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Consultative Hemostasis and Thrombosis / / Editors, Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, David A. Garcia
| Consultative Hemostasis and Thrombosis / / Editors, Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, David A. Garcia |
| Edizione | [Fourth ed.] |
| Pubbl/distr/stampa | Philadelphia, PA : , : Elsevier, , 2018, ©2019 |
| Descrizione fisica | 1 online resource (xvi, 869 pages : color illustrations |
| Collana | ClinicalKey |
| Soggetto topico |
Blood coagulation disorders
Anticoagulants (Medicine) Blood platelet disorders Fibrinolytic agents Hemostasis - Physiological aspects Thrombosis - Pathophysiology Blood Coagulation Disorders Thrombosis - pathology Blood Platelet Disorders Hemostasis - physiology Fibrinolytic Agents - therapeutic use Anticoagulants - therapeutic use |
| ISBN | 0-323-47785-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part 1: Hemorrhagic processes. Consultative process -- An approach to the bleeding patient: correlation of clinical symptoms and signs with laboratory testing -- Hemophilia A and B -- Less common congenital disorders of hemostasis -- Acquired coagulation disorders due to inhibitors -- von Willebrand disease -- General aspects of thrombocytopenia, platelet transfusions, and thrombopoietic growth factors -- Primary immune thrombocytopenia -- Congenital and acquired disorders of platelet function and number -- Purpura and other hematovascular disorders -- HHT -- Disseminated intravascular coagulation -- The cross-talk of inflammation and coagulation in infectious disease and their roles in disseminated intravascular coagulation -- Part 2: Thrombotic processes. Thrombophilia: clinical and laboratory assessment and management -- Pediatric aspects of thrombophilia -- Deep vein thrombosis, pulmonary embolism and primary pulmonary hypertension -- Venous thromboses at unusual sites -- The post thrombotic syndrome -- Thrombocytosis: essential thrombocytemia and reactive causes -- Antiphospholipid syndrome -- Antiplatelet treatment in cardiovascular medicine -- Non-arteriosclerotic arterial occlusive disease -- Thrombosis and cancer -- Thrombotic thrombocytopenic purpura -- Hemostatic disorders of complement activation (PNH and aHUS) -- Heparin-induced thrombocytopenia -- Part 3: Therapeutic agents. Antithrombotic agents -- Blood component and pharmacological agents -- Therapeutic apheresis: applications for hemorrhagic & thrombotic disorders -- Vena caval filters -- Part 4: Issues specific to women. Thrombotic risk of contraceptives and other hormonal therapies -- Bleeding and the management of hemorrhagic disorders in pregnancy -- Thrombophilia in pregnancy -- Part 5: Special issues. Surgery and hemostasis -- Anticoagulation in the perioperative period -- Understanding and managing the coagulopathy of liver disease -- Outpatient anticoagulant therapy -- Hematologic interventions for acute central nervous system disease -- Pending: atrial septal abnormalities and cryptogenic stroke -- Hemorrhage control and thrombosis following severe injury -- Hemostatic aspects of sickle cell disease |
| Record Nr. | UNINA-9910899900003321 |
| Philadelphia, PA : , : Elsevier, , 2018, ©2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets [[electronic resource] /] / editor, Alan D. Michelson
| Platelets [[electronic resource] /] / editor, Alan D. Michelson |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (1398 p.) |
| Disciplina |
612.1
612.1/17 612.117 |
| Altri autori (Persone) | MichelsonAlan D |
| Soggetto topico |
Blood platelets
Blood platelet disorders |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-70649-0
0-12-387838-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Platelets; Copyright Page; Contents; List of Contributors; Preface; Foreword: A Brief History of Ideas About Platelets in Health and Disease; I. The Role of Platelets in Human Hemostasis, Platelet Transfusion, and the Bleeding Time; II. Immune Thrombocytopenia; III. Alloantigens, Single Nucleotide Polymorphisms, and Alloimmune Thrombocytopenias; IV. Platelet Physiology, Assays of Platelet "Adhesiveness", ADP, Platelet Aggregation, Myocardial Infarction, and P2Y12 Anta...
