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1939-1989, fifty years progress in allergy : a tribute to Paul Kallós
1939-1989, fifty years progress in allergy : a tribute to Paul Kallós
Pubbl/distr/stampa [Place of publication not identified], : Karger, 1990
Descrizione fisica 1 online resource (XII + 284 pages) : : 47 figures, 16 tables
Collana Chemical immunology 1939-1989, fifty years progress in allergy
Soggetto topico Allergy
Immunologic diseases
Immune System Diseases
Medicine
Diseases
Health Occupations
Disciplines and Occupations
Allergy and Immunology
Hypersensitivity
Health & Biological Sciences
Clinical Immunology
ISBN 3-318-01627-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910155293703321
[Place of publication not identified], : Karger, 1990
Materiale a stampa
Lo trovi qui: Univ. Federico II
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[Medical text, in part discussing gout, written in English and Latin] [[electronic resource]]
[Medical text, in part discussing gout, written in English and Latin] [[electronic resource]]
Pubbl/distr/stampa [S.l., : s.n., before 1700?]
Descrizione fisica [2] p
Soggetto topico Diseases
Gout
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNISA-996393727703316
[S.l., : s.n., before 1700?]
Materiale a stampa
Lo trovi qui: Univ. di Salerno
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Accompany Me : A Life in Vulnerability and Faith
Accompany Me : A Life in Vulnerability and Faith
Autore Gallagher Nora
Pubbl/distr/stampa , : Knopf Doubleday Publishing Group, , 2017
Descrizione fisica 1 online resource (37 pages)
Disciplina 616.00189999999998
Collana A Vintage Short
Soggetto topico Critically ill
Diseases
Adjustment (Psychology)
ISBN 0-525-43516-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910163079303321
Gallagher Nora  
, : Knopf Doubleday Publishing Group, , 2017
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Acquired immunodeficiency syndrome
Acquired immunodeficiency syndrome
Pubbl/distr/stampa [Place of publication not identified], : Karger, 1986
Descrizione fisica 1 online resource (X + 398 pages) : : 103 figures, 29 tables
Soggetto topico Slow Virus Diseases
HIV Infections
Immunologic Deficiency Syndromes
Sexually Transmitted Diseases, Viral
Lentivirus Infections
Virus Diseases
Diseases
Retroviridae Infections
Sexually Transmitted Diseases
Immune System Diseases
RNA Virus Infections
Acquired Immunodeficiency Syndrome
ISBN 3-318-01862-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910155293603321
[Place of publication not identified], : Karger, 1986
Materiale a stampa
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Acute stroke : evaluation and treatment
Acute stroke : evaluation and treatment
Pubbl/distr/stampa [Place of publication not identified], : AHRQ, 2005
Descrizione fisica 1 online resource
Collana Evidence Reports/Technology Assessments
AHRQ publication
Soggetto topico Cerebrovascular Disorders
Drug Therapy
Brain Diseases
Vascular Diseases
Therapeutics
Diagnostic Techniques and Procedures
Central Nervous System Diseases
Cardiovascular Diseases
Nervous System Diseases
Diseases
Stroke
Thrombolytic Therapy
Medicine
Health & Biological Sciences
Neurology
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910698112503321
[Place of publication not identified], : AHRQ, 2005
Materiale a stampa
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ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
Autore Tsaioun Katya
Pubbl/distr/stampa Hoboken, : Wiley, 2012
Descrizione fisica 1 online resource (524 p.)
Disciplina 615.19
615/.19
Altri autori (Persone) KatesSteven A
Soggetto topico Drug Design
Drug Toxicity
Drugs - Testing
Drugs --Testing --Juvenile literature
Pharmaceutical Preparations - chemistry
Pharmacokinetics
Metabolic Phenomena
Drug Discovery
Pharmacological Phenomena
Natural Science Disciplines
Kinetics
Chemicals and Drugs
Poisoning
Biochemical Phenomena
Chemistry, Pharmaceutical
Substance-Related Disorders
Disciplines and Occupations
Investigative Techniques
Physiological Phenomena
Phenomena and Processes
Chemical Phenomena
Diseases
Pharmacology
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Chemistry
Pharmaceutical Preparations
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-280-59122-6
9786613621054
0-470-91509-9
0-470-91511-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs
2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods
2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution
4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools
4.5.7 Tools for Studying Drug Excretion
Record Nr. UNINA-9910133588303321
Tsaioun Katya  
Hoboken, : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
Autore Tsaioun Katya
Pubbl/distr/stampa Hoboken, : Wiley, 2012
Descrizione fisica 1 online resource (524 p.)
