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Advanced Blood-Brain Barrier Drug Delivery / / edited by William M Pardridge
| Advanced Blood-Brain Barrier Drug Delivery / / edited by William M Pardridge |
| Pubbl/distr/stampa | [Place of publication not identified] : , : MDPI AG, , 2023 |
| Descrizione fisica | 1 online resource (496 pages) |
| Disciplina | 612.824 |
| Soggetto topico | Blood-brain barrier |
| ISBN | 3-0365-6416-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910647220103321 |
| [Place of publication not identified] : , : MDPI AG, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton
| Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
| Descrizione fisica | 1 online resource (156 pages) : color illustrations |
| Disciplina | 362.29 |
| Soggetto topico |
Brain - Effect of drugs on
Neuropharmacology Drugs - Physiological transport Blood-brain barrier |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-909453-97-8
1-909453-93-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910467801803321 |
| London, England : , : Future Science Ltd, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton
| Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
| Descrizione fisica | 1 online resource (156 pages) : color illustrations |
| Disciplina | 362.29 |
| Soggetto topico |
Brain - Effect of drugs on
Neuropharmacology Drugs - Physiological transport Blood-brain barrier |
| ISBN |
1-909453-97-8
1-909453-93-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910794873603321 |
| London, England : , : Future Science Ltd, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton
| Advances in non-invasive drug delivery to the brain / / editor, Richard Egleton |
| Pubbl/distr/stampa | London, England : , : Future Science Ltd, , 2015 |
| Descrizione fisica | 1 online resource (156 pages) : color illustrations |
| Disciplina | 362.29 |
| Soggetto topico |
Brain - Effect of drugs on
Neuropharmacology Drugs - Physiological transport Blood-brain barrier |
| ISBN |
1-909453-97-8
1-909453-93-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910814283703321 |
| London, England : , : Future Science Ltd, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The blood-brain barrier [[electronic resource] ] : new research / / Pedro A. Montenegro and Stefanee M. Juárez, editors
| The blood-brain barrier [[electronic resource] ] : new research / / Pedro A. Montenegro and Stefanee M. Juárez, editors |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, c2012 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 573.8621 |
| Altri autori (Persone) |
MontenegroPedro A
JuárezStefanee M |
| Collana |
Neuroscience research progress
Neurology--laboratory and clinical research developments |
| Soggetto topico | Blood-brain barrier |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-62100-812-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Local and temporal regulation of the blood-brain barrier during normal and altered physiological states / Beatriz Gómez-González, Gabriela Hurtado-Alvarado, Javier Velázquez-Moctezuma -- Angiogenesis and its mechanistic implications in the pathology of neurodegenerative disorders / Aditiben Patel ... [et al.] -- It takes two to tango : protein-protein interactions in the translocation of pathogens across blood-brain barrier / L. Pulzova ... [et al.] -- Efflux-transporters at the blood-brain barrier : therapeutic opportunities / Alan Talevi ... [et al.] -- Novel strategies to restore blood brain barrier integrity after brain injury / Winfried Neuhaus ... [et al.] -- Evaluation of the blood-cerebrospinal fluid barrier in neurological diseases / Alina González-Quevedo ... [et al.] -- Blood-brain barrier in health and disease / Inês Palmela, Dora Brites, Maria Alexandra Brito -- HIV-1 gp120 induces blood-brain barrier abnormalities : pathophysiology and therapeutic consequences / Jean-Pierre Louboutin, David S. Strayer -- Blood brain barrier in hepatic encephalopathy / Cuiming Sun, Pei Liu -- Blood-brain barrier (BBB) : morphology and disease / L. Colin-Barenque ... [et al.]. |
