Autore	Elisabeth Chamorand
Pubbl/distr/stampa	Paris
Descrizione fisica	1 online resource (118 p.)
Soggetto topico	Drug accessibility - History - 21st century - Developing countries Pharmaceutical industry - History - 21st century - Developing countries Pharmaceutical policy - History - 21st century - Developing countries Public health - History - 21st century - Developing countries Pharmaceutical Preparations International Cooperation History, Modern 1601- Internationality History Chemicals and Drugs Humanities Social Sciences Anthropology, Education, Sociology and Social Phenomena Drugs, Essential History, 21st Century Developing Countries
ISBN	2-336-67270-7
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	fre
Altri titoli varianti	L'accès aux médicaments dans les pays en développement - De 2001
Record Nr.	UNINA-9910153340703321

Autore	Tsaioun Katya
Pubbl/distr/stampa	Hoboken, : Wiley, 2012
Descrizione fisica	1 online resource (524 p.)
Disciplina	615.19 615/.19
Altri autori (Persone)	KatesSteven A
Soggetto topico	Drug Design Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology
ISBN	1-280-59122-6 9786613621054 0-470-91509-9 0-470-91511-0
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions 2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion
Record Nr.	UNINA-9910133588303321

Pubbl/distr/stampa	[Place of publication not identified], : University of California Press, 1992
Disciplina	614.5/993
Soggetto topico	AIDS (Disease) - History Financial Support Health Personnel Homosexuality Mass Media Social Control, Formal State Government Substance-Related Disorders Blood Donors Confidentiality Delivery of Health Care Government Acquired Immunodeficiency Syndrome Blood Transfusion Education History Legislation Local Government Health Policy Hemophilia A Human Experimentation Jurisprudence Public Health Minority Groups Federal Government Government Regulation HIV Seropositivity Public Policy International Cooperation Developing Countries Chronic Disease Women Politics AIDS Serodiagnosis Ethics, Medical Internationality Pharmaceutical Preparations Employment Poverty Prejudice Epidemiology Publication Formats Patient Care Management Tissue Donors Environment and Public Health Economics Health Care Facilities, Manpower, and Services Medicine Patient Rights Forensic Psychiatry Diseases Health Sociology Disease Attributes Persons HIV Infections Blood Coagulation Disorders, Inherited Social Control Policies Health Care Quality, Access, and Evaluation Investigative Techniques Biological Therapy Serologic Tests Organizations Social Sciences Sexuality Coagulation Protein Disorders Anthropology, Education, Sociology and Social Phenomena Humanities Psychology, Social Social Problems Hemorrhagic Disorders Socioeconomic Factors Health Care Economics and Organizations Chemicals and Drugs Ethics, Clinical Research Slow Virus Diseases Occupational Groups Biomedical Research Communications Media Mental Disorders Health Care Genetic Diseases, Inborn Policy Behavior and Behavior Mechanisms Immunologic Deficiency Syndromes Human Rights Immunologic Tests Science Sexually Transmitted Diseases, Viral Population Characteristics Therapeutics Virus Diseases Psychiatry and Psychology Publication Characteristics Sexual Behavior Psychiatry Reproductive Physiological Phenomena Health Services Administration Named Groups Information Science Analytical, Diagnostic and Therapeutic Techniques and Equipment Ethics, Professional Blood Coagulation Disorders Pathologic Processes Lentivirus Infections Hematologic Diseases Health Occupations Congenital, Hereditary, and Neonatal Diseases and Abnormalities Ethics Immunologic Techniques Sexually Transmitted Diseases Immune System Diseases Laboratory Techniques and Procedures Behavior Pathological Conditions, Signs and Symptoms Retroviridae Infections Hemic and Lymphatic Diseases Reproductive and Urinary Physiological Phenomena Natural Science Disciplines Disciplines and Occupations Behavioral Sciences RNA Virus Infections Diagnosis Phenomena and Processes Behavioral Disciplines and Activities Communicable Diseases Health & Biological Sciences
ISBN	0-520-07569-2
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Altri titoli varianti	AIDS
Record Nr.	UNINA-9910495891403321