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Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton
| Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
| Descrizione fisica | 1 online resource (156 pages) : color illustrations |
| Disciplina | 362.29 |
| Soggetto topico |
Brain - Effect of drugs on
Neuropharmacology Drugs - Physiological transport Blood-brain barrier |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-909453-97-8
1-909453-93-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910467801803321 |
| London, England : , : Future Science Ltd, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton
| Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
| Descrizione fisica | 1 online resource (156 pages) : color illustrations |
| Disciplina | 362.29 |
| Soggetto topico |
Brain - Effect of drugs on
Neuropharmacology Drugs - Physiological transport Blood-brain barrier |
| ISBN |
1-909453-97-8
1-909453-93-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910794873603321 |
| London, England : , : Future Science Ltd, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton
| Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
| Descrizione fisica | 1 online resource (156 pages) : color illustrations |
| Disciplina | 362.29 |
| Soggetto topico |
Brain - Effect of drugs on
Neuropharmacology Drugs - Physiological transport Blood-brain barrier |
| ISBN |
1-909453-97-8
1-909453-93-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910814283703321 |
| London, England : , : Future Science Ltd, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / / edited by Li Di, Edward H. Kerns
| Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / / edited by Li Di, Edward H. Kerns |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : John Wiley & Sons Inc., , [2015] |
| Descrizione fisica | 1 online resource (607 p.) |
| Disciplina | 615.7/8 |
| Soggetto topico |
Brain - Effect of drugs on
Blood-brain barrier |
| ISBN |
1-118-78852-4
1-118-78854-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Summary List of Chapters1. Overview/Introduction / Li Di (Pfizer Inc.), Edward H. Kerns (Pharmacokinetics of Brain Exposure)2. Pharmacokinetics of CNS penetration / Andreas Reichel (Bayer)3. Free Drug Hyposthesis for CNS Drug Candidates / Xingrong Liu (Genentech)4. Species Differences and impact of desease state on BBB / Jean-Marie Nicolas (UCB Pharma S.A.)Mechanisms of Drugs Across the Blood-Brain Barrier5. Passive diffusion permeability of the BBB - examples and SAR / Phil Jeffrey (GSK)6. Efflux transport at the BBB - examples and SAR / Jerome Hochman (Merck)7. Uptake transport at the BBB - examples and SAR / Zack Cheng (AstraZeneca)8. Uptake of proteins and antibodies at the BBB / William Pardridge (UCLA)Predicting and Measuring Brain Exposure of Drugs9. In silico tools for assessing brain exposure / Hongming Chen (AstraZeneca)10. In vitro assays for assessing BBB permeability - vascular cells, artificial membranes, brain slice, cell uptake / Winfried Neuhaus (University of Vienna)11. Human-based in vitro endothelial cell models / Eric Shusta (University of Wisconsin)12. In vitro assays for assessing brain binding / Li Di (Pfizer)13. In vivo studies of brain exposure / Edward H. Kerns14. PBPK models for BBB / Elizabeth de Lange (Leiden University)15. PK/PD modeling of CNS drug candidates / Johan Gabrielsson (Swedish University)16. Microdialysis to assess free drug concentration in brain / William Kielbasa (Lilly)17. Imaging technique for CNS drug discovery / Lei Zhang (Pfizer Inc.)Modulating Brain Penetration of Leads During Drug Discovery18. Designing CNS drugs for optimal brain exposure / Zoran Rankovic (Lilly)19. Case studies of CNS drug optimization - medicinal chemistry and CNS biology perspectives / Kevin J. Hodgetts (Harvard NeuroDiscovery Center)20. Designing peripheral drugs for minimal brain exposue / Peter Bungay (Pfizer)21. Case studies of non-CNS drugs to minimize brain penetration - Nonsudative antihistamines / Andrew Crowe (Curtin University)Case Studies in CNS Drug Discovery22. Case study 1 on discovery of a successful CNS drug - Fycompa (AMPA Receptor Antagonist) / Andrew Satlin and Antonio Laurenza (Eisai)23. Case study 2 on discovery of a successful CNS drug - Vortioxetine (Serotonin Modulator and Stimulator) / Benny Bang-Andersen (Lundbeck)Drug Delivery Techniques to CNS24. Brain delivery using nanotechnology / Xinguo Jiang (Fudan University)25. Intranasal delivery to CNS / Lisbeth Illum (University of Nottingham)Future Prospective in Blood Brain Barrier Advancement26. Conclusion Remarks / Joan Abbott (King's College). |
| Record Nr. | UNINA-9910132304003321 |
| Hoboken, New Jersey : , : John Wiley & Sons Inc., , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / / edited by Li Di, Edward H. Kerns
| Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / / edited by Li Di, Edward H. Kerns |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : John Wiley & Sons Inc., , [2015] |
| Descrizione fisica | 1 online resource (607 p.) |
| Disciplina | 615.7/8 |
| Soggetto topico |
Brain - Effect of drugs on
Blood-brain barrier |
| ISBN |
1-118-78852-4
