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Development of selective DNA-interacting ligands : understanding the function of non-canonical DNA structures / / Sefan Asamitsu
| Development of selective DNA-interacting ligands : understanding the function of non-canonical DNA structures / / Sefan Asamitsu |
| Autore | Asamitsu Sefan |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Singapore : , : Springer, , [2020] |
| Descrizione fisica | 1 online resource (XIII, 111 p. 68 illus., 56 illus. in color.) |
| Disciplina | 572.864 |
| Collana | Springer Theses |
| Soggetto topico |
DNA-ligand interactions
Bioorganic chemistry Genetics |
| ISBN | 981-15-7716-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. General Introduction -- 2. Sequence-specific DNA alkylation and transcriptional inhibition by long-chain hairpin pyrrole–imidazole polyamide–chlorambucil conjugates targeting CAG/CTG trinucleotide repeats -- 3. Ligand-Mediated G-Quadruplex Induction in a Double-Stranded DNA Context by Cyclic Imidazole/Lysine Polyamide -- 4. Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-Binding Components to a G-Quadruplex and Its Proximal Duplex. |
| Record Nr. | UNINA-9910420949803321 |
Asamitsu Sefan
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| Singapore : , : Springer, , [2020] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Metal complex-DNA interactions [[electronic resource] /] / edited by Nick Hadjiliadis, Einar Sletten
| Metal complex-DNA interactions [[electronic resource] /] / edited by Nick Hadjiliadis, Einar Sletten |
| Pubbl/distr/stampa | Oxford, : Wiley, c2009 |
| Descrizione fisica | 1 online resource (558 p.) |
| Disciplina |
572.864
612.01524 |
| Altri autori (Persone) |
HadjiliadisNick D
SlettenEinar |
| Soggetto topico |
Metals - Physiological effect
DNA-ligand interactions |
| ISBN |
1-282-12409-9
9786612124099 1-4443-1208-1 1-4051-9410-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Metal Complex-DNA Interactions; Contents; Preface; List of Contributors; Acknowledgements; Part A: Basic Structural and Kinetic Aspects; 1: Sequence-Selective Binding of Transition Metal Complexes to DNA; 1.1 Introduction; 1.2 Ab initio Calculations and Photo-Cleavage Studies; 1.3 NMR Spectroscopic Studies of Metal Binding to DNA Oligonucleotides; 1.4 Summary of Theoretical and Experimental Evidence for Sequence-Selective Binding to DNA; 1.5 Sequence-Specific Groove Binding; Abbreviations; References; 2: Thermodynamic Models of Metal Ion-DNA Interactions; 2.1 Introduction
2.2 Interactions of Metal Ions with DNA2.3 Model and Mechanisms of Metal-Induced Formation of Point Defects; 2.4 Conclusions; Acknowledgements; Abbreviations; References; 3: Metal Ion Coordination in G-Quadruplexes; 3.1 Introduction; 3.2 Cation Coordination and Stability of G-Quadruplexes; 3.3 Structure of Sequences Consisting of Human Telomere Repeats; 3.4 G-Quadruplexes Adopted by Promoter Regions; 3.5 Bimolecular G-Quadruplexes of Analogues of the Oxytricha Telomere Repeat; 3.6 Coordination of Cations within d[(TG4T)4]; 3.7 Coordination of Cations within d[(G4T4G4)2] 3.8 Cation Movement within G-Quadruplexes3.9 Summary; Acknowledgements; References; 4: Supramolecular Chemistry of Metal-Nucleobase Complexes; 4.1 Introduction; 4.2 Discrete Architectures; 4.3 Infinite Architectures; 4.4 Overview of Metal Coordination Sites and Base-Base Hydrogen Bonding; 4.5 M-DNA; 4.6 Conclusion; Acknowledgements; References; Part B: Medical Applications; 5: Platinum Drugs, Nucleotides and DNA: The Role of Interligand Interactions; 5.1 Introduction; 5.2 Internucleotide Interactions; 5.3 Guanine cis Amine Interactions; 5.4 Solid-State Structures of Dynamic Nucleotides 5.5 Conformer Distribution in Cisplatin Adducts of G Derivatives5.6 Retro Models Applied to Adducts with Tethered Guanine Bases; 5.7 Conclusions and Perspectives; Acknowledgements; References; 6: Role of DNA Repair in Antitumour Effects of Platinum Drugs; 6.1 Introduction; 6.2 Human DNA Repair Systems; 