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The chemistry of contrast agents in medical magnetic resonance imaging [[electronic resource] /] / edited by André E. Merbach, Lothar Helm, Éva Tóth
| The chemistry of contrast agents in medical magnetic resonance imaging [[electronic resource] /] / edited by André E. Merbach, Lothar Helm, Éva Tóth |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons Inc., 2013 |
| Descrizione fisica | 1 online resource (514 p.) |
| Disciplina | 616.07/548 |
| Altri autori (Persone) |
HelmLothar
MerbachAndré E TóthÉva |
| Soggetto topico |
Contrast-enhanced magnetic resonance imaging
Magnetic resonance imaging |
| ISBN |
1-118-50365-1
1-299-24263-4 1-118-50366-X 1-118-50367-8 |
| Classificazione | SCI078000 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Chapter 1 General Principles of MRI; 1.1 Introduction; 1.2 Theoretical basis of NMR; 1.2.1 Short description of NMR; 1.2.2 Relaxation times; 1.2.3 Saturation transfer; 1.2.4 Concept of localization by magnetic field gradients; 1.3 Principles of magnetic resonance imaging; 1.3.1 Spatial encoding; 1.4 MRI pulse sequences; 1.4.1 Definition; 1.4.2 k-Space trajectory; 1.4.3 Basic pulse sequences
1.5 Basic image contrast: Tissue characterization without injection of contrast agents (main contrast of an MRI sequence: Proton density (P), T_1 and T_2, T_2^*)1.5.1 Proton density weighting; 1.5.2 T1 weighting; 1.5.3 T2 weighting; 1.5.4 T2* weighting; 1.6 Main contrast agents; 1.6.1 Gadolinium (Gd) complex agents; 1.6.2 Iron oxide (IO) agents; 1.6.3 CEST agents; 1.7 Examples of specialized MRI pulse sequences for angiography (MRA); 1.7.1 Time of flight angiography: No contrast agent; 1.7.2 Angiography using intravascular contrast agent (Blood pool CA) injection; 1.7.3 DSC DCE MRI ReferencesChapter 2 Relaxivity of Gadolinium(III) Complexes: Theory and Mechanism; 2.1 Introduction; 2.2 Inner-sphere proton relaxivity; 2.2.1 Hydration number and hydration equilibria; 2.2.2 Gd-H distance; 2.2.3 Proton/water exchange; 2.2.4 Rotation; 2.3 Second- and outer-sphere relaxation; 2.4 Relaxivity and NMRD profiles; 2.4.1 Fitting of NMRD profiles; 2.4.2 Relaxivity of low-molecular-weight Gd(III) complexes; 2.4.3 Relaxivity of macromolecular MRI contrast agents; 2.4.4 Contrast agents optimized for application at high magnetic field; 2.5 Design of high relaxivity agents: Summary ReferencesChapter 3 Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes; 3.1 Introduction-general requirements for the ligands and complexes; 3.2 Contrast agents employing linear polyamine scaffold; 3.2.1 Synthesis of linear polyamine backbone; 3.2.2 N-functionalization of linear polyamine scaffold; 3.3 Contrast agents employing cyclen scaffold; 3.3.1 Synthesis of the macrocyclic skeleton; 3.3.2 N-functionalization of macrocyclic scaffold; 3.4 Other types of ligands; 3.4.1 H4TRITA and related ligands; 3.4.2 H3PCTA and related ligands; 3.4.3 TACN derivatives 3.4.4 Ligands with HOPO coordinating arms and related groups3.4.5 H4AAZTA and related ligands; 3.5 Bifunctional ligands and their conjugations; 3.6 Synthesis and characterization of the Ln(III) complexes; 3.6.1 General synthetic remarks; 3.6.2 Characterization of the complexes; List of Abbreviations; References; Chapter 4 Stability and Toxicity of Contrast Agents; 4.1 Introduction; 4.2 Equilibrium calculations 4.2.1 Constants that characterize metal ligand interactions (protonation constants of the ligands, stability constants of the complexes, conditional stability constants, ligand selectivity, and concentration of free Gd^3+: pM) |
| Record Nr. | UNINA-9910141649103321 |
