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"Topics in anti-cancer research." . Volume 4 / / editors, Atta-ur-Rahman, FRS, Kings College, University of Cambridge, Cambridge, UK & Khurshid Zaman, Bentham Science Publishers, USA
| "Topics in anti-cancer research." . Volume 4 / / editors, Atta-ur-Rahman, FRS, Kings College, University of Cambridge, Cambridge, UK & Khurshid Zaman, Bentham Science Publishers, USA |
| Pubbl/distr/stampa | Sharjah : , : Bentham Science Publishers, Limited, , [2015] |
| Descrizione fisica | 1 online resource (817 p.) |
| Collana | Topics in Anti-Cancer Research |
| Soggetto topico |
Cancer - Research
Cancer - Prevention |
| ISBN | 1-68108-076-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONTENTS; FOREWORD ; List of Contributors ; Targeted Cancer Therapy: The Roles Played by Antibody-Drug and Antibody-Toxin Conjugates ; 1. INTRODUCTION; 2. IMMUNOTOXINS; 2.1. Pseudomonas Exotoxin-Based Immunotoxins; 2.2. Pseudomonas Exotoxin-Based ITs in Treating Solid Tumors; 2.3. Diphtheria Toxin-Based Immunotoxins; 2.4. Ribosome Inactivating Proteins-Based Immunotoxins; 2.4.1. Ricin; 2.4.2. Recombinant constructs of RIP I toxins; 2.5. Ribonucleases-Based IT; 2.6. Proapoptotic Proteins Used As Targeted Immunotoxins/Chimeric Proteins; 2.7. Current & Future Developments of ITs
3. ANTIBODY-DRUG CONJUGATES 3.1. DNA Interacting Agents-Calicheamicins; 3.2. DNA Interacting Agents-Duocarmycins; 3.3. DNA Interacting Agents-Pyrrolo[1,4]Benzodiazepines; 3.4. Tubulin Interacting Agents-Auristatins; 3.5. Tubulin Interacting Agents-Maytansinoids; 3.6. Other Anticancer Drugs Conjugated to mAbs; 4. CURRENT AND FUTURE DEVELOPMENTS OF ADC ; DISCLOSURE; CONFLICTS OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Targeting Cell Surface Nucleolin in Cancer ; INTRODUCTION; CELL SURFACE LOCALIZATION OF NCL; LIGANDS OF CELL SURFACE NCL CELL SURFACE NCL-DEPENDENT LIGAND SPECIFIC INTERNALIZATIONCELL SURFACE NCL AND SIGNALING COMPLEXES; TARGETING CELL SURFACE NCL; CELL SURFACE NCL AS BIOMARKER FOR CANCER; PATENTS RELATED TO NCL; CURRENT & FUTURE DEVELOPMENTS; DISCLOSURE; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Anticancer Agents Targeting Tubulin ; 1. INTRODUCTION; 2. MICROTUBULE DESTABLIZERS; 2.1. Colchicine; 2.2. Combretastatin A-4 (CA-A4); 2.3. Chalcones; 2.4. Phenstatins; 2.5. Podophyllotoxin; 2.6. Vinca Alkaloids; 2.7. Other Tubulin Polymerization Inhibitors; 3. MICROTUBULE STABLIZERS; 3.1. Taxol® 3.2. Other Tubulin Depolymerization InhibitorsDrugs Bind to Microtubule-Associated Proteins (MAPs); Peripheral Neuropathy Induced by Anti Mitotic Agents [177]; Role of β-Tubulin Isotypes in Drug Binding [178]; 4. RECENT PATENTS; 4.1. Research Corporation Technologies Patents; 4.2. Brandeis University Patents; 4.3. Tuse et al. Patents; 4.4. Pinney et al. Patents; 4.5. Aventis Pharma Patents (2001); 4.6. Davis et al. Patents; 4.7. Aventis Pharma Patents (2003); 4.8. Chang et al. Patents; 4.9. Hadfield et al. Patents; 4.10. Rigel Pharmaceuticals Patents; 4.11. NIH Patents 4.12. Cytopia Pty Ltd Patents4.13. Galemmo et al. Patents; 4.14. Pettit et al. Patents; 4.15. Patent by Aneja et al.; 4.16. Wyeth Holding Corporation Patents; 4.17. Champions Biotechnologypatents; 4.18. Bionomics Ltd. Patents; 4.19. Janssen Pharmaceutica Patents; 4.20. Exonhit Patents; 4.21. Centre National De La Recherche Scientifique Patents; 4.22. Development Centre of Biotechnology Patents; 4.23. Y M Biosciences Pty Ltd. Patents ; 4.24. Patents by Gangjee et al.; 4.25. Thorson et al. Patents; 4.26. Bionomics Ltd. Patents ; 4.27. Chen et al. (2014); 4.28. Wang et al. (2014) 4.29. Burns et al. (2014) |
| Record Nr. | UNINA-9910797787003321 |
| Sharjah : , : Bentham Science Publishers, Limited, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
"Topics in anti-cancer research." . Volume 4 / / editors, Atta-ur-Rahman, FRS, Kings College, University of Cambridge, Cambridge, UK & Khurshid Zaman, Bentham Science Publishers, USA
