Autore	Nyvlt Jaroslav
Pubbl/distr/stampa	Weinheim ; ; New York, : VCH, c1995
Descrizione fisica	1 online resource (397 p.)
Disciplina	615.19 660.284298
Altri autori (Persone)	UlrichJoachim
Soggetto topico	Crystallization - Industrial applications Crystals - Additives
ISBN	9786611758615 9781281758613 1281758612 9783527615315 3527615318 9783527615308 352761530X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Admixtures in Crystallization; Contents; 1. Introduction; 2. Classification of Admixtures; 3. Influence of Admixtures on Nucleation; 3.1. Homogeneous Nucleation; 3.2. Heterogeneous Nucleation; 3.3. Secondary Nucleation; 4. Influence of Admixtures on Crystal Growth; 4.1. The Role of the Solid Surface; 4.2. The Role of the Interphase Solid - Liquid; 5. Influence of Admixtures on Crystal Shape; 6. Influence of Solvents; 7. Distribution of Admixtures; 7.1. Solid Solutions; 7.2. Isomorphous Inclusion; 7.3. Anomalous Mixed Crystals; 7.4. Adsorption Inclusion; 7.5. Mechanism of Internal Adsorption 7.6. Mechanical Inclusions7.7. Materials Balance for Crystallization in Presence of Impurities; 7.8. Cascade Purification; 8 . Notations; 9 . References; 10 . Tables; Formula Index; 11 . References to Tables; 12 . Subject Index
Record Nr.	UNINA-9911019161103321

Autore	Nývlt Jaroslav
Pubbl/distr/stampa	Weinheim ; ; New York, : VCH, c1995
Descrizione fisica	1 online resource (397 p.)
Disciplina	615.19 660.284298
Altri autori (Persone)	UlrichJoachim
Soggetto topico	Crystallization - Industrial applications Crystals - Additives
Soggetto genere / forma	Electronic books.
ISBN	1-281-75861-2 9786611758615 3-527-61531-8 3-527-61530-X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Admixtures in Crystallization; Contents; 1. Introduction; 2. Classification of Admixtures; 3. Influence of Admixtures on Nucleation; 3.1. Homogeneous Nucleation; 3.2. Heterogeneous Nucleation; 3.3. Secondary Nucleation; 4. Influence of Admixtures on Crystal Growth; 4.1. The Role of the Solid Surface; 4.2. The Role of the Interphase Solid - Liquid; 5. Influence of Admixtures on Crystal Shape; 6. Influence of Solvents; 7. Distribution of Admixtures; 7.1. Solid Solutions; 7.2. Isomorphous Inclusion; 7.3. Anomalous Mixed Crystals; 7.4. Adsorption Inclusion; 7.5. Mechanism of Internal Adsorption 7.6. Mechanical Inclusions7.7. Materials Balance for Crystallization in Presence of Impurities; 7.8. Cascade Purification; 8 . Notations; 9 . References; 10 . Tables; Formula Index; 11 . References to Tables; 12 . Subject Index
Record Nr.	UNINA-9910144330103321

Pubbl/distr/stampa	Amsterdam, The Netherlands, : IOS Press, 2007
Descrizione fisica	1 online resource (284 p.)
Disciplina	660 660/.284298
Altri autori (Persone)	LewisAlison <1963-> OlsenChristine
Soggetto topico	Crystallization - Industrial applications Chemical engineering
Soggetto genere / forma	Electronic books.
