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Carbohydrate-based drug discovery [[electronic resource] /] / Chi-Huey Wong (ed.)
| Carbohydrate-based drug discovery [[electronic resource] /] / Chi-Huey Wong (ed.) |
| Pubbl/distr/stampa | Weinheim ; ; [New York], : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (981 p.) |
| Disciplina |
615.3
615.7 |
| Altri autori (Persone) | WongChi-Huey |
| Soggetto topico |
Carbohydrate drugs
Carbohydrates - Synthesis Glycoconjugates - Physiological effect |
| ISBN |
1-280-52072-8
9786610520725 3-527-60578-9 3-527-60243-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Carbohydrate-based Drug Discovery; Contents; Preface; List of Contributors; Volume 1; 1 Synthetic Methodologies; 1.1 Introduction; 1.2 Tactical Analysis for Overall Synthetic Efficiency; 1.3 Methodological Improvements; 1.3.1 Chemistry; 1.3.2 Protecting Group Manipulations; 1.3.3 Modulation of the Reactivity of Glycosyl Donors; 1.3.4 Block Synthesis; 1.4 Accessibility; 1.4.1 Solution-based Chemistry; 1.4.2 One-Pot Glycosylation; 1.4.3 Solid-Phase Chemistry; 1.4.3.1 Fundamentals of Solid-Phase Oligosaccharide Synthesis; 1.4.3.2 The Support; 1.4.3.3 Linkers to the Support
1.4.3.4 Protecting Groups used in Solid-Phase Oligosaccharide Synthesis1.4.3.5 Solid-Phase Oligosaccharide Synthesis; 1.4.3.6 Monitoring of Reaction Progress; 1.4.4 Automation; 1.5 Concluding Remarks; 1.6 References; 2 Complex Carbohydrate Synthesis; 2.1 Introduction; 2.2 Synthetic Gangliosides; 2.2.1 Gangliosides GM4 and GM3, and their Analogues and Derivatives; 2.2.2 Sialylparagloboside (SPG) Analogues and Derivatives; 2.2.3 Selectin Ligands; 2.2.3.1 Sialyl Lewis x; 2.2.3.2 Novel 6-Sulfo sLe(x) Variants; 2.2.4 Siglec Ligands; 2.2.4.1 Chol-1 (α-Series) Gangliosides 2.2.4.2 Novel Sulfated Gangliosides2.3 Toxin Receptor; 2.4 Summary and Perspectives; 2.5 References; 3 The Chemistry of Sialic Acid; 3.1 Introduction; 3.2 Chemical and Enzymatic Synthesis of Sialic Acids; 3.3 Chemical Glycosidation of Sialic Acids; 3.3.1 Direct Chemical Sialylations; 3.3.1.1 2-Chloro Derivatives as Glycosyl Donors; 3.3.1.2 2-Thio Derivatives as Glycosyl Donors; 3.3.1.3 2-Xanthates as Glycosyl Donors; 3.3.1.3 2-Phosphites as Glycosyl Donors; 3.3.1.4 Miscellaneous Direct Chemical Methods; 3.3.2 Indirect Chemical Methods with the Use of a Participating Auxiliary at C-3 4.3.2 Immobilization of the Glycosyl Donor4.3.3 Bi-directional Strategy; 4.4 Support Materials; 4.4.1 Insoluble Supports; 4.4.2 Soluble Supports; 4.5 Linkers; 4.5.1 Silyl Ethers; 4.5.2 Acid- and Base-Labile Linkers; 4.5.3 Thioglycoside Linkers; 4.5.4 Linkers Cleaved by Oxidation; 4.5.5 Photocleavable Linkers; 4.5.6 Linkers Cleaved by Olefin Metathesis; 4.6 Synthesis of Oligosaccharides on Solid Support by Use of Different Glycosylating Agents; 4.6.1 1,2-Anhydrosugars - The Glycal Assembly Approach; 4.6.2 Glycosyl Sulfoxides; 4.6.3 Glycosyl Trichloroacetimidates; 4.6.4 Thioglycosides 4.6.5 Glycosyl Fluorides |
| Record Nr. | UNINA-9910146238303321 |
| Weinheim ; ; [New York], : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Polysaccharide-based nanocrystals : chemistry and applications / / edited by Jin Huang [and three others]
| Polysaccharide-based nanocrystals : chemistry and applications / / edited by Jin Huang [and three others] |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH : , : Chemical Industry Press, , 2015 |
| Descrizione fisica | 1 online resource (328 p.) |
