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Applied surrogate endpoint evaluation methods with SAS and R / / Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst
Applied surrogate endpoint evaluation methods with SAS and R / / Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst
Pubbl/distr/stampa Boca Raton : , : CRC Press, , [2017]
Descrizione fisica 1 online resource (396 pages) : illustrations
Disciplina 610.72
Collana Chapman & Hall/CRC Biostatistics Series
Soggetto topico Clinical trials - Statistical methods
Medicine - Research - Methodology
R (Computer program language)
ISBN 1-315-35536-1
1-315-37266-5
1-4822-4937-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto I. Introductory material -- II. Contemporary surrogate endpoint evaluation methods : multiple-trial methods -- III. Software tools -- IV. Additional considerations and further topics.
Record Nr. UNINA-9910154884303321
Boca Raton : , : CRC Press, , [2017]
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Bayesian adaptive methods for clinical trials / / Scott M. Berry. [et al.]
Bayesian adaptive methods for clinical trials / / Scott M. Berry. [et al.]
Pubbl/distr/stampa Boca Raton : , : Chapman & Hall/CRC, , 2011
Descrizione fisica 1 online resource (316 p.)
Disciplina 615.5072/4
Altri autori (Persone) BerryScott M
Collana Chapman & Hall/CRC biostatistics series
Soggetto topico Clinical trials - Statistical methods
Bayesian statistical decision theory
Soggetto genere / forma Electronic books.
ISBN 0-429-15242-6
1-282-90299-7
9786612902994
1-4398-2551-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front cover; Contents; Foreword; Preface; CHAPTER 1: Statistical approaches for clinical trials; CHAPTER 2: Basics of Bayesian inference; CHAPTER 3: Phase I studies; CHAPTER 4: Phase II studies; CHAPTER 5: Phase III studies; CHAPTER 6: Special topics; References; Back cover
Record Nr. UNINA-9910458802003321
Boca Raton : , : Chapman & Hall/CRC, , 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Bayesian adaptive methods for clinical trials / / Scott M. Berry. [et al.]
Bayesian adaptive methods for clinical trials / / Scott M. Berry. [et al.]
Pubbl/distr/stampa Boca Raton : , : Chapman & Hall/CRC, , 2011
Descrizione fisica 1 online resource (316 p.)
Disciplina 615.5072/4
Altri autori (Persone) BerryScott M
Collana Chapman & Hall/CRC biostatistics series
Soggetto topico Clinical trials - Statistical methods
Bayesian statistical decision theory
ISBN 0-429-15242-6
1-282-90299-7
9786612902994
1-4398-2551-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front cover; Contents; Foreword; Preface; CHAPTER 1: Statistical approaches for clinical trials; CHAPTER 2: Basics of Bayesian inference; CHAPTER 3: Phase I studies; CHAPTER 4: Phase II studies; CHAPTER 5: Phase III studies; CHAPTER 6: Special topics; References; Back cover
Record Nr. UNINA-9910785358203321
Boca Raton : , : Chapman & Hall/CRC, , 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Bayesian adaptive methods for clinical trials / / Scott M. Berry ... [et al.]
Bayesian adaptive methods for clinical trials / / Scott M. Berry ... [et al.]
Edizione [1st ed.]
Pubbl/distr/stampa Boca Raton, : Chapman & Hall/CRC, 2010
Descrizione fisica 1 online resource (316 p.)
Disciplina 615.5072/4
Altri autori (Persone) BerryScott M
Collana Chapman & Hall/CRC biostatistics series
Soggetto topico Clinical trials - Statistical methods
Bayesian statistical decision theory
ISBN 0-429-15242-6
1-282-90299-7
9786612902994
1-4398-2551-3
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front cover; Contents; Foreword; Preface; CHAPTER 1: Statistical approaches for clinical trials; CHAPTER 2: Basics of Bayesian inference; CHAPTER 3: Phase I studies; CHAPTER 4: Phase II studies; CHAPTER 5: Phase III studies; CHAPTER 6: Special topics; References; Back cover
Record Nr. UNINA-9910808949303321
Boca Raton, : Chapman & Hall/CRC, 2010
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Bayesian approaches to clinical trials and health care evaluation [[electronic resource] /] / David J. Spiegelhalter, Keith R. Abrams, Jonathan P. Myles
Bayesian approaches to clinical trials and health care evaluation [[electronic resource] /] / David J. Spiegelhalter, Keith R. Abrams, Jonathan P. Myles
Autore Spiegelhalter D. J
Pubbl/distr/stampa Chichester ; ; Hoboken, NJ, : Wiley, c2004
Descrizione fisica 1 online resource (408 p.)
