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Applications of microdialysis in pharmaceutical science / / edited by Tung-Hu Tsai
| Applications of microdialysis in pharmaceutical science / / edited by Tung-Hu Tsai |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2011 |
| Descrizione fisica | 1 online resource (585 p.) |
| Disciplina | 615/.19 |
| Altri autori (Persone) | TsaiTung-Hu |
| Soggetto topico |
Pharmaceutical chemistry
Drug development Brain microdialysis |
| ISBN |
9786613203779
9781283203777 1283203774 9781118011287 1118011287 9781118011294 1118011295 9781118011270 1118011279 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Chapter 1: Introduction to Applications of Microdialysis in Pharmaceutical Sciences. -- Chapter 2: Microdialysis in Drug Discovery. -- 1. Introduction. -- 2. Phases of Drug Development. -- 3. Role of Biomarkers in Drug Development. -- 4. Role of Pharmacokinetic-Pharmacodynamic Modeling in Drug Development. -- 5. Role of Microdialysis in Drug Development. -- 6. Current Applications and Perspective of Microdialysis Sampling for Drug Development of Specific Therapeutic Groups. -- 7. Regulary Aspects of Microdialysis Sampling in Drug Development. -- 8. Conclusions. -- Chapter 3: Analytical Considerations for Microdialysis Sampling. -- 1. Introduction. -- 2 Analytical Methodologies. -- Chapter 4: Monitoring Dopamine in the mesocorticolimbic and nigrostriatal systems by microdialysis: relevance for mood disorders and Parkinson's disease. -- 1. Introduction. -- 2. Pathophysiology of Serotonin-Dopamine Interaction: Implication for Mood Disorders. -- 3. Dopamine Depletion in the Nigrostriatal System: Parkinson'S Disease. -- 4. Conclusions. -- Chapter 5: Monitoring Neurotransmitter Amino Acids by Microdialysis: Pharmacodynamic Applications. -- 1. Introduction. -- 2. Monitoring neurotransmitter amino acids by microdialysis. -- 3. Basic Research on receptors. -- 4. Psychostimulants and addictive drugs. -- 5. Analgesia. -- 6. Ischemia/ anoxia. -- 7. Conclusion and perspectives. -- Chapter 6: Microdialysis as a tool to unravel neurobiological mechanisms of seizures and antiepileptic drug action. -- 1. Introduction. -- 2. Microdialysis to characterise the seizure-related neurobiological and metabolic changes in animal models and in humans. -- 3. Microdialysis as chemoconvulsant delivery tool in animal seizure models. -- 4. Microdialysis as an elegant tool to elucidate mechanisms of electrical brain stimulation and neuronal circuits involved in the generation and control of seizures. -- 5. Microdialysis to unravel the mechanisms of action of established antiepileptic drugs and new therapeutic strategies. -- 6. Microdialysis studies in search for mechanisms of adverse effects of clinically used drugs, drugs of abuse and toxins. -- 7. Combination of microdialysis with other complementary neurotechniques to unravel mechanisms of seizures and epilepsy. -- 8. The advantage of microdialysis to sample biophase levels of antiepileptic drugs and to monitor central neurotransmitters as pharmacodynamic markers for their anticonvulsant activity. -- 9. Microdialysis as a tool to study relationships between epilepsy and its comorbidities. -- Chapter 7: Microdialysis in lung: Monitoring of exogenous and endogenous compounds. -- 1. Introduction. -- 2. Special aspects associated with lung microdialysis compared to microdialysis in other tissues. -- 3. Insertion of microdialysis probes into lung tissue. -- 4. Insertion of microdialysis probes in the bronchial system. -- 5. Types of probes. -- 6. Endogenous compounds. -- 7. Exogenous drugs. -- 8. Animal data. -- 9. Clinical data. -- 10. Comparison of pharmacokinetic data in lung