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The base excision repair pathway : molecular mechanisms and role in disease development and therapeutic design / / editor, David M. Wilson III
| The base excision repair pathway : molecular mechanisms and role in disease development and therapeutic design / / editor, David M. Wilson III |
| Pubbl/distr/stampa | New Jersey : , : World Scientific, , [2017] |
| Descrizione fisica | 1 online resource (823 pages) : illustrations (some color) |
| Disciplina | 572.8/6459 |
| Soggetto topico |
DNA repair
DNA damage |
| ISBN | 981-4719-73-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Genomic uracil : dangers and benefits in processing / Hans Krokan -- The GO repair pathway : OGG1 and MUTYH / Sheila David -- The DNA glycosylases that recognize and remove free radical-damaged pyrimidines / Susan Wallace -- Alkyladenine DNA glycosylase / Leona Samson -- The abasic endonuclease APE1 : much more than a DNA repair enzyme / Gianluca Tell -- Central steps in mammalian BER and regulation by PARP1 / Samuel Wilson -- Processing strand break termini in the DNA single strand break repair pathway / Michael Weinfeld -- The PARP-XRCC1 axis in base excision repair / Janet Hall -- DNA ligases in base excision repair / Alan Tomkinson -- Base excision repair and epigenetic regulation / Primo Schär -- Base excision repair in the immune system / Carol Schrader -- Base excision repair in the etiology of lupus and cancer / Joann Sweasy -- Base excision repair in trinucleotide repeat expansion disorders / Margherita Bignami -- Neurodegeneration caused by accumulation of an oxidized base lesion, 8-oxoguanine, in nuclear and mitochondrial DNA: from animal models to human diseases / Yusaku Nakabeppu -- Assessing BER capacity in the human population / Zachary Nagel -- Prognostic and predictive significance of base excision repair in human cancers / Srinivasan Madhusudan -- Enzymes in the base excision repair pathway as targets for small molecule mediated therapeutics / R. Stephen Lloyd -- Mitochondrial base excision repair / Nadja de Souza Pinto -- Base excision repair in aging / Tinna Stevnsner. |
| Record Nr. | UNINA-9910163090503321 |
| New Jersey : , : World Scientific, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell cycle
| Cell cycle |
| Pubbl/distr/stampa | Georgetown, TX, : Landes Bioscience, 2002- |
| Disciplina | 611 |
| Soggetto topico |
Cell cycle
DNA damage Cells - Aging Cytology Cells Cell Cycle DNA Damage Cellular Senescence Cytologie Cellules Cycle cellulaire ADN - Lésions Cellules - Vieillissement Celcyclus |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. periodicals. Périodiques. |
| ISSN | 1551-4005 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996216612103316 |
| Georgetown, TX, : Landes Bioscience, 2002- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Cell cycle
| Cell cycle |
| Pubbl/distr/stampa | Georgetown, TX, : Landes Bioscience, 2002- |
| Disciplina | 611 |
| Soggetto topico |
Cell cycle
DNA damage Cells - Aging Cytology Cells Cell Cycle DNA Damage Cellular Senescence Cytologie Cellules Cycle cellulaire ADN - Lésions Cellules - Vieillissement Celcyclus |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. periodicals. Périodiques. |
| ISSN | 1551-4005 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910143474103321 |
| Georgetown, TX, : Landes Bioscience, 2002- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The chemical biology of DNA damage [[electronic resource] /] / edited by Nicholas E. Geacintov and Suse Broyde
| The chemical biology of DNA damage [[electronic resource] /] / edited by Nicholas E. Geacintov and Suse Broyde |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley, 2010 |
| Descrizione fisica | 1 online resource (473 p.) |
| Disciplina |
572.8
572.86 22 |
| Altri autori (Persone) |
GeacintovNicholas E
BroydeSuse |
| Soggetto topico | DNA damage |
| ISBN |
3-527-64211-0
1-282-78445-5 9786612784453 3-527-63011-2 3-527-63012-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Chemistry and biology of DNA lesions -- pt. 2 New frontiers and challenges : understanding structure-function relationships and biological activity. |
| Record Nr. | UNINA-9910139197403321 |