Disciplina 519.5/42/02461
610.72
Altri autori (Persone) AbramsK. R (Keith R.)
MylesJonathan P
Collana Statistics in practice
Soggetto topico Bayesian statistical decision theory
Medicine - Research - Statistical methods
Clinical trials - Statistical methods
Soggetto genere / forma Electronic books.
ISBN 1-280-26930-8
9786610269303
0-470-09259-9
0-470-09260-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Bayesian Approaches to Clinical Trials and Health-Care Evaluation; Contents; Preface; List of examples; 1 Introduction; 1.1 What are Bayesian methods?; 1.2 What do we mean by 'health-care evaluation'?; 1.3 A Bayesian approach to evaluation; 1.4 The aim of this book and the intended audience; 1.5 Structure of the book; 2 Basic Concepts from Traditional Statistical Analysis; 2.1 Probability; 2.1.1 What is probability?; 2.1.2 Odds and log-odds; 2.1.3 Bayes theorem for simple events; 2.2 Random variables, parameters and likelihood; 2.2.1 Random variables and their distributions
2.2.2 Expectation, variance, covariance and correlation 2.2.3 Parametric distributions and conditional independence; 2.2.4 Likelihoods; 2.3 The normal distribution; 2.4 Normal likelihoods; 2.4.1 Normal approximations for binary data; 2.4.2 Normal likelihoods for survival data; 2.4.3 Normal likelihoods for count responses; 2.4.4 Normal likelihoods for continuous responses; 2.5 Classical inference; 2.6 A catalogue of useful distributions*; 2.6.1 Binomial and Bernoulli; 2.6.2 Poisson; 2.6.3 Beta; 2.6.4 Uniform; 2.6.5 Gamma; 2.6.6 Root-inverse-gamma; 2.6.7 Half-normal; 2.6.8 Log-normal
2.6.9 Student's 2.6.10 Bivariate normal; 2.7 Key points; Exercises; 3 An Overview of the Bayesian Approach; 3.1 Subjectivity and context; 3.2 Bayes theorem for two hypotheses; 3.3 Comparing simple hypotheses: likelihood ratios and Bayes factors; 3.4 Exchangeability and parametric modelling*; 3.5 Bayes theorem for general quantities; 3.6 Bayesian analysis with binary data; 3.6.1 Binary data with a discrete prior distribution; 3.6.2 Conjugate analysis for binary data; 3.7 Bayesian analysis with normal distributions; 3.8 Point estimation, interval estimation and interval hypotheses
3.9 The prior distribution 3.10 How to use Bayes theorem to interpret trial results; 3.11 The 'credibility' of significant trial results*; 3.12 Sequential use of Bayes theorem*; 3.13 Predictions; 3.13.1 Predictions in the Bayesian framework; 3.13.2 Predictions for binary data*; 3.13.3 Predictions for normal data; 3.14 Decision-making; 3.15 Design; 3.16 Use of historical data; 3.17 Multiplicity, exchangeability and hierarchical models; 3.18 Dealing with nuisance parameters*; 3.18.1 Alternative methods for eliminating nuisance parameters*; 3.18.2 Profile likelihood in a hierarchical model*
3.19 Computational issues 3.19.1 Monte Carlo methods; 3.19.2 Markov chain Monte Carlo methods; 3.19.3 WinBUGS; 3.20 Schools of Bayesians; 3.21 A Bayesian checklist; 3.22 Further reading; 3.23 Key points; Exercises; 4 Comparison of Alternative Approaches to Inference; 4.1 A structure for alternative approaches; 4.2 Conventional statistical methods used in health-care evaluation; 4.3 The likelihood principle, sequential analysis and types of error; 4.3.1 The likelihood principle; 4.3.2 Sequential analysis; 4.3.3 Type I and Type II error; 4.4 P-values and Bayes factors*
4.4.1 Criticism of P-values
Record Nr. UNINA-9910143509603321
Spiegelhalter D. J  
Chichester ; ; Hoboken, NJ, : Wiley, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Bayesian approaches to clinical trials and health care evaluation [[electronic resource] /] / David J. Spiegelhalter, Keith R. Abrams, Jonathan P. Myles
Bayesian approaches to clinical trials and health care evaluation [[electronic resource] /] / David J. Spiegelhalter, Keith R. Abrams, Jonathan P. Myles
Autore Spiegelhalter D. J
Pubbl/distr/stampa Chichester ; ; Hoboken, NJ, : Wiley, c2004
Descrizione fisica 1 online resource (408 p.)
Disciplina 519.5/42/02461
610.72
Altri autori (Persone) AbramsK. R (Keith R.)