| Record Nr. | UNINA-9910453771803321 |
| Hauppauge, N.Y., : Nova Science Publishers, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The blood-brain barrier [[electronic resource] ] : new research / / Pedro A. Montenegro and Stefanee M. Juárez, editors
| The blood-brain barrier [[electronic resource] ] : new research / / Pedro A. Montenegro and Stefanee M. Juárez, editors |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, c2012 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 573.8621 |
| Altri autori (Persone) |
MontenegroPedro A
JuárezStefanee M |
| Collana |
Neuroscience research progress
Neurology--laboratory and clinical research developments |
| Soggetto topico | Blood-brain barrier |
| ISBN | 1-62100-812-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Local and temporal regulation of the blood-brain barrier during normal and altered physiological states / Beatriz Gómez-González, Gabriela Hurtado-Alvarado, Javier Velázquez-Moctezuma -- Angiogenesis and its mechanistic implications in the pathology of neurodegenerative disorders / Aditiben Patel ... [et al.] -- It takes two to tango : protein-protein interactions in the translocation of pathogens across blood-brain barrier / L. Pulzova ... [et al.] -- Efflux-transporters at the blood-brain barrier : therapeutic opportunities / Alan Talevi ... [et al.] -- Novel strategies to restore blood brain barrier integrity after brain injury / Winfried Neuhaus ... [et al.] -- Evaluation of the blood-cerebrospinal fluid barrier in neurological diseases / Alina González-Quevedo ... [et al.] -- Blood-brain barrier in health and disease / Inês Palmela, Dora Brites, Maria Alexandra Brito -- HIV-1 gp120 induces blood-brain barrier abnormalities : pathophysiology and therapeutic consequences / Jean-Pierre Louboutin, David S. Strayer -- Blood brain barrier in hepatic encephalopathy / Cuiming Sun, Pei Liu -- Blood-brain barrier (BBB) : morphology and disease / L. Colin-Barenque ... [et al.]. |
| Record Nr. | UNINA-9910779793303321 |
| Hauppauge, N.Y., : Nova Science Publishers, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The blood-brain barrier [[electronic resource] ] : new research / / Pedro A. Montenegro and Stefanee M. Juárez, editors
| The blood-brain barrier [[electronic resource] ] : new research / / Pedro A. Montenegro and Stefanee M. Juárez, editors |
| Pubbl/distr/stampa | Hauppauge, N.Y., : Nova Science Publishers, c2012 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 573.8621 |
| Altri autori (Persone) |
MontenegroPedro A
JuárezStefanee M |
| Collana |
Neuroscience research progress
Neurology--laboratory and clinical research developments |
| Soggetto topico | Blood-brain barrier |
| ISBN | 1-62100-812-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Local and temporal regulation of the blood-brain barrier during normal and altered physiological states / Beatriz Gómez-González, Gabriela Hurtado-Alvarado, Javier Velázquez-Moctezuma -- Angiogenesis and its mechanistic implications in the pathology of neurodegenerative disorders / Aditiben Patel ... [et al.] -- It takes two to tango : protein-protein interactions in the translocation of pathogens across blood-brain barrier / L. Pulzova ... [et al.] -- Efflux-transporters at the blood-brain barrier : therapeutic opportunities / Alan Talevi ... [et al.] -- Novel strategies to restore blood brain barrier integrity after brain injury / Winfried Neuhaus ... [et al.] -- Evaluation of the blood-cerebrospinal fluid barrier in neurological diseases / Alina González-Quevedo ... [et al.] -- Blood-brain barrier in health and disease / Inês Palmela, Dora Brites, Maria Alexandra Brito -- HIV-1 gp120 induces blood-brain barrier abnormalities : pathophysiology and therapeutic consequences / Jean-Pierre Louboutin, David S. Strayer -- Blood brain barrier in hepatic encephalopathy / Cuiming Sun, Pei Liu -- Blood-brain barrier (BBB) : morphology and disease / L. Colin-Barenque ... [et al.]. |
| Record Nr. | UNINA-9910825977903321 |