| Weinheim [Germany], : Wiley, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The chemical biology of DNA damage [[electronic resource] /] / edited by Nicholas E. Geacintov and Suse Broyde
| The chemical biology of DNA damage [[electronic resource] /] / edited by Nicholas E. Geacintov and Suse Broyde |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley, 2010 |
| Descrizione fisica | 1 online resource (473 p.) |
| Disciplina |
572.8
572.86 22 |
| Altri autori (Persone) |
GeacintovNicholas E
BroydeSuse |
| Soggetto topico | DNA damage |
| ISBN |
3-527-64211-0
1-282-78445-5 9786612784453 3-527-63011-2 3-527-63012-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Chemistry and biology of DNA lesions -- pt. 2 New frontiers and challenges : understanding structure-function relationships and biological activity. |
| Record Nr. | UNINA-9910830025803321 |
| Weinheim [Germany], : Wiley, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The chemical biology of DNA damage / / edited by Nicholas E. Geacintov and Suse Broyde
| The chemical biology of DNA damage / / edited by Nicholas E. Geacintov and Suse Broyde |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Weinheim [Germany], : Wiley, 2010 |
| Descrizione fisica | 1 online resource (473 p.) |
| Disciplina |
572.8
572.86 22 |
| Altri autori (Persone) |
GeacintovNicholas E
BroydeSuse |
| Soggetto topico | DNA damage |
| ISBN |
3-527-64211-0
1-282-78445-5 9786612784453 3-527-63011-2 3-527-63012-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Chemistry and biology of DNA lesions -- pt. 2 New frontiers and challenges : understanding structure-function relationships and biological activity. |
| Record Nr. | UNINA-9910876896003321 |
| Weinheim [Germany], : Wiley, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemically-induced DNA damage, mutagenesis, and cancer / / edited by Ashis K. Basu, Takehiko Nohmi
| Chemically-induced DNA damage, mutagenesis, and cancer / / edited by Ashis K. Basu, Takehiko Nohmi |
| Pubbl/distr/stampa | Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2018 |
| Descrizione fisica | 1 online resource (274 pages) |
| Disciplina | 571.87836 |
| Soggetto topico | DNA damage |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | About the Special Issue Editors -- Preface to "Chemically-Induced DNA Damage, Mutagenesis, and Cancer" -- DNA Damage, Mutagenesis and Cancer -- The Future of DNA Adductomic Analysis -- Every OGT Is Illuminated ... by Fluorescent and Synchrotron Lights -- Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis -- DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol -- Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways -- Magnetic Hyperthermia and Oxidative Damage to DNA of Human Hepatocarcinoma Cells -- The Role of Resveratrol in Cancer Therapy -- Supercritical-Carbon Dioxide Fluid Extract from Chrysanthemum indicum Enhances Anti-Tumor Effect and Reduces Toxicity of Bleomycin in Tumor-Bearing Mice -- Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome -- A Case-Control Study of the Genetic Variability in Reactive Oxygen Species-Metabolizing Enzymes in Melanoma Risk -- CoQ10 Deficiency May Indicate Mitochondrial Dysfunction in Cr(VI) Toxicity -- The Effect of VPA on Increasing Radiosensitivity in Osteosarcoma Cells and Primary-Culture Cells from Chemical Carcinogen-Induced Breast Cancer in Rats -- High NOTCH1 mRNA Expression Is Associated with Better Survival in HNSCC -- Dynamic Reorganization of the Cytoskeleton during Apoptosis: The Two Coffins Hypothesis. |
| Record Nr. | UNINA-9910598028503321 |
| Basel : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemically-induced DNA damage, mutagenesis, and cancer / / edited by Ashis K. Basu, Takehiko Nohmi
| Chemically-induced DNA damage, mutagenesis, and cancer / / edited by Ashis K. Basu, Takehiko Nohmi |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI, , 2018 |
| Descrizione fisica | 1 online resource (274 pages) : illustrations |
| Disciplina | 572.86 |
| Soggetto topico | DNA damage |