| Hoboken, N.J., : John Wiley & Sons Inc., 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The chemistry of contrast agents in medical magnetic resonance imaging [[electronic resource] /] / edited by André E. Merbach, Lothar Helm, Éva Tóth
| The chemistry of contrast agents in medical magnetic resonance imaging [[electronic resource] /] / edited by André E. Merbach, Lothar Helm, Éva Tóth |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons Inc., 2013 |
| Descrizione fisica | 1 online resource (514 p.) |
| Disciplina | 616.07/548 |
| Altri autori (Persone) |
HelmLothar
MerbachAndré E TóthÉva |
| Soggetto topico |
Contrast-enhanced magnetic resonance imaging
Magnetic resonance imaging |
| ISBN |
1-118-50365-1
1-299-24263-4 1-118-50366-X 1-118-50367-8 |
| Classificazione | SCI078000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Chapter 1 General Principles of MRI; 1.1 Introduction; 1.2 Theoretical basis of NMR; 1.2.1 Short description of NMR; 1.2.2 Relaxation times; 1.2.3 Saturation transfer; 1.2.4 Concept of localization by magnetic field gradients; 1.3 Principles of magnetic resonance imaging; 1.3.1 Spatial encoding; 1.4 MRI pulse sequences; 1.4.1 Definition; 1.4.2 k-Space trajectory; 1.4.3 Basic pulse sequences
1.5 Basic image contrast: Tissue characterization without injection of contrast agents (main contrast of an MRI sequence: Proton density (P), T_1 and T_2, T_2^*)1.5.1 Proton density weighting; 1.5.2 T1 weighting; 1.5.3 T2 weighting; 1.5.4 T2* weighting; 1.6 Main contrast agents; 1.6.1 Gadolinium (Gd) complex agents; 1.6.2 Iron oxide (IO) agents; 1.6.3 CEST agents; 1.7 Examples of specialized MRI pulse sequences for angiography (MRA); 1.7.1 Time of flight angiography: No contrast agent; 1.7.2 Angiography using intravascular contrast agent (Blood pool CA) injection; 1.7.3 DSC DCE MRI ReferencesChapter 2 Relaxivity of Gadolinium(III) Complexes: Theory and Mechanism; 2.1 Introduction; 2.2 Inner-sphere proton relaxivity; 2.2.1 Hydration number and hydration equilibria; 2.2.2 Gd-H distance; 2.2.3 Proton/water exchange; 2.2.4 Rotation; 2.3 Second- and outer-sphere relaxation; 2.4 Relaxivity and NMRD profiles; 2.4.1 Fitting of NMRD profiles; 2.4.2 Relaxivity of low-molecular-weight Gd(III) complexes; 2.4.3 Relaxivity of macromolecular MRI contrast agents; 2.4.4 Contrast agents optimized for application at high magnetic field; 2.5 Design of high relaxivity agents: Summary ReferencesChapter 3 Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes; 3.1 Introduction-general requirements for the ligands and complexes; 3.2 Contrast agents employing linear polyamine scaffold; 3.2.1 Synthesis of linear polyamine backbone; 3.2.2 N-functionalization of linear polyamine scaffold; 3.3 Contrast agents employing cyclen scaffold; 3.3.1 Synthesis of the macrocyclic skeleton; 3.3.2 N-functionalization of macrocyclic scaffold; 3.4 Other types of ligands; 3.4.1 H4TRITA and related ligands; 3.4.2 H3PCTA and related ligands; 3.4.3 TACN derivatives 3.4.4 Ligands with HOPO coordinating arms and related groups3.4.5 H4AAZTA and related ligands; 3.5 Bifunctional ligands and their conjugations; 3.6 Synthesis and characterization of the Ln(III) complexes; 3.6.1 General synthetic remarks; 3.6.2 Characterization of the complexes; List of Abbreviations; References; Chapter 4 Stability and Toxicity of Contrast Agents; 4.1 Introduction; 4.2 Equilibrium calculations 4.2.1 Constants that characterize metal ligand interactions (protonation constants of the ligands, stability constants of the complexes, conditional stability constants, ligand selectivity, and concentration of free Gd^3+: pM) |
