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Physicochemical and biomimetic properties in drug discovery : chromatographic techniques for lead optimization / / Klara Valko
| Physicochemical and biomimetic properties in drug discovery : chromatographic techniques for lead optimization / / Klara Valko |
| Autore | Valko Klara |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (453 pages) : color illustrations, photographs |
| Disciplina | 615.1/9 |
| Soggetto topico |
Drug development - Statistical methods
Chromatographic analysis Clinical trials - Statistical methods Pharmaceutical biotechnology |
| ISBN |
9781118770320
1118770323 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910795960503321 |
Valko Klara
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| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Physicochemical and biomimetic properties in drug discovery : chromatographic techniques for lead optimization / / Klara Valko
| Physicochemical and biomimetic properties in drug discovery : chromatographic techniques for lead optimization / / Klara Valko |
| Autore | Valko Klara |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (453 pages) : color illustrations, photographs |
| Disciplina | 615.1/9 |
| Soggetto topico |
Drug development - Statistical methods
Chromatographic analysis Clinical trials - Statistical methods Pharmaceutical biotechnology |
| ISBN |
9781118770320
1118770323 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910814674403321 |
|
Valko Klara
|
||
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Physicochemical and biomimetic properties in drug discovery : chromatographic techniques for lead optimization / / Klara Valko
| Physicochemical and biomimetic properties in drug discovery : chromatographic techniques for lead optimization / / Klara Valko |
| Autore | Valkó Klára |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (581 p.) |
| Disciplina | 615.1/9 |
| Soggetto topico |
Drug development - Statistical methods
Chromatographic analysis Clinical trials - Statistical methods Pharmaceutical biotechnology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-118-77041-2
1-118-77032-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Preface; Chapter 1: The Drug Discovery Process; Summary; Question for Review; References; Chapter 2: Drug-Likeness and Physicochemical Property Space of known Drugs; Summary; Questions for Review; References; Chapter 3: Basic Pharmacokinetic Properties; Absorption; Plasma Protein Binding; Distribution; Volume of Distribution; Unbound Volume of Distribution; Half-Life; Metabolism and Clearance; Free Drug Hypothesis; Summary; Questions for Review; References; Chapter 4: Principles and Methods of Chromatography for the Application of Property Measurements
Theoretical Background of ChromatographyRetention Factor and its Relation to the Distribution Constant Between the Mobile and the Stationary Phases; Measure of Separation Efficiency; Resolution and Separation Time; Gradient Elution; Applicability of Chromatography for Measurements of Molecular Properties; Summary; Questions for Review; References; Chapter 5: Molecular Physicochemical Properties that Influence Absorption and Distribution-Lipophilicity; Partition Coefficient; Lipophilicity Measurements by Reversed Phase Chromatography with Isocratic Elution Lipophilicity Measurements by Reversed Phase Chromatography with Gradient ElutionLipophilicity of Charged Molecules-pH Dependence of Lipophilicity; Biomimetic Lipophilicity Measurements by Chromatography; Comparing Various Lipophilicity Measures by the Solvation Equation Model; Summary; Questions for Review; References; Chapter 6: Molecular Physicochemical Properties that Influence Absorption and Distribution-Solubility; Definition of Solubility; Molecular Interactions with Water; Various Solubility Measurements that can be Applied During the Drug Discovery Process Conditions that Affect SolubilitySolubility-pH Profile; Solubility and Dissolution in Biorelevant Media; Composition of Fasted State Simulated Intestinal Fluid (FaSSIF); Preparation of FaSSIF Solution; Composition of Fed State Simulated Intestinal Fluid (FeSSIF); Preparation of FeSSIF Solution; Summary; Questions for Review; References; Chapter 7: Molecular Physicochemical Properties that Influence Absorption and Distribution-Permeability; Biological Membranes; Artificial Membranes; Physicochemical Principles of Permeability; Experimental Methods to Measure Artificial Membrane Permeability Relationships Between Permeability, Lipophilicity, and SolubilityChromatography as a Potential Tool for Measuring the Rate of Permeation; Summary; Questions for Review; References; Chapter 8: Molecular Physicochemical Properties that Influence Absorption and Distribution-Acid Dissociation Constant-pKa; Definition of pKa; Methods for Determining pKa; Spectrophotometric Determination of pKa; Determination of pKa by Capillary Electrophoresis; Chromatographic Approaches for the Determination of pKa; Summary; Questions for Review; References Chapter 9: Models with Measured Physicochemical and Biomimetic Chromatographic Descriptors-Absorption |