| "Topics in anti-cancer research." . Volume 4 / / editors, Atta-ur-Rahman, FRS, Kings College, University of Cambridge, Cambridge, UK & Khurshid Zaman, Bentham Science Publishers, USA |
| Pubbl/distr/stampa | Sharjah : , : Bentham Science Publishers, Limited, , [2015] |
| Descrizione fisica | 1 online resource (817 p.) |
| Collana | Topics in Anti-Cancer Research |
| Soggetto topico |
Cancer - Research
Cancer - Prevention |
| ISBN | 1-68108-076-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONTENTS; FOREWORD ; List of Contributors ; Targeted Cancer Therapy: The Roles Played by Antibody-Drug and Antibody-Toxin Conjugates ; 1. INTRODUCTION; 2. IMMUNOTOXINS; 2.1. Pseudomonas Exotoxin-Based Immunotoxins; 2.2. Pseudomonas Exotoxin-Based ITs in Treating Solid Tumors; 2.3. Diphtheria Toxin-Based Immunotoxins; 2.4. Ribosome Inactivating Proteins-Based Immunotoxins; 2.4.1. Ricin; 2.4.2. Recombinant constructs of RIP I toxins; 2.5. Ribonucleases-Based IT; 2.6. Proapoptotic Proteins Used As Targeted Immunotoxins/Chimeric Proteins; 2.7. Current & Future Developments of ITs
3. ANTIBODY-DRUG CONJUGATES 3.1. DNA Interacting Agents-Calicheamicins; 3.2. DNA Interacting Agents-Duocarmycins; 3.3. DNA Interacting Agents-Pyrrolo[1,4]Benzodiazepines; 3.4. Tubulin Interacting Agents-Auristatins; 3.5. Tubulin Interacting Agents-Maytansinoids; 3.6. Other Anticancer Drugs Conjugated to mAbs; 4. CURRENT AND FUTURE DEVELOPMENTS OF ADC ; DISCLOSURE; CONFLICTS OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Targeting Cell Surface Nucleolin in Cancer ; INTRODUCTION; CELL SURFACE LOCALIZATION OF NCL; LIGANDS OF CELL SURFACE NCL CELL SURFACE NCL-DEPENDENT LIGAND SPECIFIC INTERNALIZATIONCELL SURFACE NCL AND SIGNALING COMPLEXES; TARGETING CELL SURFACE NCL; CELL SURFACE NCL AS BIOMARKER FOR CANCER; PATENTS RELATED TO NCL; CURRENT & FUTURE DEVELOPMENTS; DISCLOSURE; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Anticancer Agents Targeting Tubulin ; 1. INTRODUCTION; 2. MICROTUBULE DESTABLIZERS; 2.1. Colchicine; 2.2. Combretastatin A-4 (CA-A4); 2.3. Chalcones; 2.4. Phenstatins; 2.5. Podophyllotoxin; 2.6. Vinca Alkaloids; 2.7. Other Tubulin Polymerization Inhibitors; 3. MICROTUBULE STABLIZERS; 3.1. Taxol® 3.2. Other Tubulin Depolymerization InhibitorsDrugs Bind to Microtubule-Associated Proteins (MAPs); Peripheral Neuropathy Induced by Anti Mitotic Agents [177]; Role of β-Tubulin Isotypes in Drug Binding [178]; 4. RECENT PATENTS; 4.1. Research Corporation Technologies Patents; 4.2. Brandeis University Patents; 4.3. Tuse et al. Patents; 4.4. Pinney et al. Patents; 4.5. Aventis Pharma Patents (2001); 4.6. Davis et al. Patents; 4.7. Aventis Pharma Patents (2003); 4.8. Chang et al. Patents; 4.9. Hadfield et al. Patents; 4.10. Rigel Pharmaceuticals Patents; 4.11. NIH Patents 4.12. Cytopia Pty Ltd Patents4.13. Galemmo et al. Patents; 4.14. Pettit et al. Patents; 4.15. Patent by Aneja et al.; 4.16. Wyeth Holding Corporation Patents; 4.17. Champions Biotechnologypatents; 4.18. Bionomics Ltd. Patents; 4.19. Janssen Pharmaceutica Patents; 4.20. Exonhit Patents; 4.21. Centre National De La Recherche Scientifique Patents; 4.22. Development Centre of Biotechnology Patents; 4.23. Y M Biosciences Pty Ltd. Patents ; 4.24. Patents by Gangjee et al.; 4.25. Thorson et al. Patents; 4.26. Bionomics Ltd. Patents ; 4.27. Chen et al. (2014); 4.28. Wang et al. (2014) 4.29. Burns et al. (2014) |
| Record Nr. | UNINA-9910807290903321 |
| Sharjah : , : Bentham Science Publishers, Limited, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
AACR meeting abstracts online
| AACR meeting abstracts online |
| Pubbl/distr/stampa | [Philadelphia, PA], : American Association for Cancer Research |
| Disciplina | 616.9 |
| Soggetto topico |
Cancer - Research
Neoplasms |
| Soggetto genere / forma |
Conference papers and proceedings.
Abstracts. |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Meeting abstracts online |
