix F: Triptan Sensations -- Appendix G: Assessment of Severity of Liver Disease -- Appendix H: Prescribing Guidelines for Elderly Patients -- Appendix I: Factors Affecting Efficacy of Anti-Infective Agents -- Appendix J: Assessments of Obesity.
Record Nr. UNINA-9910154926203321
[Place of publication not identified], : CRC Press, 2017
Materiale a stampa
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Antiepileptic drug interactions : a clinical guide / / P.N. Patsalos
Antiepileptic drug interactions : a clinical guide / / P.N. Patsalos
Autore Patsalos P. N
Edizione [2nd ed.]
Pubbl/distr/stampa New York, : Springer, 2013
Descrizione fisica 1 online resource (463 p.)
Disciplina 615.7045
Soggetto topico Anticonvulsants
Drug interactions
ISBN 1-283-93329-2
1-4471-2434-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto pt. I. Drug interactions between AEDs -- pt. II. Drug interactions between AEDs and non-AED drugs : interactions affecting AEDs -- pt. III. Drug interactions between AEDs and non-AED drugs : interactions affected by AEDs.
Record Nr. UNINA-9910438018603321
Patsalos P. N  
New York, : Springer, 2013
Materiale a stampa
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Antiseizure medication interactions : a clinical guide / / Philip N. Patsalos
Antiseizure medication interactions : a clinical guide / / Philip N. Patsalos
Autore Patsalos Philip N.
Edizione [4th ed.]
Pubbl/distr/stampa Cham, Switzerland : , : Springer International Publishing, , [2022]
Descrizione fisica 1 online resource (327 pages)
Disciplina 615.7045
Soggetto topico Drug interactions
Drug interactions - Data processing
Anticonvulsius
Interaccions dels medicaments
Soggetto genere / forma Llibres electrònics
ISBN 3-030-82790-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910522937103321
Patsalos Philip N.  
Cham, Switzerland : , : Springer International Publishing, , [2022]
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Antitargets [[electronic resource] ] : prediction and prevention of drug side effects / / edited by Roy J. Vaz and Thomas Klabunde
Antitargets [[electronic resource] ] : prediction and prevention of drug side effects / / edited by Roy J. Vaz and Thomas Klabunde
Pubbl/distr/stampa Weinheim, : Wiley-VCH
Descrizione fisica 1 online resource (506 p.)
Disciplina 615.704
Altri autori (Persone) VazRoy J
KlabundeThomas
Collana Methods and principles in medicinal chemistry
Soggetto topico Drugs - Side effects
Drugs - Side effects - Prevention
Drug interactions
Drug development
Drugs - Structure-activity relationships
Soggetto genere / forma Electronic books.
ISBN 1-282-78430-7
9786612784309
3-527-62147-4
3-527-62146-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Antitargets; Contents; List of Contributors; Preface; I General Aspects; 1 Why Drugs Fail - A Study on Side Effects in New Chemical Entities; 1.1 Introduction; 1.2 Drugs Withdrawn from the Market between 1992 and 2006 Listed Alphabetically; 1.2.1 Amineptine; 1.2.2 Aminophenazone (Aminopyrine); 1.2.3 Astemizole; 1.2.4 Bromfenac Sodium; 1.2.5 Cerivastatin; 1.2.6 Chlormezanone; 1.2.7 Fenfluramine and Dexfenfluramine; 1.2.8 Flosequinan; 1.2.9 Glafenine; 1.2.10 Grepafloxacin; 1.2.11 Levacetylmethadol; 1.2.12 Mibefradil; 1.2.13 Rapacuronium Bromide; 1.2.14 Rofecoxib; 1.2.15 Temafloxacin