ISBN	6611029931 1-281-02993-9 9786611029937 1-60750-278-X 600-00-0357-9 1-4356-0877-1
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Title page; Preface; Contents; Oral Presentations; Aspects of Chiral Resolution in the Presence of (Partial) Solid Solutions; In Situ Monitoring and Quantification of Crystal Shape; Adductive Crystallization of Bisphenol-A Under the Influence of Industrial Impurities; Crystallisation of Metronidazole in Semi-Solid Formulations; The Development of a Reverse Classical Resolution; Intensification of Precipitation Processes in Environmental Engineering; Polymorphism and Nucleation Kinetics in Precipitation of Calcium Carbonate in Water and Ethylene Glycol Polymorph Transformation Monitoring Using In-Situ Vibrational SpectroscopyStrategy to Improve the Shelf Life of Crystalline Fertilizers; Real-Time Dynamic Optimization of Crystal Yield in Fed-Batch Evaporative Crystallization of Ammonium Sulphate; Monitoring of Polymorph Transformation Using In-Situ Measurement of Ultrasonic Velocity; ZLD Evaporation-Crystallization Plant in the Power Industry; Population Balance Equation Modeling of the Solution Mediated Anhydrous to Monohydrate Phase Transition of Citric Acid The Effect of Different Types of Seeds on the Oxidation and Precipitation of Iron from Homogeneous SolutionsDesign and Construction of an Industrial Melt Crystallization Plant for the Ultra-Purification of Phosphoric Acid - A Case Study; Layer Development and Growth History of Polycrystalline Zeolite A Membranes Synthesised from a Clear Solution; Temperature Dependence of the Solubility Product of Calcium Dodecyl Sulfate and Modeling of the Phase Boundary; Co-Crystallization of Carbamazepine and Isonicotinamide: Two New Co-Crystal Forms?; Poster Presentations Adductive Crystallization of Bisphenol-A Under the Influence of Water and AcetoneInterpretation of the Influence of Additives on the MSZ Width of Inorganic Compounds; Width of Metastable Zone in Adductive Crystallization of Bisphenol A-Phenol; The Onset of Polycrystalline Growth in Precipitation of L-Glutamic Acid Compared to an Aromatic Amine Derivative; Separation of Zr and Hf via Fractional Crystallization of K2Zr(Hf)F6: A Theoretical Study on the Distribution Coefficient of the Hafnium Impurity; Additive Influence on the Metastable Zone Width of Solvates Example of Suppression of Concomitant PolymorphismPrecipitation Fluidized Bed Modeling Using CFD Approach: Hydrodynamic Behavior; Preparation of Iron(II) Acetate from Magnetite by Selective Precipitation; Co-Solvent Effect on Growth Habit of ADNBF by a Cooling Crystallization; The Application of Different Seeding Techniques for Solution Crystallization of Ammonium Sulphate; Controlled Batch Cooling Crystallisation of Gibbsite; Precipitation Kinetics of Nickel in the Presence of Iron; Isothermal and Auto-Seeded Polythermal Preferential Crystallisation in the Mandelic Acid System Kinetics Estimation and Single and Multi-Objective Optimization of a Seeded, Anti-Solvent, Isothermal Batch Crystallizer
Record Nr.	UNINA-9910451874103321

Pubbl/distr/stampa	London, England : , : IntechOpen, , [2022]
Descrizione fisica	1 online resource (188 pages) : illustrations
Disciplina	660.284298
Soggetto topico	Crystallization - Industrial applications
ISBN	1-83969-317-7
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-9910586653303321

Autore	Tung Hsien-Hsin <1955->
Edizione	[Second edition.]