V. Aspirin, Arachidonic Acid, Prostaglandins, Gpiib-iiia, Nitric Oxide, Endothelial Gpiib-iiia, and AngiogenesisVI. Clot Retraction, Glanzmann Thrombasthenia, GPIIb-IIIa Receptor, and GPIIb-IIIa Antagonists; VII. Bernard-Soulier Syndrome, the Gpib-IX-V Complex, von Willebrand Factor, Shear, ADAMTS-13, and Thrombotic Thrombocytopen...; VIII. Thrombin-induced Platelet Activation; IX. Platelets and Metastases; X. Reflections on the Past and Thoughts About the Future; Reference List; I. Platelet Biology; 1 The Evolution of Mammalian Platelets; I Introduction; II Invertebrates III Nonmammalian VertebratesIV Comparative Hemostasis; V A Comparison of Human Platelets and Limulus Amebocytes; VI The Evolution of Hemostasis and Blood Coagulation; VII Megakaryocytes and Mammals; A Marine Mammals; B Order Monotremata; C Order Marsupialia; D Platelet Levels; E A Comparison of Nonplacental and Placental Mammals; VIII Conclusions; Acknowledgments; References; 2 Megakaryocyte Development and Platelet Formation; I Introduction; II Megakaryocyte Development; A The Hematopoietic Program; B Committed Megakaryocyte Progenitor Cells; C Immediate Megakaryocyte Precursors D Endomitosis and Polyploid Formation E Megakaryocyte Cytoplasmic Maturation; 1 Demarcation Membrane System; 2 Dense Tubular System; 3 Granules; III Platelet Formation; A Mechanisms of Platelet Production; 1 Budding from the Megakaryocyte Surface; 2 Cytoplasmic Fragmentation via the Demarcation Membrane System; 3 Proplatelet Formation; a The Proplatelet Theory; b Proplatelet Morphogenesis; c The Cytoskeletal Mechanics of Proplatelet Formation; i Microtubules Power Proplatelet Elongation; ii Actin-Dependent Proplatelet Branching; iii Organelle Transport in Proplatelets iv Spectrin-Based Membrane Skeleton in Platelet Production v Release of Platelets; B The Sites of Platelet Formation In Vivo; 1 Platelet Formation in the Bone Marrow; 2 Platelet Formation in the Bloodstream; 3 Platelet Formation in the Lung; C Apoptosis and Platelet Production; D Production of Platelets for Infusion; IV Regulation of Megakaryocyte Development and Platelet Formation; V Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; A Transcription Factors; 1 GATA-1; 2 Nuclear Factor-Erythroid 2; B Cytoskeletal Proteins; 1 β1 Tubulin 2 Glycoprotein Ib-IX-V Complex |
| Record Nr. | UNINA-9910462043403321 |
| Amsterdam, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets [[electronic resource] /] / editor, Alan D. Michelson
| Platelets [[electronic resource] /] / editor, Alan D. Michelson |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (1398 p.) |
| Disciplina |
612.1
612.1/17 612.117 |
| Altri autori (Persone) | MichelsonAlan D |
| Soggetto topico |
Blood platelets
Blood platelet disorders |
| ISBN |
1-283-70649-0
0-12-387838-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Platelets; Copyright Page; Contents; List of Contributors; Preface; Foreword: A Brief History of Ideas About Platelets in Health and Disease; I. The Role of Platelets in Human Hemostasis, Platelet Transfusion, and the Bleeding Time; II. Immune Thrombocytopenia; III. Alloantigens, Single Nucleotide Polymorphisms, and Alloimmune Thrombocytopenias; IV. Platelet Physiology, Assays of Platelet "Adhesiveness", ADP, Platelet Aggregation, Myocardial Infarction, and P2Y12 Anta...