| Disciplina | 615.3 |
| Soggetto topico |
Carbohydrate drugs
Polymeric drug delivery systems Polysaccharides |
| ISBN |
3-527-68938-9
3-527-68937-0 3-527-68939-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Polysaccharide-Based Nanocrystals; Contents; List of Contributors; Foreword; Preface; Chapter 1 Polysaccharide Nanocrystals: Current Status and Prospects in Material Science; 1.1 Introduction to Polysaccharide Nanocrystals; 1.2 Current Application of Polysaccharide Nanocrystals in Material Science; 1.3 Prospects for Polysaccharide Nanocrystal-Based Materials; List of Abbreviations; References; Chapter 2 Structure and Properties of Polysaccharide Nanocrystals; 2.1 Introduction; 2.2 Cellulose Nanocrystals; 2.2.1 Preparation of Cellulose Nanocrystals
2.2.1.1 Acid Hydrolysis Extraction of Cellulose Nanocrystals2.2.1.2 Effects of Acid Type; 2.2.1.3 Effects of Pretreatment; 2.2.2 Structure and Properties of Cellulose Nanocrystals; 2.2.2.1 Structure and Rigidity of Cellulose Nanocrystals; 2.2.2.2 Physical Properties of Cellulose Nanocrystals; 2.3 Chitin Nanocrystals; 2.3.1 Preparation of Chitin Nanocrystals; 2.3.1.1 Extraction of Chitin Nanocrystals by Acid Hydrolysis; 2.3.1.2 Extraction of Chitin Nanocrystals by TEMPO Oxidation; 2.3.2 Structure and Properties of Chitin Nanocrystals; 2.3.2.1 Structure and Rigidity of Chitin Nanocrystals 2.3.2.2 Properties of Chitin Nanocrystal Suspensions2.4 Starch Nanocrystals; 2.4.1 Preparation of Starch Nanocrystals; 2.4.1.1 Extraction of Starch Nanocrystals by Acid Hydrolysis; 2.4.1.2 Effect of Ultrasonic Treatment; 2.4.1.3 Effect of Pretreatment; 2.4.2 Structure and Properties of Starch Nanocrystals; 2.4.2.1 Structure of Starch Nanocrystals; 2.4.2.2 Properties of Starch Nanocrystal Suspensions; 2.5 Conclusion and Prospects; List of Abbreviations; References; Chapter 3 Surface Modification of Polysaccharide Nanocrystals; 3.1 Introduction 3.2 Surface Chemistry of Polysaccharide Nanocrystals3.2.1 Surface Hydroxyl Groups; 3.2.2 Surface Groups Originating from Various Extraction Methods; 3.3 Approaches and Strategies for Surface Modification; 3.3.1 Purpose and Challenge of Surface Modification; 3.3.2 Comparison of Different Approaches and Strategies of Surface Modification; 3.4 Adsorption of Surfactant; 3.4.1 Anionic Surfactant; 3.4.2 Cationic Surfactant; 3.4.3 Nonionic Surfactant; 3.5 Hydrophobic Groups Resulting from Chemical Derivatization; 3.5.1 Acetyl and Ester Groups with Acetylation and Esterification 3.5.2 Carboxyl Groups Resulting from TEMPO-Mediated Oxidation3.5.3 Derivatization with Isocyanate Carboamination; 3.5.4 Silyl Groups Resulting from Silylation; 3.5.5 Cationic Groups Resulting from Cationization; 3.6 Polymeric Chains from Physical Absorption or Chemical Grafting; 3.6.1 Hydrophilic Polymer; 3.6.2 Polyester; 3.6.3 Polyolefin; 3.6.4 Block Copolymer; 3.6.5 Polyurethane and Waterborne Polyurethane; 3.6.6 Other Hydrophobic Polymer; 3.7 Advanced Functional Groups and Modification; 3.7.1 Fluorescent and Dye Molecules; 3.7.2 Amino Acid and DNA 3.7.3 Self-Cross-linking of Polysaccharide Nanocrystals |
| Record Nr. | UNINA-9910140485003321 |
| Weinheim, Germany : , : Wiley-VCH : , : Chemical Industry Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Polysaccharide-based nanocrystals : chemistry and applications / / edited by Jin Huang [and three others]