MylesJonathan P
Collana Statistics in practice
Soggetto topico Bayesian statistical decision theory
Medicine - Research - Statistical methods
Clinical trials - Statistical methods
ISBN 1-280-26930-8
9786610269303
0-470-09259-9
0-470-09260-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Bayesian Approaches to Clinical Trials and Health-Care Evaluation; Contents; Preface; List of examples; 1 Introduction; 1.1 What are Bayesian methods?; 1.2 What do we mean by 'health-care evaluation'?; 1.3 A Bayesian approach to evaluation; 1.4 The aim of this book and the intended audience; 1.5 Structure of the book; 2 Basic Concepts from Traditional Statistical Analysis; 2.1 Probability; 2.1.1 What is probability?; 2.1.2 Odds and log-odds; 2.1.3 Bayes theorem for simple events; 2.2 Random variables, parameters and likelihood; 2.2.1 Random variables and their distributions
2.2.2 Expectation, variance, covariance and correlation 2.2.3 Parametric distributions and conditional independence; 2.2.4 Likelihoods; 2.3 The normal distribution; 2.4 Normal likelihoods; 2.4.1 Normal approximations for binary data; 2.4.2 Normal likelihoods for survival data; 2.4.3 Normal likelihoods for count responses; 2.4.4 Normal likelihoods for continuous responses; 2.5 Classical inference; 2.6 A catalogue of useful distributions*; 2.6.1 Binomial and Bernoulli; 2.6.2 Poisson; 2.6.3 Beta; 2.6.4 Uniform; 2.6.5 Gamma; 2.6.6 Root-inverse-gamma; 2.6.7 Half-normal; 2.6.8 Log-normal
2.6.9 Student's 2.6.10 Bivariate normal; 2.7 Key points; Exercises; 3 An Overview of the Bayesian Approach; 3.1 Subjectivity and context; 3.2 Bayes theorem for two hypotheses; 3.3 Comparing simple hypotheses: likelihood ratios and Bayes factors; 3.4 Exchangeability and parametric modelling*; 3.5 Bayes theorem for general quantities; 3.6 Bayesian analysis with binary data; 3.6.1 Binary data with a discrete prior distribution; 3.6.2 Conjugate analysis for binary data; 3.7 Bayesian analysis with normal distributions; 3.8 Point estimation, interval estimation and interval hypotheses
3.9 The prior distribution 3.10 How to use Bayes theorem to interpret trial results; 3.11 The 'credibility' of significant trial results*; 3.12 Sequential use of Bayes theorem*; 3.13 Predictions; 3.13.1 Predictions in the Bayesian framework; 3.13.2 Predictions for binary data*; 3.13.3 Predictions for normal data; 3.14 Decision-making; 3.15 Design; 3.16 Use of historical data; 3.17 Multiplicity, exchangeability and hierarchical models; 3.18 Dealing with nuisance parameters*; 3.18.1 Alternative methods for eliminating nuisance parameters*; 3.18.2 Profile likelihood in a hierarchical model*
3.19 Computational issues 3.19.1 Monte Carlo methods; 3.19.2 Markov chain Monte Carlo methods; 3.19.3 WinBUGS; 3.20 Schools of Bayesians; 3.21 A Bayesian checklist; 3.22 Further reading; 3.23 Key points; Exercises; 4 Comparison of Alternative Approaches to Inference; 4.1 A structure for alternative approaches; 4.2 Conventional statistical methods used in health-care evaluation; 4.3 The likelihood principle, sequential analysis and types of error; 4.3.1 The likelihood principle; 4.3.2 Sequential analysis; 4.3.3 Type I and Type II error; 4.4 P-values and Bayes factors*
4.4.1 Criticism of P-values
Record Nr. UNINA-9910830922703321
Spiegelhalter D. J  
Chichester ; ; Hoboken, NJ, : Wiley, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Bayesian approaches to clinical trials and health care evaluation / / David J. Spiegelhalter, Keith R. Abrams, Jonathan P. Myles
Bayesian approaches to clinical trials and health care evaluation / / David J. Spiegelhalter, Keith R. Abrams, Jonathan P. Myles
Autore Spiegelhalter D. J
Pubbl/distr/stampa Chichester ; ; Hoboken, NJ, : Wiley, c2004
Descrizione fisica 1 online resource (408 p.)
Disciplina 519.5/42/02461
Altri autori (Persone) AbramsK. R (Keith R.)