1.2.16 Troglitazone1.2.17 Ximelagatran; 1.3 Borderline Cases; 1.4 Investigational Drugs That Failed in Clinical Phases from 1992 to 2002; 1.4.1 A Case Study: Fialuridine; 1.4.2 A Recent Case Study: Torcetrapib; 1.4.3 General Reasons for Project Failing in Clinical Phases I-III; 1.5 Strategies for Avoiding Failure; 1.6 An Unusual Case: The Revival of Thalidomide; References; 2 Use of Broad Biological Profiling as a Relevant Descriptor to Describe and Differentiate Compounds: Structure-In Vitro (Pharmacology-ADME)-In Vivo (Safety) Relationships; 2.1 Introduction
2.1.1 Biological Profiling/Fingerprints and Drug Discovery Applications2.1.2 Polypharmacology of Drugs; 2.2 The BioPrint(®) Approach; 2.2.1 BioPrint(®) - General; 2.2.2 BioPrint(®) Assay Selection and Profile Description; 2.2.3 Compounds in BioPrint(®); 2.2.4 BioPrint(®) In Vivo Data sets; 2.2.4.1 Compound Details; 2.2.4.2 ADR Data; 2.2.4.3 Pharmacokinetics; 2.2.4.4 Toxicity Data; 2.3 Structure-In Vitro Relationships; 2.3.1 Similarity, Chemotypes - What Is a Biologically Relevant Descriptor?; 2.3.2 Using Biological Fingerprints as a Meaningful Descriptor for Drug Leads and Candidates
2.3.2.1 Differentiation of Leads2.3.2.2 Analysis of Attrited Compounds; 2.3.3 Structural versus Experimental Differentiation - Dependence on Structure-Derived Descriptor Used; 2.3.4 Predictive Models from Pharmacological Data; 2.3.5 Predictive Models from ADME Data - BioPrint(®) Learnings; 2.4 Chemogenomic Analysis - Target-Target Relationships; 2.5 In Vitro-In Vivo Relationships - Placing Drug Candidates in the Context of BioPrint(®); 2.5.1 Analyzing Potential ADR Liabilities Based on Individual Hits; 2.5.2 Analyzing Potential ADR Liabilities Based on Profile Similarity
2.6 A Perspective for the FutureReferences; II Antitargets: Ion Channels and GPCRs; 3 Pharmacological and Regulatory Aspects of QT Prolongation; 3.1 Introduction; 3.2 hERG: Target Versus Antitarget; 3.3 Pharmacology of QT Prolongation; 3.3.1 Multiple Mechanisms Leading to QT Prolongation; 3.3.2 hERG as the Key Mechanism for the Drug-Induced Long QT Syndrome; 3.3.3 Pharmacogenetic Aspects; 3.4 Significance of Drug-Induced QT Prolongation; 3.4.1 Prolonged QT/QTc and Occurrence of TdP; 3.4.2 Dose-Response Relationship for QT Prolongation; 3.5 Regulatory Aspects of QT Prolongation
3.5.1 Regulatory Guidance Documents
Record Nr. UNINA-9910145982103321
Weinheim, : Wiley-VCH
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Antitargets [[electronic resource] ] : prediction and prevention of drug side effects / / edited by Roy J. Vaz and Thomas Klabunde
Antitargets [[electronic resource] ] : prediction and prevention of drug side effects / / edited by Roy J. Vaz and Thomas Klabunde
Pubbl/distr/stampa Weinheim, : Wiley-VCH
Descrizione fisica 1 online resource (506 p.)
Disciplina 615.704
Altri autori (Persone) VazRoy J
KlabundeThomas
Collana Methods and principles in medicinal chemistry
Soggetto topico Drugs - Side effects
Drugs - Side effects - Prevention
Drug interactions
Drug development
Drugs - Structure-activity relationships
ISBN 1-282-78430-7
9786612784309
3-527-62147-4
