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Cytochrome P450 2E1 : its role in disease and drug metabolism / / Aparajita Dey, editor
| Cytochrome P450 2E1 : its role in disease and drug metabolism / / Aparajita Dey, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Springer, 2013 |
| Descrizione fisica | 1 online resource (267 p.) |
| Disciplina | 572.791 |
| Altri autori (Persone) | DeyAparajita |
| Collana | Sub-cellular biochemistry |
| Soggetto topico | Cytochrome P-450 |
| ISBN |
1-299-40812-5
94-007-5881-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cytochrome P450 2E1 and its clinical aspects -- Nrf2 and antioxidant defense against CYP2E1 toxicity -- The role of Cytochrome P-4502E1 in ethanol-mediated carcinogenesis -- The Importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome -- Relevance of CYP2E1 to non-alcoholic fatty liver disease -- CYP2E1-catalyzed alcohol metabolism -- CYP2E1, oxidative stress, post-translational modifications and lipid metabolism -- The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system. |
| Record Nr. | UNINA-9910737299003321 |
| New York, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cytochrome P450 function and pharmacological roles in inflammation and cancer / / edited by James P. Hardwick, S. J. Enna, Lynn Lecount ; contributors, Mohamed A. Abdelmegeed [and thirty-three others]
| Cytochrome P450 function and pharmacological roles in inflammation and cancer / / edited by James P. Hardwick, S. J. Enna, Lynn Lecount ; contributors, Mohamed A. Abdelmegeed [and thirty-three others] |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (506 p.) |
| Disciplina | 572.7 |
| Collana | Advances in Pharmacology |
| Soggetto topico | Cytochrome P-450 |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-12-803120-4
0-12-803119-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer; Copyright; Contents; Contributors; Preface; References; Chapter One: Role of Cytochrome P450 Monooxygenase in Carcinogen and Chemotherapeutic Drug Metabolism; 1. Introduction; 2. Historical Aspects of Chemical Carcinogenesis Leading to Discovery of the Cytochrome P450 Monooxygenase; 2.1. Cytochromes P450; 2.2. Butter Yellow Carcinogenesis; 2.3. PAH Carcinogenesis: Protein Adducts and Induction of Metabolism
3. Cytochrome P450-Monooxygenase-Mediated Activation of Procarcinogen and Chemotherapeutic Prodrugs3.1. Aromatic Azo Compounds; 3.2. Polycyclic Aromatic Hydrocarbons; 3.3. Polychlorinated Biphenyls; 3.3.1. Polychlorinated Biphenyls with Low Chlorine Content; 3.3.2. Highly Chlorinated Biphenyls; 3.4. Vinyl Chloride; 3.5. Nitrosamines; 3.6. Furans; 3.7. Chemotherapeutic Prodrugs; 3.7.1. Cyclophosphamide; 3.7.2. Procarbazine and Other Hydrazine Derivatives; 3.7.3. Anthracycline Antibiotics; 4. Factors That Regulate Changes in Gene Expression: Differences Between Rodents and Humans 4.1. Hepatic Nuclear Receptors and Enzyme Induction4.2. Differences Between Rodent and Human Receptors; 4.3. CAR Splice Variants and Ligand Specificity; 4.4. Exogenous Compounds Acting on the PPAR; 4.5. Underlying Regulation by Other Hormones and Transcription Factors; 4.6. Effects of Environmental Agents; 5. Polymorphic Cytochrome P450 Variants Impacting Expression and Cancer Susceptibility; 5.1. Cytochrome P4501A1 and Glutathione S-Transferase M1; 5.2. Cytochrome P4502D6 and Cytochrome P4502E1; 6. Conclusion; Conflict of Interest; Acknowledgment; References Chapter Two: Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer1. Introduction; 2. Reactive Oxygen Species Formation in Biological Systems; 2.1. Oxygen Reactivity and Formation of Reactive Oxygen Species; 2.2. Types of Reactive Oxygen Species and Their Reactivities; 2.2.1. Superoxide Radical Anion; 2.2.2. Hydrogen Peroxide; 2.2.3. Hydroxyl Radical; 2.2.4. Peroxyl Radical; 2.2.5. Singlet Oxygen; 3. Protective Agents to Combat Reactive Oxygen Species; 3.1. Antioxidants; 3.1.1. Antioxidant Enzymes; 3.1.2. Nonenzymatic Antioxidants; 3.1.2.1. Glutathione 3.1.2.2. Vitamin