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Pharmaceutical blending and mixing / / edited by P.J. Cullen, School of Chemical Engineering, University of New South Wales, Australia [and three others]
| Pharmaceutical blending and mixing / / edited by P.J. Cullen, School of Chemical Engineering, University of New South Wales, Australia [and three others] |
| Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2015 |
| Descrizione fisica | 1 online resource (511 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Pharmaceutical technology
Drug factories Pharmaceutical industry |
| ISBN |
1-118-68280-7
1-118-68269-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Title Page; Copyright Page; Contents; Contributor List; Preface; Part I Fundamentals of Mixing; Chapter 1 Mixing Theory; 1.1 Introduction; 1.2 Describing Mixtures; 1.3 Scale of Scrutiny; 1.4 Quantifying Mixedness for Coarse and Fine-Grained Mixtures; 1.4.1 Coarse and Fine-Grained Mixtures; 1.4.2 Scale and Intensity of Segregation; 1.5 Determining the End-Point of Mixing: Comparison of Mixing Indices; 1.6 Continuous Flow Mixers; 1.6.1 Idealized Mixing Patterns; 1.6.2 Residence Time Distributions; 1.6.3 Back-Mixing and Filtering of Disturbances Using a CSTR; References
Chapter 2 Turbulent Mixing Fundamentals2.1 Introduction; 2.2 The Velocity Field and Turbulence; 2.3 Circulation and Macro-Mixing; 2.4 Fully Turbulent Limits and the Scaling of Turbulence; 2.5 The Spectrum of Turbulent Length Scales, Injection of a Scalar (Either Reagent or Additive) and the Macro-, Meso- and Micro-Scales of Mixing; 2.6 Turbulence and Mixing of Solids, Liquids, and Gases; 2.7 Specifying Mixing Requirements for a Process; 2.8 Conclusions; Notation; Roman Characters; Greek Characters; References; Chapter 3 Laminar Mixing Fundamentals; 3.1 Laminar Flows 3.2 Mixing in Laminar Flows3.2.1 Chaos and Laminar Chaotic Mixing; 3.2.2 Granular Chaotic Mixing; 3.3 Recent Advances; References; Chapter 4 Sampling and Determination of Adequacy of Mixing; 4.1 Introduction, Process Understanding, and Regulations; 4.2 Theory of Sampling; 4.3 Sampling of Pharmaceutical Powder Blends; 4.4 Stratified Sampling Approach; 4.5 Testing; 4.6 Process Knowledge/Process Analytical Technology; 4.7 Real Time Spectroscopic Monitoring of Powder Blending; 4.8 Looking Forward, Recommendations; 4.9 Conclusion; 4.10 Acknowledgments; References; Part II Applications Chapter 5 Particles and Blending5.1 Introduction; 5.2 Particle Geometry; 5.2.1 Particle Size and Size Distribution; 5.2.2 Particle Shape and Shape Distribution; 5.3 Particle Interactions; 5.3.1 van der Waals Forces; 5.3.2 Electrostatic Forces; 5.3.3 Adsorbed Liquid Layers and Liquid Bridges; 5.3.4 Solid Bridges; 5.3.5 Use of AFM to Measure Interparticle Forces; 5.3.6 Interparticle Friction; 5.4 Empirical Investigations of Particles and Blending; 5.4.1 Blending of Powders; 5.4.2 Impact of Particle Geometry on Blending; 5.4.3 Impact of Interparticle Forces on Blending 5.4.4 Impact of Blender Conditions on Blending5.5 Simulation Techniques; 