| Hauppauge, N.Y., : Nova Science Publishers, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / / edited by Li Di, Edward H. Kerns
| Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / / edited by Li Di, Edward H. Kerns |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : John Wiley & Sons Inc., , [2015] |
| Descrizione fisica | 1 online resource (607 p.) |
| Disciplina | 615.7/8 |
| Soggetto topico |
Brain - Effect of drugs on
Blood-brain barrier |
| ISBN |
1-118-78852-4
1-118-78854-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Summary List of Chapters1. Overview/Introduction / Li Di (Pfizer Inc.), Edward H. Kerns (Pharmacokinetics of Brain Exposure)2. Pharmacokinetics of CNS penetration / Andreas Reichel (Bayer)3. Free Drug Hyposthesis for CNS Drug Candidates / Xingrong Liu (Genentech)4. Species Differences and impact of desease state on BBB / Jean-Marie Nicolas (UCB Pharma S.A.)Mechanisms of Drugs Across the Blood-Brain Barrier5. Passive diffusion permeability of the BBB - examples and SAR / Phil Jeffrey (GSK)6. Efflux transport at the BBB - examples and SAR / Jerome Hochman (Merck)7. Uptake transport at the BBB - examples and SAR / Zack Cheng (AstraZeneca)8. Uptake of proteins and antibodies at the BBB / William Pardridge (UCLA)Predicting and Measuring Brain Exposure of Drugs9. In silico tools for assessing brain exposure / Hongming Chen (AstraZeneca)10. In vitro assays for assessing BBB permeability - vascular cells, artificial membranes, brain slice, cell uptake / Winfried Neuhaus (University of Vienna)11. Human-based in vitro endothelial cell models / Eric Shusta (University of Wisconsin)12. In vitro assays for assessing brain binding / Li Di (Pfizer)13. In vivo studies of brain exposure / Edward H. Kerns14. PBPK models for BBB / Elizabeth de Lange (Leiden University)15. PK/PD modeling of CNS drug candidates / Johan Gabrielsson (Swedish University)16. Microdialysis to assess free drug concentration in brain / William Kielbasa (Lilly)17. Imaging technique for CNS drug discovery / Lei Zhang (Pfizer Inc.)Modulating Brain Penetration of Leads During Drug Discovery18. Designing CNS drugs for optimal brain exposure / Zoran Rankovic (Lilly)19. Case studies of CNS drug optimization - medicinal chemistry and CNS biology perspectives / Kevin J. Hodgetts (Harvard NeuroDiscovery Center)20. Designing peripheral drugs for minimal brain exposue / Peter Bungay (Pfizer)21. Case studies of non-CNS drugs to minimize brain penetration - Nonsudative antihistamines / Andrew Crowe (Curtin University)Case Studies in CNS Drug Discovery22. Case study 1 on discovery of a successful CNS drug - Fycompa (AMPA Receptor Antagonist) / Andrew Satlin and Antonio Laurenza (Eisai)23. Case study 2 on discovery of a successful CNS drug - Vortioxetine (Serotonin Modulator and Stimulator) / Benny Bang-Andersen (Lundbeck)Drug Delivery Techniques to CNS24. Brain delivery using nanotechnology / Xinguo Jiang (Fudan University)25. Intranasal delivery to CNS / Lisbeth Illum (University of Nottingham)Future Prospective in Blood Brain Barrier Advancement26. Conclusion Remarks / Joan Abbott (King's College). |
| Record Nr. | UNINA-9910132304003321 |
| Hoboken, New Jersey : , : John Wiley & Sons Inc., , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / / edited by Li Di, Edward H. Kerns
| Blood-brain barrier in drug discovery : optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / / edited by Li Di, Edward H. Kerns |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : John Wiley & Sons Inc., , [2015] |
| Descrizione fisica | 1 online resource (607 p.) |
| Disciplina | 615.7/8 |
| Soggetto topico |
Brain - Effect of drugs on
Blood-brain barrier |
| ISBN |
1-118-78852-4