E, Vitamin C, and β-Carotene3.1.2.3. Lycopene; 3.1.2.4. Melatonin; 4. CYP Catalytic Cycle and Involvement of CYP Enzymes in Reactive Oxygen Species Formation; 5. Roles of Reactive Oxygen Species in Cancer; 5.1. Reactive Oxygen Species and Cell Signaling; 6. Relationship Between CYP Enzymes and Cancer; 6.1. CYP Expression in Neoplastic Tissues; 6.2. CYP Polymorphism and Cancer Risk; 6.3. CYP Enzymes and Chemical Carcinogenesis; 6.4. CYP Enzymes and Cancer Therapy; 7. Conclusion; Conflict of Interest; Acknowledgments; References Chapter Three: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases |
| Record Nr. | UNINA-9910460911303321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cytochrome P450 function and pharmacological roles in inflammation and cancer / / edited by James P. Hardwick, S. J. Enna, Lynn Lecount ; contributors, Mohamed A. Abdelmegeed [and thirty-three others]
| Cytochrome P450 function and pharmacological roles in inflammation and cancer / / edited by James P. Hardwick, S. J. Enna, Lynn Lecount ; contributors, Mohamed A. Abdelmegeed [and thirty-three others] |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (506 p.) |
| Disciplina | 572.7 |
| Collana | Advances in Pharmacology |
| Soggetto topico | Cytochrome P-450 |
| ISBN |
0-12-803120-4
0-12-803119-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer; Copyright; Contents; Contributors; Preface; References; Chapter One: Role of Cytochrome P450 Monooxygenase in Carcinogen and Chemotherapeutic Drug Metabolism; 1. Introduction; 2. Historical Aspects of Chemical Carcinogenesis Leading to Discovery of the Cytochrome P450 Monooxygenase; 2.1. Cytochromes P450; 2.2. Butter Yellow Carcinogenesis; 2.3. PAH Carcinogenesis: Protein Adducts and Induction of Metabolism
3. Cytochrome P450-Monooxygenase-Mediated Activation of Procarcinogen and Chemotherapeutic Prodrugs3.1. Aromatic Azo Compounds; 3.2. Polycyclic Aromatic Hydrocarbons; 3.3. Polychlorinated Biphenyls; 3.3.1. Polychlorinated Biphenyls with Low Chlorine Content; 3.3.2. Highly Chlorinated Biphenyls; 3.4. Vinyl Chloride; 3.5. Nitrosamines; 3.6. Furans; 3.7. Chemotherapeutic Prodrugs; 3.7.1. Cyclophosphamide; 3.7.2. Procarbazine and Other Hydrazine Derivatives; 3.7.3. Anthracycline Antibiotics; 4. Factors That Regulate Changes in Gene Expression: Differences Between Rodents and Humans 4.1. Hepatic Nuclear Receptors and Enzyme Induction4.2. Differences Between Rodent and Human Receptors; 4.3. CAR Splice Variants and Ligand Specificity; 4.4. Exogenous Compounds Acting on the PPAR; 4.5. Underlying Regulation by Other Hormones and Transcription Factors; 4.6. Effects of Environmental Agents; 5. Polymorphic Cytochrome P450 Variants Impacting Expression and Cancer Susceptibility; 5.1. Cytochrome P4501A1 and Glutathione S-Transferase M1; 5.2. Cytochrome P4502D6 and Cytochrome P4502E1; 6. Conclusion; Conflict of Interest; Acknowledgment; References Chapter Two: Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer1. Introduction; 2. Reactive Oxygen Species Formation in Biological Systems; 2.1. Oxygen Reactivity and Formation of Reactive Oxygen Species; 2.2. Types of Reactive Oxygen Species and Their Reactivities; 2.2.1. Superoxide Radical Anion; 2.2.2. Hydrogen Peroxide; 2.2.3. Hydroxyl Radical; 2.2.4. Peroxyl Radical; 2.2.5. Singlet Oxygen; 3. Protective Agents to Combat Reactive Oxygen Species; 3.1. Antioxidants; 3.1.1. Antioxidant Enzymes; 3.1.2. Nonenzymatic Antioxidants; 3.1.2.1. Glutathione 3.1.2.2. Vitamin E, Vitamin C, and β-Carotene3.1.2.3. Lycopene; 3.1.2.4. Melatonin; 4. CYP Catalytic Cycle and Involvement of CYP Enzymes in Reactive Oxygen Species Formation; 5. Roles of Reactive Oxygen Species in Cancer; 5.1. Reactive Oxygen Species and Cell Signaling; 6. Relationship Between CYP Enzymes and Cancer; 6.1. CYP Expression in Neoplastic Tissues; 6.2. CYP Polymorphism and Cancer Risk; 6.3. CYP Enzymes and Chemical Carcinogenesis; 6.4. CYP Enzymes and Cancer Therapy; 7. Conclusion; Conflict of Interest; Acknowledgments; References Chapter Three: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases |
| Record Nr. | UNINA-9910797336403321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cytochrome P450 function and pharmacological roles in inflammation and cancer / / edited by James P. Hardwick, S. J. Enna, Lynn Lecount ; contributors, Mohamed A. Abdelmegeed [and thirty-three others]
| Cytochrome P450 function and pharmacological roles in inflammation and cancer / / edited by James P. Hardwick, S. J. Enna, Lynn Lecount ; contributors, Mohamed A. Abdelmegeed [and thirty-three others] |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (506 p.) |
| Disciplina | 572.7 |
| Collana | Advances in Pharmacology |
| Soggetto topico | Cytochrome P-450 |
| ISBN |
0-12-803120-4
0-12-803119-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer; Copyright; Contents; Contributors; Preface; References; Chapter One: Role of Cytochrome P450 Monooxygenase in Carcinogen and Chemotherapeutic Drug Metabolism; 1. Introduction; 2. Historical Aspects of Chemical Carcinogenesis Leading to Discovery of the Cytochrome P450 Monooxygenase; 2.1. Cytochromes P450; 2.2. Butter Yellow Carcinogenesis; 2.3. PAH Carcinogenesis: Protein Adducts and Induction of Metabolism
3. Cytochrome P450-Monooxygenase-Mediated Activation of Procarcinogen and Chemotherapeutic Prodrugs3.1. Aromatic Azo Compounds; 3.2. Polycyclic Aromatic Hydrocarbons; 3.3. Polychlorinated Biphenyls; 3.3.1. Polychlorinated Biphenyls with Low Chlorine Content; 3.3.2. Highly Chlorinated Biphenyls; 3.4. Vinyl Chloride; 3.5. Nitrosamines; 3.6. Furans; 3.7. Chemotherapeutic Prodrugs; 3.7.1. Cyclophosphamide; 3.7.2. Procarbazine and Other Hydrazine Derivatives; 3.7.3. Anthracycline Antibiotics; 4. Factors That Regulate Changes in Gene Expression: Differences Between Rodents and Humans 4.1. Hepatic Nuclear Receptors and Enzyme Induction4.2. Differences Between Rodent and Human Receptors; 4.3. CAR Splice Variants and Ligand Specificity; 4.4. Exogenous Compounds Acting on the PPAR; 4.5. Underlying Regulation by Other Hormones and Transcription Factors; 4.6. Effects of Environmental Agents; 5. Polymorphic Cytochrome P450 Variants Impacting Expression and Cancer Susceptibility; 5.1. Cytochrome P4501A1 and Glutathione S-Transferase M1; 5.2. Cytochrome P4502D6 and Cytochrome P4502E1; 6. Conclusion; Conflict of Interest; Acknowledgment; References Chapter Two: Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer1. Introduction; 2. Reactive Oxygen Species Formation in Biological Systems; 2.1. Oxygen Reactivity and Formation of Reactive Oxygen Species; 2.2. Types of Reactive Oxygen Species and Their Reactivities; 2.2.1. Superoxide Radical Anion; 2.2.2. Hydrogen Peroxide; 2.2.3. Hydroxyl Radical; 2.2.4. Peroxyl Radical; 2.2.5. Singlet Oxygen; 3. Protective Agents to Combat Reactive Oxygen Species; 3.1. Antioxidants; 3.1.1. Antioxidant Enzymes; 3.1.2. Nonenzymatic Antioxidants; 3.1.2.1. Glutathione 3.1.2.2. Vitamin E, Vitamin C, and β-Carotene3.1.2.3. Lycopene; 3.1.2.4. Melatonin; 4. CYP Catalytic Cycle and Involvement of CYP Enzymes in Reactive Oxygen Species Formation; 5. Roles of Reactive Oxygen Species in Cancer; 5.1. Reactive Oxygen Species and Cell Signaling; 6. Relationship Between CYP Enzymes and Cancer; 6.1. CYP Expression in Neoplastic Tissues; 6.2. CYP Polymorphism and Cancer Risk; 6.3. CYP Enzymes and Chemical Carcinogenesis; 6.4. CYP Enzymes and Cancer Therapy; 7. Conclusion; Conflict of Interest; Acknowledgments; References Chapter Three: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases |
| Record Nr. | UNINA-9910817147903321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs
| Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs |
| Pubbl/distr/stampa | [Place of publication not identified], : AHRQ, 2007 |
| Descrizione fisica | 1 online resource |
| Disciplina | 615/.78 |
| Collana | Evidence report/technology assessment Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs) |
| Soggetto topico |