Pubbl/distr/stampa	Hoboken, N.J. : , : John Wiley & Sons, Inc., , [2024]
Descrizione fisica	1 online resource (ix, 368 pages) : illustrations (some color)
Disciplina	615/.19
Soggetto topico	Crystallization - Industrial applications Pharmaceutical chemistry Pharmaceutical industry
Soggetto non controllato	Chemistry, Technical Science
ISBN	1-119-87949-3 1-119-87947-7
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Cover -- Title Page -- Copyright Page -- Contents -- Preface -- Chapter 1 Introduction to Crystallization -- 1.1 Crystal Properties and Polymorphs (Chapters 2 and 3) -- 1.2 NUCLEATION AND GROWTH KINETICS (CHAPTER 4) -- 1.3 MIXING AND SCALE-UP (CHAPTER 5) -- 1.4 Critical Issues and Quality by Design (Chapter 6) -- 1.4.1 Critical Issues -- 1.4.2 Design of Experiment -- 1.5 Crystallization Process Options (Chapters 7-10) -- 1.5.1 Cooling (Chapter 7) -- 1.5.2 Evaporation Solvent (Chapter 8) -- 1.5.3 Antisolvent Addition (Chapter 9) -- 1.5.4 Reactive Crystallization (Chapter 10) -- 1.6 Downstream Operations (Chapters 11 And 12) -- 1.7 Special Applications (Chapter 13) -- Chapter 2 Properties -- 2.1 Solubility -- 2.1.1 Free Energy-Composition Phase Diagram -- 2.1.2 Temperature -- 2.1.3 Solvent -- 2.1.4 Impurities -- 2.1.5 Chemical and Physical Structure, Salt and Co-Crystal Form -- 2.1.6 Solubility Measurement and Prediction -- 2.1.7 Significance of Crystallization -- 2.2 Supersaturation, Metastable Zone, and Induction Time -- 2.2.1 Free Energy-Composition Phase Diagram -- 2.2.2 Factors Affecting Metastable Zone Width and Induction Time -- 2.2.3 Measurement and Prediction -- 2.2.4 Significance of Crystallization -- 2.3 Oil, Amorphous, and Crystalline States -- 2.3.1 Phase Diagram -- 2.3.2 Measurement -- 2.3.3 Significance to Crystallization -- 2.4 Polymorphism -- 2.4.1 Phase Diagram -- 2.4.2 Measurement and Prediction -- 2.4.3 Significance to Crystallization and Downstream Operations -- 2.5 Solvate -- 2.5.1 Phase Diagram -- 2.5.2 Measurement and Prediction -- 2.5.3 Significance to Crystallization and Downstream Operations -- 2.6 Solid Compound, Solid Solution, and Solid Mixture -- 2.6.1 Phase Diagram -- 2.6.2 Measurement and Prediction -- 2.6.3 Significance to Crystallization -- 2.7 Inclusion and Occlusion -- 2.7.1 Mechanism -- 2.7.2 Measurement. 2.7.3 Significance to Crystallization and Downstream Operations -- 2.8 Adsorption, Hygroscopicity, and Deliquesce -- 2.8.1 Phase Diagram -- 2.8.2 Measurement -- 2.8.3 Significance to Crystallization and Downstream Operations -- 2.9 Crystal Morphology -- 2.9.1 General Observations -- 2.9.2 Measurement and Prediction -- 2.9.3 Significance to Crystallization and Downstream Operations -- 2.10 Partical Size Distribution and Surface Area -- 2.10.1 Particle Distribution Definition -- 2.10.2 Measurement -- 2.10.3 Significance to Crystallization and Downstream Operations -- Chapter 3 Polymorphism -- 3.1 Phase Rule -- 3.2 Phase Transition -- 3.2.1 Enantiotropy and Monotropy -- 3.2.2 Metastable Equilibrium and Suspended Transformation -- 3.2.3 Measurement -- 3.3 Prediction of Crystal Structure and its Formation -- 3.3.1 Equilibrium Approach -- 3.3.2 Kinetic Approach -- 3.4 Selection and