V. Aspirin, Arachidonic Acid, Prostaglandins, Gpiib-iiia, Nitric Oxide, Endothelial Gpiib-iiia, and AngiogenesisVI. Clot Retraction, Glanzmann Thrombasthenia, GPIIb-IIIa Receptor, and GPIIb-IIIa Antagonists; VII. Bernard-Soulier Syndrome, the Gpib-IX-V Complex, von Willebrand Factor, Shear, ADAMTS-13, and Thrombotic Thrombocytopen...; VIII. Thrombin-induced Platelet Activation; IX. Platelets and Metastases; X. Reflections on the Past and Thoughts About the Future; Reference List; I. Platelet Biology; 1 The Evolution of Mammalian Platelets; I Introduction; II Invertebrates III Nonmammalian VertebratesIV Comparative Hemostasis; V A Comparison of Human Platelets and Limulus Amebocytes; VI The Evolution of Hemostasis and Blood Coagulation; VII Megakaryocytes and Mammals; A Marine Mammals; B Order Monotremata; C Order Marsupialia; D Platelet Levels; E A Comparison of Nonplacental and Placental Mammals; VIII Conclusions; Acknowledgments; References; 2 Megakaryocyte Development and Platelet Formation; I Introduction; II Megakaryocyte Development; A The Hematopoietic Program; B Committed Megakaryocyte Progenitor Cells; C Immediate Megakaryocyte Precursors D Endomitosis and Polyploid Formation E Megakaryocyte Cytoplasmic Maturation; 1 Demarcation Membrane System; 2 Dense Tubular System; 3 Granules; III Platelet Formation; A Mechanisms of Platelet Production; 1 Budding from the Megakaryocyte Surface; 2 Cytoplasmic Fragmentation via the Demarcation Membrane System; 3 Proplatelet Formation; a The Proplatelet Theory; b Proplatelet Morphogenesis; c The Cytoskeletal Mechanics of Proplatelet Formation; i Microtubules Power Proplatelet Elongation; ii Actin-Dependent Proplatelet Branching; iii Organelle Transport in Proplatelets iv Spectrin-Based Membrane Skeleton in Platelet Production v Release of Platelets; B The Sites of Platelet Formation In Vivo; 1 Platelet Formation in the Bone Marrow; 2 Platelet Formation in the Bloodstream; 3 Platelet Formation in the Lung; C Apoptosis and Platelet Production; D Production of Platelets for Infusion; IV Regulation of Megakaryocyte Development and Platelet Formation; V Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; A Transcription Factors; 1 GATA-1; 2 Nuclear Factor-Erythroid 2; B Cytoskeletal Proteins; 1 β1 Tubulin 2 Glycoprotein Ib-IX-V Complex |
| Record Nr. | UNINA-9910785961803321 |
| Amsterdam, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets / / editor, Alan D. Michelson
| Platelets / / editor, Alan D. Michelson |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (1398 p.) |
| Disciplina |
612.1
612.1/17 612.117 |
| Altri autori (Persone) | MichelsonAlan D |
| Soggetto topico |
Blood platelets
Blood platelet disorders |
| ISBN |
1-283-70649-0
0-12-387838-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Platelets; Copyright Page; Contents; List of Contributors; Preface; Foreword: A Brief History of Ideas About Platelets in Health and Disease; I. The Role of Platelets in Human Hemostasis, Platelet Transfusion, and the Bleeding Time; II. Immune Thrombocytopenia; III. Alloantigens, Single Nucleotide Polymorphisms, and Alloimmune Thrombocytopenias; IV. Platelet Physiology, Assays of Platelet "Adhesiveness", ADP, Platelet Aggregation, Myocardial Infarction, and P2Y12 Anta...
V. Aspirin, Arachidonic Acid, Prostaglandins, Gpiib-iiia, Nitric Oxide, Endothelial Gpiib-iiia, and AngiogenesisVI. Clot Retraction, Glanzmann Thrombasthenia, GPIIb-IIIa Receptor, and GPIIb-IIIa Antagonists; VII. Bernard-Soulier Syndrome, the Gpib-IX-V Complex, von Willebrand Factor, Shear, ADAMTS-13, and Thrombotic Thrombocytopen...; VIII. Thrombin-induced Platelet Activation; IX. Platelets and Metastases; X. Reflections on the Past and Thoughts About the Future; Reference List; I. Platelet Biology; 1 The Evolution of Mammalian Platelets; I Introduction; II Invertebrates III Nonmammalian VertebratesIV Comparative Hemostasis; V A Comparison of Human Platelets and Limulus Amebocytes; VI The Evolution of Hemostasis and Blood Coagulation; VII