3-527-62146-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Antitargets; Contents; List of Contributors; Preface; I General Aspects; 1 Why Drugs Fail - A Study on Side Effects in New Chemical Entities; 1.1 Introduction; 1.2 Drugs Withdrawn from the Market between 1992 and 2006 Listed Alphabetically; 1.2.1 Amineptine; 1.2.2 Aminophenazone (Aminopyrine); 1.2.3 Astemizole; 1.2.4 Bromfenac Sodium; 1.2.5 Cerivastatin; 1.2.6 Chlormezanone; 1.2.7 Fenfluramine and Dexfenfluramine; 1.2.8 Flosequinan; 1.2.9 Glafenine; 1.2.10 Grepafloxacin; 1.2.11 Levacetylmethadol; 1.2.12 Mibefradil; 1.2.13 Rapacuronium Bromide; 1.2.14 Rofecoxib; 1.2.15 Temafloxacin
1.2.16 Troglitazone1.2.17 Ximelagatran; 1.3 Borderline Cases; 1.4 Investigational Drugs That Failed in Clinical Phases from 1992 to 2002; 1.4.1 A Case Study: Fialuridine; 1.4.2 A Recent Case Study: Torcetrapib; 1.4.3 General Reasons for Project Failing in Clinical Phases I-III; 1.5 Strategies for Avoiding Failure; 1.6 An Unusual Case: The Revival of Thalidomide; References; 2 Use of Broad Biological Profiling as a Relevant Descriptor to Describe and Differentiate Compounds: Structure-In Vitro (Pharmacology-ADME)-In Vivo (Safety) Relationships; 2.1 Introduction
2.1.1 Biological Profiling/Fingerprints and Drug Discovery Applications2.1.2 Polypharmacology of Drugs; 2.2 The BioPrint(®) Approach; 2.2.1 BioPrint(®) - General; 2.2.2 BioPrint(®) Assay Selection and Profile Description; 2.2.3 Compounds in BioPrint(®); 2.2.4 BioPrint(®) In Vivo Data sets; 2.2.4.1 Compound Details; 2.2.4.2 ADR Data; 2.2.4.3 Pharmacokinetics; 2.2.4.4 Toxicity Data; 2.3 Structure-In Vitro Relationships; 2.3.1 Similarity, Chemotypes - What Is a Biologically Relevant Descriptor?; 2.3.2 Using Biological Fingerprints as a Meaningful Descriptor for Drug Leads and Candidates
2.3.2.1 Differentiation of Leads2.3.2.2 Analysis of Attrited Compounds; 2.3.3 Structural versus Experimental Differentiation - Dependence on Structure-Derived Descriptor Used; 2.3.4 Predictive Models from Pharmacological Data; 2.3.5 Predictive Models from ADME Data - BioPrint(®) Learnings; 2.4 Chemogenomic Analysis - Target-Target Relationships; 2.5 In Vitro-In Vivo Relationships - Placing Drug Candidates in the Context of BioPrint(®); 2.5.1 Analyzing Potential ADR Liabilities Based on Individual Hits; 2.5.2 Analyzing Potential ADR Liabilities Based on Profile Similarity
2.6 A Perspective for the FutureReferences; II Antitargets: Ion Channels and GPCRs; 3 Pharmacological and Regulatory Aspects of QT Prolongation; 3.1 Introduction; 3.2 hERG: Target Versus Antitarget; 3.3 Pharmacology of QT Prolongation; 3.3.1 Multiple Mechanisms Leading to QT Prolongation; 3.3.2 hERG as the Key Mechanism for the Drug-Induced Long QT Syndrome; 3.3.3 Pharmacogenetic Aspects; 3.4 Significance of Drug-Induced QT Prolongation; 3.4.1 Prolonged QT/QTc and Occurrence of TdP; 3.4.2 Dose-Response Relationship for QT Prolongation; 3.5 Regulatory Aspects of QT Prolongation
3.5.1 Regulatory Guidance Documents
Record Nr. UNINA-9910830632603321
Weinheim, : Wiley-VCH
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Antitargets : prediction and prevention of drug side effects / / edited by Roy J. Vaz and Thomas Klabunde
Antitargets : prediction and prevention of drug side effects / / edited by Roy J. Vaz and Thomas Klabunde
Pubbl/distr/stampa Weinheim, : Wiley-VCH
Descrizione fisica 1 online resource (506 p.)