5.5.1 Full Physics Models Using Discrete Element Modeling; 5.5.2 Continuum Models; 5.5.3 Cellular Automata; References; Chapter 6 Continuous Powder Mixing; 6.1 Introduction; 6.2 Overview; 6.3 Theoretical Characterization; 6.3.1 Residence Time Distribution (RTD) Modeling; 6.3.2 Variance Reduction Ratio; 6.4 Experimental Characterization; 6.4.1 Hold-Up; 6.4.2 Residence Time Distribution (RTD) Measurements; 6.4.3 Mean Strain; 6.5 Continuous Mixing Efficiency; 6.5.1 Variance Reduction Ratio; 6.5.2 Blend Homogeneity 6.6 Effects of Process Parameters on Mixing Behavior and Performance |
| Record Nr. | UNINA-9910140644503321 |
| Chichester, England : , : Wiley, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pharmaceutical blending and mixing / / edited by P.J. Cullen, School of Chemical Engineering, University of New South Wales, Australia [and three others]
| Pharmaceutical blending and mixing / / edited by P.J. Cullen, School of Chemical Engineering, University of New South Wales, Australia [and three others] |
| Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2015 |
| Descrizione fisica | 1 online resource (511 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Pharmaceutical technology
Drug factories Pharmaceutical industry |
| ISBN |
1-118-68280-7
1-118-68269-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Title Page; Copyright Page; Contents; Contributor List; Preface; Part I Fundamentals of Mixing; Chapter 1 Mixing Theory; 1.1 Introduction; 1.2 Describing Mixtures; 1.3 Scale of Scrutiny; 1.4 Quantifying Mixedness for Coarse and Fine-Grained Mixtures; 1.4.1 Coarse and Fine-Grained Mixtures; 1.4.2 Scale and Intensity of Segregation; 1.5 Determining the End-Point of Mixing: Comparison of Mixing Indices; 1.6 Continuous Flow Mixers; 1.6.1 Idealized Mixing Patterns; 1.6.2 Residence Time Distributions; 1.6.3 Back-Mixing and Filtering of Disturbances Using a CSTR; References
Chapter 2 Turbulent Mixing Fundamentals2.1 Introduction; 2.2 The Velocity Field and Turbulence; 2.3 Circulation and Macro-Mixing; 2.4 Fully Turbulent Limits and the Scaling of Turbulence; 2.5 The Spectrum of Turbulent Length Scales, Injection of a Scalar (Either Reagent or Additive) and the Macro-, Meso- and Micro-Scales of Mixing; 2.6 Turbulence and Mixing of Solids, Liquids, and Gases; 2.7 Specifying Mixing Requirements for a Process; 2.8 Conclusions; Notation; Roman Characters; Greek Characters; References; Chapter 3 Laminar Mixing Fundamentals; 3.1 Laminar Flows 3.2 Mixing in Laminar Flows3.2.1 Chaos and Laminar Chaotic Mixing; 3.2.2 Granular Chaotic Mixing; 3.3 Recent Advances; References; Chapter 4 Sampling and Determination of Adequacy of Mixing; 4.1 Introduction, Process Understanding, and Regulations; 4.2 Theory of Sampling; 4.3 Sampling of Pharmaceutical Powder Blends; 4.4 Stratified Sampling Approach; 4.5 Testing; 4.6 Process Knowledge/Process Analytical Technology; 4.7 Real Time Spectroscopic Monitoring of Powder Blending; 4.8 Looking Forward, Recommendations; 4.9 Conclusion; 4.10 Acknowledgments; References; Part