Megakaryocytes and Mammals; A Marine Mammals; B Order Monotremata; C Order Marsupialia; D Platelet Levels; E A Comparison of Nonplacental and Placental Mammals; VIII Conclusions; Acknowledgments; References; 2 Megakaryocyte Development and Platelet Formation; I Introduction; II Megakaryocyte Development; A The Hematopoietic Program; B Committed Megakaryocyte Progenitor Cells; C Immediate Megakaryocyte Precursors D Endomitosis and Polyploid Formation E Megakaryocyte Cytoplasmic Maturation; 1 Demarcation Membrane System; 2 Dense Tubular System; 3 Granules; III Platelet Formation; A Mechanisms of Platelet Production; 1 Budding from the Megakaryocyte Surface; 2 Cytoplasmic Fragmentation via the Demarcation Membrane System; 3 Proplatelet Formation; a The Proplatelet Theory; b Proplatelet Morphogenesis; c The Cytoskeletal Mechanics of Proplatelet Formation; i Microtubules Power Proplatelet Elongation; ii Actin-Dependent Proplatelet Branching; iii Organelle Transport in Proplatelets iv Spectrin-Based Membrane Skeleton in Platelet Production v Release of Platelets; B The Sites of Platelet Formation In Vivo; 1 Platelet Formation in the Bone Marrow; 2 Platelet Formation in the Bloodstream; 3 Platelet Formation in the Lung; C Apoptosis and Platelet Production; D Production of Platelets for Infusion; IV Regulation of Megakaryocyte Development and Platelet Formation; V Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; A Transcription Factors; 1 GATA-1; 2 Nuclear Factor-Erythroid 2; B Cytoskeletal Proteins; 1 β1 Tubulin 2 Glycoprotein Ib-IX-V Complex |
| Record Nr. | UNINA-9910826844503321 |
| Amsterdam, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets [[electronic resource] /] / editor, Alan D. Michelson
| Platelets [[electronic resource] /] / editor, Alan D. Michelson |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier Academic Press, c2007 |
| Descrizione fisica | 1 online resource (1386 p.) |
| Disciplina |
611.0185
612.17 |
| Altri autori (Persone) | MichelsonAlan D |
| Soggetto topico |
Blood platelets
Blood platelet disorders |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-70758-5
9786610707584 0-08-046586-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; PLATELETS; Copyright page; Table of contents; Contributors; Preface; Foreword: A Brief History of Ideas about Platelets in Health and Disease; Part One: Platelet Biology; CHAPTER 1: The Evolution of Mammalian Platelets; I. Introduction; II. Invertebrates; III. Nonmammalian Vertebrates; IV. Comparative Hemostasis; V. A Comparison of Human Platelets and Limulus Amebocytes; VI. The Evolution of Hemostasis and Blood Coagulation; VII. Megakaryocytes and Mammals; VIII. Conclusions; Acknowledgment; References; CHAPTER 2: Megakaryocyte Development and Platelet Formation; I. Introduction
II. Megakaryocyte Development III. Platelet Formation; IV. Regulation of Megakaryocyte Development and Platelet Formation; V. Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; References; CHAPTER 3: Platelet Structure; I. Introduction; II. Peripheral Zone; III. The Sol-Gel Zone; IV. Organelle Zone; V. Platelet Membrane Systems; References; CHAPTER 4: The Platelet Cytoskeleton; I. Introduction; II. The Structure of the Resting Platelet; III. The Cytoskeleton of the Resting Platelet; IV. The Structure of the Activated Platelet; V. Signals Activating Actin Assembly VI. Membrane Dynamics and Actin Filament Turnover in Platelets VII. Platelet Contraction; VIII. Diseases of the Platelet Cytoskeleton; References; CHAPTER 5: Platelet Genomics and Proteomics; I. Introduction; II. Platelet Genomics; III. Platelet Proteomics; IV. Overview and Future Directions; Acknowledgment; References; CHAPTER 6: Platelet Receptors; I. Introduction; II. Integrins; III. Leucine-Rich Repeat (LRR) Family; IV. Seven Transmembrane Receptors; V. Immunoglobulin Superfamily; VI. C-Type Lectin Receptor Family; VII. Tetraspanins VIII. Glycosyl Phosphatidylinositol (GPI)-Anchored Proteins IX. Glycosaminoglycan-Carrying Receptors; X. Tyrosine Kinase