1-118-78854-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Summary List of Chapters1. Overview/Introduction / Li Di (Pfizer Inc.), Edward H. Kerns (Pharmacokinetics of Brain Exposure)2. Pharmacokinetics of CNS penetration / Andreas Reichel (Bayer)3. Free Drug Hyposthesis for CNS Drug Candidates / Xingrong Liu (Genentech)4. Species Differences and impact of desease state on BBB / Jean-Marie Nicolas (UCB Pharma S.A.)Mechanisms of Drugs Across the Blood-Brain Barrier5. Passive diffusion permeability of the BBB - examples and SAR / Phil Jeffrey (GSK)6. Efflux transport at the BBB - examples and SAR / Jerome Hochman (Merck)7. Uptake transport at the BBB - examples and SAR / Zack Cheng (AstraZeneca)8. Uptake of proteins and antibodies at the BBB / William Pardridge (UCLA)Predicting and Measuring Brain Exposure of Drugs9. In silico tools for assessing brain exposure / Hongming Chen (AstraZeneca)10. In vitro assays for assessing BBB permeability - vascular cells, artificial membranes, brain slice, cell uptake / Winfried Neuhaus (University of Vienna)11. Human-based in vitro endothelial cell models / Eric Shusta (University of Wisconsin)12. In vitro assays for assessing brain binding / Li Di (Pfizer)13. In vivo studies of brain exposure / Edward H. Kerns14. PBPK models for BBB / Elizabeth de Lange (Leiden University)15. PK/PD modeling of CNS drug candidates / Johan Gabrielsson (Swedish University)16. Microdialysis to assess free drug concentration in brain / William Kielbasa (Lilly)17. Imaging technique for CNS drug discovery / Lei Zhang (Pfizer Inc.)Modulating Brain Penetration of Leads During Drug Discovery18. Designing CNS drugs for optimal brain exposure / Zoran Rankovic (Lilly)19. Case studies of CNS drug optimization - medicinal chemistry and CNS biology perspectives / Kevin J. Hodgetts (Harvard NeuroDiscovery Center)20. Designing peripheral drugs for minimal brain exposue / Peter Bungay (Pfizer)21. Case studies of non-CNS drugs to minimize brain penetration - Nonsudative antihistamines / Andrew Crowe (Curtin University)Case Studies in CNS Drug Discovery22. Case study 1 on discovery of a successful CNS drug - Fycompa (AMPA Receptor Antagonist) / Andrew Satlin and Antonio Laurenza (Eisai)23. Case study 2 on discovery of a successful CNS drug - Vortioxetine (Serotonin Modulator and Stimulator) / Benny Bang-Andersen (Lundbeck)Drug Delivery Techniques to CNS24. Brain delivery using nanotechnology / Xinguo Jiang (Fudan University)25. Intranasal delivery to CNS / Lisbeth Illum (University of Nottingham)Future Prospective in Blood Brain Barrier Advancement26. Conclusion Remarks / Joan Abbott (King's College). |
| Record Nr. | UNINA-9910829110403321 |
| Hoboken, New Jersey : , : John Wiley & Sons Inc., , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The blood-brain barrier in health and disease / / William G. Mayhan, Denise M. Arrick
| The blood-brain barrier in health and disease / / William G. Mayhan, Denise M. Arrick |
| Autore | Mayhan William G. |
| Pubbl/distr/stampa | [San Rafael, California] : , : Morgan & Claypool Life Sciences, , 2017 |
| Descrizione fisica | 1 online resource (77 pages) : illustrations (some color) |
| Disciplina | 612.824 |
| Collana | Colloquium Series on Integrated Systems Physiology: From Molecule to Function |
| Soggetto topico |
Blood-brain barrier
Blood-brain barrier disorders |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-61504-740-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
1. Introduction --
2. Characteristics of the blood-brain barrier -- 2.1 Development of the blood-brain barrier -- 2.2 Endothelial transport systems -- 3. Ultrastructural components of the blood-brain barrier -- 3.1 Tight junctional proteins -- 3.1.1 Occludin -- 3.1.2 Claudin -- 3.1.3 Junctional adhesion molecule -- 3.1.4 Accessory proteins -- 3.2 Adherens junctions -- 4. Cellular components of the blood-brain barrier -- 4.1 Astrocytes -- 4.2 Pericytes -- 4.3 Neurons -- 4.4 Microglia -- 5. Compromising the blood-brain barrier -- 5.1 Site of disruption of the blood-brain-barrier -- 5.2 Seizures/acute hypertension -- 5.3 Neuroinflammatory diseases -- 5.4 Diabetes -- 5.5 Traumatic brain injury -- 5.6 Cerebral ischemia/stroke -- 6. Summary -- References -- About the authors. |
| Record Nr. | UNINA-9910156411503321 |
Mayhan William G.
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| [San Rafael, California] : , : Morgan & Claypool Life Sciences, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