II Applications Chapter 5 Particles and Blending5.1 Introduction; 5.2 Particle Geometry; 5.2.1 Particle Size and Size Distribution; 5.2.2 Particle Shape and Shape Distribution; 5.3 Particle Interactions; 5.3.1 van der Waals Forces; 5.3.2 Electrostatic Forces; 5.3.3 Adsorbed Liquid Layers and Liquid Bridges; 5.3.4 Solid Bridges; 5.3.5 Use of AFM to Measure Interparticle Forces; 5.3.6 Interparticle Friction; 5.4 Empirical Investigations of Particles and Blending; 5.4.1 Blending of Powders; 5.4.2 Impact of Particle Geometry on Blending; 5.4.3 Impact of Interparticle Forces on Blending 5.4.4 Impact of Blender Conditions on Blending5.5 Simulation Techniques; 5.5.1 Full Physics Models Using Discrete Element Modeling; 5.5.2 Continuum Models; 5.5.3 Cellular Automata; References; Chapter 6 Continuous Powder Mixing; 6.1 Introduction; 6.2 Overview; 6.3 Theoretical Characterization; 6.3.1 Residence Time Distribution (RTD) Modeling; 6.3.2 Variance Reduction Ratio; 6.4 Experimental Characterization; 6.4.1 Hold-Up; 6.4.2 Residence Time Distribution (RTD) Measurements; 6.4.3 Mean Strain; 6.5 Continuous Mixing Efficiency; 6.5.1 Variance Reduction Ratio; 6.5.2 Blend Homogeneity 6.6 Effects of Process Parameters on Mixing Behavior and Performance |
| Record Nr. | UNINA-9910821820103321 |
| Chichester, England : , : Wiley, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Verfahrenstechnische Methoden in der Wirkstoffherstellung [[electronic resource] ] : Tipps und Tricks / / Heinz G. Kandel
| Verfahrenstechnische Methoden in der Wirkstoffherstellung [[electronic resource] ] : Tipps und Tricks / / Heinz G. Kandel |
| Autore | Kandel Heinz G |
| Edizione | [1. Aufl.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley-VCH, 2006 |
| Descrizione fisica | 1 online resource (202 p.) |
| Disciplina |
615.19
615/.19 |
| Soggetto topico |
Pharmaceutical industry
Drugs - Design Drug factories |
| Soggetto genere / forma | Electronic books. |
| ISBN |
3-527-66042-9
1-280-66314-6 9786613640079 3-527-66096-8 3-527-60780-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto |
Title Page; Inhaltsverzeichnis; Vorwort; 1 Einleitung; 2 Der Rohstoff: Blut, Blutplasma [1]; 3 Besondere Spezifitaumalten fuumalr die Verfahrenstechnik; 3.1 Molekuumallgroumalbe und Struktur; 3.2 Anzahl der Prozessstufen; 3.3 Analytik, Messmethoden; 3.4 Zulassungsproblematik; 4 Blutplasmafraktionierung; 4.1 Beschreibung des Prozesses; 4.1.1 Kryogewinnung; 4.1.2 Faumalllungsschritte; 4.1.3 Adsorptionsschritte; 4.1.4 Reinigung der Proteine, Bulkherstellung, Abfuumalllung, Gefriertrocknung; 4.2 Verfahrenstechnische Gesichtspunkte; 4.2.1 Behaumallter und Ruumalhrwerke