Receptors; XI. Miscellaneous Platelet Membrane Glycoproteins; Acknowledgment; References; CHAPTER 7: The Glycoprotein Ib-IX-V Complex; I. Introduction/Structure; II. Function; III. Signaling; IV. The End of the Beginning; References; CHAPTER 8: Integrin a IIbb3; I. Introduction; II. aIIbb3 as an Integrin and a Platelet Protein; III. Structure of aIIbb3; IV. "Inside-Out" Signaling and aIIbb3 Activation; V. Conclusion; References; CHAPTER 9: Thrombin Receptors I. IntroductionII. Cellular Actions of Thrombin; III. Role of PARs in Disease; IV. Molecular and Developmental Genetics of PARs; V. Thrombin Signaling in Platelets; VI. Development of PAR Inhibitors; References; CHAPTER 10: The Platelet P2 Receptors; I. Introduction; II. Roles of Adenine Nucleotides in Platelet Function; III. P2Y1; IV. P2Y12; V. P2X1; VI. Interplay between the Platelet P2 Receptors; VII. Desensitization of the Platelet P2 Receptors; VIII. Conclusions; References; CHAPTER 11: PECAM-1; I. Introduction; II. PECAM-1 Genomic Organization and Protein Domain Structure III. Expression and Adhesive Properties of the Extracellular Domain |
| Record Nr. | UNINA-9910458953703321 |
| Amsterdam, : Elsevier Academic Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets [[electronic resource] /] / editor, Alan D. Michelson
| Platelets [[electronic resource] /] / editor, Alan D. Michelson |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier Academic Press, c2007 |
| Descrizione fisica | 1 online resource (1386 p.) |
| Disciplina |
611.0185
612.17 |
| Altri autori (Persone) | MichelsonAlan D |
| Soggetto topico |
Blood platelets
Blood platelet disorders |
| ISBN |
1-280-70758-5
9786610707584 0-08-046586-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; PLATELETS; Copyright page; Table of contents; Contributors; Preface; Foreword: A Brief History of Ideas about Platelets in Health and Disease; Part One: Platelet Biology; CHAPTER 1: The Evolution of Mammalian Platelets; I. Introduction; II. Invertebrates; III. Nonmammalian Vertebrates; IV. Comparative Hemostasis; V. A Comparison of Human Platelets and Limulus Amebocytes; VI. The Evolution of Hemostasis and Blood Coagulation; VII. Megakaryocytes and Mammals; VIII. Conclusions; Acknowledgment; References; CHAPTER 2: Megakaryocyte Development and Platelet Formation; I. Introduction
II. Megakaryocyte Development III. Platelet Formation; IV. Regulation of Megakaryocyte Development and Platelet Formation; V. Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; References; CHAPTER 3: Platelet Structure; I. Introduction; II. Peripheral Zone; III. The Sol-Gel Zone; IV. Organelle Zone; V. Platelet Membrane Systems; References; CHAPTER 4: The Platelet Cytoskeleton; I. Introduction; II. The Structure of the Resting Platelet; III. The Cytoskeleton of the Resting Platelet; IV. The Structure of the Activated Platelet; V. Signals Activating Actin Assembly VI. Membrane Dynamics and Actin Filament Turnover in Platelets VII. Platelet Contraction; VIII. Diseases of the Platelet Cytoskeleton; References; CHAPTER 5: Platelet Genomics and Proteomics; I. Introduction; II. Platelet Genomics; III. Platelet Proteomics; IV. Overview and Future Directions; Acknowledgment; References; CHAPTER 6: Platelet Receptors; I. Introduction; II. Integrins; III. Leucine-Rich Repeat (LRR) Family; IV. Seven Transmembrane Receptors; V. Immunoglobulin Superfamily; VI. C-Type Lectin Receptor Family; VII. Tetraspanins VIII. Glycosyl Phosphatidylinositol (GPI)-Anchored Proteins IX. Glycosaminoglycan-Carrying Receptors; X. Tyrosine Kinase Receptors; XI. Miscellaneous Platelet Membrane Glycoproteins; Acknowledgment; References; CHAPTER 7: The Glycoprotein Ib-IX-V Complex; I. Introduction/Structure; II. Function; III. Signaling; IV. The End of the Beginning; References; CHAPTER 8: Integrin a IIbb3; I. Introduction; II. aIIbb3 as an Integrin and a Platelet Protein; III. Structure of aIIbb3; IV. "Inside-Out" Signaling and aIIbb3 Activation; V. Conclusion; References; CHAPTER 9: Thrombin Receptors