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Delivery technologies for biopharmaceuticals : peptides, proteins, nucleic acids, and vaccines / / editors, Lene Jorgensen, Hanne Mrck Nielsen
| Delivery technologies for biopharmaceuticals : peptides, proteins, nucleic acids, and vaccines / / editors, Lene Jorgensen, Hanne Mrck Nielsen |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, : John Wiley, 2009 |
| Descrizione fisica | 1 online resource (443 p.) |
| Disciplina | 615.6 |
| Altri autori (Persone) |
JrgensenLene
NielsenHanne Mrck |
| Soggetto topico |
Drug delivery systems
Drug carriers (Pharmacy) |
| ISBN |
1-282-36222-4
9786612362224 0-470-68839-4 0-470-68840-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Delivery Technologies for Biopharmaceuticals; Contents; Preface; List of Contributors; Introduction; Delivery of Biopharmaceuticals; Delivery Technologies for Biopharmaceuticals; Peptides and Proteins; Nucleic Acids; Vaccines; Final Comments; Index |
| Record Nr. | UNINA-9910139896103321 |
| Chichester, West Sussex ; ; Hoboken, : John Wiley, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug delivery strategies for poorly water-soluble drugs [[electronic resource] /] / edited by Dennis Douroumis and Alfred Fahr
| Drug delivery strategies for poorly water-soluble drugs [[electronic resource] /] / edited by Dennis Douroumis and Alfred Fahr |
| Pubbl/distr/stampa | Chichester, West Sussex, : John Wiley & Sons, 2012 |
| Descrizione fisica | 1 online resource (644 p.) |
| Disciplina | 615.1 |
| Altri autori (Persone) |
DouroumisDennis
FahrAlfred |
| Collana | Advances in pharmaceutical technology |
| Soggetto topico |
Drug delivery systems
Pharmaceutical chemistry Drug carriers (Pharmacy) Solubility |
| ISBN |
1-118-44472-8
1-299-25270-2 1-118-44477-9 1-118-44467-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Self-assembled delivery vehicles for poorly water-soluble drugs : basic theoretical considerations and modeling concepts / Silvio May and Alfred Fahr -- Liposome as intravenous solubilizers for poorly water soluble drugs / Peter van Hoogevest, Mathew Leigh and Alfred Fahr -- Drug solubilization and stabilization of cyclodextrin drug carriers / Thorsteinn Loftsson and Marcus Eli Brewster -- Solid lipid nanoparticles for drug delivery / Sonja Joseph and Heike Bunjes -- Polymeric drug delivery systems for encapsulating hydrophobic drugs / Naveed Ahmed, C.E. Mora-Heurtas, Chiraz Jaafar-Maalej, Hatem Fessi and Abdelhamid Elaissari -- Polymeric drug delivery systems for encapsulating hydrophobic drugs / Dagmar Fischer -- Development of self-emulsifying drug delivery systems (SEDDS) for oral ioavailability enhancement of poorly soluble drugs / Dimitrios G. Fatouros and Anette Müllertz -- Novel top-down technologies : effective production of ultra-fine drug nanocrystals / Cornelia.M. Keck, S. Kobierski, R. Mauludin and Rainer H. Müller -- Nanosuspensions with enhanced drug dissolution rates of poorly water-soluble drugs / Dennis Douroumis -- Microemulsions for drug solubilization and delivery / X.Q. Wang and Qiang Zhang -- Enhancing drug solubility and bioavailability using hot melt extruded solid dispersions / Shu Li, David S. Jones and Gavin P. Andrews -- Penetration enhancers, solvents and the skin / Jonathan Hadgraft and Majella E. Lane -- Dendrimers for enhanced drug solubilization / Narendra K. Jain and Rakesh K. Tekade -- Polymeric micelles for the delivery of poorly soluble drugs / Swati Biswas, Onkar S.Vaze, Sara Movassaghian and Vladimir P. Torchilin -- Nanostructured silicon-based materials as a drug delivery system for water insoluble drugs / Vesa-Pekka Lehto, Jarno Salonen, Helder Santos and Joakim Riikonen -- Micro- and nanosizing of poorly soluble drugs by grinding techniques / Stefan Scheler -- Enhanced solubility of poorly soluble drugs via spray drying / Cordin Arpagaus, David Rütti and Marco Meuri. |