MylesJonathan P
Collana Statistics in practice
Soggetto topico Bayesian statistical decision theory
Medicine - Research - Statistical methods
Clinical trials - Statistical methods
ISBN 1-280-26930-8
9786610269303
0-470-09259-9
0-470-09260-2
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Bayesian Approaches to Clinical Trials and Health-Care Evaluation; Contents; Preface; List of examples; 1 Introduction; 1.1 What are Bayesian methods?; 1.2 What do we mean by 'health-care evaluation'?; 1.3 A Bayesian approach to evaluation; 1.4 The aim of this book and the intended audience; 1.5 Structure of the book; 2 Basic Concepts from Traditional Statistical Analysis; 2.1 Probability; 2.1.1 What is probability?; 2.1.2 Odds and log-odds; 2.1.3 Bayes theorem for simple events; 2.2 Random variables, parameters and likelihood; 2.2.1 Random variables and their distributions
2.2.2 Expectation, variance, covariance and correlation 2.2.3 Parametric distributions and conditional independence; 2.2.4 Likelihoods; 2.3 The normal distribution; 2.4 Normal likelihoods; 2.4.1 Normal approximations for binary data; 2.4.2 Normal likelihoods for survival data; 2.4.3 Normal likelihoods for count responses; 2.4.4 Normal likelihoods for continuous responses; 2.5 Classical inference; 2.6 A catalogue of useful distributions*; 2.6.1 Binomial and Bernoulli; 2.6.2 Poisson; 2.6.3 Beta; 2.6.4 Uniform; 2.6.5 Gamma; 2.6.6 Root-inverse-gamma; 2.6.7 Half-normal; 2.6.8 Log-normal
2.6.9 Student's 2.6.10 Bivariate normal; 2.7 Key points; Exercises; 3 An Overview of the Bayesian Approach; 3.1 Subjectivity and context; 3.2 Bayes theorem for two hypotheses; 3.3 Comparing simple hypotheses: likelihood ratios and Bayes factors; 3.4 Exchangeability and parametric modelling*; 3.5 Bayes theorem for general quantities; 3.6 Bayesian analysis with binary data; 3.6.1 Binary data with a discrete prior distribution; 3.6.2 Conjugate analysis for binary data; 3.7 Bayesian analysis with normal distributions; 3.8 Point estimation, interval estimation and interval hypotheses
3.9 The prior distribution 3.10 How to use Bayes theorem to interpret trial results; 3.11 The 'credibility' of significant trial results*; 3.12 Sequential use of Bayes theorem*; 3.13 Predictions; 3.13.1 Predictions in the Bayesian framework; 3.13.2 Predictions for binary data*; 3.13.3 Predictions for normal data; 3.14 Decision-making; 3.15 Design; 3.16 Use of historical data; 3.17 Multiplicity, exchangeability and hierarchical models; 3.18 Dealing with nuisance parameters*; 3.18.1 Alternative methods for eliminating nuisance parameters*; 3.18.2 Profile likelihood in a hierarchical model*
3.19 Computational issues 3.19.1 Monte Carlo methods; 3.19.2 Markov chain Monte Carlo methods; 3.19.3 WinBUGS; 3.20 Schools of Bayesians; 3.21 A Bayesian checklist; 3.22 Further reading; 3.23 Key points; Exercises; 4 Comparison of Alternative Approaches to Inference; 4.1 A structure for alternative approaches; 4.2 Conventional statistical methods used in health-care evaluation; 4.3 The likelihood principle, sequential analysis and types of error; 4.3.1 The likelihood principle; 4.3.2 Sequential analysis; 4.3.3 Type I and Type II error; 4.4 P-values and Bayes factors*
4.4.1 Criticism of P-values
Record Nr. UNINA-9910877647303321
Spiegelhalter D. J  
Chichester ; ; Hoboken, NJ, : Wiley, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Bayesian methods in pharmaceutical research / / edited by Emmanuel Lesaffre, Gianluca Baio, Bruno Boulanger
Bayesian methods in pharmaceutical research / / edited by Emmanuel Lesaffre, Gianluca Baio, Bruno Boulanger
Pubbl/distr/stampa Boca Raton, Florida ; ; London ; ; New York : , : CRC Press, , [2020]
Descrizione fisica 1 online resource (xxx, 516 pages) : illustrations
Disciplina 610.724
Collana Chapman & Hall/CRC biostatistics series
Soggetto topico Clinical trials - Statistical methods
ISBN 1-351-71866-5
1-315-18021-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910794147603321
Boca Raton, Florida ; ; London ; ; New York : , : CRC Press, , [2020]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Bayesian methods in pharmaceutical research / / edited by Emmanuel Lesaffre, Gianluca Baio, Bruno Boulanger
Bayesian methods in pharmaceutical research / / edited by Emmanuel Lesaffre, Gianluca Baio, Bruno Boulanger
Pubbl/distr/stampa Boca Raton, Florida ; ; London ; ; New York : , : CRC Press, , [2020]
Descrizione fisica 1 online resource (xxx, 516 pages) : illustrations
Disciplina 610.724
Collana Chapman & Hall/CRC biostatistics series
Soggetto topico Clinical trials - Statistical methods
ISBN 1-351-71866-5
1-315-18021-9
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910819240403321
Boca Raton, Florida ; ; London ; ; New York : , : CRC Press, , [2020]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Binary data analysis of randomized clinical trials with noncompliance [[electronic resource] /] / Kung-Jong Lui
Binary data analysis of randomized clinical trials with noncompliance [[electronic resource] /] / Kung-Jong Lui
Autore Lui Kung-Jong
Pubbl/distr/stampa Chichester, West Sussex, United Kingdom, : John Wiley & Sons Inc., 2011
Descrizione fisica 1 online resource (332 p.)