Disciplina 615.704
Altri autori (Persone) VazRoy J
KlabundeThomas
Collana Methods and principles in medicinal chemistry
Soggetto topico Drugs - Side effects
Drugs - Side effects - Prevention
Drug interactions
Drug development
Drugs - Structure-activity relationships
ISBN 1-282-78430-7
9786612784309
3-527-62147-4
3-527-62146-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Antitargets; Contents; List of Contributors; Preface; I General Aspects; 1 Why Drugs Fail - A Study on Side Effects in New Chemical Entities; 1.1 Introduction; 1.2 Drugs Withdrawn from the Market between 1992 and 2006 Listed Alphabetically; 1.2.1 Amineptine; 1.2.2 Aminophenazone (Aminopyrine); 1.2.3 Astemizole; 1.2.4 Bromfenac Sodium; 1.2.5 Cerivastatin; 1.2.6 Chlormezanone; 1.2.7 Fenfluramine and Dexfenfluramine; 1.2.8 Flosequinan; 1.2.9 Glafenine; 1.2.10 Grepafloxacin; 1.2.11 Levacetylmethadol; 1.2.12 Mibefradil; 1.2.13 Rapacuronium Bromide; 1.2.14 Rofecoxib; 1.2.15 Temafloxacin
1.2.16 Troglitazone1.2.17 Ximelagatran; 1.3 Borderline Cases; 1.4 Investigational Drugs That Failed in Clinical Phases from 1992 to 2002; 1.4.1 A Case Study: Fialuridine; 1.4.2 A Recent Case Study: Torcetrapib; 1.4.3 General Reasons for Project Failing in Clinical Phases I-III; 1.5 Strategies for Avoiding Failure; 1.6 An Unusual Case: The Revival of Thalidomide; References; 2 Use of Broad Biological Profiling as a Relevant Descriptor to Describe and Differentiate Compounds: Structure-In Vitro (Pharmacology-ADME)-In Vivo (Safety) Relationships; 2.1 Introduction
2.1.1 Biological Profiling/Fingerprints and Drug Discovery Applications2.1.2 Polypharmacology of Drugs; 2.2 The BioPrint(®) Approach; 2.2.1 BioPrint(®) - General; 2.2.2 BioPrint(®) Assay Selection and Profile Description; 2.2.3 Compounds in BioPrint(®); 2.2.4 BioPrint(®) In Vivo Data sets; 2.2.4.1 Compound Details; 2.2.4.2 ADR Data; 2.2.4.3 Pharmacokinetics; 2.2.4.4 Toxicity Data; 2.3 Structure-In Vitro Relationships; 2.3.1 Similarity, Chemotypes - What Is a Biologically Relevant Descriptor?; 2.3.2 Using Biological Fingerprints as a Meaningful Descriptor for Drug Leads and Candidates
2.3.2.1 Differentiation of Leads2.3.2.2 Analysis of Attrited Compounds; 2.3.3 Structural versus Experimental Differentiation - Dependence on Structure-Derived Descriptor Used; 2.3.4 Predictive Models from Pharmacological Data; 2.3.5 Predictive Models from ADME Data - BioPrint(®) Learnings; 2.4 Chemogenomic Analysis - Target-Target Relationships; 2.5 In Vitro-In Vivo Relationships - Placing Drug Candidates in the Context of BioPrint(®); 2.5.1 Analyzing Potential ADR Liabilities Based on Individual Hits; 2.5.2 Analyzing Potential ADR Liabilities Based on Profile Similarity
2.6 A Perspective for the FutureReferences; II Antitargets: Ion Channels and GPCRs; 3 Pharmacological and Regulatory Aspects of QT Prolongation; 3.1 Introduction; 3.2 hERG: Target Versus Antitarget; 3.3 Pharmacology of QT Prolongation; 3.3.1 Multiple Mechanisms Leading to QT Prolongation; 3.3.2 hERG as the Key Mechanism for the Drug-Induced Long QT Syndrome; 3.3.3 Pharmacogenetic Aspects; 3.4 Significance of Drug-Induced QT Prolongation; 3.4.1 Prolonged QT/QTc and Occurrence of TdP; 3.4.2 Dose-Response Relationship for QT Prolongation; 3.5 Regulatory Aspects of QT Prolongation
3.5.1 Regulatory Guidance Documents
Record Nr. UNINA-9910877316903321
Weinheim, : Wiley-VCH
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Antitargets and drug safety / / edited by Lásló Urbán, Vinod F. Patel, and Roy J. Vaz
Antitargets and drug safety / / edited by Lásló Urbán, Vinod F. Patel, and Roy J. Vaz
Pubbl/distr/stampa Weinheim, Germany : , : Wiley-VCH, , [2015]
Descrizione fisica 1 online resource (1266 p.)
Disciplina 615.19
Collana Methods and principles in medicinal chemistry
Soggetto topico Drugs - Side effects
Drugs - Side effects - Prevention
Drug interactions
Drug development
Drugs - Structure-activity relationships
Drug-Related Side Effects and Adverse Reactions
Protein Kinase Inhibitors - adverse effects
Pharmacovigilance
ISBN 3-527-67364-4
3-527-67366-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto section 1. General concept for target-based safety assessment -- section 2. Hepatic side effects -- section 3. Cardiovascular side effects -- section 4. Kinase antitargets -- section 5. Examples of clinical translation.