| Record Nr. | UNINA-9910141512303321 |
| Chichester, West Sussex, : John Wiley & Sons, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug delivery strategies for poorly water-soluble drugs / / edited by Dennis Douroumis and Alfred Fahr
| Drug delivery strategies for poorly water-soluble drugs / / edited by Dennis Douroumis and Alfred Fahr |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, West Sussex, : John Wiley & Sons, 2012 |
| Descrizione fisica | 1 online resource (644 p.) |
| Disciplina | 615.1 |
| Altri autori (Persone) |
DouroumisDennis
FahrAlfred |
| Collana | Advances in pharmaceutical technology |
| Soggetto topico |
Drug delivery systems
Pharmaceutical chemistry Drug carriers (Pharmacy) Solubility |
| ISBN |
1-118-44472-8
1-299-25270-2 1-118-44477-9 1-118-44467-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Self-assembled delivery vehicles for poorly water-soluble drugs : basic theoretical considerations and modeling concepts / Silvio May and Alfred Fahr -- Liposome as intravenous solubilizers for poorly water soluble drugs / Peter van Hoogevest, Mathew Leigh and Alfred Fahr -- Drug solubilization and stabilization of cyclodextrin drug carriers / Thorsteinn Loftsson and Marcus Eli Brewster -- Solid lipid nanoparticles for drug delivery / Sonja Joseph and Heike Bunjes -- Polymeric drug delivery systems for encapsulating hydrophobic drugs / Naveed Ahmed, C.E. Mora-Heurtas, Chiraz Jaafar-Maalej, Hatem Fessi and Abdelhamid Elaissari -- Polymeric drug delivery systems for encapsulating hydrophobic drugs / Dagmar Fischer -- Development of self-emulsifying drug delivery systems (SEDDS) for oral ioavailability enhancement of poorly soluble drugs / Dimitrios G. Fatouros and Anette Müllertz -- Novel top-down technologies : effective production of ultra-fine drug nanocrystals / Cornelia.M. Keck, S. Kobierski, R. Mauludin and Rainer H. Müller -- Nanosuspensions with enhanced drug dissolution rates of poorly water-soluble drugs / Dennis Douroumis -- Microemulsions for drug solubilization and delivery / X.Q. Wang and Qiang Zhang -- Enhancing drug solubility and bioavailability using hot melt extruded solid dispersions / Shu Li, David S. Jones and Gavin P. Andrews -- Penetration enhancers, solvents and the skin / Jonathan Hadgraft and Majella E. Lane -- Dendrimers for enhanced drug solubilization / Narendra K. Jain and Rakesh K. Tekade -- Polymeric micelles for the delivery of poorly soluble drugs / Swati Biswas, Onkar S.Vaze, Sara Movassaghian and Vladimir P. Torchilin -- Nanostructured silicon-based materials as a drug delivery system for water insoluble drugs / Vesa-Pekka Lehto, Jarno Salonen, Helder Santos and Joakim Riikonen -- Micro- and nanosizing of poorly soluble drugs by grinding techniques / Stefan Scheler -- Enhanced solubility of poorly soluble drugs via spray drying / Cordin Arpagaus, David Rütti and Marco Meuri. |
| Record Nr. | UNINA-9910817900703321 |
| Chichester, West Sussex, : John Wiley & Sons, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug design and discovery
| Drug design and discovery |
| Pubbl/distr/stampa | [London], : Gordon and Breach |
| Disciplina | 615 |
| Soggetto topico |
Pharmaceutical chemistry
Drug carriers (Pharmacy) Drug Design Pharmaceutical Preparations |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1029-2322 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910154528003321 |