Serotonin uptake inhibitors - Chemotherapy
Cytochrome P-450 Depression, Mental Pharmacogenetics Genetic Variation Depressive Disorder Serotonin Agents Age Groups Neurotransmitter Uptake Inhibitors Cytochromes Mixed Function Oxygenases Hemeproteins Genetic Phenomena Mood Disorders Persons Neurotransmitter Agents Oxygenases Enzymes and Coenzymes Proteins Molecular Mechanisms of Pharmacological Action Physiological Effects of Drugs Oxidoreductases Mental Disorders Pharmacologic Actions Amino Acids, Peptides, and Proteins Enzymes Chemical Actions and Uses Polymorphism, Genetic Cytochrome P-450 Enzyme System Adult Depressive Disorder, Major Serotonin Uptake Inhibitors Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910698235503321 |
| [Place of publication not identified], : AHRQ, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The ubiquitous roles of cytochrome P450 proteins [[electronic resource] /] / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel
| The ubiquitous roles of cytochrome P450 proteins [[electronic resource] /] / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel |
| Pubbl/distr/stampa | Chichester, : John Wiley, c2007 |
| Descrizione fisica | 1 online resource (680 p.) |
| Disciplina |
572.6
572.7 |
| Altri autori (Persone) |
SigelAstrid
SigelHelmut SigelRoland K. O |
| Collana | Metal ions in life sciences |
| Soggetto topico |
Cytochrome P-450
Cytochromes |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-85473-1
9786610854738 0-470-02815-7 0-470-02814-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Metal Ions in Life Sciences; Historical Development and Perspectives of the Series; Preface to Volume 3; Contents; Contributors to Volume 3; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; 1 Diversities and Similarities in P450 Systems: An Introduction; 1. Oxygenases: Mediators of Biochemical Diversity; 2. P450 Superfamily: Diversity at the Sequence Level; 3. Diversity of P450 Structures: Folds and Conformations for Functions; 4. Diversity in P450 Mechanisms; 5. Diversity in Regulation Across the Superfamily
6. Diversity in the Evolution of Common Metabolic Functions7. Summary and Outlook; Acknowledgments; Abbreviations; References; 2 Structural and Functional Mimics of Cytochromes P450; 1. Introduction; 2. Iron Porphyrins Carrying a Thiolate or Modified Thiolate Ligand; 3. Structurally Remote P450 Mimics; 4. Concluding Remarks; Acknowledgments; Abbreviations; References; 3 Structures of P450 Proteins and Their Molecular Phylogeny; 1. Introduction; 2. P450 Evolution; 3. P450 Families and Subfamilies; 4. P450 Structures; 5. Variation in P450 Function and Fold; 6. Archaeon P450s 7. Summary and ConclusionsAcknowledgments; Abbreviations; References; 4 Aquatic P450 Species; 1. Introduction. 'P450s Under the Surface'; 2. Diversity of Aquatic Species; 3. P450 Activities in Aquatic Invertebrates; 4. Aquatic P450 Gene Families Identified; 5. How Can We Use Information About P450s in Aquatic Species?; 6. Conclusions and Outlook; Acknowledgments; Abbreviations; References; 5 The Electrochemistry of Cytochrome P450; 1. Introduction; 2. Redox Titration (Potentiometric Equilibrium) Measurements; 3. Voltammetric (Dynamic) Measurements; 4. Conclusions; Acknowledgments AbbreviationsReferences; 6 P450 Electron Transfer Reactions; 1. Introduction; 2. Catalytic Cycles; 3. Electron Tunneling Wires; 4. Concluding Remarks; Acknowledgments; Abbreviations; References; 7 Leakage in Cytochrome P450 Reactions in Relation to Protein Structural Properties; 1. Introduction; 2. Protein Structural Parameters; 3. The Reaction Cycle of Cytochrome P450; 4. Protein Structural Parameters and Extent of Competitive Reactions; 5. Concluding Remarks; Acknowledgments; Abbreviations; References; 8 Cytochromes P450 - Structural Basis for Binding and Catalysis; 1. Introduction 2. Ligand Binding: Substrate Recognition and Access to the Distal Pocket3. Architecture of the Active Site of CYP101; 4. The Distal Acid-Alcohol Pair; 5. Experimental Characterization of Reaction Intermediates. Radiolysis as a Tool to Study Redox Reactions; 6. Crystal Structures of Oxy-Ferrous Complexes; 7. Mechanism: Summary, Conclusions, Speculations; Acknowledgments; Abbreviations; References; 9 Beyond Heme-Thiolate Interactions: Roles of the Secondary Coordination Sphere in Cytochrome P450 Systems; 1. Overview of Cytochrome P450 Active Site Structure 2. Secondary Coordination Sphere on the Proximal Side |