4.2.1.1 Allgemeine Ausruumalstung, Spezifikation4.2.1.2 Funktionstypicals; 4.2.1.3 Ruumalhrwerke; 4.2.1.4 Spezielle Einsatzfaumallle fuumal r Behaumallter; 4.2.2 Fest-Fluumalssig-Trennung; 4.2.2.1 Separatoren, Zentrifugen; 4.2.2.2 Filter; 4.2.3 Pumpen; 4.2.3.1 Kreiselpumpe; 4.2.3.2 Kolbenpumpe und Membrankolbenpumpe; 4.2.3.3 Kreiskolbenpumpe; 4.2.3.4 Schlauchpumpe; 4.2.4 Rohrleitungen, Ventile, Verbindungstechnik; 4.2.4.1 Rohrleitungen; 4.2.4.2 Schweibverbindungen; 4.2.4.3 Verbindungstechnik; 4.2.4.4 Ventiltechnik; 4.2.4.5 Messtechnik; 4.2.5 Membrantrennverfahren [10, 11] 6.5 Scale-up von Zentrifugen aus Laboroder Produktionslaumalufen6.6 Schubspannungen in Rohrleitungen; 6.7 Scale-up von Ultrafiltrationskassetten; 6.8 Scale-up von Filtern; 6.9 Berechnung der maximal moumalglichen Dosiergeschwindigkeiten von Aumalthanol bei der Faumalllung; 6.10 Schnelle Dimensionierung eines Behaumallters; 6.11 Instationaumalre Aufheizund Abkuumalhlvorgaumalnge in einem Ruumalhrbehaumallter; 6.12 Temperierung eines Behaumallters durch externen Produktkreislauf; 6.13 Temperierung eines Behaumallters mittels eines Waumalrmetraumalgerkreislaufes 6.14 Waumalrmeverlust einer isolierten Rohrleitung |
| Record Nr. | UNINA-9910144004603321 |
Kandel Heinz G
|
||
| Weinheim [Germany], : Wiley-VCH, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Verfahrenstechnische Methoden in der Wirkstoffherstellung [[electronic resource] ] : Tipps und Tricks / / Heinz G. Kandel
| Verfahrenstechnische Methoden in der Wirkstoffherstellung [[electronic resource] ] : Tipps und Tricks / / Heinz G. Kandel |
| Autore | Kandel Heinz G |
| Edizione | [1. Aufl.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley-VCH, 2006 |
| Descrizione fisica | 1 online resource (202 p.) |
| Disciplina |
615.19
615/.19 |
| Soggetto topico |
Pharmaceutical industry
Drugs - Design Drug factories |
| ISBN |
3-527-66042-9
1-280-66314-6 9786613640079 3-527-66096-8 3-527-60780-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto |
Title Page; Inhaltsverzeichnis; Vorwort; 1 Einleitung; 2 Der Rohstoff: Blut, Blutplasma [1]; 3 Besondere Spezifitaumalten fuumalr die Verfahrenstechnik; 3.1 Molekuumallgroumalbe und Struktur; 3.2 Anzahl der Prozessstufen; 3.3 Analytik, Messmethoden; 3.4 Zulassungsproblematik; 4 Blutplasmafraktionierung; 4.1 Beschreibung des Prozesses; 4.1.1 Kryogewinnung; 4.1.2 Faumalllungsschritte; 4.1.3 Adsorptionsschritte; 4.1.4 Reinigung der Proteine, Bulkherstellung, Abfuumalllung, Gefriertrocknung; 4.2 Verfahrenstechnische Gesichtspunkte; 4.2.1 Behaumallter und Ruumalhrwerke
4.2.1.1 Allgemeine Ausruumalstung, Spezifikation4.2.1.2 Funktionstypicals; 4.2.1.3 Ruumalhrwerke; 4.2.1.4 Spezielle Einsatzfaumallle fuumal r Behaumallter; 4.2.2 Fest-Fluumalssig-Trennung; 4.2.2.1 Separatoren, Zentrifugen; 4.2.2.2 Filter; 4.2.3 Pumpen; 4.2.3.1 Kreiselpumpe; 4.2.3.2 Kolbenpumpe und Membrankolbenpumpe; 4.2.3.3 Kreiskolbenpumpe; 4.2.3.4 Schlauchpumpe; 4.2.4 Rohrleitungen, Ventile, Verbindungstechnik; 4.2.4.1 Rohrleitungen; 4.2.4.2 Schweibverbindungen; 4.2.4.3 Verbindungstechnik; 4.2.4.4 Ventiltechnik; 4.2.4.5 Messtechnik; 4.2.5 Membrantrennverfahren [10, 11] 6.5 Scale-up von Zentrifugen aus Laboroder Produktionslaumalufen6.6 Schubspannungen in Rohrleitungen; 6.7 Scale-up von Ultrafiltrationskassetten; 6.8 Scale-up von Filtern; 6.9 Berechnung der maximal moumalglichen Dosiergeschwindigkeiten von Aumalthanol bei der Faumalllung; 6.10 Schnelle Dimensionierung eines Behaumallters; 6.11 Instationaumalre Aufheizund Abkuumalhlvorgaumalnge in einem Ruumalhrbehaumallter; 6.12 Temperierung eines Behaumallters durch externen Produktkreislauf; 6.13 Temperierung eines Behaumallters mittels eines Waumalrmetraumalgerkreislaufes 6.14 Waumalrmeverlust einer isolierten Rohrleitung |