Screening of Crystal Forms -- 3.4.1 Selection Criteria -- 3.4.2 Candidates for Forming Salts and Co-crystals -- 3.4.3 High Throughput and Process-Based Screening -- 3.5 Examples -- EXAMPLE 3.1 -- EXAMPLE 3.2 -- EXAMPLE 3.3 -- EXAMPLE 3.4 -- EXAMPLE 3.5 -- EXAMPLE 3.6 -- EXAMPLE 3.7 -- EXAMPLE 3.8 -- EXAMPLE 3.9 -- Chapter 4 Kinetics -- 4.1 SUPERSATURATION AND RATE PROCESSES -- 4.2 Nucleation -- 4.2.1 Homogeneous Nucleation -- 4.2.2 Heterogeneous Nucleation -- 4.2.3 Secondary Nucleation -- 4.3 Crystal Growth and Agglomeration -- 4.3.1 Crystal Growth Mechanisms -- 4.3.2 Agglomeration Mechanism -- 4.3.3 Measurement of Crystal Growth Rate -- 4.3.4 Crystal Population Balance -- 4.4 Nucleate/Seed Aging and Ostwald Ripening -- 4.5 DELIVERED PRODUCT: PURITY, CYSTAL FORM, SIZE AND MORPHOLOGY, AND CHEMICAL and PHYSICAL STABILITY -- 4.6 Design of Experiment (DOE)-Model-Based Approach -- 4.7 Model-Free Feedback Control -- Chapter 5 Mixing and Crystallization -- 5.1 INTRODUCTION. 5.2 Mixing Considerations and Factors -- 5.2.1 Mixing Time -- 5.2.2 Mixing Intensity -- 5.2.3 Mixing Distribution -- 5.3 Mixing Effects on Nucleation -- 5.3.1 Primary Nucleation -- 5.3.2 Secondary Nucleation and Particle Breakage -- 5.3.3 Damkoehler Number for Nucleation -- 5.3.4 Scale-Up of Nucleation-Based Processes -- 5.4 Mixing Effects on Crystal Growth -- 5.4.1 Mass Transfer Rate -- 5.4.2 Da Number for Crystallization -- 5.4.3 Conflicting Mixing Effects -- 5.4.4 Experimentation on Mixing Effects -- 5.4.5 Effects of Mixing on PSD -- 5.5 Mixing Distribution and Scale-Up -- 5.5.1 Power -- 5.5.2 Off-Bottom Suspension -- 5.6 Crystallization Equipment -- 5.6.1 Stirred Vessels -- 5.6.2 Fluidized Bed Crystallizer -- 5.6.3 Impinging Jet Crystallizer -- 5.7 Process Design and Examples -- EXAMPLE 5.1 -- EXAMPLE 5.2 -- Chapter 6 Critical Issues and Quality by Design -- 6.1 Quality By Design -- 6.2 Basic Properties -- 6.2.1 Solubility and Crystal Forms -- 6.2.2 Particle Size and Morphology -- 6.3 Seed -- 6.3.1 Determination of Seed Form, Size, and Quantity -- 6.3.2 Effectiveness of Seeding -- 6.4 Supersaturation -- 6.4.1 Generation of Supersaturation -- 6.4.2 Oiling Out, Agglomeration/Aggregation -- 6.4.3 Nucleation -- 6.4.4 Crystal Growth -- 6.5 Mixing and Scale-Selection of Equipment and Operating Procedures -- 6.5.1 Stirred Vessels -- 6.5.2 In-line Mixers -- 6.5.3 Fluidized Bed -- 6.6 Strategic Considerations for Crystallization Process Development -- 6.7 Summary of Critical Issues -- Chapter 7 Cooling Crystallization -- 7.1 Batch Operation -- 7.1.1 Rate of Cooling -- 7.1.2 Metastable Region -- 7.1.3 Seeding Versus Spontaneous Nucleation -- 7.1.4 Mixing and Mass Transfer -- 7.1.5 Solvent -- 7.1.6 Impurities (Dissolved and Undissolved) -- 7.2 Continuous Operations -- 7.2.1 The Attraction of Continuous Processing. 