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Nuclear oncology : from pathophysiology to clinical applications / / Duccio Volterrani [and four others], editors
| Nuclear oncology : from pathophysiology to clinical applications / / Duccio Volterrani [and four others], editors |
| Edizione | [Third edition.] |
| Pubbl/distr/stampa | Cham, Switzerland : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (2241 pages) |
| Disciplina | 616.99407575 |
| Soggetto topico |
Cancer - Radionuclide imaging
Cancer - Radiotherapy Nuclear medicine |
| ISBN | 3-031-05494-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Preface to the Third Edition -- Preface to the Second Edition -- Preface to the First Edition -- Acknowledgments -- Contents -- About the Editors -- Contributors -- Part I: Basic Science -- 1 Cancer Biology of Molecular Imaging -- Introduction -- The Evolving Context of Molecular Imaging: Cancer Genomics and Epigenomics -- Hallmarks of Cancer -- The Tumor Mass -- Imaging the Tumor Mass -- Neovasculature -- Hypoxia -- Cellular Constituents and Cell-Cell Synergism of the Tumor Mass -- Immune Cell Cancer Immunotherapy -- Immune Checkpoint Blockade -- Imaging the Immune T Cells -- The Metastatic Process -- Imaging the Cancer Cell -- Total Lesion Glycolysis (TLG) as a Predictive Marker of Prognosis and Tumor Responsiveness -- Proliferation Imaging -- 18F-FLT Imaging of Proliferation After Chemotherapy -- The Cancer Biology of Cellular Lineage Plasticity and the Nuclear Imaging Phenotype -- Lineage Plasticity and Relevance to Molecular Imaging in Prostate Cancer -- Molecular Imaging of Fibroblast-Activating Protein, a Molecule Expressed in Tumor Stroma -- Oncogene and Non-oncogene Addiction -- Examples of Imaging the Action Driver Mutations in Cancer Cells Indirectly Through the Effects on Metabolism -- BRAF Inhibition in Advanced Melanoma with V600E Mutation -- Inhibition of MEK, a Downstream Signal Transduction Molecule in the RAS/BRAF/ERK Pathway, Can Reverse 131I Resistance in Patie... -- Future Applications -- References -- 2 Principles of Molecular Targeting for Radionuclide Therapy -- Introduction -- The Choice of Radionuclide -- Nuclear Properties -- Radioisotope Production -- Theranostics -- Instrument Resolution and Biological Resolution -- Radiobiological Properties Affecting the Choice of Radionuclide -- Radiation Microdosimetry and Particle Range -- The Choice of a Chemical Platform -- Salts and Covalent Bonds -- Chelating Agents.
Coordination of Tc(V) and Re(V) -- Nanoparticles -- Location of the Target: The Challenges of Designing Radiotracers for Intracellular Compartments -- Critical Subcellular Sites of Interaction with Ionizing Radiation (Direct Effects) -- Radiation-Induced Biological Bystander Effects (RIBBEs) -- Critical Subcellular Sites of Interaction with Ionizing Radiation (Indirect Effects) -- Cell Membrane -- Mitochondria -- Transfectant Mosaic Spheroid Model -- Transfectant Mosaic Xenograft Model -- Media Transfer -- LET and Dose Rate -- Conclusion -- References -- 3 Single-Photon Emitting Radiopharmaceuticals for Diagnostic Applications -- Introduction -- 99mTc-Labeled Radiopharmaceuticals -- 99mTc-Sodium Pertechnetate -- 99mTc-Diphosphonates -- 99mTc-Radiocolloids -- 99mTc-Magroaggregated