Disciplina 615.5072/4
Collana Statistics in practice
Soggetto topico Clinical trials - Statistical methods
Drugs - Testing - Statistical methods
ISBN 1-283-40536-9
9786613405364
1-119-99160-9
1-119-99161-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Binary Data Analysis of Randomized Clinical Trials with Noncompliance; Contents; Preface; About the Author; 1 Randomized clinical trials with noncompliance: issues, definitions and problems of commonly used analyses; 1.1 Randomized encouragement design (RED); 1.2 Randomized consent designs; 1.2.1 Single-consent randomized design (SCRD); 1.2.2 Double-consent randomized design (DCRD); 1.3 Treatment efficacy versus programmatic effectiveness; 1.4 Definitions of commonly used terms and assumptions; 1.5 Most commonly used analyses for a RCT with noncompliance; Exercises
2 Randomized clinical trials with noncompliance under parallel groups design 2.1 Testing superiority; 2.2 Testing noninferiority; 2.2.1 Using the difference in proportions; 2.2.2 Using the ratio of proportions; 2.2.3 Using the odds ratio of proportions; 2.3 Testing equivalence; 2.3.1 Using the difference in proportions; 2.3.2 Using the ratio of proportions; 2.3.3 Using the odds ratio of proportions; 2.4 Interval estimation; 2.4.1 Estimation of the proportion difference; 2.4.2 Estimation of the proportion ratio; 2.4.3 Estimation of the odds ratio; 2.5 Sample size determination
2.5.1 Sample size calculation for testing superiority 2.5.2 Sample size calculation for testing noninferiority; 2.5.3 Sample size calculation for testing equivalence; 2.6 Risk model-based approach; 2.6.1 Constant risk additive model; 2.6.2 Constant risk multiplicative model; 2.6.3 Generalized risk additive model; 2.6.4 Generalized risk multiplicative model; Exercises; Appendix; 3 Randomized clinical trials with noncompliance in stratified sampling; 3.1 Testing superiority; 3.2 Testing noninferiority; 3.2.1 Using the difference in proportions; 3.2.2 Using the ratio of proportions
3.2.3 Using the odds ratio of proportions 3.3 Testing equivalence; 3.3.1 Using the difference in proportions; 3.3.2 Using the ratio of proportions; 3.3.3 Using the odds ratio of proportions; 3.4 Interval estimation; 3.4.1 Estimation of the proportion difference; 3.4.2 Estimation of the proportion ratio; 3.4.3 Estimation of the odds ratio; 3.5 Test homogeneity of index in large strata; 3.5.1 Testing homogeneity of the proportion difference; 3.5.2 Testing homogeneity of the proportion ratio; 3.5.3 Test homogeneity of the odds ratio; Exercises; Appendix
4 Randomized clinical trials with noncompliance under cluster sampling 4.1 Testing superiority; 4.2 Testing noninferiority; 4.2.1 Using the difference in proportions; 4.2.2 Using the ratio of proportions; 4.2.3 Using the odds ratio of proportions; 4.3 Testing equivalence; 4.3.1 Using the difference in proportions; 4.3.2 Using the ratio of proportions; 4.3.3 Using the odds ratio of proportions; 4.4 Interval estimation; 4.4.1 Estimation of the proportion difference; 4.4.2 Estimation of the proportion ratio; 4.4.3 Estimation of the odds ratio; 4.5 Sample size determination
4.5.1 Sample size calculation for testing superiority
Record Nr. UNINA-9910131022703321
Lui Kung-Jong  
Chichester, West Sussex, United Kingdom, : John Wiley & Sons Inc., 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui