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Bone morphogenetic protein and collagen [[electronic resource] ] : an advances in tissue banking specialist publication / / editor, Glyn O. Phillips
| Bone morphogenetic protein and collagen [[electronic resource] ] : an advances in tissue banking specialist publication / / editor, Glyn O. Phillips |
| Pubbl/distr/stampa | River Edge, NJ, : World Scientific, c2003 |
| Descrizione fisica | 1 online resource (169 p.) |
| Disciplina | 612.75 |
| Altri autori (Persone) | PhillipsGlyn O |
| Collana | Series in allografts in bone healing |
| Soggetto topico |
Bone morphogenetic proteins
Collagen |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-93570-0
9786611935702 981-279-529-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONTENTS ; Introduction to the Series ; Preface ; List of Contributors ; Chapter 1 From Bone Allografts to Synthetic Bone Grafts: Bone Morphogenetic Proteins and Osteoinduction ; 1. Introduction ; 2. Bone Morphogenesis is a Cascade
3. Purification Cloning and Expression of Recombinant BMPs 4. BMPs and Chondrogenesis and Cartilage Maintenance ; 5. BMPs: Pleiotropy and Thresholds ; 6. BMP Receptors and Smads ; 7. BMPs: Clinical Applications ; 8. Acknowledgements ; 9. References Chapter 2 The Osteoinductive Properties of Demineralised Bone Matrix Grafts 1. Introduction ; 2. Factors Affecting the Osteoinductivity of DBM Grafts ; 3. Cellular Effects of DBM Grafts ; 4. The BMPs ; 5. DBM Grafts in Clinical Use ; 6. Assays For DBM Activity ; 7. References Chapter 3 Processing Factors Contributing To Production Of Maximally Osteoinductive Demineralised Ground Bone For Use In Orthopaedic Or Periodontal Applications 1. Introduction ; 2. Cleaning of Bone ; 3. Demineralization of Bone ; 4. Determination of Osteoinductive Potential of Bone 5. Summary and Conclusions 6. References ; Chapter 4 Clinical Effectiveness of Demineralised Bone Matrix Assayed in Human Cell Culture ; 1. Introduction ; 2. Material and Methods ; 3. Results ; 4. Discussion ; 5. Acknowledgement ; 6. References Chapter 5 The Influence of Sterilisation on the Osteoinductive Properties of Bone in Rat Bone Marrow Cell Culture |
| Record Nr. | UNINA-9910454281503321 |
| River Edge, NJ, : World Scientific, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bone morphogenetic protein and collagen [[electronic resource] ] : an advances in tissue banking specialist publication / / editor, Glyn O. Phillips
| Bone morphogenetic protein and collagen [[electronic resource] ] : an advances in tissue banking specialist publication / / editor, Glyn O. Phillips |
| Pubbl/distr/stampa | River Edge, NJ, : World Scientific, c2003 |
| Descrizione fisica | 1 online resource (169 p.) |
| Disciplina | 612.75 |
| Altri autori (Persone) | PhillipsGlyn O |
| Collana | Series in allografts in bone healing |
| Soggetto topico |
Bone morphogenetic proteins
Collagen |
| ISBN |
1-281-93570-0
9786611935702 981-279-529-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CONTENTS ; Introduction to the Series ; Preface ; List of Contributors ; Chapter 1 From Bone Allografts to Synthetic Bone Grafts: Bone Morphogenetic Proteins and Osteoinduction ; 1. Introduction ; 2. Bone Morphogenesis is a Cascade
3. Purification Cloning and Expression of Recombinant BMPs 4. BMPs and Chondrogenesis and Cartilage Maintenance ; 5. BMPs: Pleiotropy and Thresholds ; 6. BMP Receptors and Smads ; 7. BMPs: Clinical Applications ; 8. Acknowledgements ; 9. References Chapter 2 The Osteoinductive Properties of Demineralised Bone Matrix Grafts 1. Introduction ; 2. Factors Affecting the Osteoinductivity of DBM Grafts ; 3. Cellular Effects of DBM Grafts ; 4. The BMPs ; 5. DBM Grafts in Clinical Use ; 6. Assays For DBM Activity ; 7. References Chapter 3 Processing Factors Contributing To Production Of Maximally Osteoinductive Demineralised Ground Bone For Use In Orthopaedic Or Periodontal Applications 1. Introduction ; 2. Cleaning of Bone ; 3. Demineralization of Bone ; 4. Determination of Osteoinductive Potential of Bone 5. Summary and Conclusions 6. References ; Chapter 4 Clinical Effectiveness of Demineralised Bone Matrix Assayed in Human Cell Culture ; 1. Introduction ; 2. Material and Methods ; 3. Results ; 4. Discussion ; 5. Acknowledgement ; 6. References Chapter 5 The Influence of Sterilisation on the Osteoinductive Properties of Bone in Rat Bone Marrow Cell Culture |