Albumin -- 99mTc-Sestamibi -- 99mTc-Tetrofosmin -- 99mTc-EDDA/HYNIC-Octreotide or Octreotate -- Lung Ventilation Radiopharmaceuticals -- 99mTc-DTPA -- 99mTc-Technegas -- Xenon-133 -- Xenon-127 -- Radioiodinated Agents -- Sodium Iodide -- Radioiodinated Metaiodobenzylguanidine -- 201Tl-Chloride -- 111In-Pentetreotide -- 111In-Capromab Pendetide -- 67Ga-Citrate -- Suggested Readings -- 4 Positron-Emitting Radiopharmaceuticals for Diagnostic Applications in Oncology -- Introduction -- Positron-Emitting Radionuclides -- Carbon-11 (11C) -- Nitrogen-13 (13N) -- Oxygen-15 (15O) -- Fluorine-18 (18F) -- Copper-64 (64Cu) -- Gallium-68 (68Ga) -- Rubidium-82 (82Rb) -- PET Radiopharmaceuticals -- Deoxy-[18F]fluoro-d-glucose -- Nitrogen-13 Ammonia -- Oxygen-15 Water -- Rubidium-82 Chloride -- [11C]Methionine and Other Tracers for Protein Synthesis -- Choline-Based Tracers for Phospholipid Synthesis -- Fluorine-18 Fluciclovine -- Gallium-68 PSMA Ligands -- Fluorine-18 Sodium Fluoride -- Fluorine-18 Misonidazole and Other Hypoxia Tracers. Fluorine-18 Fluorothymidine and Other Substrates for DNA Synthesis -- Fluorine-18 DOPA and Other Amine Precursors -- Gallium-68 DOTATOC, Copper-64 DOTATATE, and Other Somatostatin Analogs -- Suggested Readings -- 5 Radiopharmaceuticals for Therapy -- Background -- Alpha-Particle Emitters -- Radium-223 (223Ra) -- Auger Electron Emitters -- Emitters of β- Particles -- Iodine-131 (131I) -- Yttrium-90 (90Y) -- Lutetium-177 (177Lu) -- Samarium-153 (153Sm) -- Strontium-89 (89Sr) -- Rhenium-186 (186Re) and Rhenium-188 (188Re) -- Phosphorus-32 (32P) -- Holmium-166 (166Ho) -- Treatment of Thyroid Disease with 131I-Iodide -- Treatment of Neuroendocrine Neoplasms Originating from the Neural Crest with [131I]MIBG -- Peptide Receptor Radionuclide Therapy -- Bone-Seeking Radiopharmaceuticals and Prostate Cancer -- Radioimmunotherapy for Hematologic Malignancies -- Radionuclide Therapy of Primary and Metastatic Liver Tumors -- Suggested Readings -- 6 Novel Single-Photon-Emitting Radiopharmaceuticals for Diagnostic Applications -- Introduction and Background -- Peptide Receptor Targeting -- 99mTc-EDDA/HYNIC-TOC -- 99mTc-PSMA-Ligands -- 99mTc-CAIX -- Apoptosis -- 99mTc-Annexin V -- 99mTc-Duramycin -- Angiogenesis -- 99mTc-HYNIC-VEGF -- Integrins -- 99mTc-αP2 -- 99mTc-NC100692 (or 99mTc-Maraciclatide) -- 99mTc-3PRGD2 -- 99mTc-RGD-BBN -- Hybrid Radioactive/Fluorescent RGD -- Agents Targeting the Extracellular Matrix -- 99mTc-AP39 -- Matrix Metalloproteinases -- Epidermal Growth Factor Receptor (EGFR) -- 99mTc-ADAPT6 -- Folate Receptor Overexpression -- 99mTc-HYNIC-folate -- References -- 7 Novel Positron-Emitting Radiopharmaceuticals -- Introduction -- Targeting Cellular Transport and Metabolism -- Overview -- Imaging Amino Acid Transport and Metabolism -- [11C]Methionine -- O-(2-[18F]Fluoroethyl)-L-Tyrosine ([18F]FET). 