| Record Nr. | UNINA-9910895652503321 |
| [Philadelphia, PA], : American Association for Cancer Research | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
An Act to Direct the Comptroller General of the United States to Complete a Study on Barriers to Participation in Federally Funded Cancer Clinical Trials by Populations That Have Been Traditionally Underrepresented in Such Trials
| An Act to Direct the Comptroller General of the United States to Complete a Study on Barriers to Participation in Federally Funded Cancer Clinical Trials by Populations That Have Been Traditionally Underrepresented in Such Trials |
| Pubbl/distr/stampa | [Washington, D.C.] : , : [U.S. Government Publishing Office], , [2021] |
| Descrizione fisica | 1 online resource (2 unnumbered pages) |
| Soggetto topico |
Cancer - Research - United States
HeLa cells Minorities - Health and hygiene - United States Cancer - Research Minorities - Health and hygiene |
| Soggetto genere / forma | Statutes and codes. |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910715457103321 |
| [Washington, D.C.] : , : [U.S. Government Publishing Office], , [2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advancements in cancer research [[electronic resource] /] / Kajsa Viktorsson, editor
| Advancements in cancer research [[electronic resource] /] / Kajsa Viktorsson, editor |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, c2012 |
| Descrizione fisica | 1 online resource (291 p.) |
| Disciplina | 616.99/40072 |
| Altri autori (Persone) | ViktorssonKajsa |
| Collana | Cancer etiology, diagnosis and treatments |
| Soggetto topico | Cancer - Research |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-61470-260-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | An outlook on uterine neoplasms : from hormonal and DNA damaging to cervical and endometrial cancer development and minimally invasive management / Andrea Tinelli ... [et al.] -- Breast cancer knowledge, risk factors, and screening among adult Saudi women at primary care setting / Tarek Tawfik Amin, Amira Gamal Al Din Abdul Rahman, and Abdullalh Al Meqihwi -- Dendritic cell immunotherapy for the treatment of malignant melanoma / Filamer D. Kabigting and Doru T. Alexandrescu -- Matrix metalloproteinases : MMP-1, MMP-2, MMP-9 and their endogenous inhibitors : TIMP-1 and TIMP-2 in -- Squoamous cell cervical carcinomas / N.I. Solovyeva ... [et al.] -- Over expression of peripheral benzodiazepine receptors in breast cancer development / Sutapa Mukhopadhyay and Salil K. Das -- Role of effectors on hypoxia due to nitric oxide production in human alveolar epithelial cells and oxygen -- Depletion in human hepatocytes / Soonjo Kwon and Rakesh Sharma -- Pathogenesis of Kaposi sarcoma associated with human herpesvirus-8 infection / Masachika Senba and Naoki Mori -- Complementary and alternative medicine approaches in the treatment of cancer / Sanjiv K. Duggal, Amritpal S. Saroya, and Jaswinder S. Chauhan -- Intrinsic and extrinsic mechanisms of drug resistance / Malathy P.V. Shekhar -- Bee venom and melittin are cytotoxic against different types of tumor and non-tumor cell lines in vitro / Goran Gajski ... [et al.] -- Adjuvant chemotherapy for resected colorectal cancer / N.S. Brown, S.A. Mullamitha, and J.W. Valle -- High-dose-rate interstitial brachytherapy in the management of primary and recurrent gynaecologic malignancies : clinical experience and review of the literature / Isabelle Thibault and Eric Vigneault -- An introductory in metabolism of xenobiotics / Tarek H. EL-Metwally. |
| Record Nr. | UNINA-9910453032503321 |
| Hauppauge, N.Y., : Nova Science Publishers, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advancements in cancer research [[electronic resource] /] / Kajsa Viktorsson, editor
| Advancements in cancer research [[electronic resource] /] / Kajsa Viktorsson, editor |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, c2012 |