| Record Nr. | UNINA-9910782116903321 |
| River Edge, NJ, : World Scientific, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bone morphogenetic proteins [[electronic resource] ] : from local to systemic therapeutics / / Slobodan Vukicevic, Kuber T. Sampath, editors
| Bone morphogenetic proteins [[electronic resource] ] : from local to systemic therapeutics / / Slobodan Vukicevic, Kuber T. Sampath, editors |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | Basel ; ; Boston, : Birkhäuser, c2008 |
| Descrizione fisica | 1 online resource (348 p.) |
| Disciplina |
612.75
616.7/1061 |
| Altri autori (Persone) |
VukicevicSlobodan <1951->
SampathKuber T |
| Collana | Progress in inflammation research |
| Soggetto topico |
Bone morphogenetic proteins
Bone morphogenetic proteins - Therapeutic use |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-86256-8
9786611862565 3-7643-8552-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results -- Use of recombinant human BMP-2 in orthopedic trauma -- The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects -- Clinical outcomes using rhBMP-2 in spinal fusion applications -- Bone morphogenetic protein signaling is fine-tuned on multiple levels -- Dissection of bone morphogenetic protein signaling using genome-engineering tools -- Alterations of BMP signaling pathway(s) in skeletal diseases -- Signaling cross-talk by bone morphogenetic proteins -- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development -- The role of bone morphogenetic protein 4 (BMP-4) in tooth development -- Bone morphogenetic protein antagonists and kidney -- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins -- Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation -- Bone morphogenetic proteins in cartilage biology -- Systemic administration of bone morphogenetic proteins. |
| Record Nr. | UNINA-9910451688703321 |
| Basel ; ; Boston, : Birkhäuser, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bone morphogenetic proteins [[electronic resource] ] : from local to systemic therapeutics / / Slobodan Vukicevic, Kuber T. Sampath, editors
| Bone morphogenetic proteins [[electronic resource] ] : from local to systemic therapeutics / / Slobodan Vukicevic, Kuber T. Sampath, editors |
| Edizione | [1st ed. 2008.] |
| Pubbl/distr/stampa | Basel ; ; Boston, : Birkhäuser, c2008 |
| Descrizione fisica | 1 online resource (348 p.) |
| Disciplina |
612.75
616.7/1061 |
| Altri autori (Persone) |
VukicevicSlobodan <1951->
SampathKuber T |
| Collana | Progress in inflammation research |
| Soggetto topico |
Bone morphogenetic proteins
Bone morphogenetic proteins - Therapeutic use |
| ISBN |
1-281-86256-8
9786611862565 3-7643-8552-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results -- Use of recombinant human BMP-2 in orthopedic trauma -- The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects -- Clinical outcomes using rhBMP-2 in spinal fusion applications -- Bone morphogenetic protein signaling is fine-tuned on multiple levels -- Dissection of bone morphogenetic protein signaling using genome-engineering tools -- Alterations of BMP signaling pathway(s) in skeletal diseases -- Signaling cross-talk by bone morphogenetic proteins -- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development -- The role of bone morphogenetic protein 4 (BMP-4) in tooth development -- Bone morphogenetic protein antagonists and kidney -- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins -- Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation -- Bone morphogenetic proteins in cartilage biology -- Systemic administration of bone morphogenetic proteins. |
| Record Nr. | UNINA-9910782099303321 |
| Basel ; ; Boston, : Birkhäuser, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California
| Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, MA : , : Elsevier, , 2015 |
| Descrizione fisica | 1 online resource (367 p.) |
| Disciplina | 612.75 |
| Collana | Vitamins and Hormones |
| Soggetto topico | Bone morphogenetic proteins |
| Soggetto genere / forma | Electronic books. |
| ISBN | 0-12-802592-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity
6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation 3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors 4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud 5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References Chapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc... |