3,4-Dihydroxy-6-[18F]Fluorophenylalanine ([18F]FDOPA) -- 18F-Labeled Glutamine -- Imaging Lipid Biosynthesis -- Targeting Cell Surface Receptors -- Overview -- Imaging the Expression of Integrins -- Imaging the Expression of Gastrin-Releasing Peptide Receptors -- ImmunoPET Imaging -- ImmunoPET of HER2 -- ImmunoPET of EGFR -- ImmunoPET of PD-1/PD-L1 -- Targeting the Tumor Microenvironment -- Overview -- Imaging Tumor Hypoxia -- Imaging Tumor Acidosis -- Radiotheranostics -- Overview -- Targeting Somatostatin Receptors -- Targeting Prostate-Specific Membrane Antigen -- Radioimmunotherapy -- Concluding Remarks -- References -- 8 Novel Radiopharmaceuticals for Therapy -- Introduction -- Alpha-Emitting Agents -- Radium-223 (223Ra) -- Astatine-211 (211At) -- Actinium-225 (225Ac) -- Thorium-227 (227Th) -- Bismuth-213 (213Bi) -- Lead-212 (212Pb) -- Agents Emitting β- Particles -- Iodine-131 (131I) -- Lutetium-177 (177Lu) -- Holmium-166 (166Ho) -- Ytterbium-175 (175Yb) -- Samarium-153 (153Sm) -- Thulium-170 (170Tm) -- Copper-67 (67Cu) -- Yttrium-90 (90Y) -- Gold-198 (198Au) -- Promethium-149 (149Pm) -- Rhodium-105 (105Rh) -- Other Radionuclides -- Concluding Remarks -- References -- 9 Physics of Nuclear Oncology -- Structure of the Atom -- Energy and Mass -- Energy and Frequency -- Energy and Mass -- Radioactivity and Radiation -- Electromagnetic Radiation -- X-Rays -- Gamma Radiation (γ) -- Annihilation Radiation (γ±) -- Particulate Radiations -- Alpha Radiation (α) -- Beta Radiation (β-) -- β- Dosimetry -- Positron Decay (β+) and Electron Capture (EC) -- Auger Electrons -- Isomeric Transition (IT) and Internal Conversion (IC) -- Radioactive Decay -- Interaction of Radiation with Matter -- Interaction of Particulate Radiation with Matter -- Interaction of Photons with Matter -- Photoelectric Effect -- Compton Scattering -- Pair Production. Attenuation and Scattering of Photons -- Photon Attenuation -- Radionuclides Used in Nuclear Oncology -- References -- 10 Instrumentation for Positron Emission Tomography -- Introduction -- Basic Physics and Technology of PET -- Scintillation Crystals -- Silicon Photomultiplier (SiPM)-Based Scintillation Detectors -- Time-of-Flight (TOF) PET -- Total-Body PET -- PET/MRI -- Concluding Remarks -- References -- 11 Instrumentation for Single-Photon Emission Computed Tomography (SPECT) -- Introduction -- Radiation Detectors for SPECT -- Radionuclides for SPECT -- Gamma Camera Design -- SPECT Data-Acquisition -- Data ``Corrections´´ and Activity Quantitation -- Image Reconstruction -- Commercial Devices -- Concluding Remarks -- References -- 12 Instrumentation for Intraoperative Detection and Imaging -- Introduction -- Nuclear Counting and Imaging -- Optical and Near-Infrared (NIR) Imaging -- Cerenkov Imaging -- Photoacoustic Imaging -- Diffuse Optical Tomography -- Optical Coherence Tomography -- Raman Spectroscopic Imaging -- Intraoperative US, CT, and MRI -- Concluding Remarks -- References -- 13 Radiobiology and Radiation Dosimetry in Nuclear Medicine -- Introduction -- Radiobiology -- Conventional Radiobiological Models -- Cell Death Mechanisms -- Possible Contributing Mechanisms to RNT Tumor Responses -- Low-Dose/Dose-Rate Apoptosis -- Low-Dose Hyper-radiosensitivity-Increased Radioresistance -- G2 Synchronization, Bystander, and Cross-Fire Effects -- Adaptive Responses -- Fractionated RNT and Hypoxia -- Future Directions -- Dosimetry: Overview on Methods -- Clinical Experience -- 131I-Iodide Therapy of Differentiated Thyroid Carcinoma -- Peptide Receptor Radionuclide Therapy -- Radioimmunotherapy of Lymphoma -- Dosimetry in the Radioembolization of Liver Tumors -- Therapy of Neuroectodermal Neuroendocrine Malignancies. Treatment of Metastatic Bone Pain. |
