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Biophysical basis of physiology and calcium signaling mechanism in cardiac and smooth muscle / / Tetsuya Watanabe
Biophysical basis of physiology and calcium signaling mechanism in cardiac and smooth muscle / / Tetsuya Watanabe
Autore Watanabe T (Tetsuya)
Pubbl/distr/stampa London, England : , : Academic Press, , 2018
Descrizione fisica 1 online resource (234 pages)
Disciplina 574.191
Soggetto topico Biophysics
Calcium channels
ISBN 0-12-814951-5
0-12-814950-7
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910583500703321
Watanabe T (Tetsuya)  
London, England : , : Academic Press, , 2018
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Lo trovi qui: Univ. Federico II
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Calcium and Signal Transduction / / edited by John N. Buchholz
Calcium and Signal Transduction / / edited by John N. Buchholz
Pubbl/distr/stampa London, United Kingdom : , : IntechOpen, , 2018
Descrizione fisica 1 online resource (202 pages) : illustrations some color
Disciplina 612.01524
Collana Physiology
Soggetto topico Cytology
Calcium - Physiological effect
Calcium channels
ISBN 1-83881-797-2
1-78984-250-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910317781503321
London, United Kingdom : , : IntechOpen, , 2018
Materiale a stampa
Lo trovi qui: Univ. Federico II
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The "calcium paradox" and its impact on neurological and psychiatric diseases / / by Leandro Bueno Bergantin and Afonso Caricati-Neto
The "calcium paradox" and its impact on neurological and psychiatric diseases / / by Leandro Bueno Bergantin and Afonso Caricati-Neto
Autore Bergantin Leandro Bueno
Edizione [Second edition.]
Pubbl/distr/stampa Newcastle upon Tyne, UK : , : Cambridge Scholars Publishing, , 2018
Descrizione fisica 1 online resource (136 pages)
Disciplina 616.8
Soggetto topico Nervous system - Diseases - Pathophysiology
Calcium channels
Soggetto genere / forma Electronic books.
ISBN 1-5275-1834-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910480631303321
Bergantin Leandro Bueno  
Newcastle upon Tyne, UK : , : Cambridge Scholars Publishing, , 2018
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Lo trovi qui: Univ. Federico II
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The "calcium paradox" and its impact on neurological and psychiatric diseases / / by Leandro Bueno Bergantin and Afonso Caricati-Neto
The "calcium paradox" and its impact on neurological and psychiatric diseases / / by Leandro Bueno Bergantin and Afonso Caricati-Neto
Autore Bergantin Leandro Bueno
Edizione [Second edition.]
Pubbl/distr/stampa Newcastle upon Tyne, UK : , : Cambridge Scholars Publishing, , 2018
Descrizione fisica 1 online resource (136 pages)
Disciplina 616.8
Soggetto topico Nervous system - Diseases - Pathophysiology
Calcium channels
ISBN 1-5275-1834-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910793126003321
Bergantin Leandro Bueno  
Newcastle upon Tyne, UK : , : Cambridge Scholars Publishing, , 2018
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The "calcium paradox" and its impact on neurological and psychiatric diseases / / by Leandro Bueno Bergantin and Afonso Caricati-Neto
The "calcium paradox" and its impact on neurological and psychiatric diseases / / by Leandro Bueno Bergantin and Afonso Caricati-Neto
Autore Bergantin Leandro Bueno
Edizione [Second edition.]
Pubbl/distr/stampa Newcastle upon Tyne, UK : , : Cambridge Scholars Publishing, , 2018
Descrizione fisica 1 online resource (136 pages)
Disciplina 616.8
Soggetto topico Nervous system - Diseases - Pathophysiology
Calcium channels
ISBN 1-5275-1834-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910812294403321
Bergantin Leandro Bueno  
Newcastle upon Tyne, UK : , : Cambridge Scholars Publishing, , 2018
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Calcium waves, gradients and oscillations [[electronic resource] /] / [editors, Gregory R. Bock (organizer) and Kate Ackrill]
Calcium waves, gradients and oscillations [[electronic resource] /] / [editors, Gregory R. Bock (organizer) and Kate Ackrill]
Pubbl/distr/stampa Chichester [England] ; ; New York, : J. Wiley & Sons, 1995
Descrizione fisica 1 online resource (302 p.)
Disciplina 574.87
Altri autori (Persone) BockGregory
AckrillKate
Collana Ciba Foundation symposium
Soggetto topico Calcium ions - Physiological effect
Cellular signal transduction
Calcium ions - Physiological transport
Calcium channels
Soggetto genere / forma Electronic books.