Disciplina 615.19
615/.19
Altri autori (Persone) KatesSteven A
Soggetto topico Drug Design
Drug Toxicity
Drugs - Testing
Drugs --Testing --Juvenile literature
Pharmaceutical Preparations - chemistry
Pharmacokinetics
Metabolic Phenomena
Drug Discovery
Pharmacological Phenomena
Natural Science Disciplines
Kinetics
Chemicals and Drugs
Poisoning
Biochemical Phenomena
Chemistry, Pharmaceutical
Substance-Related Disorders
Disciplines and Occupations
Investigative Techniques
Physiological Phenomena
Phenomena and Processes
Chemical Phenomena
Diseases
Pharmacology
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Biological Science Disciplines
Chemistry
Pharmaceutical Preparations
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-280-59122-6
9786613621054
0-470-91509-9
0-470-91511-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs
2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods
2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution
4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools
4.5.7 Tools for Studying Drug Excretion
Record Nr. UNINA-9910830164603321
Tsaioun Katya  
Hoboken, : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Adolescents, alcohol, and substance abuse : reaching teens through brief interventions
Adolescents, alcohol, and substance abuse : reaching teens through brief interventions
Pubbl/distr/stampa [Place of publication not identified], : Guilford Press, 2001
Descrizione fisica 1 online resource (683 pages)
Disciplina 616.86/00835
Soggetto topico Teenagers - Substance use
Teenagers - Alcohol use
Substance abuse - Prevention
Alcoholism - Prevention
Brief psychotherapy for teenagers - Counseling of
Teenagers
Age Groups
Mental Disorders
Diseases
Psychotherapy
Behavioral Disciplines and Activities
Persons
Psychiatry and Psychology
Named Groups
Psychotherapy, Brief
Substance-Related Disorders
Adolescent
Medicine
Health & Biological Sciences
Pediatrics
ISBN 1-4625-0597-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Cover -- Title Page -- Copyright Page -- Dedication -- About the Editors -- Contributors -- Foreword -- Preface -- Contents -- Introduction -- PART I. BACKGROUND AND CONTEXT: THEORY, DEVELOPMENTAL, AND MEASUREMENT CONSIDERATIONS -- 1. Development Matters: Taking the Long View on Substance Abuse Etiology and Intervention during Adolescence -- 2. The Harm Reduction Approach to the Secondary Prevention of Alcohol Problems in Adolescents and Young Adults: Considerations across a Developmental Spectrum -- 3. Assessing Adolescent Substance Use Problems and Other Areas of Functioning: State of the Art -- 4. Personality and Learning Factors Combine to Create Risk for Adolescent Problem Drinking: A Model and Suggestions for Intervention -- PART II. EMPIRICAL ILLUSTRATIONS LINKED TO PART 1/ CLINICAL APPLICATIONS OF BRIEF INTERVENTIONS -- 5. Motivational Enhancement for Alcohol-Involved Adolescents -- 6. Alcohol Skills Training for College Students -- 7. Integrative Behavioral and Family Therapy for Adolescent Substance Abuse -- 8. Motivational Interviewing and the Prevention of HIV among Adolescents -- 9. Toward Brief Interventions for Adolescents with Substance Abuse and Comorbid Psychiatric Problems -- 10. New Frontiers: Using the Internet to Engage Teens in Substance Abuse Prevention and Treatment -- PART III. FUTURE DIRECTIONS -- 11. Transdisciplinary Research to Improve Brief Interventions for Addictive Behaviors -- Index -- About Guilford Publications -- Discover More Guilford Titles.
Altri titoli varianti Adolescents, Alcohol, and Substance Abuse
Record Nr. UNINA-9910162831003321
[Place of publication not identified], : Guilford Press, 2001
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Advanced Therapy for Hepatitis C [[electronic resource]]
Advanced Therapy for Hepatitis C [[electronic resource]]
Autore McCaughan Geoffrey W
Pubbl/distr/stampa Hoboken, : Wiley, 2011
Descrizione fisica 1 online resource (233 p.)
