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Comparative pathophysiology and toxicology of cyclooxygenases [[electronic resource] /] / Zaher A. Radi
| Comparative pathophysiology and toxicology of cyclooxygenases [[electronic resource] /] / Zaher A. Radi |
| Autore | Radi Zaher A |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
| Descrizione fisica | 1 online resource (338 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Cyclooxygenases - Pathophysiology
Cyclooxygenases - Toxicology |
| ISBN |
1-283-57607-4
9786613888525 1-118-35191-6 1-118-35190-8 1-118-35188-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPARATIVE PATHOPHYSIOLOGY AND TOXICOLOGY OF CYCLOOXYGENASES; CONTENTS; PREFACE; INTRODUCTION: DISCOVERY OF CYCLOOXYGENASES AND HISTORICAL PERSPECTIVE; Aspirin; Prostaglandins; Cyclooxygenases; COX-2 Selective NSAIDs; References; CHAPTER 1 GASTROINTESTINAL TRACT; Introduction; Comparative COX-1 and COX-2 Expression in the GI Tract; Effects of ns-NSAIDs on the GI Tract; Effects of Arylpropionic Acid ns-NSAIDs on the GI Tract; Effects of Enolic Acid (Oxicam) ns-NSAIDs on the GI Tract; Effects of Acetic Acid Derivative ns-NSAIDs on the GI Tract
Effects of Aminonicotinic Acid Derivative ns-NSAIDs on the GI TractEffects of Pyrazolone Derivative ns-NSAIDs on the GI Tract; Effects of Salicylic Acid Derivative ns-NSAIDs on the GI Tract; Effects of Anthranilic Acid Derivative ns-NSAIDs on the GI Tract; Effects of COX-1 Inhibitors on the GI Tract; Effects of COX-2 s-NSAIDs on the GI Tract; Pathophysiology and Mechanisms of NSAID-Associated GI Toxicity; Role of Cyclooxygenase Potency; Species Differences in NSAID-Associated Susceptibility to GI Injury; GI Anatomical Differences; Enterohepatic Recirculation and NSAID Toxicity Role of Xenobiotic GlucuronidationAging and Stress and NSAID GI Effects; Disruption of GI Physiological Mucosal Defense Mechanisms; GI Disequilibrium; Effects on Physiological GI Mucosal Cell Renewal Mechanisms After Mucosal Injury; Effects on Leukocyte Adhesion Molecules and Trafficking; Effects of GI Physiological Local pH, Gut Absorption, and Fasting; NSAID Topical Effect-Mediated Injury; Changes in GI Motility, Microcirculation, and Enterobacteria; Decreased Phosphatidylcholine Levels; Impaired Drug Metabolism; Role of Toll-like Receptor (TLR)-4/MyD88 and Enteric Bacteria Role of Uncoupling of Mitochondrial Oxidative PhosphorylationRole of Peroxisome Proliferator-Activated Receptor g; Role of Mitogen-Activated Protein Kinases; NSAID GI Injury-Associated Risk Factors; Conclusions; References; CHAPTER 2 BONE-TENDON-LIGAMENT SYSTEM; Introduction; Comparative Physiological and Anatomical Aspects of the Skeleton; Role of Prostaglandins in Skeleton Metabolism; The Process of Bone Healing and Potential Role of Prostaglandins; Inflammatory Response; Bone Resorption; Bone Formation COX-1 and COX-2 Expression in Bone, Tendon, and Ligament During Repair and in Pathological ConditionsEffects of ns-NSAIDs on Bone Healing; Effects of COX-2 s-NSAIDs on Bone Healing; Effects of ns-NSAIDs on Ligament and Tendon Healing; Effects of COX-2 s-NSAIDs on Ligament and Tendon Healing; Conclusions; References; CHAPTER 3 RENAL SYSTEM; Introduction; Comparative Physiological, Developmental, and Anatomical Aspects of the Renal System; Role of Prostaglandins in the Renal System; COX-1 and COX-2 Expression in the Kidney; Effects of ns-NSAIDs on the Kidney Effects of COX-2 s-NSAIDs on the Kidney |
| Record Nr. | UNINA-9910141413203321 |
Radi Zaher A
|
||