| [London], : Gordon and Breach | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs : Formulation Challenges and Potential Benefits
| Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs : Formulation Challenges and Potential Benefits |
| Autore | Čalija Bojan |
| Pubbl/distr/stampa | San Diego : , : Elsevier Science & Technology, , 2017 |
| Descrizione fisica | 1 online resource (286 pages) |
| Disciplina |
615.1
615.7 |
| Altri autori (Persone) | ČalijaBojan |
| Soggetto topico |
Nonsteroidal anti-inflammatory agents
Drug carriers (Pharmacy) |
| ISBN |
0-12-804080-7
0-12-804017-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title page -- Copyright page -- Contents -- List of Contributors -- Editor Biography -- Preface -- Chapter 1 - Clinical Uses of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Potential Benefits of NSAIDs Modified-Releas... -- 1.1 - Nonsteroidal Anti-inflammatory drugs -- 1.1.1 - Classification and Mechanism of Action -- 1.1.1.1 - Classification -- 1.1.1.2 - COX Isoforms and Their Roles -- 1.1.1.3 - NSAIDs Mechanism of Action -- 1.1.2 - Pharmacokinetic Properties -- 1.1.2.1 - Biopharmaceutical/Pharmacokinetic Considerations of Topically Administered NSAIDs -- 1.1.3 - Therapeutic Actions and Uses -- 1.1.3.1 - Musculoskeletal Disorders -- 1.1.3.1.1 - Osteoarthritis -- 1.1.3.1.2 - Rheumatoid Arthritis -- 1.1.3.2 - Mild to Moderate Pain -- 1.1.3.3 - Fever -- 1.1.3.4 - Cardioprotection (Aspirin) -- 1.1.4 - Adverse Effects -- 1.1.4.1 - Gastrointestinal Side Effects -- 1.1.4.2 - Cardiovascular Side Effects -- 1.1.4.3 - Renal Side Effects -- 1.1.5 - Interactions -- 1.2 - Potential benefits of NSAIDs modified-release preparations -- 1.2.1 - Oral NSAIDs Modified-Release Preparations -- 1.2.2 - Topical NSAIDs Modified-Release Preparations -- 1.3 - Conclusions -- Acknowledgment -- References -- Chapter 2 - Polymeric Microparticles and Inorganic Micro/Nanoparticulate Drug Carriers: An Overview and Pharmaceutical Appl... -- 2.1 - Introduction -- 2.2 - Polymeric microparticles as drug carriers -- 2.2.1 - Microencapsulation Techniques -- 2.2.1.1 - Chemical Microencapsulation Techniques -- 2.2.1.2 - Physicochemical Microencapsulation Techniques -- 2.2.1.3 - Physicomechanical Microencapsulation Techniques -- 2.2.2 - Characteristics of Polymeric Microparticles -- 2.2.3 - Pharmaceutical Application of Polymeric Microparticles -- 2.3 - Porous inorganic materials as drug carriers -- 2.3.1 - Characteristics of Porous Inorganic Materials Used in Drug Delivery.
2.3.2 - Structured Porous Inorganic Materials Used in Drug Delivery: An Overview -- 2.3.3 - Pharmaceutical Application of Structured Porous Inorganic Materials -- 2.4 - Conclusions -- Acknowledgment -- References -- Chapter 3 - Microemulsions and Nanoemulsions as Carriers for Delivery of NSAIDs -- 3.1 - Introduction -- 3.2 - Microemulsions and nanoemulsions as drug-delivery carriers -- 3.3 - Design and characterization of biocompatible microemulsion/nanoemulsion drug-delivery systems -- 3.4 - Evaluation of potential of microemulsion/nanoemulsion systems for oral delivery of NSAIDs -- 3.5 - Conclusions -- References -- Chapter 4 - Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers -- 4.1 - Introduction -- 4.2 - Functionality and performance of excipients: definitions and compendial status -- 4.3 - Biodegradable polymeric materials in micro/nanoparticles -- 4.3.1 - Definition, Structure, and Characteristics of Polymers -- 4.3.2 - Classification of Biodegradable Encapsulating Polymers -- 4.3.3 - The Selection of Encapsulating Polymer -- 4.3.4 - Functionality of Biodegradable Polymers as Excipients for Micro/Nanosized Drug Carriers -- 4.4 - Natural and synthetic silica-based materials