| Descrizione fisica | 1 online resource (291 p.) |
| Disciplina | 616.99/40072 |
| Altri autori (Persone) | ViktorssonKajsa |
| Collana | Cancer etiology, diagnosis and treatments |
| Soggetto topico | Cancer - Research |
| ISBN | 1-61470-260-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | An outlook on uterine neoplasms : from hormonal and DNA damaging to cervical and endometrial cancer development and minimally invasive management / Andrea Tinelli ... [et al.] -- Breast cancer knowledge, risk factors, and screening among adult Saudi women at primary care setting / Tarek Tawfik Amin, Amira Gamal Al Din Abdul Rahman, and Abdullalh Al Meqihwi -- Dendritic cell immunotherapy for the treatment of malignant melanoma / Filamer D. Kabigting and Doru T. Alexandrescu -- Matrix metalloproteinases : MMP-1, MMP-2, MMP-9 and their endogenous inhibitors : TIMP-1 and TIMP-2 in -- Squoamous cell cervical carcinomas / N.I. Solovyeva ... [et al.] -- Over expression of peripheral benzodiazepine receptors in breast cancer development / Sutapa Mukhopadhyay and Salil K. Das -- Role of effectors on hypoxia due to nitric oxide production in human alveolar epithelial cells and oxygen -- Depletion in human hepatocytes / Soonjo Kwon and Rakesh Sharma -- Pathogenesis of Kaposi sarcoma associated with human herpesvirus-8 infection / Masachika Senba and Naoki Mori -- Complementary and alternative medicine approaches in the treatment of cancer / Sanjiv K. Duggal, Amritpal S. Saroya, and Jaswinder S. Chauhan -- Intrinsic and extrinsic mechanisms of drug resistance / Malathy P.V. Shekhar -- Bee venom and melittin are cytotoxic against different types of tumor and non-tumor cell lines in vitro / Goran Gajski ... [et al.] -- Adjuvant chemotherapy for resected colorectal cancer / N.S. Brown, S.A. Mullamitha, and J.W. Valle -- High-dose-rate interstitial brachytherapy in the management of primary and recurrent gynaecologic malignancies : clinical experience and review of the literature / Isabelle Thibault and Eric Vigneault -- An introductory in metabolism of xenobiotics / Tarek H. EL-Metwally. |
| Record Nr. | UNINA-9910779636003321 |
| Hauppauge, N.Y., : Nova Science Publishers, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advancements in cancer research [[electronic resource] /] / Kajsa Viktorsson, editor
| Advancements in cancer research [[electronic resource] /] / Kajsa Viktorsson, editor |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, c2012 |
| Descrizione fisica | 1 online resource (291 p.) |
| Disciplina | 616.99/40072 |
| Altri autori (Persone) | ViktorssonKajsa |
| Collana | Cancer etiology, diagnosis and treatments |
| Soggetto topico | Cancer - Research |
| ISBN | 1-61470-260-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | An outlook on uterine neoplasms : from hormonal and DNA damaging to cervical and endometrial cancer development and minimally invasive management / Andrea Tinelli ... [et al.] -- Breast cancer knowledge, risk factors, and screening among adult Saudi women at primary care setting / Tarek Tawfik Amin, Amira Gamal Al Din Abdul Rahman, and Abdullalh Al Meqihwi -- Dendritic cell immunotherapy for the treatment of malignant melanoma / Filamer D. Kabigting and Doru T. Alexandrescu -- Matrix metalloproteinases : MMP-1, MMP-2, MMP-9 and their endogenous inhibitors : TIMP-1 and TIMP-2 in -- Squoamous cell cervical carcinomas / N.I. Solovyeva ... [et al.] -- Over expression of peripheral benzodiazepine receptors in breast cancer development / Sutapa Mukhopadhyay and Salil K. Das -- Role of effectors on hypoxia due to nitric oxide production in human alveolar epithelial cells and oxygen -- Depletion in human hepatocytes / Soonjo Kwon and Rakesh Sharma -- Pathogenesis of Kaposi sarcoma associated with human herpesvirus-8 infection / Masachika Senba and Naoki Mori -- Complementary and alternative medicine