| Hoboken, N.J., : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Comparative pathophysiology and toxicology of cyclooxygenases [[electronic resource] /] / Zaher A. Radi
| Comparative pathophysiology and toxicology of cyclooxygenases [[electronic resource] /] / Zaher A. Radi |
| Autore | Radi Zaher A |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
| Descrizione fisica | 1 online resource (338 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Cyclooxygenases - Pathophysiology
Cyclooxygenases - Toxicology |
| ISBN |
1-283-57607-4
9786613888525 1-118-35191-6 1-118-35190-8 1-118-35188-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPARATIVE PATHOPHYSIOLOGY AND TOXICOLOGY OF CYCLOOXYGENASES; CONTENTS; PREFACE; INTRODUCTION: DISCOVERY OF CYCLOOXYGENASES AND HISTORICAL PERSPECTIVE; Aspirin; Prostaglandins; Cyclooxygenases; COX-2 Selective NSAIDs; References; CHAPTER 1 GASTROINTESTINAL TRACT; Introduction; Comparative COX-1 and COX-2 Expression in the GI Tract; Effects of ns-NSAIDs on the GI Tract; Effects of Arylpropionic Acid ns-NSAIDs on the GI Tract; Effects of Enolic Acid (Oxicam) ns-NSAIDs on the GI Tract; Effects of Acetic Acid Derivative ns-NSAIDs on the GI Tract
Effects of Aminonicotinic Acid Derivative ns-NSAIDs on the GI TractEffects of Pyrazolone Derivative ns-NSAIDs on the GI Tract; Effects of Salicylic Acid Derivative ns-NSAIDs on the GI Tract; Effects of Anthranilic Acid Derivative ns-NSAIDs on the GI Tract; Effects of COX-1 Inhibitors on the GI Tract; Effects of COX-2 s-NSAIDs on the GI Tract; Pathophysiology and Mechanisms of NSAID-Associated GI Toxicity; Role of Cyclooxygenase Potency; Species Differences in NSAID-Associated Susceptibility to GI Injury; GI Anatomical Differences; Enterohepatic Recirculation and NSAID Toxicity Role of Xenobiotic GlucuronidationAging and Stress and NSAID GI Effects; Disruption of GI Physiological Mucosal Defense Mechanisms; GI Disequilibrium; Effects on Physiological GI Mucosal Cell Renewal Mechanisms After Mucosal Injury; Effects on Leukocyte Adhesion Molecules and Trafficking; Effects of GI Physiological Local pH, Gut Absorption, and Fasting; NSAID Topical Effect-Mediated Injury; Changes in GI Motility, Microcirculation, and Enterobacteria; Decreased Phosphatidylcholine Levels; Impaired Drug Metabolism; Role of Toll-like Receptor (TLR)-4/MyD88 and Enteric Bacteria Role of Uncoupling of Mitochondrial Oxidative PhosphorylationRole of Peroxisome Proliferator-Activated Receptor g; Role of Mitogen-Activated Protein Kinases; NSAID GI Injury-Associated Risk Factors; Conclusions; References; CHAPTER 2 BONE-TENDON-LIGAMENT SYSTEM; Introduction; Comparative Physiological and Anatomical Aspects of the Skeleton; Role of Prostaglandins in Skeleton Metabolism; The Process of Bone Healing and Potential Role of Prostaglandins; Inflammatory Response; Bone Resorption; Bone Formation COX-1 and COX-2 Expression in Bone, Tendon, and Ligament During Repair and in Pathological ConditionsEffects of ns-NSAIDs on Bone Healing; Effects of COX-2 s-NSAIDs on Bone Healing; Effects of ns-NSAIDs on Ligament and Tendon Healing; Effects of COX-2 s-NSAIDs on Ligament and Tendon Healing; Conclusions; References; CHAPTER 3 RENAL SYSTEM; Introduction; Comparative Physiological, Developmental, and Anatomical Aspects of the Renal System; Role of Prostaglandins in the Renal System; COX-1 and COX-2 Expression in the Kidney; Effects of ns-NSAIDs on the Kidney Effects of COX-2 s-NSAIDs on the Kidney |
| Record Nr. | UNINA-9910817130503321 |
|
Radi Zaher A
|
||
| Hoboken, N.J., : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