as micro/nanosized drug carriers -- 4.4.1 - Structure and Functional Characteristics of Silica-Based Materials -- 4.4.2 - Functionalization of Natural and Synthetic Silica-Based Materials as Micro/Nanosized Drug Carriers -- 4.5 - Natural surfactants in micro/nanoemulsions -- 4.5.1 - Surfactant Role in Micro/Nanoemulsions -- 4.5.2 - Definition, Structure, and Classification of Natural Surfactants -- 4.5.3 - Functionality of Natural Surfactants as Excipients in Micro/Nanoemulsions -- 4.5.3.1 - Lecithin -- 4.5.3.2 - Sucrose Esters -- 4.5.3.3 - Alkyl Polyglucosides -- 4.6 - Conclusions -- Acknowledgment -- References. Chapter 5 - Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced Via Polyel... -- 5.1 - Introduction -- 5.2 - Chitosans: an overview on properties, functionality, and safety -- 5.2.1 - Source and Structural Characteristics of Chitosans -- 5.2.2 - Physicochemical Properties and Reactivity of Chitosans -- 5.2.3 - Safety and Regulatory Status of Chitosans -- 5.3 - Alginate-chitosan micro/nanoparticles as drug carriers -- 5.3.1 - Ca-Alginate Hydrogels as Drug Carriers: Characteristics and Disadvantages -- 5.3.2 - Chitosans as Cationic Modifiers of Ca-Alginate Micro/Nanoparticles -- 5.3.3 - Preparation Methods of Alginate-Chitosan Micro/Nanoparticles -- 5.4 - Influence of chitosans functional properties on characteristics of alginate-chitosan micro/nanoparticles loaded with ... -- 5.5 - Conclusions -- Acknowledgment -- References -- Chapter 6 - PLA-Based Nanoparticulate Drug Carriers as a Percutaneous Delivery System for Ketoprofen -- 6.1 - Introduction -- 6.2 - Ketoprofen-loaded PLA nanoparticles: preparation and characterization aspects -- 6.3 - In vitro evaluation of ketoprofen-loaded PLA nanoparticles as colloidal systems for percutaneous drug delivery -- 6.4 - Conclusions -- References -- Chapter 7 - Natural Surfactants-Based Micro/Nanoemulsion Systems for NSAIDs-Practical Formulation Approach, Physicochemical... -- 7.1 - Introduction -- 7.2 - Sucrose ester-based microemulsions: phase behavior, physicochemical characterization, and imaging properties -- 7.2.1 - Phase Behavior of Sucrose Ester-Based Systems -- 7.2.1.1 - Effect of the Tail Length of SEs -- 7.2.1.2 - Effect of Monoester Content of SEs -- 7.2.1.3 - Effect of Cosurfactant/Cosolvent Choice and Surfactant/Cosurfactant Weight Ratio -- 7.2.1.4 - Effect of HLB Values of SE. 7.2.2 - Physicochemical Properties of Sucrose Ester-Based Microemulsions -- 7.2.2.1 - Electrical Conductivity -- 7.2.2.2 - Viscosity -- 7.2.2.3 - Thermal Behavior -- 7.2.3 - Imaging Properties of Sucrose Ester-Based Microemulsions -- 7.2.3.1 - Cryo-Transmission Electron Microscopy -- 7.2.3.2 - Freeze Fracture-Transmission Electron Microscopy -- 7.2.3.3 - Atomic Force Microscopy -- 7.3 - Lecithin- and sucrose ester-based nanoemulsions-formulation design aspects, physicochemical characterization, and sta... -- 7.3.1 - The Selection of Emulsifiers-Lecithin and Sucrose Esters -- 7.3.2 - The Selection of Oil and Aqueous Phase -- 7.3.3 - Nanoemulsion Formulation and Preparation-QbD Approach -- 7.3.4 - Physicochemical Characterization and Stability Testing -- 7.3.4.1 - Droplet Size Analysis and Microstructure Evaluation -- 7.3.4.2 - Zeta Potential and pH Value Determination -- 7.3.4.3 - Viscosity Measurements -- 7.3.4.4 - Assessment of Drug Chemical Stability -- 7.4 - NSAID-loaded micro/nanoemulsions: in vitro/ex vivo/in vivo dermal and transdermal availability -- 7.5 - Conclusions -- Acknowledgment -- References -- Chapter 8 - Natural and Modified Silica-Based Materials as Carriers for NSAIDs -- 8.1 - Introduction -- 8.2 - Natural and modified aluminosilicates: characterization