| Polysaccharide-based nanocrystals : chemistry and applications / / edited by Jin Huang [and three others] |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH : , : Chemical Industry Press, , 2015 |
| Descrizione fisica | 1 online resource (328 p.) |
| Disciplina | 615.3 |
| Soggetto topico |
Carbohydrate drugs
Polymeric drug delivery systems Polysaccharides |
| ISBN |
3-527-68938-9
3-527-68937-0 3-527-68939-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Polysaccharide-Based Nanocrystals; Contents; List of Contributors; Foreword; Preface; Chapter 1 Polysaccharide Nanocrystals: Current Status and Prospects in Material Science; 1.1 Introduction to Polysaccharide Nanocrystals; 1.2 Current Application of Polysaccharide Nanocrystals in Material Science; 1.3 Prospects for Polysaccharide Nanocrystal-Based Materials; List of Abbreviations; References; Chapter 2 Structure and Properties of Polysaccharide Nanocrystals; 2.1 Introduction; 2.2 Cellulose Nanocrystals; 2.2.1 Preparation of Cellulose Nanocrystals
2.2.1.1 Acid Hydrolysis Extraction of Cellulose Nanocrystals2.2.1.2 Effects of Acid Type; 2.2.1.3 Effects of Pretreatment; 2.2.2 Structure and Properties of Cellulose Nanocrystals; 2.2.2.1 Structure and Rigidity of Cellulose Nanocrystals; 2.2.2.2 Physical Properties of Cellulose Nanocrystals; 2.3 Chitin Nanocrystals; 2.3.1 Preparation of Chitin Nanocrystals; 2.3.1.1 Extraction of Chitin Nanocrystals by Acid Hydrolysis; 2.3.1.2 Extraction of Chitin Nanocrystals by TEMPO Oxidation; 2.3.2 Structure and Properties of Chitin Nanocrystals; 2.3.2.1 Structure and Rigidity of Chitin Nanocrystals 2.3.2.2 Properties of Chitin Nanocrystal Suspensions2.4 Starch Nanocrystals; 2.4.1 Preparation of Starch Nanocrystals; 2.4.1.1 Extraction of Starch Nanocrystals by Acid Hydrolysis; 2.4.1.2 Effect of Ultrasonic Treatment; 2.4.1.3 Effect of Pretreatment; 2.4.2 Structure and Properties of Starch Nanocrystals; 2.4.2.1 Structure of Starch Nanocrystals; 2.4.2.2 Properties of Starch Nanocrystal Suspensions; 2.5 Conclusion and Prospects; List of Abbreviations; References; Chapter 3 Surface Modification of Polysaccharide Nanocrystals; 3.1 Introduction 3.2 Surface Chemistry of Polysaccharide Nanocrystals3.2.1 Surface Hydroxyl Groups; 3.2.2 Surface Groups Originating from Various Extraction Methods; 3.3 Approaches and Strategies for Surface Modification; 3.3.1 Purpose and Challenge of Surface Modification; 3.3.2 Comparison of Different Approaches and Strategies of Surface Modification; 3.4 Adsorption of Surfactant; 3.4.1 Anionic Surfactant; 3.4.2 Cationic Surfactant; 3.4.3 Nonionic Surfactant; 3.5 Hydrophobic Groups Resulting from Chemical Derivatization; 3.5.1 Acetyl and Ester Groups with Acetylation and Esterification 3.5.2 Carboxyl Groups Resulting from TEMPO-Mediated Oxidation3.5.3 Derivatization with Isocyanate Carboamination; 3.5.4 Silyl Groups Resulting from Silylation; 3.5.5 Cationic Groups Resulting from Cationization; 3.6 Polymeric Chains from Physical Absorption or Chemical Grafting; 3.6.1 Hydrophilic Polymer; 3.6.2 Polyester; 3.6.3 Polyolefin; 3.6.4 Block Copolymer; 3.6.5 Polyurethane and Waterborne Polyurethane; 3.6.6 Other Hydrophobic Polymer; 3.7 Advanced Functional Groups and Modification; 3.7.1 Fluorescent and Dye Molecules; 3.7.2 Amino Acid and DNA 3.7.3 Self-Cross-linking of Polysaccharide Nanocrystals |
| Record Nr. | UNINA-9910814265203321 |
| Weinheim, Germany : , : Wiley-VCH : , : Chemical Industry Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
