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Lysophospholipid receptors [[electronic resource] ] : signaling and biochemistry / / edited by Jerold Chun ... [et al.]
| Lysophospholipid receptors [[electronic resource] ] : signaling and biochemistry / / edited by Jerold Chun ... [et al.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2013 |
| Descrizione fisica | 1 online resource (813 p.) |
| Disciplina | 571.7/4 |
| Altri autori (Persone) | ChunJerold <1959-> |
| Soggetto topico |
Cell receptors - Physiology
Cell receptors - Metabolism Cellular signal transduction - Physiology |
| ISBN |
1-118-53142-6
1-118-53135-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title page; Copyright page; Contents; Preface; Contributors; CHAPTER 1: Lysophosphatidic Acid (LPA) Receptor Signaling; 1.1. Introduction; 1.2. LPA Metabolism; 1.3. Autotaxin; 1.4. LPA Receptors; 1.4.1. LPA1; 1.4.2. LPA2; 1.4.3. LPA3; 1.4.4. LPA4; 1.4.5. LPA5; 1.4.6. LPA6; 1.5. LPA Receptor Agonists and Antagonists; References; CHAPTER 2: Sphingosine 1-Phosphate (S1P) Receptors; 2.1. Introduction; 2.2. S1P Metabolism/Enzyme, and Transport; 2.2.1. S1P Metabolism and Enzymes; 2.2.2. Sphingosine Kinases; 2.2.3. S1P Phosphatases and S1P Lyase
2.3. S1P Receptor Subtypes, and Physiological Functions2.3.1. S1P1; 2.3.2. S1P2; 2.3.3. S1P3; 2.3.4. S1P4; 2.3.5. S1P5; 2.4. Concluding Remarks; References; CHAPTER 3: Global Gene Expression Program of Lysophosphatidic Acid (LPA)-Stimulated Fibroblasts; 3.1. Introduction; 3.2. The Global Transcriptional Response of MEFs to LPA; 3.3. Upregulated Genes; 3.4. Downregulated Genes; 3.5. Induction of Genes that Encode Secreted Factors; 3.6. Overlap between the Expression Profiles of LPA and EGF; 3.7. Conclusions; Acknowledgments; References CHAPTER 4: Identification of Direct Intracellular Targets of Sphingosine 1-Phosphate (S1P)4.1. Introduction; 4.2. Intracellular Targets for S1P; 4.3. Methods to Identify Intracellular S1P Targets; 4.3.1. S1P Immobilized on Agarose Beads; 4.3.2. Binding of 32P-Labeled S1P to Targets; 4.3.3. Mass Measurement of Endogenous S1P in Immunoprecipitates of Target Proteins; 4.4. Other Potentially Useful Methods to Identify Lipid Binding Proteins; 4.4.1. Lipid Strips for Identification of Binding Proteins (Protein-Lipid Overlay) 4.4.2. Detection of Lipid Binding Proteins by Enzyme-Linked Immunadsorbent Assays4.4.3. Liposome Pull Down; 4.5. Concluding Remarks; Acknowledgments; References; CHAPTER 5: Lysophospholipid Receptor Signaling Platforms: The Receptor Tyrosine Kinase-G Protein-Coupled Receptor Signaling Complex; 5.1. Introduction; 5.2. Lysophospholipid Receptor-Receptor Tyrosine Kinase Complexes; 5.3. Other Lysophospholipid Receptor Signaling Platforms; 5.4. Other Examples of RTK-GPCR Signaling Platforms 5.5. Interaction of RGS Proteins with Receptor Tyrosine Kinase-Lysophospholipid Receptor Signaling Complexes5.6. S1P and RTK Transactivation; 5.7. Approaches for the Study of Receptor Tyrosine Kinase-Lysophospholipid Receptor Signaling Complexes; 5.8. Some Useful Protocols for Studying RTK-Lysophospholipid Receptor Signaling Platforms; 5.8.1. Compounds; 5.8.2. Cells; 5.8.3. Immunoprecipitation; 5.8.4. Immunofluorescence; 5.8.5. GTP-γ-S Binding Assay; 5.8.6. Cell Migration; 5.9. Conclusion; Acknowledgment; References CHAPTER 6: Autotaxin: A Unique Ecto-Type Pyrophosphodiesterase with Diverse Functions |
| Record Nr. | UNINA-9910141615303321 |
| Hoboken, N.J., : Wiley, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Lysophospholipid receptors : signaling and biochemistry / / edited by Jerold Chun ... [et al.]