and application in drug delivery -- 8.2.1 - Physicochemical and Functionality-Related Characteristics of Natural and Modified Aluminosilicates: An Overview -- 8.2.2 - Natural and Modified Aluminosilicates: Application as Carriers for NSAIDs -- 8.3 - Modified biosilica structures from diatomite frustules: preparation, physicochemical characterization, and application -- 8.3.1 - Diatomite Processing and Its Physicochemical Characteristics -- 8.3.2 - Applications of Natural and Modified Diatomites in Drug Delivery -- 8.4 - Conclusions -- Acknowledgment -- References -- Index. Back cover. |
| Record Nr. | UNINA-9910583323303321 |
Čalija Bojan
|
||
| San Diego : , : Elsevier Science & Technology, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba
| Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2009 |
| Descrizione fisica | 1 online resource (451 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
EckerGerhard
ChibaPeter |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug carriers (Pharmacy)
Drugs - Physiological transport Drug resistance |
| ISBN |
1-282-30246-9
9786612302466 3-527-62742-1 3-527-62743-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Transporters as Drug Carriers: Structure, Function, Substrates; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Human Transporter Families - Structure, Function, Physiology; 1 The ABC Transporters: Structural Insights into Drug Transport; 1.1 ABC Proteins - Structure and Function; 1.1.1 ABC Proteins; 1.1.2 Predicted Topology of ABC Proteins; 1.1.3 Nucleotide Binding Domains; 1.1.3.1 Conserved Motifs of NBDs; 1.1.4 Transmembrane Domains; 1.1.5 Mechanisms of Transport; 1.1.6 Energy for Translocation; 1.1.7 Coupling of ATP Hydrolysis to Transport
1.2 Structures of ABC Transporters1.2.1 Tertiary Structure; 1.2.2 Quaternary Structure of ABC Proteins; 1.3 Multidrug Resistance and ABC Transporters; 1.3.1 P-Glycoprotein; 1.3.1.1 Historical Background; 1.3.1.2 The Role of P-gp in Drug Resistance; 1.3.1.3 Tissue Distribution and Physiological Roles; 1.3.2 Conformational Changes in the Mechanism of P-gp; 1.3.3 Comparison of Sav1866 and P-gp Structures; 1.3.4 Drug Binding Sites in P-Glycoprotein; 1.3.5 Structural Interpretation of Drug Binding; 1.3.6 Inhibitors of P-gp 1.3.7 What Properties Are Shared by Drugs that Interact with P-Glycoprotein?1.3.8 Postscript: Further X-Ray Crystallographic Studies and a Structure for the Nucleotide-Free State of P-Glycoprotein; 1.4 Summary; References; 2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters; 2.1 Nucleoside and Nucleobase Transporters; 2.1.1 Equilibrative Nucleoside Transporters; 2.1.2 Concentrative Nucleoside Transporters; 2.2 ENT and CNT Tissue Distribution, Regulation, and Physiological Roles; 2.2.1 ENT Tissue Distribution and Regulation 2.2.2 CNT Tissue Distribution and Regulation2.2.2.1 CNTs in Absorptive Epithelia; 2.2.2.2 CNTs in Liver Parenchymal Cells; 2.2.2.3 CNTs in Immune System Cells; 2.2.2.4 CNTs in CNS; 2.2.2.5 CNTs in Other Specialized Tissues; 2.2.3 NTs as ""Transceptors""; 2.3 Nucleoside- and Nucleobase-Derived Drug Transport into Cells; 2.3.1 Transport of Anticancer Drugs; 2.3.2 Transport of Antiviral Drugs; 2.4 Drug Transport and Responsiveness to Treatment; 2.4.1 Analysis of the Role of NTs in Sensitivity to Nucleoside Anticancer Drugs in Cultured Cell Models 2.4.2 Studies Linking NT Function to Drug Sensitivity and Clinical Outcome in Cancer Patients2.5 Future Perspectives; References; 3 Organic Anion Transporting Polypeptides (Oatps/OATPs); 3.1 Introduction; 3.2 Nomenclature and Classification; 3.3 Tissue Distribution, Structure, and Functions; 3.4 Substrate Spectrum; 3.5 Members of the Rodent Oatp Family; 3.5.1 Oatp1a1; 3.5.2 Oatp1a3-v1/v2; 3.5.3 Oatp1a4; 3.5.4 Oatp1a5; 3.5.5 Oatp1a6; 3.5.6 Oatp1b2; 3.5.7 Oatp1c1; 3.5.8 Oatp2a1; 3.5.9 Oatp2b1; 3.5.10 Oatp3a1; 3.5.11 Oatp4a1; 3.5.12 Oatp4c1; 3.5.13 Oatp6b1/Oatp6c1; 3.5.14 PGT-2 3.5.15 TST-1 and TST-2 |