7.2.2 Operating Strategy for Continuous Cooling Crystallizers -- 7.2.3 Plug Flow and Cascade Operation -- 7.2.4 Fluidized Bed Continuous Cooling Crystallizer Designs -- 7.3 Process Design-Examples -- EXAMPLE 7.1 -- EXAMPLE 7.2 -- EXAMPLE 7.3 -- EXAMPLE 7.4 -- EXAMPLE 7.5 -- EXAMPLE 7.6 -- Chapter 8 Evaporative Crystallization -- 8.1 INTRODUCTION -- 8.2 Solubility Diagrams -- 8.2.1 Increasing Solubility -- 8.2.2 Decreasing Solubility -- 8.2.3 Change in Solvent -- 8.3 FACTORS AFFECTING NUCLEATION AND GROWTH -- 8.4 Scale-Up -- 8.5 Equipment -- 8.5.1 Heat Transfer -- 8.5.2 Overconcentration -- 8.5.3 Combination of Evaporation and Cooling -- 8.6 Process Design and Examples -- EXAMPLE 8.1 -- EXAMPLE 8.2 -- EXAMPLE 8.3 -- Chapter 9 Anti-solvent Crystallization -- 9.1 Operation -- 9.1.1 Normal Mode of Addition -- 9.1.2 Reverse Addition -- 9.1.3 Simultaneous Mode of Addition -- 9.1.4 Addition Strategy -- 9.1.5 Seeding -- 9.2 IN-LINE MIXING CRYSTALLIZATION -- 9.3 Process Design and Examples -- EXAMPLE 9.1 -- EXAMPLE 9.2 -- EXAMPLE 9.3 -- EXAMPLE 9.4 -- EXAMPLE 9.5 -- EXAMPLE 9.6 -- EXAMPLE 9.7 -- Chapter 10 Reactive Crystallization -- 10.1 INTRODUCTION -- 10.1.1 Utilization -- 10.1.2 Literature -- 10.2 Control of Particle Size -- 10.2.1 Controlling for Growth -- 10.3 Key Issues in Organic Reactive Crystallization -- 10.3.1 Mixing Issues -- 10.3.2 Mixing and Growth -- 10.3.3 Induction Time and Nucleation -- 10.3.4 Supersaturation Control -- 10.3.5 Seeding -- 10.3.6 Crystal Growth -- 10.3.7 Impurities/Additives -- 10.3.8 Secondary Effects -- 10.4 Creation of Fine Particles-In-Line Reactive Crystallization -- 10.5 Process Design and Scale-Up -- EXAMPLE 10.1 -- EXAMPLE 10.2 -- EXAMPLE 10.3 -- EXAMPLE 10.4 -- Chapter 11 Filtration -- 11.1 INTRODUCTION -- 11.2 BASIC PROPERTIES -- 11.2.1 Particle Size -- 11.2.2 Filter Medium -- 11.2.3 Wash Solvents. 11.2.4 Temperature -- 11.3 KINETICS -- 11.3.1 Filtrate Concentration Profile During Filtration/Washing -- 11.3.2 Filtration and Cake Wash Protocol -- 11.3.3 Filtration Model -- 11.3.4 Settling Rate vs Filtration Rate -- 11.4 process design and scale-up -- 11.4.1 Agitated Filter Dryer -- 11.4.2 Centrifuge Filter -- 11.4.3 Other Operation Complications -- Chapter 12 Drying -- 12.1 INTRODUCTION -- 12.2 BASIC PROPERTIES -- 12.2.1 Vapor-Liquid Equilibrium -- 12.2.2 Solvation and Desolvation -- 12.2.3 Hardness and Brittleness of Solid Particles -- 12.2.4 Agglomerates and Granules of Solid Particles -- 12.3 KINETICS -- 12.3.1 Drying Profiles -- 12.3.2 Particle Fracture and Agglomeration -- 12.3.3 Inter-Relationship Between Drying Stage and Particle Behavior -- 12.4 PROCESS DESIGN AND SCALE-UP -- 12.4.1 Process Design -- 12.4.2 Scale-up -- Chapter 13 Special Applications -- 13.1 INTRODUCTION -- 13.2 CRYSTALLIZATION WITH SUPERCRITICAL FLUIDS -- 13.3 Resolution of Stereo-Isomers -- 13.3.1 Option 1: Use of a Chiral Additive to Create a Diastereoisomeric Set of Compounds -- 13.3.2 Option 2: Chiral Chemistry to Improve Reaction Chiral Selectivity of the Desired Isomer -- 13.3.3 Option 3: Kinetic and Dynamic Resolution -- 13.3.4 Option 4: Use of Chromatography, Membrane, Enzyme, or Other Separation Technology -- 13.4 WET MILLS IN CRYSTALLIZATION -- 13.5 COMPUTATIONAL FLUID DYNAMICS IN CRYSTALLIZATION -- 13.6 Solid Dispersion-Crystalline and/or Amorphous Drugs -- 13.7 Process Design and Examples -- EXAMPLE 13.1 -- EXAMPLE 13.2 -- EXAMPLE 13.3 -- EXAMPLE 13.4 -- EXAMPLE 13.5 -- EXAMPLE 13.6 -- EXAMPLE 13.7 -- References -- Index -- EULA.
Record Nr.	UNINA-9910830743603321