I. IntroductionII. Cellular Actions of Thrombin; III. Role of PARs in Disease; IV. Molecular and Developmental Genetics of PARs; V. Thrombin Signaling in Platelets; VI. Development of PAR Inhibitors; References; CHAPTER 10: The Platelet P2 Receptors; I. Introduction; II. Roles of Adenine Nucleotides in Platelet Function; III. P2Y1; IV. P2Y12; V. P2X1; VI. Interplay between the Platelet P2 Receptors; VII. Desensitization of the Platelet P2 Receptors; VIII. Conclusions; References; CHAPTER 11: PECAM-1; I. Introduction; II. PECAM-1 Genomic Organization and Protein Domain Structure III. Expression and Adhesive Properties of the Extracellular Domain |
| Record Nr. | UNINA-9910784648503321 |
| Amsterdam, : Elsevier Academic Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets / / editor, Alan D. Michelson
| Platelets / / editor, Alan D. Michelson |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier Academic Press, c2007 |
| Descrizione fisica | 1 online resource (1386 p.) |
| Disciplina |
611.0185
612.17 |
| Altri autori (Persone) | MichelsonAlan D |
| Soggetto topico |
Blood platelets
Blood platelet disorders |
| ISBN |
1-280-70758-5
9786610707584 0-08-046586-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front cover; PLATELETS; Copyright page; Table of contents; Contributors; Preface; Foreword: A Brief History of Ideas about Platelets in Health and Disease; Part One: Platelet Biology; CHAPTER 1: The Evolution of Mammalian Platelets; I. Introduction; II. Invertebrates; III. Nonmammalian Vertebrates; IV. Comparative Hemostasis; V. A Comparison of Human Platelets and Limulus Amebocytes; VI. The Evolution of Hemostasis and Blood Coagulation; VII. Megakaryocytes and Mammals; VIII. Conclusions; Acknowledgment; References; CHAPTER 2: Megakaryocyte Development and Platelet Formation; I. Introduction
II. Megakaryocyte Development III. Platelet Formation; IV. Regulation of Megakaryocyte Development and Platelet Formation; V. Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; References; CHAPTER 3: Platelet Structure; I. Introduction; II. Peripheral Zone; III. The Sol-Gel Zone; IV. Organelle Zone; V. Platelet Membrane Systems; References; CHAPTER 4: The Platelet Cytoskeleton; I. Introduction; II. The Structure of the Resting Platelet; III. The Cytoskeleton of the Resting Platelet; IV. The Structure of the Activated Platelet; V. Signals Activating Actin Assembly VI. Membrane Dynamics and Actin Filament Turnover in Platelets VII. Platelet Contraction; VIII. Diseases of the Platelet Cytoskeleton; References; CHAPTER 5: Platelet Genomics and Proteomics; I. Introduction; II. Platelet Genomics; III. Platelet Proteomics; IV. Overview and Future Directions; Acknowledgment; References; CHAPTER 6: Platelet Receptors; I. Introduction; II. Integrins; III. Leucine-Rich Repeat (LRR) Family; IV. Seven Transmembrane Receptors; V. Immunoglobulin Superfamily; VI. C-Type Lectin Receptor Family; VII. Tetraspanins VIII. Glycosyl Phosphatidylinositol (GPI)-Anchored Proteins IX. Glycosaminoglycan-Carrying Receptors; X. Tyrosine Kinase Receptors; XI. Miscellaneous Platelet Membrane Glycoproteins; Acknowledgment; References; CHAPTER 7: The Glycoprotein Ib-IX-V Complex; I. Introduction/Structure; II. Function; III. Signaling; IV. The End of the Beginning; References; CHAPTER 8: Integrin a IIbb3; I. Introduction; II. aIIbb3 as an Integrin and a Platelet Protein; III. Structure of aIIbb3; IV. "Inside-Out" Signaling and aIIbb3 Activation; V. Conclusion; References; CHAPTER 9: Thrombin Receptors I. IntroductionII. Cellular Actions of Thrombin; III. Role of PARs in Disease; IV. Molecular and Developmental Genetics of PARs; V. Thrombin Signaling in Platelets; VI. Development of PAR Inhibitors; References; CHAPTER 10: The Platelet P2 Receptors; I. Introduction; II. Roles of Adenine Nucleotides in Platelet Function; III. P2Y1; IV. P2Y12; V. P2X1; VI. Interplay between the Platelet P2 Receptors; VII. Desensitization of the Platelet P2 Receptors; VIII. Conclusions; References; CHAPTER 11: PECAM-1; I. Introduction; II. PECAM-1 Genomic Organization and Protein Domain Structure III. Expression and Adhesive Properties of the Extracellular Domain |