Disciplina 616.3/62306
616.362306
Altri autori (Persone) McHutchisonJohn
PawlotskyJean-Michel
Soggetto topico Antiviral agents
Antiviral Agents - therapeutic use
Antiviral Agents -- therapeutic use
Hepatitis C - therapy
Hepatitis C -- therapy
Hepatitis C - Treatment
Hepatitis C -- Treatment
Hepatitis, Viral, Human
Flaviviridae Infections
Anti-Infective Agents
RNA Virus Infections
Therapeutic Uses
Virus Diseases
Hepatitis
Diseases
Liver Diseases
Pharmacologic Actions
Chemical Actions and Uses
Digestive System Diseases
Antiviral Agents
Hepatitis C
Medicine
Health & Biological Sciences
Gastroenterology
ISBN 1-283-28323-9
9786613283238
1-4443-4634-2
1-4443-4631-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Therapy for Hepatitis C; Contents; Contributors; Preface; Section I Foundations for Understanding Antiviral Therapies in HCV; 1 HCV Replication; 2 Hepatitis C Virus Genotypes; 3 Immune Responses to HCV: Implications for Therapy; 4 Mechanisms of Action of Antiviral Drugs: The Interferons; 5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs; 6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors; 7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors; 8 Measuring Antiviral Responses
Section II Efficacy and Clinical Use of Antiviral Therapies9 Genotype 1: Standard Treatment; 10 Individually Tailored Treatment Strategies in Treatment-naïve Chronic Hepatitis C Genotype 1 Patients; 11 Genotype 1 Relapsers and Non-responders; 12 Standard Therapy for Genotypes 2/3; 13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3; 14 Genotypes 2 and 3 Relapse and Non-response; 15 Hepatitis C Genotype 4 Therapy: Progress and Challenges; 16 Antivirals in Acute Hepatitis C; 17 Antivirals in Cirrhosis and Portal Hypertension
18 Treatment of Recurrent Hepatitis C Following Liver Transplantation19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations; 20 Cytopenias: How they Limit Therapy and Potential Correction; 21 The Problem of Insulin Resistance and its Effect on Therapy; 22 HIV and Hepatitis C Co-infection; 23 HCV and Racial Differences; 24 HCV and the Pediatric Population; 25 New Horizons: IL28, Direct-acting Antiviral Therapy for HCV; Index
Record Nr. UNINA-9910139591503321
McCaughan Geoffrey W  
Hoboken, : Wiley, 2011
Materiale a stampa
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Advances in Nutrition and Cancer / / edited by Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione
Advances in Nutrition and Cancer / / edited by Vincenzo Zappia, Salvatore Panico, Gian Luigi Russo, Alfredo Budillon, Fulvio Della Ragione
Edizione [1st ed. 2014.]
Pubbl/distr/stampa Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014
Descrizione fisica 1 online resource (450 p.)
Disciplina 616.99
616.99/4071
616.994071
Collana Cancer Treatment and Research
Soggetto topico Oncology
Medicine, Preventive
Health promotion
Epidemiology
Medicine - Research
Biology - Research
Medical genetics
Diseases
Health Promotion and Disease Prevention
Biomedical Research
Medical Genetics
ISBN 3-642-38007-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Part I: Life Style, Diet and Cancer: The role of metabolic carcinogenesis in cancer causation and prevention: evidence from the European prospective investigation into cancer and nutrition -- Obesity, energy balance and cancer: a mechanistic perspective -- Fruits and vegetables. Updating the epidemiologic evidence for the WCRF-AICR lifestyle recommendations for cancer prevention -- The diet as a cause of human prostate cancer -- Mediterranean dietary pattern and chronic diseases -- Dietary salt intake and risk of gastric cancer -- Alcoholic beverages and carbonated soft drinks: consumption and gastrointestinal cancer risks -- Part II: Natural Dietary Molecules: Anti-inflammatory and anti-cancer drugs from nature -- Selenium and cancer: a story that should not be forgotten – Insights from genomics -- Resveratrol: from basic studies to bedside -- Quercetin: a pleiotropic kinase inhibitor against cancer -- Sulforaphane as a promising molecule for fighting cancer -- Part III: Genetics and Epigenetics: Functions, aberrations and advances for chromatin modulation in cancer -- Epigenetics and epidemiology: models of study and examples -- Dietary epigenetics in cancer and aging -- Breast cancer and the importance of early life nutrition -- Part IV: Olive Oil in Cancer Prevention -- Olive oil and other dietary lipids in breast cancer -- A holistic approach to study the effects of natural antioxidants on inflammation and liver cancer -- Extra virgin olive oil: from composition to ‘molecular  fastronomy’ -- Part V: Life Style Prevention of Cancer: Life style prevention of cancer recurrence: the yin and the yang -- Part VI: Emerging Breakthroughs: New perspective for an old antidiabetic drug: metformin as anticancer agent -- Gut microbes, diet and cancer -- Inflammatory angiogenesis and the tumor microenvironment as targets for cancer therapy and prevention -- Nutriomes and personalised nutrition for DNA damage prevention, telomere integrity maintenance and cancer growth control -- Novel approaches in melanoma prevention and therapy -- Concluding remarks.
Record Nr. UNINA-9910300071903321
Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014
Materiale a stampa
Lo trovi qui: Univ. Federico II
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