obtained by microdialysis and other techniques. -- 11. Predictability of lung concentrations by measurements in other tissues. -- Chapter 8: Microdialysis in the hepatobiliary system: Monitoring drug metabolism, hepatobiliary excretion and enterohepatic circulation. -- 1. Introduction. -- 2. Experimental considerations of pharmacokinetic studies. -- 3. Pharmacokinetic and hepatobiliary excretion studies employing microdialysis. -- 4. Conclusions. -- Chapter 9: Microdialysis on the metabolism of glucose, lactate and glycerol. -- 1. Introduction. -- 2. Glucose. -- 3. Lactate. -- 4. Lactate/pyruvate ratio. -- 5. Glycerol. -- Chapter 10: Clinical microdialysis in skin and soft tissues. -- 1. Introduction. -- 2. Tissue Bioavailability. -- 3. PK/PD Indices. -- 4. Topical Bioequivalence. -- 5. Endogenous Compounds. -- 6. Conclusion. -- Chapter 11: Microdialysis on Adipose Tissue: Monitoring Tissue Metabolism and Blood Flow in Humans. -- 1. Introduction. -- 2. Principle and Practical Considerations for Application of Microdialysis on Adipose Tissue. -- 3. Application of Microdialysis on Adipose Tissue in Humans. -- 4. Summary and Conclusions. -- Chapter 12: Microdialysis as a monitoring system for human diabetes. -- 1. Introduction. -- 2. Monitoring of the acute complications of diabetes. -- Chapter 13: Microdialysis in Tumors: Drug Disposition and Tumor Response. -- 1. Introduction. -- 2. Considerations of microdialysis as a sampling technique in oncology. -- 3. Experimental considerations. -- 4. Examples of using microdialysis techniques to characterize drug disposition in tumor. -- 5. Application of microdialysis in evaluation of tumor response to therapy. -- 6. Conclusions and future perspective. -- Chapter 14: Microdialysis versus imaging techniques for in vivo drug distribution measurements. -- 1. Introduction. -- 2. Microdialysis. -- 3. Imaging techniques. -- 4. Magnetic resonance imaging and magnetic resonance spectroscopy. -- 5. Positron Emission Tomography (PET). -- 6. Combination of Microdialysis and Imaging Techniques. -- 7. Summary and Conclusion. -- Chapter 15: In vitro applications of microdialysis. -- 1. Introduction. -- 2. Microdialysis applied in culture systems. -- 3. Microdialysis applied in enzyme kinetics. -- 4. Microdialysis applied in protein binding. -- 5. Conclusions. -- Chapter 16: Microdialysis in Drug-Drug Interaction. -- 1. Introduction. -- 2. Pharmacokinetic drug interaction. -- 3. Pharmacodynamic drug interaction. -- 4. Conclusions. -- Chapter 17. Microdialysis in environmental monitoring. -- 1. Introduction. -- 2. In-vivo sampling vis-à-vis in-situ sampling: Similarities and differences. -- 3. Critical parameters influencing relative recoveries. -- 4. Detection techniques. -- 5. Calibration methods. -- 6. Environmental applications of microdialysis. -- 7. Conclusions and future trends. |
| Record Nr. | UNINA-9910818321003321 |
| Hoboken, N.J., : Wiley, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microdialysis in drug development / / Markus Muller, editor
| Microdialysis in drug development / / Markus Muller, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Springer, 2013 |
| Descrizione fisica | 1 online resource (341 p.) |
| Disciplina |
615/.19
616.8/04754 |
| Altri autori (Persone) | MüllerMarkus <1967 August 23-> |
| Collana | AAPS advances in the pharmaceutical sciences series |
| Soggetto topico |
Drug development
Brain microdialysis |
| ISBN |
1-283-62448-6
9786613936936 1-4614-4815-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. General aspects -- pt. 2. Specific topics. |
| Record Nr. | UNINA-9910437827103321 |
| New York, : Springer, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