ISBN 1-282-12244-4
9786612122446
0-470-51469-8
0-470-51470-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CALCIUM WAVES, GRADIENTS AND OSClLLATlONS; Contents; Participants; Introduction; Calcium waves and development; Subcellular organization signalling in hepatocytes liver of calcium and the intact; Calcium puffs in Xenopus oocytes; Spiral calcium waves: implications for signalling; Local calcium spiking in pancreatic acinar cel Is; Pancreatic calcium waves and secretion; Calcium signalling during chemotaxis; General discussion I; Calcium signalling in cardiac muscle cells; General discussion I I; Intercellular calcium waves mediated by inositol trisphosphate
The triggering of astrocytic calcium waves by NMDA-induced neuronal activation Calcium oscillations in neurons; Calcium signalling during mammalian fertiIization; Regulation of nuclear calcium concentration; kina1 discussion; Summing UP; Index of contributors; Subject index
Record Nr. UNINA-9910144011903321
Chichester [England] ; ; New York, : J. Wiley & Sons, 1995
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Lo trovi qui: Univ. Federico II
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Calcium waves, gradients and oscillations [[electronic resource] /] / [editors, Gregory R. Bock (organizer) and Kate Ackrill]
Calcium waves, gradients and oscillations [[electronic resource] /] / [editors, Gregory R. Bock (organizer) and Kate Ackrill]
Pubbl/distr/stampa Chichester [England] ; ; New York, : J. Wiley & Sons, 1995
Descrizione fisica 1 online resource (302 p.)
Disciplina 574.87
Altri autori (Persone) BockGregory
AckrillKate
Collana Ciba Foundation symposium
Soggetto topico Calcium ions - Physiological effect
Cellular signal transduction
Calcium ions - Physiological transport
Calcium channels
ISBN 1-282-12244-4
9786612122446
0-470-51469-8
0-470-51470-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CALCIUM WAVES, GRADIENTS AND OSClLLATlONS; Contents; Participants; Introduction; Calcium waves and development; Subcellular organization signalling in hepatocytes liver of calcium and the intact; Calcium puffs in Xenopus oocytes; Spiral calcium waves: implications for signalling; Local calcium spiking in pancreatic acinar cel Is; Pancreatic calcium waves and secretion; Calcium signalling during chemotaxis; General discussion I; Calcium signalling in cardiac muscle cells; General discussion I I; Intercellular calcium waves mediated by inositol trisphosphate
The triggering of astrocytic calcium waves by NMDA-induced neuronal activation Calcium oscillations in neurons; Calcium signalling during mammalian fertiIization; Regulation of nuclear calcium concentration; kina1 discussion; Summing UP; Index of contributors; Subject index
Record Nr. UNINA-9910830377503321
Chichester [England] ; ; New York, : J. Wiley & Sons, 1995
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Calcium waves, gradients and oscillations / / [editors, Gregory R. Bock (organizer) and Kate Ackrill]
Calcium waves, gradients and oscillations / / [editors, Gregory R. Bock (organizer) and Kate Ackrill]
Pubbl/distr/stampa Chichester [England] ; ; New York, : J. Wiley & Sons, 1995
Descrizione fisica 1 online resource (302 p.)
Disciplina 574.87
Altri autori (Persone) BockGregory
AckrillKate
Collana Ciba Foundation symposium
Soggetto topico Calcium ions - Physiological effect
Cellular signal transduction
Calcium ions - Physiological transport
Calcium channels
ISBN 9786612122446
9781282122444
1282122444
9780470514696
0470514698
9780470514702
0470514701
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto CALCIUM WAVES, GRADIENTS AND OSClLLATlONS; Contents; Participants; Introduction; Calcium waves and development; Subcellular organization signalling in hepatocytes liver of calcium and the intact; Calcium puffs in Xenopus oocytes; Spiral calcium waves: implications for signalling; Local calcium spiking in pancreatic acinar cel Is; Pancreatic calcium waves and secretion; Calcium signalling during chemotaxis; General discussion I; Calcium signalling in cardiac muscle cells; General discussion I I; Intercellular calcium waves mediated by inositol trisphosphate
The triggering of astrocytic calcium waves by NMDA-induced neuronal activation Calcium oscillations in neurons; Calcium signalling during mammalian fertiIization; Regulation of nuclear calcium concentration; kina1 discussion; Summing UP; Index of contributors; Subject index
Record Nr. UNINA-9911019616503321
Chichester [England] ; ; New York, : J. Wiley & Sons, 1995
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Modulation of presynaptic calcium channels / / Gary Stephens, Sumiko Mochida, editors
Modulation of presynaptic calcium channels / / Gary Stephens, Sumiko Mochida, editors
Edizione [1st ed. 2013.]