| Record Nr. | UNINA-9910830633603321 |
|
Kandel Heinz G
|
||
| Weinheim [Germany], : Wiley-VCH, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Verfahrenstechnische Methoden in der Wirkstoffherstellung : Tipps und Tricks / / Heinz G. Kandel
| Verfahrenstechnische Methoden in der Wirkstoffherstellung : Tipps und Tricks / / Heinz G. Kandel |
| Autore | Kandel Heinz G |
| Edizione | [1. Aufl.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley-VCH, 2006 |
| Descrizione fisica | 1 online resource (202 p.) |
| Disciplina |
615.19
615/.19 |
| Soggetto topico |
Pharmaceutical industry
Drugs - Design Drug factories |
| ISBN |
9786613640079
9783527660421 3527660429 9781280663147 1280663146 9783527660964 3527660968 9783527607808 3527607803 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto |
Title Page; Inhaltsverzeichnis; Vorwort; 1 Einleitung; 2 Der Rohstoff: Blut, Blutplasma [1]; 3 Besondere Spezifitaumalten fuumalr die Verfahrenstechnik; 3.1 Molekuumallgroumalbe und Struktur; 3.2 Anzahl der Prozessstufen; 3.3 Analytik, Messmethoden; 3.4 Zulassungsproblematik; 4 Blutplasmafraktionierung; 4.1 Beschreibung des Prozesses; 4.1.1 Kryogewinnung; 4.1.2 Faumalllungsschritte; 4.1.3 Adsorptionsschritte; 4.1.4 Reinigung der Proteine, Bulkherstellung, Abfuumalllung, Gefriertrocknung; 4.2 Verfahrenstechnische Gesichtspunkte; 4.2.1 Behaumallter und Ruumalhrwerke
4.2.1.1 Allgemeine Ausruumalstung, Spezifikation4.2.1.2 Funktionstypicals; 4.2.1.3 Ruumalhrwerke; 4.2.1.4 Spezielle Einsatzfaumallle fuumal r Behaumallter; 4.2.2 Fest-Fluumalssig-Trennung; 4.2.2.1 Separatoren, Zentrifugen; 4.2.2.2 Filter; 4.2.3 Pumpen; 4.2.3.1 Kreiselpumpe; 4.2.3.2 Kolbenpumpe und Membrankolbenpumpe; 4.2.3.3 Kreiskolbenpumpe; 4.2.3.4 Schlauchpumpe; 4.2.4 Rohrleitungen, Ventile, Verbindungstechnik; 4.2.4.1 Rohrleitungen; 4.2.4.2 Schweibverbindungen; 4.2.4.3 Verbindungstechnik; 4.2.4.4 Ventiltechnik; 4.2.4.5 Messtechnik; 4.2.5 Membrantrennverfahren [10, 11] 6.5 Scale-up von Zentrifugen aus Laboroder Produktionslaumalufen6.6 Schubspannungen in Rohrleitungen; 6.7 Scale-up von Ultrafiltrationskassetten; 6.8 Scale-up von Filtern; 6.9 Berechnung der maximal moumalglichen Dosiergeschwindigkeiten von Aumalthanol bei der Faumalllung; 6.10 Schnelle Dimensionierung eines Behaumallters; 6.11 Instationaumalre Aufheizund Abkuumalhlvorgaumalnge in einem Ruumalhrbehaumallter; 6.12 Temperierung eines Behaumallters durch externen Produktkreislauf; 6.13 Temperierung eines Behaumallters mittels eines Waumalrmetraumalgerkreislaufes 6.14 Waumalrmeverlust einer isolierten Rohrleitung |
| Record Nr. | UNINA-9911019806103321 |
|
Kandel Heinz G
|
||
| Weinheim [Germany], : Wiley-VCH, 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