| Lysophospholipid receptors : signaling and biochemistry / / edited by Jerold Chun ... [et al.] |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2013 |
| Descrizione fisica | 1 online resource (813 p.) |
| Disciplina | 571.7/4 |
| Altri autori (Persone) | ChunJerold <1959-> |
| Soggetto topico |
Cell receptors - Physiology
Cell receptors - Metabolism Cellular signal transduction - Physiology |
| ISBN |
1-118-53142-6
1-118-53135-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title page; Copyright page; Contents; Preface; Contributors; CHAPTER 1: Lysophosphatidic Acid (LPA) Receptor Signaling; 1.1. Introduction; 1.2. LPA Metabolism; 1.3. Autotaxin; 1.4. LPA Receptors; 1.4.1. LPA1; 1.4.2. LPA2; 1.4.3. LPA3; 1.4.4. LPA4; 1.4.5. LPA5; 1.4.6. LPA6; 1.5. LPA Receptor Agonists and Antagonists; References; CHAPTER 2: Sphingosine 1-Phosphate (S1P) Receptors; 2.1. Introduction; 2.2. S1P Metabolism/Enzyme, and Transport; 2.2.1. S1P Metabolism and Enzymes; 2.2.2. Sphingosine Kinases; 2.2.3. S1P Phosphatases and S1P Lyase
2.3. S1P Receptor Subtypes, and Physiological Functions2.3.1. S1P1; 2.3.2. S1P2; 2.3.3. S1P3; 2.3.4. S1P4; 2.3.5. S1P5; 2.4. Concluding Remarks; References; CHAPTER 3: Global Gene Expression Program of Lysophosphatidic Acid (LPA)-Stimulated Fibroblasts; 3.1. Introduction; 3.2. The Global Transcriptional Response of MEFs to LPA; 3.3. Upregulated Genes; 3.4. Downregulated Genes; 3.5. Induction of Genes that Encode Secreted Factors; 3.6. Overlap between the Expression Profiles of LPA and EGF; 3.7. Conclusions; Acknowledgments; References CHAPTER 4: Identification of Direct Intracellular Targets of Sphingosine 1-Phosphate (S1P)4.1. Introduction; 4.2. Intracellular Targets for S1P; 4.3. Methods to Identify Intracellular S1P Targets; 4.3.1. S1P Immobilized on Agarose Beads; 4.3.2. Binding of 32P-Labeled S1P to Targets; 4.3.3. Mass Measurement of Endogenous S1P in Immunoprecipitates of Target Proteins; 4.4. Other Potentially Useful Methods to Identify Lipid Binding Proteins; 4.4.1. Lipid Strips for Identification of Binding Proteins (Protein-Lipid Overlay) 4.4.2. Detection of Lipid Binding Proteins by Enzyme-Linked Immunadsorbent Assays4.4.3. Liposome Pull Down; 4.5. Concluding Remarks; Acknowledgments; References; CHAPTER 5: Lysophospholipid Receptor Signaling Platforms: The Receptor Tyrosine Kinase-G Protein-Coupled Receptor Signaling Complex; 5.1. Introduction; 5.2. Lysophospholipid Receptor-Receptor Tyrosine Kinase Complexes; 5.3. Other Lysophospholipid Receptor Signaling Platforms; 5.4. Other Examples of RTK-GPCR Signaling Platforms 5.5. Interaction of RGS Proteins with Receptor Tyrosine Kinase-Lysophospholipid Receptor Signaling Complexes5.6. S1P and RTK Transactivation; 5.7. Approaches for the Study of Receptor Tyrosine Kinase-Lysophospholipid Receptor Signaling Complexes; 5.8. Some Useful Protocols for Studying RTK-Lysophospholipid Receptor Signaling Platforms; 5.8.1. Compounds; 5.8.2. Cells; 5.8.3. Immunoprecipitation; 5.8.4. Immunofluorescence; 5.8.5. GTP-γ-S Binding Assay; 5.8.6. Cell Migration; 5.9. Conclusion; Acknowledgment; References CHAPTER 6: Autotaxin: A Unique Ecto-Type Pyrophosphodiesterase with Diverse Functions |
| Record Nr. | UNINA-9910808700503321 |
| Hoboken, N.J., : Wiley, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