| Record Nr. | UNINA-9910461143403321 |
| Waltham, MA : , : Elsevier, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California
| Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, MA : , : Elsevier, , 2015 |
| Descrizione fisica | 1 online resource (367 p.) |
| Disciplina | 612.75 |
| Collana | Vitamins and Hormones |
| Soggetto topico | Bone morphogenetic proteins |
| ISBN | 0-12-802592-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity
6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation 3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors 4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud 5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References Chapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc... |
| Record Nr. | UNINA-9910797425103321 |
| Waltham, MA : , : Elsevier, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California
| Bone morphogenic protein / / series editor Gerald Litwack, PhD, Toluca Lake, North Hollywood, California |
| Edizione | [First edition.] |
| Pubbl/distr/stampa | Waltham, MA : , : Elsevier, , 2015 |
| Descrizione fisica | 1 online resource (367 p.) |
| Disciplina | 612.75 |
| Collana | Vitamins and Hormones |
| Soggetto topico | Bone morphogenetic proteins |
| ISBN | 0-12-802592-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Bone Morphogenic Protein; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Mechanisms of BMP-Receptor Interaction and Activation; 1. Evolutionary Expansion and Diversification of the Transforming Growth Factor β Superfamily; 2. Phylogenetic Analysis Reveals Four Functional Subfamilies for TGFβ Ligands; 3. Expression as Protease-Activated Proproteins and a Cystine-Knot Motif in the C-Terminal Mature Region as Key Features ...; 4. TGFβ Receptor Activation and Its Downstream Signaling Cascade; 5. Too Few Receptors for Too Many Ligands Lead to Promiscuity
6. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Multiple Hot Spots of Binding7. Molecular Mechanisms to Ensure Ligand-Receptor Promiscuity and Specificity: The Concept of Structural Adaptability; 8. Consequences of Promiscuity and Specificity in the TGFβ Superfamily: Conclusions; References; Chapter Two: The Bone Morphogenetic Proteins and Their Antagonists; 1. Bone Morphogenetic Proteins; 2. BMP Antagonist Proteins; 2.1. Chordin Family; 2.2. Follistatin and Follistatin-Like Proteins; 2.3. Noggin; 2.4. Twisted Gastrulation 3. Cerberus and Dan Family BMP Antagonists3.1. Cerberus; 3.2. Coco; 3.3. Dan; 3.4. Gremlin; 3.5. PRDC/Gremlin 2; 3.6. Sclerostin; 3.7. USAG-1/Wise; 4. BMP-Antagonists Binding to Heparin/HS; References; Chapter Three: BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic K ...; 1. Introduction; 2. The TGF-β/BMP Protein Superfamily; 3. The BMP-7 Protein; 4. TGF-β/BMP Signaling Pathways; 4.1. SMAD-Dependent Mechanisms for TGF-β/BMP Signaling; 4.1.1. Ligand Binding and Receptor Activation; 4.1.2. Activation of SMAD Transcription Factors 4.1.3. Heterodimerization and Nuclear Translocation of SMAD Transcription Factors4.1.4. SMAD-Dependent Regulation of Transcription; 4.2. SMAD-Independent Mechanisms for TGF-β/BMP Signaling; 4.3. Key Regulatory Steps in TGF-β/BMP Signaling; 4.3.1. Ligand Expression; 4.3.2. Ligand Availability; 4.3.3. Receptor Activation; 4.3.4. SMAD Activation; 4.3.5. Formation of Transcription Factor Complexes; 5. The Role of BMP-7 in Kidney Development; 5.1. Effects of BMP-7 Genetic Ablation on Development; 5.2. Functions of BMP-7 in the Metanephric Mesenchyme; 5.3. Functions of BMP-7 in the Ureteric Bud 5.4. Functions of BMP-7 in Stromal Cell Populations6. BMP-7, Congenital Renal Abnormalities, and Pediatric Kidney Disease; 7. The Role of BMP-7 in the Pathogenesis of CKD; 7.1. Therapeutic Effects of Recombinant BMP-7 in Models of CKD; 7.2. Renal Protective Mechanisms of Recombinant BMP-7; 7.2.1. Inhibition of Renal Fibrosis; 7.2.2. Other Important Renal Protective Mechanisms; 8. A Model for the Role of Endogenous BMP-7 in Regulating the Responses to Renal Injury; 9. Clinical Implications for BMP-7 in Patients with CKD; Acknowledgments; References Chapter Four: The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vasc... |
| Record Nr. | UNINA-9910820372003321 |
| Waltham, MA : , : Elsevier, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