6.3 Specific Binding of Repair Proteins to DNA Modified by Antitumour Platinum Compounds; 6.4 Repair of DNA Damage by Antitumour Platinum Compounds; 6.5 Implications for Design of Antitumour Platinum Compounds; Acknowledgements; References 7: Telomeres and Telomerase: Potential Targets for Platinum Complexes7.1 Function of Telomeres; 7.2 Structure of Telomeres; 7.3 Telomerase; 7.4 G-Quadruplex Structures and Small Molecules; 7.5 Cisplatin; 7.6 Interaction of Cisplatin and Related Platinum Complexes with G-Quadruplex Structures; 7.7 Interaction of Cisplatin and Related Platinum Complexes with Telomeric DNA Duplexes; 7.8 Interaction of Cisplatin and Related Platinum Complexes with Telomerase; 7.9 Conclusion; Acknowledgements; Abbreviations; References 8: Towards Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes |
| Record Nr. | UNINA-9910146146303321 |
| Oxford, : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Metal complex-DNA interactions [[electronic resource] /] / edited by Nick Hadjiliadis, Einar Sletten
| Metal complex-DNA interactions [[electronic resource] /] / edited by Nick Hadjiliadis, Einar Sletten |
| Pubbl/distr/stampa | Oxford, : Wiley, c2009 |
| Descrizione fisica | 1 online resource (558 p.) |
| Disciplina |
572.864
612.01524 |
| Altri autori (Persone) |
HadjiliadisNick D
SlettenEinar |
| Soggetto topico |
Metals - Physiological effect
DNA-ligand interactions |
| ISBN |
1-282-12409-9
9786612124099 1-4443-1208-1 1-4051-9410-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Metal Complex-DNA Interactions; Contents; Preface; List of Contributors; Acknowledgements; Part A: Basic Structural and Kinetic Aspects; 1: Sequence-Selective Binding of Transition Metal Complexes to DNA; 1.1 Introduction; 1.2 Ab initio Calculations and Photo-Cleavage Studies; 1.3 NMR Spectroscopic Studies of Metal Binding to DNA Oligonucleotides; 1.4 Summary of Theoretical and Experimental Evidence for Sequence-Selective Binding to DNA; 1.5 Sequence-Specific Groove Binding; Abbreviations; References; 2: Thermodynamic Models of Metal Ion-DNA Interactions; 2.1 Introduction
2.2 Interactions of Metal Ions with DNA2.3 Model and Mechanisms of Metal-Induced Formation of Point Defects; 2.4 Conclusions; Acknowledgements; Abbreviations; References; 3: Metal Ion Coordination in G-Quadruplexes; 3.1 Introduction; 3.2 Cation Coordination and Stability of G-Quadruplexes; 3.3 Structure of Sequences Consisting of Human Telomere Repeats; 3.4 G-Quadruplexes Adopted by Promoter Regions; 3.5 Bimolecular G-Quadruplexes of Analogues of the Oxytricha Telomere Repeat; 3.6 Coordination of Cations within d[(TG4T)4]; 3.7 Coordination of Cations within d[(G4T4G4)2] 3.8 Cation Movement within G-Quadruplexes3.9 Summary; Acknowledgements; References; 4: Supramolecular Chemistry of Metal-Nucleobase Complexes; 4.1 Introduction; 4.2 Discrete Architectures; 4.3 Infinite Architectures; 4.4 Overview of Metal Coordination Sites and Base-Base Hydrogen Bonding; 4.5 M-DNA; 4.6 Conclusion; Acknowledgements; References; Part B: Medical Applications; 5: Platinum Drugs, Nucleotides and DNA: The Role of Interligand Interactions; 5.1 Introduction; 5.2 Internucleotide Interactions; 5.3 Guanine cis Amine Interactions; 5.4 Solid-State Structures of Dynamic Nucleotides 5.5 Conformer Distribution in Cisplatin Adducts of G Derivatives5.6 Retro Models Applied to Adducts with Tethered Guanine Bases; 5.7 Conclusions and Perspectives; Acknowledgements; References; 6: Role of DNA Repair in Antitumour Effects of Platinum Drugs; 6.1 Introduction; 6.2 Human DNA Repair Systems; 6.3 Specific Binding of Repair Proteins to DNA Modified by Antitumour Platinum Compounds; 6.4 Repair of DNA Damage by Antitumour Platinum Compounds; 6.5 Implications for Design of Antitumour Platinum Compounds; Acknowledgements; References 7: Telomeres and Telomerase: Potential Targets for Platinum Complexes7.1 Function of Telomeres; 7.2 Structure of Telomeres; 7.3 Telomerase; 7.4 G-Quadruplex Structures and Small Molecules; 7.5 Cisplatin; 7.6 Interaction of Cisplatin and Related Platinum Complexes with G-Quadruplex Structures; 7.7 Interaction of Cisplatin and Related Platinum Complexes with Telomeric DNA Duplexes; 7.8 Interaction of Cisplatin and Related Platinum Complexes with Telomerase; 7.9 Conclusion; Acknowledgements; Abbreviations; References 8: Towards Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes |
| Record Nr. | UNINA-9910830211203321 |
| Oxford, : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Metal complex-DNA interactions / / edited by Nick Hadjiliadis, Einar Sletten
| Metal complex-DNA interactions / / edited by Nick Hadjiliadis, Einar Sletten |
| Pubbl/distr/stampa | Oxford, : Wiley, c2009 |
| Descrizione fisica | 1 online resource (558 p.) |
| Disciplina | 612.01524 |
| Altri autori (Persone) |
HadjiliadisNick D
SlettenEinar |
| Soggetto topico |
Metals - Physiological effect
DNA-ligand interactions |
| ISBN |
1-282-12409-9
9786612124099 1-4443-1208-1 1-4051-9410-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Metal Complex-DNA Interactions; Contents; Preface; List of Contributors; Acknowledgements; Part A: Basic Structural and Kinetic Aspects; 1: Sequence-Selective Binding of Transition Metal Complexes to DNA; 1.1 Introduction; 1.2 Ab initio Calculations and Photo-Cleavage Studies; 1.3 NMR Spectroscopic Studies of Metal Binding to DNA Oligonucleotides; 1.4 Summary of Theoretical and Experimental Evidence for Sequence-Selective Binding to DNA; 1.5 Sequence-Specific Groove Binding; Abbreviations; References; 2: Thermodynamic Models of Metal Ion-DNA Interactions; 2.1 Introduction
2.2 Interactions of Metal Ions with DNA2.3 Model and Mechanisms of Metal-Induced Formation of Point Defects; 2.4 Conclusions; Acknowledgements; Abbreviations; References; 3: Metal Ion Coordination in G-Quadruplexes; 3.1 Introduction; 3.2 Cation Coordination and Stability of G-Quadruplexes; 3.3 Structure of Sequences Consisting of Human Telomere Repeats; 3.4 G-Quadruplexes Adopted by Promoter Regions; 3.5 Bimolecular G-Quadruplexes of Analogues of the Oxytricha Telomere Repeat; 3.6 Coordination of Cations within d[(TG4T)4]; 3.7 Coordination of Cations within d[(G4T4G4)2] 3.8 Cation Movement within G-Quadruplexes3.9 Summary; Acknowledgements; References; 4: Supramolecular Chemistry of Metal-Nucleobase Complexes; 4.1 Introduction; 4.2 Discrete Architectures; 4.3 Infinite Architectures; 4.4 Overview of Metal Coordination Sites and Base-Base Hydrogen Bonding; 4.5 M-DNA; 4.6 Conclusion; Acknowledgements; References; Part B: Medical Applications; 5: Platinum Drugs, Nucleotides and DNA: The Role of Interligand Interactions; 5.1 Introduction; 5.2 Internucleotide Interactions; 5.3 Guanine cis Amine Interactions; 5.4 Solid-State Structures of Dynamic Nucleotides 5.5 Conformer Distribution in Cisplatin Adducts of G Derivatives5.6 Retro Models Applied to Adducts with Tethered Guanine Bases; 5.7 Conclusions and Perspectives; Acknowledgements; References; 6: Role of DNA Repair in Antitumour Effects of Platinum Drugs; 6.1 Introduction; 6.2 Human DNA Repair Systems; 6.3 Specific Binding of Repair Proteins to DNA Modified by Antitumour Platinum Compounds; 6.4 Repair of DNA Damage by Antitumour Platinum Compounds; 6.5 Implications for Design of Antitumour Platinum Compounds; Acknowledgements; References 7: Telomeres and Telomerase: Potential Targets for Platinum Complexes7.1 Function of Telomeres; 7.2 Structure of Telomeres; 7.3 Telomerase; 7.4 G-Quadruplex Structures and Small Molecules; 7.5 Cisplatin; 7.6 Interaction of Cisplatin and Related Platinum Complexes with G-Quadruplex Structures; 7.7 Interaction of Cisplatin and Related Platinum Complexes with Telomeric DNA Duplexes; 7.8 Interaction of Cisplatin and Related Platinum Complexes with Telomerase; 7.9 Conclusion; Acknowledgements; Abbreviations; References 8: Towards Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes |
| Record Nr. | UNINA-9910876710603321 |
| Oxford, : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