approaches in the treatment of cancer / Sanjiv K. Duggal, Amritpal S. Saroya, and Jaswinder S. Chauhan -- Intrinsic and extrinsic mechanisms of drug resistance / Malathy P.V. Shekhar -- Bee venom and melittin are cytotoxic against different types of tumor and non-tumor cell lines in vitro / Goran Gajski ... [et al.] -- Adjuvant chemotherapy for resected colorectal cancer / N.S. Brown, S.A. Mullamitha, and J.W. Valle -- High-dose-rate interstitial brachytherapy in the management of primary and recurrent gynaecologic malignancies : clinical experience and review of the literature / Isabelle Thibault and Eric Vigneault -- An introductory in metabolism of xenobiotics / Tarek H. EL-Metwally. |
| Record Nr. | UNINA-9910816362703321 |
| Hauppauge, N.Y., : Nova Science Publishers, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in cancer research . Volume 125 ABC transporters and cancer / / edited by John D. Schuetz, Toshihisa Ishikawa ; contributors Suresh V. Ambudkar [and thirty one others]
| Advances in cancer research . Volume 125 ABC transporters and cancer / / edited by John D. Schuetz, Toshihisa Ishikawa ; contributors Suresh V. Ambudkar [and thirty one others] |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (280 p.) |
| Disciplina | 616.9940072 |
| Soggetto topico |
Cancer - Research
Drug resistance in cancer cells Cancer - Chemotherapy |
| Soggetto genere / forma | Electronic books. |
| ISBN | 0-12-801361-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; ABC Transporters and Cancer; Copyright; Dedication; Contents; Contributors; Preface; Chapter 1: Apical ABC Transporters and Cancer Chemotherapeutic Drug Disposition; 1. Introduction to Apical ABC Transporters; 2. Impact of Apical ABC Transporters on Intestinal Absorption of Oral Chemotherapeutic Drugs; 2.1. Apical ABC transporters affecting the oral bioavailability of taxanes; 2.1.1. ABCB1 and oral taxane availability; 2.1.2. ABCC2 and oral taxane availability; 2.1.3. ABCB1 inhibitors to improve taxane oral availability
2.1.4. Assessing CNS toxicity risks of using ABCB1 inhibitors to improve oral taxane availability2.1.5. Possible effects of ABCB1 inhibitors on enhancing taxane antitumor efficacy; 2.2. Apical ABC transporters in the oral bioavailability of rationally designed anticancer drugs; 2.2.1. Tyrosine kinase inhibitors; 2.2.2. PARP inhibitors; 2.2.3. Chemical inhibition of transporters to increase oral availability of rationally designed anticancer drugs; 2.2.4. Importance of the sensitivity and specificity of in vitro assays used to assess ABC transporter substrates 3. Impact of Apical ABC Transporters on Brain Disposition of Oral Chemotherapeutic Drugs3.1. Does the BBB matter in drug delivery to brain tumors?; 3.2. Apical efflux transporters in the BBB affecting brain accumulation of anticancer drugs; 3.2.1. Drugs affected mostly by Abcb1a but also by Abcg2 in their brain accumulation; 3.2.2. Drugs only affected by Abcb1a in their brain accumulation; 3.2.3. Drugs affected mostly by Abcg2 but also by Abcb1a in their brain accumulation; 3.2.4. Three different apical BBB ABC efflux transporters affect brain accumulation of some camptothecins 3.2.5. Models to explain the disproportionate effect of combined deficiency of Abcb1 and Abcg2 on brain accumulation of s...3.2.6. Why are many rationally designed anticancer drugs still ABCB1 and/or ABCG2 substrates?; 3.2.7. Limitations of knockout mouse models to study ABC transporter functions at the BBB; 3.2.8. Tissue and cellular context may affect the in vivo impact of apical ABC efflux transporters; 3.2.9. Use of chemical inhibitors to enhance brain accumulation of ABC transporter substrate drugs; 4. Concluding Remarks; References Chapter 2: Regulation of ABC Transporters Blood-Brain Barrier: The Good, the Bad, and the Ugly1. Introduction; 2. Blood-Brain Barriers; 2.1. Assessing blood-brain barrier function; 3. ABC Transporters at the Blood-Brain Barrier; 4. The Bad and the Ugly: Mechanisms that Increase Transporter Expression and Reduce Drug Delivery to the CNS; 4.1. Xenobiotic-activated transcription factors; 4.2. Stress-activated transcription factors; 4.3. Disease; 5. The Good: Mechanisms that Reduce Transporter Activity/Expression and Have the Potential to Improve Drug Delivery to th...; 5.1. P-glycoprotein 5.2. BCRP |