| Record Nr. | UNINA-9910616204703321 |
| Cham, Switzerland : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nuclear oncology / / [edited by] Cumali Aktolun, MD, MSc, Visiting Professor, Department of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Standford University, Palo Alto, California, Stanley J. Goldsmith, MD, Professor, Department of Radiology and Medicine, Sanford and Joan Weill College of Medicine at Cornell University, Director-Emeritus, Division of Nuclear Medicine and Molecular Imaging, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York
| Nuclear oncology / / [edited by] Cumali Aktolun, MD, MSc, Visiting Professor, Department of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Standford University, Palo Alto, California, Stanley J. Goldsmith, MD, Professor, Department of Radiology and Medicine, Sanford and Joan Weill College of Medicine at Cornell University, Director-Emeritus, Division of Nuclear Medicine and Molecular Imaging, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York |
| Pubbl/distr/stampa | Philadelphia : , : Wolters Kluwer, , [2015] |
| Descrizione fisica | 1 online resource (733 p.) |
| Disciplina | 616.99/407575 |
| Soggetto topico |
Cancer - Radionuclide imaging
Cancer - Radiotherapy |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-4963-2443-9
1-4698-8349-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
NUCLEAR ONCOLOGY; Contributors; Foreword; Preface; Acknowledgment; Contents; PART I Organ Malignancies; 1 Brain Tumors; 2 Head and Neck Carcinomas; 3 Thyroid Carcinoma; 4 Parathyroid Tumors; 5Esophageal Carcinoma; 6Gastric Carcinoma-I; 7Gastric Carcinoma-II; 8Pancreatic Carcinoma; 9Colorectal Carcinoma; 10Liver Tumors; 11Breast Carcinoma; 12Pulmonary Carcinoma; 13 Renal Carcinoma; 14Bladder Carcinoma; 15Prostate Carcinoma; 16Uterine and Cervical Carcinoma; 17Ovarian Carcinoma; 18Testicular Germ Cell Tumors; 19Tumors of the Adrenal Glands; PART II Malignancies Involving the Entire Body
20Neuroendocrine Tumors21Lymphoma and Leukemia; 22Melanoma; 23Neuroblastoma; 24Bone Tumors; PART III Special Topics In Nuclear Oncology; 25Pediatric Tumors; 26Cancer of Unknown Primary; 27Assessment of Lymph Nodes in Oncology; 28Sentinel Lymph Node Detection and Imaging in Oncology; 29PET/CT Hybrid Imaging in Radiothe rapy Planning; 30Bone Mineral Densitometry in Oncology; 31Non-FDG PET/CT Imaging in Onc ology; 32Assessment of Response to Antitumor Tr eatment; 33Radionuclide Imaging for the Assessment of Toxicity Due to Chemotherapy PART IV Investigative Methods for Studying Tumor Biology and Microenvironment34Radionuclide Imaging of Multidrug Resistance; 35Radionuclide Imaging of Tumor Hypoxia and Its Clinical Implications; 36Radionuclide Imaging of Tumor Cell Apoptosis; 37Radionuclide Imaging of Tumor Angiogenesis; 38Radionuclide Imaging of Tumor Cell Proliferation; 39Radionuclide Imaging of Human Epidermal Receptors; 40Radionuclide Imaging of Integrins; 41 Radionuclide Imaging of Annexins; PART V Technical Issues; 42 Radiochemistry in Nuclear Oncology 43 Advances in Nuclear and Optical Imaging of Tumors: Multi-Modality, Small-Animal, and Intraoperative TechnologiesINDEX |
| Record Nr. | UNINA-9910465429703321 |