Pubbl/distr/stampa New York, : Springer, 2013
Descrizione fisica 1 online resource (365 p.)
Disciplina 574.872
Altri autori (Persone) StephensGary
MochidaSumiko
Soggetto topico Calcium channels
Calcium in the body
ISBN 94-007-6334-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Spatial and temporal regulation of Ca2+ channels -- Neuronal functions of auxiliary calcium channel subunits.- Reciprocal regulation of neuronal calcium channels by synaptic proteins -- Molecular architecture of Ca2+ channel complexes organized by β subunits in presynaptic active zones -- Control of CaV2 calcium channels and neurosecretion by heterotrimeric G protein coupled receptors -- Regulation of CaV2 channels by small GTPases -- Protein interaction partners of Cav2.3 R-type voltage-gated calcium channels -- Voltage-gated calcium channel signaling to the nucleus -- Presynaptic Ca2+ influx and its modulation at auditory calyceal terminals -- Use of synthetic Ca2+ channel peptides to study presynaptic function -- Impact of a loss-of-function P/Q type Ca2+ channel mutation on excitatory synaptic control of cerebellar Purkinje neurons -- CaV2.1 (P/Q) voltage activated Ca2+ channels and synaptic transmission in genetic and autoimmune diseases -- Splicing and editing to customize CaV channel structures for optimal neural function -- Presynaptic calcium channels as drug targets for pain -- Sensory pathway modulation by calcium channel a2d1 subunit.
Record Nr. UNINA-9910739415603321
New York, : Springer, 2013
Materiale a stampa
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Voltage-gated calcium channels / / Gerald Werner Zamponi and Norbert Weiss, editors
Voltage-gated calcium channels / / Gerald Werner Zamponi and Norbert Weiss, editors
Pubbl/distr/stampa Cham, Switzerland : , : Springer, , 2022
Descrizione fisica 1 online resource (705 pages)
Disciplina 572.516
Soggetto topico Calcium channels
RNA editing
Neurosciences
ISBN 3-031-08881-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Preface -- Contents -- A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century -- Ca2+ as Central Ion for Muscle Contraction -- The "Ca-Spikes" of Crustacean Skeletal Muscles -- "Ca-Spikes" in Heart and Neurons -- How to Look at Ca2+ Currents Through Voltage-Clamp Recordings -- Ca2+ Currents in the Heart and Mollusc Neurons: The Problem of Blocking K+ Currents -- A Convergent View on the Existence of "a" Ca2+ Channel in Excitable Cells -- The "Patch-Clamp" Technique and the Explosive Interest on Ca2+ Channels -- The Discovery of the "Low-Voltage Activated" T-Type Channel -- The Unique Properties of T-Type (LVA) Channels -- The Explosive Interest on T-Type Channels -- The Ca2+ Channel Family Growths -- The N-Type Channel -- The P/Q-Type Channel -- The R-Type Channel -- From Ionic Currents to the Molecular Structure of Ca2+ Channels -- The cAMP-Mediated Enhancement of Cardiac L-Type Channels as First Example of Ca2+ Channel Modulation -- Early Observations on the GPCR-Mediated Inhibition of Neuronal Ca2+ Channels -- Towards a Full Understanding of the GPCR-Induced Delayed Activation of HVA Channels -- Looking Deeper to the Structure and Function of Cav2 Channels Modulation by G proteins -- Take-Home Message -- References -- Part I: Structural and Molecular Aspects of VGCCs -- Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels -- Introduction -- Purification and Biochemical Characterization of Skeletal Muscle Calcium Channels -- Structures of NaVAb and CaVAb Channels -- Structure of the Skeletal Muscle CaV1.1 Calcium Channel -- Molecular Properties of the CaV2 Family of Calcium Channels -- Structure of CaV2.2 Calcium Channels and Implications for Regulation -- Molecular Properties and Structure of CaV3 Calcium Channels -- Pharmacology of Calcium Channels -- Conclusion -- References.
Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels -- Generation of mRNA Diversity by A-to-I RNA Editing and Alternative Splicing -- Splice Variations in High Voltage-Activated Calcium Channels -- CaV1.1 Splice Variant in Myotonic Dystrophy -- CaV1.2 Splice Variants in Health and Disease -- Exon 9* in Cardiovascular Diseases -- Mutually Exclusive Exons 1a/1 and Exons 8a/8 -- Exons 21/22 -- Exon 33 and Exon 33L -- CaV1.3 in Health and Disease -- The Pathophysiological Roles of CaV1.3 -- The Unique Biophysical and Pharmacological Properties of CaV1.3 Channels and Modulation -- Regulation of α1D Transcripts by Alternative Splicing and A-to-I RNA Editing -- CaV1.4 in Health and Disease -- Structure-Function Relationship Learnt from Human Mutations and Alternative Splicing Patterns -- The CaV2 Channel Family -- Pathophysiological Roles of CaV2 Channel Family -- Alternative Splicing in CaV2 Channel Family -- Exon 37 -- Exon 43/44 -- Exon 47 -- Novel Approaches to Uncover the Pathophysiological Consequences of Alternative Splicing or Gene Mutations of Ion Channels: Moving Away from Heterologous Systems -- Summary -- References -- Voltage-Gated Calcium Channel Auxiliary β Subunits -- Physiological Roles of High-Voltage-Activated Calcium Channels -- Subunits of Voltage-Gated Calcium Channels -- Physiological Roles of CaVβ Subunits -- Functional Effects of CaVβ Subunits in HVACC Complexes -- CaVβ Regulation of HVACC Membrane Trafficking -- CaVβ Regulation of HVACC Activation Gating -- CaVβ Regulation of HVACC Open Probability -- CaVβ Regulation of HVACC Inactivation Gating -- Structure-Function of CaVβ Regulation of HVACCs -- CaVβ-Interacting Proteins That Regulate HVACCs -- Regulation of HVACCs by RGK Proteins -- Roles of CaVβ and Rad in Sympathetic Regulation of Cardiac CaV1.2 -- RIM-Binding Protein Regulation of HVACCs.
Association of CaVβ Subunits with Disease -- Pharmacological Targeting of CaVβ Subunits -- References -- Regulation of Calcium Channels and Synaptic Function by Auxiliary α2δ Subunits -- Introduction -- Discovery of α2δ Subunits -- Identification of α2δ Subunits -- Cloning -- Splice Variants -- Tissue Distribution of α2δ Subunits -- α2δ-1 -- α2δ-2 -- α2δ-3 -- α2δ-4 -- Structure of α2δ Subunits -- Biochemical and Bioinformatic Studies -- GPI Anchoring -- VWA Domain -- Cache Domains -- Proteolytic Maturation of α2δ -- Cachd1 Protein -- Molecular Structure of α2δ-1 -- Functions of α2δ Subunits as Calcium Channel Subunits -- Effects of Cloned α2δ Subunits on Calcium Currents -- Effects of α2δ Subunits on Biophysical Properties of Calcium Currents -- Effects of α2δ Subunits on Calcium Channel Trafficking -- Cachd1 Function -- Synaptic Functions of α2δ Proteins Beyond Their Role as Calcium Channel Subunits -- Importance of α2δ Proteins in Neuronal and Synaptic Functions -- Postsynaptic Functions of α2δ-1 -- Presynaptic and Trans-synaptic Roles of α2δ Proteins -- Diseases Associated with α2δ Subunits -- Ducky Mice and Human Mutations of the α2δ-2 Gene -- Mutations in the α2δ-1 Gene Associated with Cardiac Phenotypes -- Neuropathic Injury and the Role of α2δ-1 -- Disorders Associated with α2δ-3 -- Disorders Associated with α2δ-4 -- Psychiatric Disorders -- Pharmacology Involving α2δ Subunits -- Therapeutic Uses of Gabapentinoids -- Gabapentinoid Drug Binding to α2δ Subunits and Potential Mechanisms of Action -- The First Double Cache Domain in α2δ-1 Has Structural Homology to a Universal Amino Acid Binding Domain -- Effect of α2δ Subunits on Ziconotide Binding -- Other Interactions of α2δ Proteins -- Summary and Outlook -- References -- Voltage-Gated Calcium Channels in Invertebrates -- Introduction: Invertebrates and Calcium Channel Discovery.