Record Nr. UNINA-9910132261703321
Weinheim, Germany : , : Wiley-VCH, , [2015]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Antitargets and drug safety / / edited by Lásló Urbán, Vinod F. Patel, and Roy J. Vaz
Antitargets and drug safety / / edited by Lásló Urbán, Vinod F. Patel, and Roy J. Vaz
Pubbl/distr/stampa Weinheim, Germany : , : Wiley-VCH, , [2015]
Descrizione fisica 1 online resource (1266 p.)
Disciplina 615.19
Collana Methods and principles in medicinal chemistry
Soggetto topico Drugs - Side effects
Drugs - Side effects - Prevention
Drug interactions
Drug development
Drugs - Structure-activity relationships
Drug-Related Side Effects and Adverse Reactions
Protein Kinase Inhibitors - adverse effects
Pharmacovigilance
ISBN 3-527-67364-4
3-527-67366-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto section 1. General concept for target-based safety assessment -- section 2. Hepatic side effects -- section 3. Cardiovascular side effects -- section 4. Kinase antitargets -- section 5. Examples of clinical translation.
Record Nr. UNINA-9910823349403321
Weinheim, Germany : , : Wiley-VCH, , [2015]
Materiale a stampa
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Applications of Mass Spectrometry in Microbiology : From Strain Characterization to Rapid Screening for Antibiotic Resistance / / edited by Plamen Demirev, Todd R. Sandrin
Applications of Mass Spectrometry in Microbiology : From Strain Characterization to Rapid Screening for Antibiotic Resistance / / edited by Plamen Demirev, Todd R. Sandrin
Edizione [1st ed. 2016.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Descrizione fisica 1 online resource (336 p.)
Disciplina 540
Soggetto topico Mass spectrometry
Microbiology
Epidemiology
Drug interactions
Mass Spectrometry
Applied Microbiology
Drug Resistance
ISBN 3-319-26070-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Introduction -- SECTION I. METHODOLOGY AND TECHNIQUES.-  Methods and instrumentation in mass spectrometry for the differentiation of closely related microorganisms.- Sample preparation methods for the rapid MS analysis of microorganisms.-  Advantages offered by proteomic strategies for rapid biodetection.- Bottom Up Proteomics Methods for Strain-Level Typing and Identification of Bacteria.- Maximizing the taxonomic resolution of MALDI-TOF-MS-based approaches to bacterial characterization:  From culture conditions through data analysis -- SECTION II. SUB-SPECIES DISCRIMINATION.-   Modulation of the Discriminatory Power of MALDI-TOF MS Profiling for Distinguishing between Closely Related Bacterial Strains.-  Discriminatory Power of MALDI-TOF Mass Spectrometry for Phylogenetically Closely Related Microbial Strains.- MALDI-TOF MS as a novel tool for dereplication and characterization of microbiota in bacterial diversity studies.- Bacterial Identification at the Serovar level by Top-down Mass Spectrometry -- SECTION III. DRUG RESISTANCE MONITORING AND ASSAYS.- Rapid profiling of human pathogenic bacteria and antibiotic resistance employing specific tryptic peptides as biomarkers.- Detection of β-lactamases and their activity using MALDI-TOF MS.- Stable-isotope based strategies for rapid determination of drug resistance by mass spectrometry.
Record Nr. UNINA-9910254053303321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Dangerous drug interactions
Dangerous drug interactions
Pubbl/distr/stampa [Rockville, Md.] : , : Department of Health & Human Services, Substance Abuse and Mental Health Services Administration
Descrizione fisica 1 online resource (1 unnumbered page) : illustrations
Collana Rx pain medications: know the options, get the facts
SMA
Soggetto topico Drug interactions
Opioids - Administration
Drugs - Prescribing - Management
Pain - Treatment - Management
Pain medicine
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910716900603321
[Rockville, Md.] : , : Department of Health & Human Services, Substance Abuse and Mental Health Services Administration
Materiale a stampa
Lo trovi qui: Univ. Federico II
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