| Philadelphia : , : Wolters Kluwer, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nuclear oncology / / [edited by] Cumali Aktolun, MD, MSc, Visiting Professor, Department of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Standford University, Palo Alto, California, Stanley J. Goldsmith, MD, Professor, Department of Radiology and Medicine, Sanford and Joan Weill College of Medicine at Cornell University, Director-Emeritus, Division of Nuclear Medicine and Molecular Imaging, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York
| Nuclear oncology / / [edited by] Cumali Aktolun, MD, MSc, Visiting Professor, Department of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Standford University, Palo Alto, California, Stanley J. Goldsmith, MD, Professor, Department of Radiology and Medicine, Sanford and Joan Weill College of Medicine at Cornell University, Director-Emeritus, Division of Nuclear Medicine and Molecular Imaging, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York |
| Pubbl/distr/stampa | Philadelphia : , : Wolters Kluwer Health, , [2015] |
| Descrizione fisica | 1 online resource (xxii, 711 pages) : illustrations (some color) |
| Disciplina | 616.99/407575 |
| Collana | Gale eBooks |
| Soggetto topico |
Cancer - Radionuclide imaging
Cancer - Radiotherapy |
| ISBN |
1-4963-2443-9
1-4698-8349-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
NUCLEAR ONCOLOGY; Contributors; Foreword; Preface; Acknowledgment; Contents; PART I Organ Malignancies; 1 Brain Tumors; 2 Head and Neck Carcinomas; 3 Thyroid Carcinoma; 4 Parathyroid Tumors; 5Esophageal Carcinoma; 6Gastric Carcinoma-I; 7Gastric Carcinoma-II; 8Pancreatic Carcinoma; 9Colorectal Carcinoma; 10Liver Tumors; 11Breast Carcinoma; 12Pulmonary Carcinoma; 13 Renal Carcinoma; 14Bladder Carcinoma; 15Prostate Carcinoma; 16Uterine and Cervical Carcinoma; 17Ovarian Carcinoma; 18Testicular Germ Cell Tumors; 19Tumors of the Adrenal Glands; PART II Malignancies Involving the Entire Body
20Neuroendocrine Tumors21Lymphoma and Leukemia; 22Melanoma; 23Neuroblastoma; 24Bone Tumors; PART III Special Topics In Nuclear Oncology; 25Pediatric Tumors; 26Cancer of Unknown Primary; 27Assessment of Lymph Nodes in Oncology; 28Sentinel Lymph Node Detection and Imaging in Oncology; 29PET/CT Hybrid Imaging in Radiothe rapy Planning; 30Bone Mineral Densitometry in Oncology; 31Non-FDG PET/CT Imaging in Onc ology; 32Assessment of Response to Antitumor Tr eatment; 33Radionuclide Imaging for the Assessment of Toxicity Due to Chemotherapy PART IV Investigative Methods for Studying Tumor Biology and Microenvironment34Radionuclide Imaging of Multidrug Resistance; 35Radionuclide Imaging of Tumor Hypoxia and Its Clinical Implications; 36Radionuclide Imaging of Tumor Cell Apoptosis; 37Radionuclide Imaging of Tumor Angiogenesis; 38Radionuclide Imaging of Tumor Cell Proliferation; 39Radionuclide Imaging of Human Epidermal Receptors; 40Radionuclide Imaging of Integrins; 41 Radionuclide Imaging of Annexins; PART V Technical Issues; 42 Radiochemistry in Nuclear Oncology 43 Advances in Nuclear and Optical Imaging of Tumors: Multi-Modality, Small-Animal, and Intraoperative TechnologiesINDEX |
| Record Nr. | UNINA-9910792139803321 |