| Record Nr. | UNINA-9910143726503321 |
| Chichester, : John Wiley, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The ubiquitous roles of cytochrome P450 proteins [[electronic resource] /] / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel
| The ubiquitous roles of cytochrome P450 proteins [[electronic resource] /] / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel |
| Pubbl/distr/stampa | Chichester, : John Wiley, c2007 |
| Descrizione fisica | 1 online resource (680 p.) |
| Disciplina |
572.6
572.7 |
| Altri autori (Persone) |
SigelAstrid
SigelHelmut SigelRoland K. O |
| Collana | Metal ions in life sciences |
| Soggetto topico |
Cytochrome P-450
Cytochromes |
| ISBN |
1-280-85473-1
9786610854738 0-470-02815-7 0-470-02814-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Metal Ions in Life Sciences; Historical Development and Perspectives of the Series; Preface to Volume 3; Contents; Contributors to Volume 3; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; 1 Diversities and Similarities in P450 Systems: An Introduction; 1. Oxygenases: Mediators of Biochemical Diversity; 2. P450 Superfamily: Diversity at the Sequence Level; 3. Diversity of P450 Structures: Folds and Conformations for Functions; 4. Diversity in P450 Mechanisms; 5. Diversity in Regulation Across the Superfamily
6. Diversity in the Evolution of Common Metabolic Functions7. Summary and Outlook; Acknowledgments; Abbreviations; References; 2 Structural and Functional Mimics of Cytochromes P450; 1. Introduction; 2. Iron Porphyrins Carrying a Thiolate or Modified Thiolate Ligand; 3. Structurally Remote P450 Mimics; 4. Concluding Remarks; Acknowledgments; Abbreviations; References; 3 Structures of P450 Proteins and Their Molecular Phylogeny; 1. Introduction; 2. P450 Evolution; 3. P450 Families and Subfamilies; 4. P450 Structures; 5. Variation in P450 Function and Fold; 6. Archaeon P450s 7. Summary and ConclusionsAcknowledgments; Abbreviations; References; 4 Aquatic P450 Species; 1. Introduction. 'P450s Under the Surface'; 2. Diversity of Aquatic Species; 3. P450 Activities in Aquatic Invertebrates; 4. Aquatic P450 Gene Families Identified; 5. How Can We Use Information About P450s in Aquatic Species?; 6. Conclusions and Outlook; Acknowledgments; Abbreviations; References; 5 The Electrochemistry of Cytochrome P450; 1. Introduction; 2. Redox Titration (Potentiometric Equilibrium) Measurements; 3. Voltammetric (Dynamic) Measurements; 4. Conclusions; Acknowledgments AbbreviationsReferences; 6 P450 Electron Transfer Reactions; 1. Introduction; 2. Catalytic Cycles; 3. Electron Tunneling Wires; 4. Concluding Remarks; Acknowledgments; Abbreviations; References; 7 Leakage in Cytochrome P450 Reactions in Relation to Protein Structural Properties; 1. Introduction; 2. Protein Structural Parameters; 3. The Reaction Cycle of Cytochrome P450; 4. Protein Structural Parameters and Extent of Competitive Reactions; 5. Concluding Remarks; Acknowledgments; Abbreviations; References; 8 Cytochromes P450 - Structural Basis for Binding and Catalysis; 1. Introduction 2. Ligand Binding: Substrate Recognition and Access to the Distal Pocket3. Architecture of the Active Site of CYP101; 4. The Distal Acid-Alcohol Pair; 5. Experimental Characterization of Reaction Intermediates. Radiolysis as a Tool to Study Redox Reactions; 6. Crystal Structures of Oxy-Ferrous Complexes; 7. Mechanism: Summary, Conclusions, Speculations; Acknowledgments; Abbreviations; References; 9 Beyond Heme-Thiolate Interactions: Roles of the Secondary Coordination Sphere in Cytochrome P450 Systems; 1. Overview of Cytochrome P450 Active Site Structure 2. Secondary Coordination Sphere on the Proximal Side |