| Record Nr. | UNINA-9910819757903321 |
| Amsterdam, : Elsevier Academic Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets in thrombotic and non-thrombotic disorders : pathophysiology, pharmacology and therapeutics / / edited by Paolo Gresele [and others] [[electronic resource]]
| Platelets in thrombotic and non-thrombotic disorders : pathophysiology, pharmacology and therapeutics / / edited by Paolo Gresele [and others] [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2002 |
| Descrizione fisica | 1 online resource (xxii, 1101 pages) : digital, PDF file(s) |
| Disciplina | 616.1/5 |
| Soggetto topico |
Blood platelet disorders
Blood platelets - Receptors Blood platelets - Aggregation |
| ISBN |
1-107-13072-7
1-280-17783-7 9786610177837 0-511-11948-8 1-139-14718-8 0-511-06353-9 0-511-05720-2 0-511-54528-2 0-511-30828-0 0-511-07199-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; Part I Physiology; Part II Methodology; Part III Pathology A Hemostasis; Part III B Thrombosis; Part III C Non-hemostatic disorders; Part IV Pharmacology; Part V Therapy; Afterword Platelets: a personal story; Index |
| Altri titoli varianti | Platelets in Thrombotic & Non-Thrombotic Disorders |
| Record Nr. | UNINA-9910450063103321 |
| Cambridge : , : Cambridge University Press, , 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets in thrombotic and non-thrombotic disorders : pathophysiology, pharmacology and therapeutics / / edited by Paolo Gresele [and others] [[electronic resource]]
| Platelets in thrombotic and non-thrombotic disorders : pathophysiology, pharmacology and therapeutics / / edited by Paolo Gresele [and others] [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2002 |
| Descrizione fisica | 1 online resource (xxii, 1101 pages) : digital, PDF file(s) |
| Disciplina | 616.1/5 |
| Soggetto topico |
Blood platelet disorders
Blood platelets - Receptors Blood platelets - Aggregation |
| ISBN |
1-107-13072-7
1-280-17783-7 9786610177837 0-511-11948-8 1-139-14718-8 0-511-06353-9 0-511-05720-2 0-511-54528-2 0-511-30828-0 0-511-07199-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; Part I Physiology; Part II Methodology; Part III Pathology A Hemostasis; Part III B Thrombosis; Part III C Non-hemostatic disorders; Part IV Pharmacology; Part V Therapy; Afterword Platelets: a personal story; Index |
| Altri titoli varianti | Platelets in Thrombotic & Non-Thrombotic Disorders |
| Record Nr. | UNINA-9910783573103321 |
| Cambridge : , : Cambridge University Press, , 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets in thrombotic and non-thrombotic disorders : pathophysiology, pharmacology and therapeutics / / edited by Paolo Gresele ... [et al.]
| Platelets in thrombotic and non-thrombotic disorders : pathophysiology, pharmacology and therapeutics / / edited by Paolo Gresele ... [et al.] |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cambridge, U.K. ; ; New York, : Cambridge University Press, 2002 |
| Descrizione fisica | 1 online resource (xxii, 1101 pages) : digital, PDF file(s) |
| Disciplina | 616.1/5 |
| Altri autori (Persone) | GreselePaolo <1953-> |
| Soggetto topico |
Blood platelet disorders
Blood platelets - Receptors Blood platelets - Aggregation |
| ISBN |
1-107-13072-7
1-280-17783-7 9786610177837 0-511-11948-8 1-139-14718-8 0-511-06353-9 0-511-05720-2 0-511-54528-2 0-511-30828-0 0-511-07199-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; Half-title; Title; Copyright; Contents; Contributors; Preface; Part I Physiology; Part II Methodology; Part III Pathology A Hemostasis; Part III B Thrombosis; Part III C Non-hemostatic disorders; Part IV Pharmacology; Part V Therapy; Afterword Platelets: a personal story; Index |
| Record Nr. | UNINA-9910811835703321 |
| Cambridge, U.K. ; ; New York, : Cambridge University Press, 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