| Philadelphia : , : Wolters Kluwer Health, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nuclear oncology / / [edited by] Cumali Aktolun, MD, MSc, Visiting Professor, Department of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Standford University, Palo Alto, California, Stanley J. Goldsmith, MD, Professor, Department of Radiology and Medicine, Sanford and Joan Weill College of Medicine at Cornell University, Director-Emeritus, Division of Nuclear Medicine and Molecular Imaging, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York
| Nuclear oncology / / [edited by] Cumali Aktolun, MD, MSc, Visiting Professor, Department of Radiology, Molecular Imaging Program at Stanford, School of Medicine, Standford University, Palo Alto, California, Stanley J. Goldsmith, MD, Professor, Department of Radiology and Medicine, Sanford and Joan Weill College of Medicine at Cornell University, Director-Emeritus, Division of Nuclear Medicine and Molecular Imaging, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York |
| Pubbl/distr/stampa | Philadelphia : , : Wolters Kluwer Health, , [2015] |
| Descrizione fisica | 1 online resource (xxii, 711 pages) : illustrations (some color) |
| Disciplina | 616.99/407575 |
| Collana | Gale eBooks |
| Soggetto topico |
Cancer - Radionuclide imaging
Cancer - Radiotherapy |
| ISBN |
1-4963-2443-9
1-4698-8349-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
NUCLEAR ONCOLOGY; Contributors; Foreword; Preface; Acknowledgment; Contents; PART I Organ Malignancies; 1 Brain Tumors; 2 Head and Neck Carcinomas; 3 Thyroid Carcinoma; 4 Parathyroid Tumors; 5Esophageal Carcinoma; 6Gastric Carcinoma-I; 7Gastric Carcinoma-II; 8Pancreatic Carcinoma; 9Colorectal Carcinoma; 10Liver Tumors; 11Breast Carcinoma; 12Pulmonary Carcinoma; 13 Renal Carcinoma; 14Bladder Carcinoma; 15Prostate Carcinoma; 16Uterine and Cervical Carcinoma; 17Ovarian Carcinoma; 18Testicular Germ Cell Tumors; 19Tumors of the Adrenal Glands; PART II Malignancies Involving the Entire Body
20Neuroendocrine Tumors21Lymphoma and Leukemia; 22Melanoma; 23Neuroblastoma; 24Bone Tumors; PART III Special Topics In Nuclear Oncology; 25Pediatric Tumors; 26Cancer of Unknown Primary; 27Assessment of Lymph Nodes in Oncology; 28Sentinel Lymph Node Detection and Imaging in Oncology; 29PET/CT Hybrid Imaging in Radiothe rapy Planning; 30Bone Mineral Densitometry in Oncology; 31Non-FDG PET/CT Imaging in Onc ology; 32Assessment of Response to Antitumor Tr eatment; 33Radionuclide Imaging for the Assessment of Toxicity Due to Chemotherapy PART IV Investigative Methods for Studying Tumor Biology and Microenvironment34Radionuclide Imaging of Multidrug Resistance; 35Radionuclide Imaging of Tumor Hypoxia and Its Clinical Implications; 36Radionuclide Imaging of Tumor Cell Apoptosis; 37Radionuclide Imaging of Tumor Angiogenesis; 38Radionuclide Imaging of Tumor Cell Proliferation; 39Radionuclide Imaging of Human Epidermal Receptors; 40Radionuclide Imaging of Integrins; 41 Radionuclide Imaging of Annexins; PART V Technical Issues; 42 Radiochemistry in Nuclear Oncology 43 Advances in Nuclear and Optical Imaging of Tumors: Multi-Modality, Small-Animal, and Intraoperative TechnologiesINDEX |
| Record Nr. | UNINA-9910807671303321 |
| Philadelphia : , : Wolters Kluwer Health, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