| Record Nr. | UNINA-9910139773003321 |
| Weinheim, : Wiley-VCH, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba
| Transporters as drug carriers [[electronic resource] ] : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2009 |
| Descrizione fisica | 1 online resource (451 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
EckerGerhard
ChibaPeter |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug carriers (Pharmacy)
Drugs - Physiological transport Drug resistance |
| ISBN |
1-282-30246-9
9786612302466 3-527-62742-1 3-527-62743-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Transporters as Drug Carriers: Structure, Function, Substrates; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Human Transporter Families - Structure, Function, Physiology; 1 The ABC Transporters: Structural Insights into Drug Transport; 1.1 ABC Proteins - Structure and Function; 1.1.1 ABC Proteins; 1.1.2 Predicted Topology of ABC Proteins; 1.1.3 Nucleotide Binding Domains; 1.1.3.1 Conserved Motifs of NBDs; 1.1.4 Transmembrane Domains; 1.1.5 Mechanisms of Transport; 1.1.6 Energy for Translocation; 1.1.7 Coupling of ATP Hydrolysis to Transport
1.2 Structures of ABC Transporters1.2.1 Tertiary Structure; 1.2.2 Quaternary Structure of ABC Proteins; 1.3 Multidrug Resistance and ABC Transporters; 1.3.1 P-Glycoprotein; 1.3.1.1 Historical Background; 1.3.1.2 The Role of P-gp in Drug Resistance; 1.3.1.3 Tissue Distribution and Physiological Roles; 1.3.2 Conformational Changes in the Mechanism of P-gp; 1.3.3 Comparison of Sav1866 and P-gp Structures; 1.3.4 Drug Binding Sites in P-Glycoprotein; 1.3.5 Structural Interpretation of Drug Binding; 1.3.6 Inhibitors of P-gp 1.3.7 What Properties Are Shared by Drugs that Interact with P-Glycoprotein?1.3.8 Postscript: Further X-Ray Crystallographic Studies and a Structure for the Nucleotide-Free State of P-Glycoprotein; 1.4 Summary; References; 2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters; 2.1 Nucleoside and Nucleobase Transporters; 2.1.1 Equilibrative Nucleoside Transporters; 2.1.2 Concentrative Nucleoside Transporters; 2.2 ENT and CNT Tissue Distribution, Regulation, and Physiological Roles; 2.2.1 ENT Tissue Distribution and Regulation 2.2.2 CNT Tissue Distribution and Regulation2.2.2.1 CNTs in Absorptive Epithelia; 2.2.2.2 CNTs in Liver Parenchymal Cells; 2.2.2.3 CNTs in Immune System Cells; 2.2.2.4 CNTs in CNS; 2.2.2.5 CNTs in Other Specialized Tissues; 2.2.3 NTs as ""Transceptors""; 2.3 Nucleoside- and Nucleobase-Derived Drug Transport into Cells; 2.3.1 Transport of Anticancer Drugs; 2.3.2 Transport of Antiviral Drugs; 2.4 Drug Transport and Responsiveness to Treatment; 2.4.1 Analysis of the Role of NTs in Sensitivity to Nucleoside Anticancer Drugs in Cultured Cell Models 2.4.2 Studies Linking NT Function to Drug Sensitivity and Clinical Outcome in Cancer Patients2.5 Future Perspectives; References; 3 Organic Anion Transporting Polypeptides (Oatps/OATPs); 3.1 Introduction; 3.2 Nomenclature and Classification; 3.3 Tissue Distribution, Structure, and Functions; 3.4 Substrate Spectrum; 3.5 Members of the Rodent Oatp Family; 3.5.1 Oatp1a1; 3.5.2 Oatp1a3-v1/v2; 3.5.3 Oatp1a4; 3.5.4 Oatp1a5; 3.5.5 Oatp1a6; 3.5.6 Oatp1b2; 3.5.7 Oatp1c1; 3.5.8 Oatp2a1; 3.5.9 Oatp2b1; 3.5.10 Oatp3a1; 3.5.11 Oatp4a1; 3.5.12 Oatp4c1; 3.5.13 Oatp6b1/Oatp6c1; 3.5.14 PGT-2 3.5.15 TST-1 and TST-2 |
| Record Nr. | UNINA-9910830216303321 |