Phylogenetic Properties of the CaV Channel α1 Subunit -- Phylogenetic Properties of the CaV Channel β Subunit -- Phylogenetic Properties of the CaV Channel α2δ Subunit -- CaV Channels in Deuterostome Invertebrates -- Since Hagiwara's Discovery of LVA and HVA Ca2+ Currents in Starfish Eggs -- Tunicates and the Evolution of CaV1.1 Channels and Ryanodine Receptor Tetrad Coupling -- CaV Channels in Protostome Invertebrates -- The Atypical Nature of Calcium Channels in Parasitic Flatworms -- Functional Studies of Calcium Channels of the Pond Snail Lymnaea Stagnalis -- Genetic Studies of Ecdysozoan β and α2δ Subunits Highlight Gene Duplication as a Mechanism for Functional Diversification and the Emergence of Pleiotropic Functions -- Genetic and Functional Studies of Ecdysozoan CaV1-CaV3 Channels Reveal Deep Conservation of C-Terminal Protein Interactions and Sub-cellular Localization -- CaV Channels in Early-Diverging Animals -- Cnidaria: Our Most Distant Neural Ancestors? -- Evolutionary Insights from Functional Studies of the Placozoan CaV1 to CaV3 Channels -- A Calcium Channel Regulates Choanocyte Ciliary Beating and the Feeding Current in Sponges -- Ctenophores -- Conclusions -- References -- Untitled -- Part II: Regulation of VGCCs -- Modulation of VGCCs by G-Protein Coupled Receptors and Their Second Messengers -- Introduction -- Modulation of Cav1 Channels by GPCRs and Second Messengers -- β-Adrenergic Modulation of L-Type Channels: Activation of the Gs Signaling Pathway -- Gq-Coupled GPCR Modulation of L-Type Channels -- Gi/o-Coupled GPCR Modulation of L-Type Channels -- GPCR-Mediated Modulation of Cav1.4 in the Retina -- Modulation of Cav2 Channels by GPCRs and Second Messengers -- Mechanisms Gi/o Mediated Inhibition: Fast, Direct, Voltage-Dependent -- Cav2 Channel Interaction Sites with Gβγ Subunits.
Gβγ and Cavβ Subunit Diversity and Interaction Sites with Cav2 Channels -- Modulation of G Protein-Mediated Inhibition by Synaptic Associated and Other Proteins -- Regulation of Cav2 Channels by Lipids -- Mechanisms of Gq/11-Mediated Inhibition: Slow, Indirect, Voltage-Independent -- Conclusion for Cav2 Channels -- Modulation of Cav3 Channels by GPCRs and Second Messengers -- Direct Modulation by Gβγ Subunits -- Modulation by Kinases -- Protein Kinase A -- Protein Kinase C -- Calmodulin-Dependent Kinase II -- Protein Kinase G -- Rho-Kinase -- Tyrosine Kinase -- GPCR-Mediated Change in T-Type Channel Expression -- Conclusion for T-Type Channels -- Summary -- References -- Trafficking of Neuronal Calcium Channels -- Introduction -- Regulation of VGCCs by Ancillary Subunits -- Cavβ-Subunit -- Cavα2δ-Subunit -- Cavγ-Subunit -- Regulation of VGCCs by Other Interacting Proteins -- Calmodulin -- Collapsin Response Mediator Proteins -- Stac Adaptor Proteins -- Kelch-like 1 -- Calnexin -- Secretory Carrier-Associated Membrane Proteins -- Receptor for Activated C kinase 1 -- Regulation of VGCCs by Posttranslational Modifications -- Ubiquitination -- Glycosylation -- Subcellular Targeting of VGCCs -- Concluding Remarks and Perspectives -- References -- Calmodulin Regulation of Voltage-Gated Calcium Channels -- Introduction -- Ca2+/CaM-Dependent Regulation of VGCCs -- Ca2+/CaM-Dependent Regulation Responds Differentially to Spatially Distinct Ca2+ Sources -- Molecular Mechanism of Calmodulation -- Ca2+ Regulation of VGCCs in Disease -- References -- Cav3 Calcium Channel Interactions with Potassium Channels -- Introduction -- Cav3-Kv4 Complex -- Cav3.2-IK Complex -- Cav3.2-BK Complex -- Perspectives and Conclusions -- References -- Part III: (Patho)physiology of VGCCs -- Voltage-Gated Ca2+ Channels. Lessons from Knockout and Knock-in Mice -- Introduction -- CaV1.
CaV1.1.
Record Nr. UNISA-996499863803316
Cham, Switzerland : , : Springer, , 2022
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