| Record Nr. | UNINA-9910830041303321 |
| Chichester, : John Wiley, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The ubiquitous roles of cytochrome P450 proteins / / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel
| The ubiquitous roles of cytochrome P450 proteins / / edited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel |
| Pubbl/distr/stampa | Chichester, : John Wiley, c2007 |
| Descrizione fisica | 1 online resource (680 p.) |
| Disciplina |
572.6
572.7 |
| Altri autori (Persone) |
SigelAstrid
SigelHelmut SigelRoland K. O |
| Collana | Metal ions in life sciences |
| Soggetto topico |
Cytochrome P-450
Cytochromes |
| ISBN |
1-280-85473-1
9786610854738 0-470-02815-7 0-470-02814-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Metal Ions in Life Sciences; Historical Development and Perspectives of the Series; Preface to Volume 3; Contents; Contributors to Volume 3; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; 1 Diversities and Similarities in P450 Systems: An Introduction; 1. Oxygenases: Mediators of Biochemical Diversity; 2. P450 Superfamily: Diversity at the Sequence Level; 3. Diversity of P450 Structures: Folds and Conformations for Functions; 4. Diversity in P450 Mechanisms; 5. Diversity in Regulation Across the Superfamily
6. Diversity in the Evolution of Common Metabolic Functions7. Summary and Outlook; Acknowledgments; Abbreviations; References; 2 Structural and Functional Mimics of Cytochromes P450; 1. Introduction; 2. Iron Porphyrins Carrying a Thiolate or Modified Thiolate Ligand; 3. Structurally Remote P450 Mimics; 4. Concluding Remarks; Acknowledgments; Abbreviations; References; 3 Structures of P450 Proteins and Their Molecular Phylogeny; 1. Introduction; 2. P450 Evolution; 3. P450 Families and Subfamilies; 4. P450 Structures; 5. Variation in P450 Function and Fold; 6. Archaeon P450s 7. Summary and ConclusionsAcknowledgments; Abbreviations; References; 4 Aquatic P450 Species; 1. Introduction. 'P450s Under the Surface'; 2. Diversity of Aquatic Species; 3. P450 Activities in Aquatic Invertebrates; 4. Aquatic P450 Gene Families Identified; 5. How Can We Use Information About P450s in Aquatic Species?; 6. Conclusions and Outlook; Acknowledgments; Abbreviations; References; 5 The Electrochemistry of Cytochrome P450; 1. Introduction; 2. Redox Titration (Potentiometric Equilibrium) Measurements; 3. Voltammetric (Dynamic) Measurements; 4. Conclusions; Acknowledgments AbbreviationsReferences; 6 P450 Electron Transfer Reactions; 1. Introduction; 2. Catalytic Cycles; 3. Electron Tunneling Wires; 4. Concluding Remarks; Acknowledgments; Abbreviations; References; 7 Leakage in Cytochrome P450 Reactions in Relation to Protein Structural Properties; 1. Introduction; 2. Protein Structural Parameters; 3. The Reaction Cycle of Cytochrome P450; 4. Protein Structural Parameters and Extent of Competitive Reactions; 5. Concluding Remarks; Acknowledgments; Abbreviations; References; 8 Cytochromes P450 - Structural Basis for Binding and Catalysis; 1. Introduction 2. Ligand Binding: Substrate Recognition and Access to the Distal Pocket3. Architecture of the Active Site of CYP101; 4. The Distal Acid-Alcohol Pair; 5. Experimental Characterization of Reaction Intermediates. Radiolysis as a Tool to Study Redox Reactions; 6. Crystal Structures of Oxy-Ferrous Complexes; 7. Mechanism: Summary, Conclusions, Speculations; Acknowledgments; Abbreviations; References; 9 Beyond Heme-Thiolate Interactions: Roles of the Secondary Coordination Sphere in Cytochrome P450 Systems; 1. Overview of Cytochrome P450 Active Site Structure 2. Secondary Coordination Sphere on the Proximal Side |
| Record Nr. | UNINA-9910876637503321 |
| Chichester, : John Wiley, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Cytochrome P-450
(8)
- Cytochromes (4)
- Adult (1)
- Age Groups (1)
- Amino Acids, Peptides, and Proteins (1)