| Record Nr. | UNINA-9910460672103321 |
| London, England : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in cancer research . Volume 125 ABC transporters and cancer / / edited by John D. Schuetz, Toshihisa Ishikawa ; contributors Suresh V. Ambudkar [and thirty one others]
| Advances in cancer research . Volume 125 ABC transporters and cancer / / edited by John D. Schuetz, Toshihisa Ishikawa ; contributors Suresh V. Ambudkar [and thirty one others] |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (280 p.) |
| Disciplina | 616.9940072 |
| Soggetto topico |
Cancer - Research
Drug resistance in cancer cells Cancer - Chemotherapy |
| ISBN | 0-12-801361-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; ABC Transporters and Cancer; Copyright; Dedication; Contents; Contributors; Preface; Chapter 1: Apical ABC Transporters and Cancer Chemotherapeutic Drug Disposition; 1. Introduction to Apical ABC Transporters; 2. Impact of Apical ABC Transporters on Intestinal Absorption of Oral Chemotherapeutic Drugs; 2.1. Apical ABC transporters affecting the oral bioavailability of taxanes; 2.1.1. ABCB1 and oral taxane availability; 2.1.2. ABCC2 and oral taxane availability; 2.1.3. ABCB1 inhibitors to improve taxane oral availability
2.1.4. Assessing CNS toxicity risks of using ABCB1 inhibitors to improve oral taxane availability2.1.5. Possible effects of ABCB1 inhibitors on enhancing taxane antitumor efficacy; 2.2. Apical ABC transporters in the oral bioavailability of rationally designed anticancer drugs; 2.2.1. Tyrosine kinase inhibitors; 2.2.2. PARP inhibitors; 2.2.3. Chemical inhibition of transporters to increase oral availability of rationally designed anticancer drugs; 2.2.4. Importance of the sensitivity and specificity of in vitro assays used to assess ABC transporter substrates 3. Impact of Apical ABC Transporters on Brain Disposition of Oral Chemotherapeutic Drugs3.1. Does the BBB matter in drug delivery to brain tumors?; 3.2. Apical efflux transporters in the BBB affecting brain accumulation of anticancer drugs; 3.2.1. Drugs affected mostly by Abcb1a but also by Abcg2 in their brain accumulation; 3.2.2. Drugs only affected by Abcb1a in their brain accumulation; 3.2.3. Drugs affected mostly by Abcg2 but also by Abcb1a in their brain accumulation; 3.2.4. Three different apical BBB ABC efflux transporters affect brain accumulation of some camptothecins 3.2.5. Models to explain the disproportionate effect of combined deficiency of Abcb1 and Abcg2 on brain accumulation of s...3.2.6. Why are many rationally designed anticancer drugs still ABCB1 and/or ABCG2 substrates?; 3.2.7. Limitations of knockout mouse models to study ABC transporter functions at the BBB; 3.2.8. Tissue and cellular context may affect the in vivo impact of apical ABC efflux transporters; 3.2.9. Use of chemical inhibitors to enhance brain accumulation of ABC transporter substrate drugs; 4. Concluding Remarks; References Chapter 2: Regulation of ABC Transporters Blood-Brain Barrier: The Good, the Bad, and the Ugly1. Introduction; 2. Blood-Brain Barriers; 2.1. Assessing blood-brain barrier function; 3. ABC Transporters at the Blood-Brain Barrier; 4. The Bad and the Ugly: Mechanisms that Increase Transporter Expression and Reduce Drug Delivery to the CNS; 4.1. Xenobiotic-activated transcription factors; 4.2. Stress-activated transcription factors; 4.3. Disease; 5. The Good: Mechanisms that Reduce Transporter Activity/Expression and Have the Potential to Improve Drug Delivery to th...; 5.1. P-glycoprotein 5.2. BCRP |