| Weinheim, : Wiley-VCH, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Transporters as drug carriers : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba
| Transporters as drug carriers : structure, function, substrates / / edited by Gerhard Ecker and Peter Chiba |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2009 |
| Descrizione fisica | 1 online resource (451 p.) |
| Disciplina | 615.19 |
| Altri autori (Persone) |
EckerGerhard
ChibaPeter |
| Collana | Methods and principles in medicinal chemistry |
| Soggetto topico |
Drug carriers (Pharmacy)
Drugs - Physiological transport Drug resistance |
| ISBN |
1-282-30246-9
9786612302466 3-527-62742-1 3-527-62743-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Transporters as Drug Carriers: Structure, Function, Substrates; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Human Transporter Families - Structure, Function, Physiology; 1 The ABC Transporters: Structural Insights into Drug Transport; 1.1 ABC Proteins - Structure and Function; 1.1.1 ABC Proteins; 1.1.2 Predicted Topology of ABC Proteins; 1.1.3 Nucleotide Binding Domains; 1.1.3.1 Conserved Motifs of NBDs; 1.1.4 Transmembrane Domains; 1.1.5 Mechanisms of Transport; 1.1.6 Energy for Translocation; 1.1.7 Coupling of ATP Hydrolysis to Transport
1.2 Structures of ABC Transporters1.2.1 Tertiary Structure; 1.2.2 Quaternary Structure of ABC Proteins; 1.3 Multidrug Resistance and ABC Transporters; 1.3.1 P-Glycoprotein; 1.3.1.1 Historical Background; 1.3.1.2 The Role of P-gp in Drug Resistance; 1.3.1.3 Tissue Distribution and Physiological Roles; 1.3.2 Conformational Changes in the Mechanism of P-gp; 1.3.3 Comparison of Sav1866 and P-gp Structures; 1.3.4 Drug Binding Sites in P-Glycoprotein; 1.3.5 Structural Interpretation of Drug Binding; 1.3.6 Inhibitors of P-gp 1.3.7 What Properties Are Shared by Drugs that Interact with P-Glycoprotein?1.3.8 Postscript: Further X-Ray Crystallographic Studies and a Structure for the Nucleotide-Free State of P-Glycoprotein; 1.4 Summary; References; 2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters; 2.1 Nucleoside and Nucleobase Transporters; 2.1.1 Equilibrative Nucleoside Transporters; 2.1.2 Concentrative Nucleoside Transporters; 2.2 ENT and CNT Tissue Distribution, Regulation, and Physiological Roles; 2.2.1 ENT Tissue Distribution and Regulation 2.2.2 CNT Tissue Distribution and Regulation2.2.2.1 CNTs in Absorptive Epithelia; 2.2.2.2 CNTs in Liver Parenchymal Cells; 2.2.2.3 CNTs in Immune System Cells; 2.2.2.4 CNTs in CNS; 2.2.2.5 CNTs in Other Specialized Tissues; 2.2.3 NTs as ""Transceptors""; 2.3 Nucleoside- and Nucleobase-Derived Drug Transport into Cells; 2.3.1 Transport of Anticancer Drugs; 2.3.2 Transport of Antiviral Drugs; 2.4 Drug Transport and Responsiveness to Treatment; 2.4.1 Analysis of the Role of NTs in Sensitivity to Nucleoside Anticancer Drugs in Cultured Cell Models 2.4.2 Studies Linking NT Function to Drug Sensitivity and Clinical Outcome in Cancer Patients2.5 Future Perspectives; References; 3 Organic Anion Transporting Polypeptides (Oatps/OATPs); 3.1 Introduction; 3.2 Nomenclature and Classification; 3.3 Tissue Distribution, Structure, and Functions; 3.4 Substrate Spectrum; 3.5 Members of the Rodent Oatp Family; 3.5.1 Oatp1a1; 3.5.2 Oatp1a3-v1/v2; 3.5.3 Oatp1a4; 3.5.4 Oatp1a5; 3.5.5 Oatp1a6; 3.5.6 Oatp1b2; 3.5.7 Oatp1c1; 3.5.8 Oatp2a1; 3.5.9 Oatp2b1; 3.5.10 Oatp3a1; 3.5.11 Oatp4a1; 3.5.12 Oatp4c1; 3.5.13 Oatp6b1/Oatp6c1; 3.5.14 PGT-2 3.5.15 TST-1 and TST-2 |
| Record Nr. | UNINA-9910876940303321 |
| Weinheim, : Wiley-VCH, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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