| Record Nr. | UNINA-9910819818403321 |
| Hoboken, N.J., : John Wiley & Sons Inc., 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Contrast-enhanced clinical magnetic resonance imaging / / Val M. Runge, editor ; contributors, J. Randy Jinkins [and four others]
| Contrast-enhanced clinical magnetic resonance imaging / / Val M. Runge, editor ; contributors, J. Randy Jinkins [and four others] |
| Pubbl/distr/stampa | Lexington, Kentucky : , : The University Press of Kentucky, , 1997 |
| Descrizione fisica | 1 online resource (196 p.) |
| Disciplina | 616.07/548 |
| Soggetto topico |
Magnetic resonance imaging
Contrast-enhanced magnetic resonance imaging |
| Soggetto genere / forma | Electronic books. |
| ISBN | 0-8131-5906-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Principles of MR contrast / Kevin L. Nelson and Val M. Runge -- Brain : neopiastic disease / Lawrence R. Muroff and Val M. Runge -- Brain : non-neoplastic disease / Val M. Runge -- Spine : neopiastic and non-neoplatic disease / J. Randy Jinkins and Val M. Runge -- Body applications / Val M. Runge -- Safety, new applications, and new MR agents / Val M. Runge and John W. Wells. |
| Record Nr. | UNINA-9910459595903321 |
| Lexington, Kentucky : , : The University Press of Kentucky, , 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Contrast-enhanced clinical magnetic resonance imaging / / Val M. Runge, editor ; contributors, J. Randy Jinkins [and four others]
| Contrast-enhanced clinical magnetic resonance imaging / / Val M. Runge, editor ; contributors, J. Randy Jinkins [and four others] |
| Pubbl/distr/stampa | Lexington, Kentucky : , : The University Press of Kentucky, , 1997 |
| Descrizione fisica | 1 online resource (196 p.) |
| Disciplina | 616.07/548 |
| Soggetto topico |
Magnetic resonance imaging
Contrast-enhanced magnetic resonance imaging |
| ISBN | 0-8131-5906-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Principles of MR contrast / Kevin L. Nelson and Val M. Runge -- Brain : neopiastic disease / Lawrence R. Muroff and Val M. Runge -- Brain : non-neoplastic disease / Val M. Runge -- Spine : neopiastic and non-neoplatic disease / J. Randy Jinkins and Val M. Runge -- Body applications / Val M. Runge -- Safety, new applications, and new MR agents / Val M. Runge and John W. Wells. |
| Record Nr. | UNINA-9910787385403321 |
| Lexington, Kentucky : , : The University Press of Kentucky, , 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Contrast-enhanced clinical magnetic resonance imaging / / Val M. Runge, editor ; contributors, J. Randy Jinkins [and four others]
| Contrast-enhanced clinical magnetic resonance imaging / / Val M. Runge, editor ; contributors, J. Randy Jinkins [and four others] |
| Pubbl/distr/stampa | Lexington, Kentucky : , : The University Press of Kentucky, , 1997 |
| Descrizione fisica | 1 online resource (196 p.) |
| Disciplina | 616.07/548 |
| Soggetto topico |
Magnetic resonance imaging
Contrast-enhanced magnetic resonance imaging |
| ISBN | 0-8131-5906-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Principles of MR contrast / Kevin L. Nelson and Val M. Runge -- Brain : neopiastic disease / Lawrence R. Muroff and Val M. Runge -- Brain : non-neoplastic disease / Val M. Runge -- Spine : neopiastic and non-neoplatic disease / J. Randy Jinkins and Val M. Runge -- Body applications / Val M. Runge -- Safety, new applications, and new MR agents / Val M. Runge and John W. Wells. |
| Record Nr. | UNINA-9910820704403321 |
| Lexington, Kentucky : , : The University Press of Kentucky, , 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