| Record Nr. | UNINA-9910787425603321 |
| London, England : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in cancer research . Volume 125 ABC transporters and cancer / / edited by John D. Schuetz, Toshihisa Ishikawa ; contributors Suresh V. Ambudkar [and thirty one others]
| Advances in cancer research . Volume 125 ABC transporters and cancer / / edited by John D. Schuetz, Toshihisa Ishikawa ; contributors Suresh V. Ambudkar [and thirty one others] |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | London, England : , : Academic Press, , 2015 |
| Descrizione fisica | 1 online resource (280 p.) |
| Disciplina | 616.9940072 |
| Soggetto topico |
Cancer - Research
Drug resistance in cancer cells Cancer - Chemotherapy |
| ISBN | 0-12-801361-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; ABC Transporters and Cancer; Copyright; Dedication; Contents; Contributors; Preface; Chapter 1: Apical ABC Transporters and Cancer Chemotherapeutic Drug Disposition; 1. Introduction to Apical ABC Transporters; 2. Impact of Apical ABC Transporters on Intestinal Absorption of Oral Chemotherapeutic Drugs; 2.1. Apical ABC transporters affecting the oral bioavailability of taxanes; 2.1.1. ABCB1 and oral taxane availability; 2.1.2. ABCC2 and oral taxane availability; 2.1.3. ABCB1 inhibitors to improve taxane oral availability
2.1.4. Assessing CNS toxicity risks of using ABCB1 inhibitors to improve oral taxane availability2.1.5. Possible effects of ABCB1 inhibitors on enhancing taxane antitumor efficacy; 2.2. Apical ABC transporters in the oral bioavailability of rationally designed anticancer drugs; 2.2.1. Tyrosine kinase inhibitors; 2.2.2. PARP inhibitors; 2.2.3. Chemical inhibition of transporters to increase oral availability of rationally designed anticancer drugs; 2.2.4. Importance of the sensitivity and specificity of in vitro assays used to assess ABC transporter substrates 3. Impact of Apical ABC Transporters on Brain Disposition of Oral Chemotherapeutic Drugs3.1. Does the BBB matter in drug delivery to brain tumors?; 3.2. Apical efflux transporters in the BBB affecting brain accumulation of anticancer drugs; 3.2.1. Drugs affected mostly by Abcb1a but also by Abcg2 in their brain accumulation; 3.2.2. Drugs only affected by Abcb1a in their brain accumulation; 3.2.3. Drugs affected mostly by Abcg2 but also by Abcb1a in their brain accumulation; 3.2.4. Three different apical BBB ABC efflux transporters affect brain accumulation of some camptothecins 3.2.5. Models to explain the disproportionate effect of combined deficiency of Abcb1 and Abcg2 on brain accumulation of s...3.2.6. Why are many rationally designed anticancer drugs still ABCB1 and/or ABCG2 substrates?; 3.2.7. Limitations of knockout mouse models to study ABC transporter functions at the BBB; 3.2.8. Tissue and cellular context may affect the in vivo impact of apical ABC efflux transporters; 3.2.9. Use of chemical inhibitors to enhance brain accumulation of ABC transporter substrate drugs; 4. Concluding Remarks; References Chapter 2: Regulation of ABC Transporters Blood-Brain Barrier: The Good, the Bad, and the Ugly1. Introduction; 2. Blood-Brain Barriers; 2.1. Assessing blood-brain barrier function; 3. ABC Transporters at the Blood-Brain Barrier; 4. The Bad and the Ugly: Mechanisms that Increase Transporter Expression and Reduce Drug Delivery to the CNS; 4.1. Xenobiotic-activated transcription factors; 4.2. Stress-activated transcription factors; 4.3. Disease; 5. The Good: Mechanisms that Reduce Transporter Activity/Expression and Have the Potential to Improve Drug Delivery to th...; 5.1. P-glycoprotein 5.2. BCRP |
| Record Nr. | UNINA-9910811415603321 |
| London, England : , : Academic Press, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Soggetto topico
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Cancer - Research
(166)
- Neoplasms (45)
- Oncology (28)
- Cancer - Treatment (27)
- Neoplasms - therapy (20)