| ISBN | 3-03897-130-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | About the Special Issue Editors -- Preface to "Chemically-Induced DNA Damage, Mutagenesis, and Cancer" -- DNA Damage, Mutagenesis and Cancer -- The Future of DNA Adductomic Analysis -- Every OGT Is Illuminated ... by Fluorescent and Synchrotron Lights -- Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis -- DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol -- Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways -- Magnetic Hyperthermia and Oxidative Damage to DNA of Human Hepatocarcinoma Cells -- The Role of Resveratrol in Cancer Therapy -- Supercritical-Carbon Dioxide Fluid Extract from Chrysanthemum indicum Enhances Anti-Tumor Effect and Reduces Toxicity of Bleomycin in Tumor-Bearing Mice -- Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome -- A Case-Control Study of the Genetic Variability in Reactive Oxygen Species-Metabolizing Enzymes in Melanoma Risk -- CoQ10 Deficiency May Indicate Mitochondrial Dysfunction in Cr(VI) Toxicity -- The Effect of VPA on Increasing Radiosensitivity in Osteosarcoma Cells and Primary-Culture Cells from Chemical Carcinogen-Induced Breast Cancer in Rats -- High NOTCH1 mRNA Expression Is Associated with Better Survival in HNSCC -- Dynamic Reorganization of the Cytoskeleton during Apoptosis: The Two Coffins Hypothesis. |
| Record Nr. | UNINA-9910688206903321 |
| Basel, Switzerland : , : MDPI, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mutagenesis and Mitochondrial-Associated Pathologies / / Michael Fasullo, Angel Catala, editors
| Mutagenesis and Mitochondrial-Associated Pathologies / / Michael Fasullo, Angel Catala, editors |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2022 |
| Descrizione fisica | 1 online resource (116 pages) |
| Disciplina | 616.042 |
| Soggetto topico |
DNA damage
Mutagenicity testing |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910688183903321 |
| London : , : IntechOpen, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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RNA damage and repair / / Ioly Kotta-Loizou, editor
| RNA damage and repair / / Ioly Kotta-Loizou, editor |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2021] |
| Descrizione fisica | 1 online resource (180 pages) |
| Disciplina | 572.88 |
| Soggetto topico |
RNA
DNA damage ADN Reparació de l'ADN Biomolècules Procariotes |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-76571-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface -- Contents -- Part I: RNA Damage and Repair in Prokaryotes -- Endoribonucleases of the Toxin-Antitoxin Systems Induce Abortive Infection -- 1 Introduction -- 1.1 The Arms Race Between Bacteria and Phages -- 1.2 The Abortive Infection (Abi) System -- 1.3 The Toxin-Antitoxin (TA) System -- 2 Functions, Structures, and Regulation of the MazF Endoribonuclease -- 2.1 The Abortive Infection Induced by the MazF Endoribonuclease -- 2.2 Phage Mechanism to Overcome MazF-Induced Abi -- 3 Functions, Structures, and Regulation of RnlA Endoribonuclease -- 3.1 The Abortive Infection Induced by RnlA Endoribonuclease -- 3.2 Phage Mechanisms to Overcome RnlA-Induced Abi -- 4 Functions, Structures, and Regulations of ToxN Endoribonuclease -- 4.1 The Abortive Infection Induced by ToxN Endoribonuclease -- 4.2 Phage Mechanisms to Overcome ToxN-Induced Abi -- 5 Conclusion -- References -- The Lifecycle of Ribosomal RNA in Bacteria -- 1 Introduction -- 2 Localisation and Copy Number of rDNA Operons in Bacteria -- 3 Organisation of rDNA Operons in Bacteria -- 4 Transcription Regulation of rDNA Genes Along the Microbial Growth Curve -- 4.1 Ribosomal DNA Promoters and Cis-Regulatory Elements -- 4.2 Trans-regulatory Elements -- 4.2.1 Regulation by Transcription Factors -- 4.2.2 Regulation by NTP and (p)ppGpp -- 5 Processing of Premature rRNA into Functional rRNAs -- 5.1 Maturation of 23S rRNA in E. coli -- 5.2 Maturation of 16S rRNA in E. coli -- 5.3 Maturation of 5S rRNA in E. coli -- 6 Bacterial rRNA Fragmentation -- 7 Chemical Modification of rRNA Molecules -- 8 Assembly of rRNAs into Ribosomes -- 9 rRNA Quality Control -- 10 Damage and Repair of Bacterial rRNA -- 11 Conclusion -- References -- The Rtc RNA End Healing and Sealing System -- 1 Introduction -- 2 Biological RNA Damage -- 2.1 CRISPR-Cas Systems -- 3 RNA Repair -- 4 The RtcA and RtcB Enzymes.