1-118-78854-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Summary List of Chapters1. Overview/Introduction / Li Di (Pfizer Inc.), Edward H. Kerns (Pharmacokinetics of Brain Exposure)2. Pharmacokinetics of CNS penetration / Andreas Reichel (Bayer)3. Free Drug Hyposthesis for CNS Drug Candidates / Xingrong Liu (Genentech)4. Species Differences and impact of desease state on BBB / Jean-Marie Nicolas (UCB Pharma S.A.)Mechanisms of Drugs Across the Blood-Brain Barrier5. Passive diffusion permeability of the BBB - examples and SAR / Phil Jeffrey (GSK)6. Efflux transport at the BBB - examples and SAR / Jerome Hochman (Merck)7. Uptake transport at the BBB - examples and SAR / Zack Cheng (AstraZeneca)8. Uptake of proteins and antibodies at the BBB / William Pardridge (UCLA)Predicting and Measuring Brain Exposure of Drugs9. In silico tools for assessing brain exposure / Hongming Chen (AstraZeneca)10. In vitro assays for assessing BBB permeability - vascular cells, artificial membranes, brain slice, cell uptake / Winfried Neuhaus (University of Vienna)11. Human-based in vitro endothelial cell models / Eric Shusta (University of Wisconsin)12. In vitro assays for assessing brain binding / Li Di (Pfizer)13. In vivo studies of brain exposure / Edward H. Kerns14. PBPK models for BBB / Elizabeth de Lange (Leiden University)15. PK/PD modeling of CNS drug candidates / Johan Gabrielsson (Swedish University)16. Microdialysis to assess free drug concentration in brain / William Kielbasa (Lilly)17. Imaging technique for CNS drug discovery / Lei Zhang (Pfizer Inc.)Modulating Brain Penetration of Leads During Drug Discovery18. Designing CNS drugs for optimal brain exposure / Zoran Rankovic (Lilly)19. Case studies of CNS drug optimization - medicinal chemistry and CNS biology perspectives / Kevin J. Hodgetts (Harvard NeuroDiscovery Center)20. Designing peripheral drugs for minimal brain exposue / Peter Bungay (Pfizer)21. Case studies of non-CNS drugs to minimize brain penetration - Nonsudative antihistamines / Andrew Crowe (Curtin University)Case Studies in CNS Drug Discovery22. Case study 1 on discovery of a successful CNS drug - Fycompa (AMPA Receptor Antagonist) / Andrew Satlin and Antonio Laurenza (Eisai)23. Case study 2 on discovery of a successful CNS drug - Vortioxetine (Serotonin Modulator and Stimulator) / Benny Bang-Andersen (Lundbeck)Drug Delivery Techniques to CNS24. Brain delivery using nanotechnology / Xinguo Jiang (Fudan University)25. Intranasal delivery to CNS / Lisbeth Illum (University of Nottingham)Future Prospective in Blood Brain Barrier Advancement26. Conclusion Remarks / Joan Abbott (King's College). |
| Record Nr. | UNINA-9910829110403321 |
| Hoboken, New Jersey : , : John Wiley & Sons Inc., , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The brain's response to inhalants
| The brain's response to inhalants |
| Pubbl/distr/stampa | Rockville, MD : , : National Institute on Drug Abuse, National Institutes of Health, , 2006 |
| Descrizione fisica | 1 online resource (2 unnumbered pages) : color illustrations |
| Collana |
Mind over matter
NIH publication |
| Soggetto topico |
Inhalant abuse
Brain - Effect of drugs on |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910699062103321 |
| Rockville, MD : , : National Institute on Drug Abuse, National Institutes of Health, , 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The brain's response to methamphetamine
| The brain's response to methamphetamine |
| Pubbl/distr/stampa | Rockville, Md : , : National Institute on Drug Abuse, National Institutes of Health, , 2006 |
| Descrizione fisica | 1 online resource (2 unnumbered pages) : color illustrations |
| Collana |
Mind over matter
NIH publication |
| Soggetto topico |
Methamphetamine abuse
Brain - Effect of drugs on |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910699061903321 |
| Rockville, Md : , : National Institute on Drug Abuse, National Institutes of Health, , 2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The brain's response to nicotine
| The brain's response to nicotine |
| Pubbl/distr/stampa | Rockville, Md. : , : National Institute on Drug Abuse, National Institutes of Health, U.S. Dept. of Health and Human Services, , 1998 |
| Descrizione fisica | 1 online resource (2 unnumbered pages) : color illustrations |
| Collana |
NIH publication
Mind over matter |
| Soggetto topico |
Nicotine addiction
Brain - Effect of drugs on |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Mind over matter |
| Record Nr. | UNINA-9910699061103321 |
| Rockville, Md. : , : National Institute on Drug Abuse, National Institutes of Health, U.S. Dept. of Health and Human Services, , 1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The brain's response to prescription drugs
| The brain's response to prescription drugs |
| Pubbl/distr/stampa | [Rockville, Md.?] : , : National Institute on Drug Abuse, National Institutes of Health, U.S. Dept. of Health and Human Services, , [2009] |
| Descrizione fisica | 1 online resource (2 pages) : color illustrations |
| Collana |
Mind over matter
NIH publication |
| Soggetto topico |
Brain - Effect of drugs on
Medication abuse - Prevention Drugs - Physiological effect Youth - Drug use - Prevention |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910699308903321 |
| [Rockville, Md.?] : , : National Institute on Drug Abuse, National Institutes of Health, U.S. Dept. of Health and Human Services, , [2009] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Las drogas, el cerebro y el comportamiento : la ciencia de la adicción
| Las drogas, el cerebro y el comportamiento : la ciencia de la adicción |
| Pubbl/distr/stampa | [Rockville, Md.] : , : National Insitute on Drug Abuse, Departamento de Salud y Servicios Humanos de los Estados Unidos, Institutos Nacionales de la Salud |
| Descrizione fisica | 1 online resource (volumes) |
| Collana | NIH publications |
| Soggetto topico |
Brain - Effect of drugs on
Drug abuse |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | spa |
| Altri titoli varianti | Drugs, brains, and behavior |
| Record Nr. | UNINA-9910714248603321 |
| [Rockville, Md.] : , : National Insitute on Drug Abuse, Departamento de Salud y Servicios Humanos de los Estados Unidos, Institutos Nacionales de la Salud | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