| Record Nr. | UNINA-9910462987203321 |
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Valkó Klára
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||
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Statistical issues in drug development / / Stephen Senn
| Statistical issues in drug development / / Stephen Senn |
| Autore | Senn Stephen |
| Edizione | [Third edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey ; ; West, Sussex, England : , : Wiley Blackwell, , [2021] |
| Descrizione fisica | 1 online resource (643 pages) |
| Disciplina | 615.19 |
| Collana | Statistics in practice |
| Soggetto topico | Drug development - Statistical methods |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-119-23859-5
1-119-23860-9 1-119-23861-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910555274803321 |
|
Senn Stephen
|
||
| Hoboken, New Jersey ; ; West, Sussex, England : , : Wiley Blackwell, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Statistical issues in drug development / / Stephen Senn
| Statistical issues in drug development / / Stephen Senn |
| Autore | Senn Stephen |
| Edizione | [Third edition.] |
| Pubbl/distr/stampa | Hoboken, New Jersey ; ; West, Sussex, England : , : Wiley Blackwell, , [2021] |
| Descrizione fisica | 1 online resource (643 pages) |
| Disciplina | 615.19 |
| Collana | Statistics in practice |
| Soggetto topico | Drug development - Statistical methods |
| ISBN |
1-119-23859-5
1-119-23860-9 1-119-23861-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | A Brief and Superficial History of Statistics for Drug Developers -- Design and Interpretation of Clinical Trials as Seen by a Statistician -- Probability, Bayes, P-values, Tests of Hypotheses and Confidence Intervals -- The Work of the Pharmaceutical Statistician -- Allocating Treatments to Patients in Clinical Trials -- Baselines and Covariate Information -- The Measurement of Treatment Effects -- Demographic Subgroups : Representation and Analysis -- Multiplicity -- Intention to Treat, Missing Data and Related Matters -- One-sided and Two-sided Tests and other Issues to Do with Significance and P-values -- Determining the Sample Size -- Multicentre Trials -- Active Control Equivalence Studies -- Meta-Analysis -- Cross-over Trials -- n-of-1 Trials -- Sequential Trial -- Dose-finding -- Concerning Pharmacokinetics and Pharmacodynamics -- Bioequivalence Studies -- Safety Data, Harms, Drug Monitoring and Pharmaco-epidemiology -- Pharmaco-economics and Portfolio Management -- Concerning Pharmacogenetics, Pharmacogenomics and Related Matters. |
| Record Nr. | UNINA-9910830834503321 |
|
Senn Stephen
|
||
| Hoboken, New Jersey ; ; West, Sussex, England : , : Wiley Blackwell, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Statistical issues in drug development / / Stephen Senn
| Statistical issues in drug development / / Stephen Senn |
| Autore | Senn Stephen |
| Edizione | [2nd edition.] |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 |
| Descrizione fisica | 1 online resource (522 p.) |
| Disciplina | 615/.190727 |
| Collana | Statistics in practice |
| Soggetto topico | Drug development - Statistical methods |
| ISBN |
1-281-30834-X
9786611308346 0-470-72358-0 0-470-72357-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmaceutical statistician -- Allocating treatments to patients in clinical trials -- Baselines and covariate information --
The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-values -- Determining the sample size -- Multicentre trials -- Active control equivalence studies -- Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco-economics and portfolio management -- Concerning pharmacogenetics, pharmacogenomics, and related matters. |
| Record Nr. | UNINA-9910784775903321 |
|
Senn Stephen
|
||
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Statistical issues in drug development / / Stephen Senn
| Statistical issues in drug development / / Stephen Senn |
| Autore | Senn Stephen |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 |
| Descrizione fisica | 1 online resource (522 p.) |
| Disciplina | 615/.190727 |
| Collana | Statistics in practice |
| Soggetto topico | Drug development - Statistical methods |
| ISBN |
1-281-30834-X
9786611308346 0-470-72358-0 0-470-72357-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmaceutical statistician -- Allocating treatments to patients in clinical trials -- Baselines and covariate information --
The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-values -- Determining the sample size -- Multicentre trials -- Active control equivalence studies -- Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco-economics and portfolio management -- Concerning pharmacogenetics, pharmacogenomics, and related matters. |
| Record Nr. | UNINA-9910810135003321 |
|
Senn Stephen
|
||
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