4.1 The RtcA RNA Cyclase -- 4.2 The RtcB RNA Ligase -- 4.3 The RtcB RNA Ligase in Prokaryotes -- 4.4 The RtcB RNA Ligase in Metazoans -- 5 The Bacterial Rtc RNA Repair System -- 5.1 Diversity of the rtc Operon in Bacteria -- 5.2 The RtcR Transcriptional Regulator and Its CARF Domain -- 5.3 Expression and Function of the Rtc System in Bacteria -- 6 Conclusions -- References -- Part II: RNA Damage and Repair in Eukaryotes -- Oxidative and Nitrative RNA Modifications in Plants -- 1 Introduction -- 2 Oxidative Modifications of RNA in Plants -- 3 Nitrative Modifications of RNA in Plants -- 4 Conclusions -- References -- The Role of Ribonucleases in RNA Damage, Inactivation and Degradation -- 1 Introduction -- 2 Quality Control Mechanisms to Manage Damaged RNA -- 3 Ribosome Quality Control (RQC) and No-Go-Decay (NGD) -- 4 Xrn1, a 5'-3' Exoribonuclease, and the Exosome, a 3'-5' Exoribonuclease Complex -- 5 Cue2 as a Potential NGD Endonuclease -- 6 The Role of Ribonucleases in Targeting and Inactivating Host and Foreign RNA -- 7 Regulatory RNase 1 (Regnase-1) -- 8 NEDD4-Binding Protein 1 (N4BP1) -- 9 Zinc Finger Antiviral Protein (ZAP) and Co-Factor Nucleases -- 10 ZAP and KHNYN -- 11 ZAP and the Exosome Complex -- 12 The 2',5'-Oligoadenylate Synthetase (OAS)/RNAse L System -- 13 Conclusion -- References -- Cytoplasmic mRNA Recapping: An Unexpected Form of RNA Repair -- 1 The Nature of the Cap and Its Role in mRNA Metabolism -- 2 Decapping and 5' Decay -- 3 Early Evidence for Uncapped and Recapped Transcripts -- 4 The Discovery of Cytoplasmic Capping -- 5 The Proteins of the Cytoplasmic Capping Complex -- 6 Cap Homeostasis as an RNA Repair Mechanism That Modulates Translation, mRNA Decay, and Translational Control -- 7 Is There a Relationship Between Recapped Ends and CAGE Tags? -- 8 Does Cytoplasmic Capping Impact the Proteome?. 9 Conclusion and Future Questions -- References -- Part III: RNA Damage in Human Diseases -- Adenosine-to-Inosine RNA Editing: A Key RNA Processing Step Rewriting Transcriptome in Normal Physiology and Diseases -- 1 Regulatory Mechanisms of A-to-I RNA Editing -- 1.1 Editing Regulation by Altering ADAR Expression and Activity -- 1.2 Editing Regulation by Affecting Subcellular Localization of ADAR -- 1.3 Additional Layers of A-to-I RNA Editing Regulation -- 2 Cross Talk of RNA Editing with Other RNA Processing and Cellular Pathways -- 2.1 Roles of ADARs and RNA Editing in miRNA Targeting and Biogenesis -- 2.2 ADARs and Splicing Regulation -- 2.3 ADAR Directly Promotes Proximal Polyadenylation Site -- 2.4 ADAR and N6-Methyladenosine -- 2.5 ADAR and Apoptosis -- 2.6 ADAR and Innate Immunity -- 2.7 ADAR2 and Circadian Rhythm -- References -- RNA-Mediated Metabolic Defects in Microsatellite Expansion Diseases -- 1 Overview of Microsatellite Expansion Diseases -- 2 RNA Structure and RNA-Mediated Toxicity -- 3 Repeat Associated Non-AUG Translation -- 4 Emerging Pathological Roles of microRNA -- 5 Defects in Nucleocytoplasmic Transport -- 6 Liquid-Liquid Phase Separation (LLPS) and Stress Granules -- 7 Conclusions and Future Perspectives -- References. |
| Record Nr. | UNINA-9910490024403321 |
| Cham, Switzerland : , : Springer, , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
-
DNA damage
(12)
- DNA repair (3)
- ADN - Lésions (2)
- Celcyclus (2)
- Cell Cycle (2)